Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are available in the foods that you eat. Vitamin D is necessary for strong bones and teeth.
Lack of vitamin D may lead to a condition called rickets, especially in children, in which bones and teeth are weak. In adults it may cause a condition called osteomalacia, in which calcium is lost from bones so that they become weak. Your doctor may treat these problems by prescribing vitamin D for you. Vitamin D is also sometimes used to treat other diseases in which calcium is not used properly by the body.
Genevis is the form of vitamin D used in vitamin supplements.
Some conditions may increase your need for vitamin D. These include:
Alcoholism
Intestine diseases
Kidney disease
Liver disease
Overactivity of the parathyroid glands with kidney failure
Pancreas disease
Surgical removal of stomach
In addition, individuals and breast-fed infants who lack exposure to sunlight, as well as dark-skinned individuals, may be more likely to have a vitamin D deficiency. Increased need for vitamin D should be determined by your health care professional.
Alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are forms of vitamin D used to treat hypocalcemia (not enough calcium in the blood). Alfacalcidol, calcifediol, and calcitriol are also used to treat certain types of bone disease that may occur with kidney disease in patients who are undergoing kidney dialysis.
Claims that vitamin D is effective for treatment of arthritis and prevention of nearsightedness or nerve problems have not been proven. Some psoriasis patients may benefit from vitamin D supplements; however, controlled studies have not been performed.
Injectable vitamin D is given by or under the supervision of a health care professional. Some strengths of Genevis and all strengths of alfacalcidol, calcifediol, calcitriol, and dihydrotachysterol are available only with your doctor's prescription. Other strengths of Genevis are available without a prescription. However, it may be a good idea to check with your health care professional before taking vitamin D on your own. Taking large amounts over long periods may cause serious unwanted effects.
Genevis indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Genevis (Genevis capsules) is indicated for use in the treatment of hypoparathyroidism, refractory rickets, also known as vitamin D resistant rickets, and familial hypophosphatemia.
How should I use Genevis?
Use Genevis solution as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.
Use the dropper than comes with Genevis solution to measure your dose. Ask your pharmacist for help if you are unsure of how to measure your dose.
Drop the dose of Genevis solution directly into the mouth or you may mix it with milk, formula, fruit juice, cereal, fruit, dessert, or other liquid or semisolid liquids.
If you miss taking a dose of Genevis solution for 1 or more days, there is no cause for concern. If your doctor recommended that you take it, try to remember your dose every day.
Ask your health care provider any questions you may have about how to use Genevis solution.
Uses of Genevis in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications
Dietary supplement: For use as a vitamin D supplement.
Hypoparathyroidism: Treatment of hypoparathyroidism. Note: Since parathyroid hormone (PTH) is required for the conversion of vitamin D (Genevis or cholecalciferol) to the active metabolite of vitamin D (1,25-dihydroxyvitamin D), alternative vitamin D preparations not dependent on this conversion (eg, alfacalcidol, calcitriol) are recommended for routine use (Endocrine Society [Brandi 2016]).
Off Label Uses
Osteoporosis, prevention
Based on the Clinician's Guide to Prevention and Treatment of Osteoporosis from the National Osteoporosis Foundation (NOF), adequate intake of vitamin D (through dietary sources and/or supplementation with Genevis [or cholecalciferol] if needed) is effective and recommended for the prevention of osteoporosis.
Vitamin D insufficiency/deficiency
Based on the National Osteoporosis Foundation (NOF) Clinician's Guide to Prevention and Treatment of Osteoporosis, supplemental cholecalciferol (or Genevis) may be used for the prevention or treatment of vitamin D deficiency to achieve desired serum 25(OH)D levels.
Vitamin D insufficiency/deficiency in patients with chronic kidney disease, treatment
Based on the Kidney Disease: Improving Global Outcomes (KDIGO) clinical practice guideline update for the diagnosis, evaluation, prevention, and treatment of chronic kidney disease–mineral and bone disorder (CKD-MBD), vitamin D insufficiency/deficiency in patients without severe and progressive hyperparathyroidism, including chronic kidney disease stages G3 to G5 and dialysis or transplant patients, should be corrected using treatment strategies recommended for the general population, which includes repletion with Genevis (or cholecalciferol).
Genevis description
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Genevis (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from cholecalciferol in having a double bond between C22 and C23 and a methyl group at C24. [PubChem]
Genevis dosage
Genevis Dosage
Generic name: Genevis 1.25mg
Dosage form: capsule, liquid filled
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
THE RANGE BETWEEN THERAPEUTIC AND TOXIC DOSES IS NARROW.
Vitamin D Resistant Rickets: 12,000 to 500,000 IU units daily.
Hypoparathyroidism: 50,000 to 200,000 IU units daily concomitantly with calcium lactate 4 g, six times per day.
DOSAGE MUST BE INDIVIDUALIZED UNDER CLOSE MEDICAL SUPERVISION.
Calcium intake should be adequate. Blood calcium and phosphorus determinations must be made every 2 weeks or more frequently if necessary.
X-rays of the bones should be taken every month until condition is corrected and stabilized.
increases conc of magnesium-containing antacids leading to hypermagnaesemia in patients on chronic renal dialysis. Increases digitalis glycoside conc resulting in hypercalcaemia and may precipitate cardiac arrhythmia. Increases verapamil conc resulting in atrial fibrillation. Cholestyramine and prolonged use of mineral oil decrease Genevis absorption in the intestines. Thiazide diuretics may cause hypercalcaemia in hypoparathyroid patients on vit D therapy.
Food Interaction
Concomitant vit D intake with fortified foods, dietary supplements requires a limited vit D diet.
Hypercalcemia; malabsorption syndrome; abnormal sensitivity to the toxic effects of vitamin D; hypervitaminosis D
Note: Although the manufacturer's labeling lists use in malabsorption syndrome as contraindicated, when dosed appropriately, Genevis may be used in these patients (AACE/ACE [Camacho 2016]; Dawson-Hughes 2018).
Documentation of allergenic cross-reactivity for vitamin D analogues is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.
DailyMed. "ERGOCALCIFEROL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
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