Hydrocortisone Dosage

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How do you administer this medicine?

Dosage of Hydrocortisone in details

infoThe dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient. Let us see what a dose of Hydrocortisone drug for various conditions is.

Usual Adult Dose for Adrenocortical Insufficiency:

Acute Adrenal Gland Failure:

100 mg IV bolus, then 300 mg/day in divided doses every 8 hours or as a continuous infusion for 48 hours. When patient stable, change to oral, 50 mg every 8 hours for 6 doses, then taper to 30 - 50 mg/day.

Usual Adult Dose for Anti-inflammatory:

Oral,

Intramuscular or

Intravenous: 15 to 240 mg/day.

Usual Adult Dose for Shock:

200 mg per day by continuous intravenous infusion

Comment:

Recommendations from the International Guidelines for Management of Severe Sepsis and Septic Shock 2012:

-Do not use intravenous hydrocortisone if adequate fluid resuscitation and vasopressor therapy restore hemodynamic stability

-Use hydrocortisone alone

-Do not administer for sepsis in the absence of shock

-Do not use ACTH stimulation test to identify adults with septic shock requiring hydrocortisone

-Use continuous infusion rather than repetitive bolus injections

-Taper hydrocortisone treatment when vasopressors no longer required

Usual Adult Dose for Asthma -- Acute:

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Intravenous: 100 to 500 mg every 6 hours.

Usual Adult Dose for Ulcerative Colitis:

100 mg rectal suspension (retention enema) nightly for 21 days or until clinical remission occurs. Difficult cases may require 2 or 3 months of treatment. Clinical symptoms should subside within 3 to 5 days; discontinue use if no improvement within 2 to 3 weeks; some patients may require 2 to 3 months of therapy; if therapy lasts more than 21 days, discontinue slowly by decreasing use to every other night for 2 to 3 weeks.

Usual Adult Dose for Ulcerative Proctitis:

One applicatorful (10% rectal foam with applicator) rectally once or twice daily for two to three weeks, then every second day thereafter.

Usual Pediatric Dose for Adrenocortical Insufficiency:

Acute Adrenal Gland Failure:

Infants and young children: 1 to 2 mg/kg/dose intravenous bolus, then 25 to 100 mg/day in divided doses every 6 to 8 hours.

Older children: 100 mg intravenous bolus, then 300 mg/day in divided doses every 8 hours or as a continuous infusion for 48 hours; once patient is stable change to 50 mg orally every 8 hours for 6 doses, then taper to 30 to 50 mg per day in divided doses.

Usual Pediatric Dose for Anti-inflammatory:

Infants and children:

Oral: 2.5 to 10 mg/kg/day divided every 6 to 8 hours.

Intramuscular or intravenous: 1 to 5 mg/kg/day divided every 12 to 24 hours.

Adolescents:

Oral, intramuscular or intravenous: 15 to 240 mg every 12 hours.

Usual Pediatric Dose for Shock:

Children:

Initial: 50 mg/m2/day by continuous intravenous infusion

Infusions up to 50 mg/kg/day may be required for shock reversal

Adolescents:

200 mg per day by continuous intravenous infusion

Comment:

Recommendations from the International Guidelines for Management of Severe Sepsis and Septic Shock 2012:

-Do not use intravenous hydrocortisone if adequate fluid resuscitation and vasopressor therapy restore hemodynamic stability

-Use hydrocortisone alone

-Do not administer for sepsis in the absence of shock

-Do not use ACTH stimulation test to identify adults with septic shock requiring hydrocortisone

-Use continuous infusion rather than repetitive bolus injections

-Taper hydrocortisone treatment when vasopressors no longer required

Usual Pediatric Dose for Asthma -- Acute:

Children:

Intravenous: optional loading dose: 4 to 8 mg/kg; maximum: 250 mg; then

Maintenance: 2 mg/kg/dose every 6 hours.

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What other drugs will affect Hydrocortisone?

There are many other medicines that can interact with steroids. Below is only a partial list of these medicines:

  • aspirin (taken on a daily basis or at high doses);

  • a diuretic (water pill);

  • a blood thinner such as warfarin (Coumadin);

  • cyclosporine (Gengraf, Neoral, Sandimmune);

  • insulin or diabetes medications you take by mouth;

  • ketoconazole (Nizoral);

  • rifampin (Rifadin, Rifater, Rifamate, Rimactane); or

  • seizure medications such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton).

This list is not complete and there may be other drugs that can interact with hydrocortisone. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Hydrocortisone interactions

infoInteractions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Hydrocortisone, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious. The below-mentioned interactions of Hydrocortisone drug are worth giving a glance!

With simultaneous use of hydrocortisone increases the toxicity of cardiac glycosides (because of the emerging hypokalemia increases the risk of arrhythmias); with acetylsalicylic acid - accelerates its excretion and reduces its concentration in blood plasma (with the abolition of hydrocortisone concentration of salicylates in the blood increases, and increases the risk of side effects); with paracetamol - increased risk of hepatotoxic action of paracetamol (induction of hepatic enzymes and formation of a toxic metabolite of paracetamol); with cyclosporine - increased side effects of hydrocortisone as a result of inhibition of its metabolism; with ketoconazole - increased side effects of hydrocortisone as a result of reduction of its clearance.

Hydrocortisone Xepa-Soul Pattinson reduces the effectiveness of hypoglycemic; intensifies the effect of indirect anticoagulants of coumarin derivatives.

Hydrocortisone reduces the effect of vitamin D on the absorption of calcium ions into the lumen of the intestine. Ergocalciferol and parathyroid hormone hinder the development of osteopathy caused by GCS.

Hydrocortisone Xepa-Soul Pattinson increases the metabolism of isoniazid, meksiletina (especially in "fast acetylators"), which leads to a decrease in their plasma concentrations; increases (with prolonged therapy) the content of folic acid reduces the concentration of praziquantel in blood.

Hydrocortisone in high doses reduces the effect somatropina.

Hypokalemia caused by GCS, may increase the severity and duration of muscle blockade on the background of muscle relaxants.

Antacids reduce the absorption of the GCS.

At simultaneous application with SCS thiazides, carbonic anhydrase inhibitors, other GCS, amphotericin B increase the risk of hypokalemia, drugs containing sodium ions - swelling and increase blood pressure.

NSAIDs and ethanol increases the risk of gastrointestinal ulcerations and bleeding, in combination with NSAIDs to treat arthritis may reduce the dose of GCS due to summation of therapeutic effect. Indomethacin displacing the SCS from its association with albumin, increases the risk of its side effects.

Amphotericin B and carbonic anhydrase inhibitors increase the risk of osteoporosis.

The therapeutic effect of GCS is reduced under the influence of inducers of microsomal liver enzymes (including phenytoin, barbiturates, ephedrine, theophylline, rifampin) due to increased rate of metabolism of these substances.

Inhibitors of the function of the adrenal cortex (including mitotan) may necessitate higher doses of GCS.

Clearance GCS increased against the background of preparations of thyroid hormones.

Immunosuppressants increase the risk of infection and lymphoma or other lymphoproliferative disorders associated with Epstein-Barr virus.

Estrogens (including oral contraceptives containing estrogen) reduce the clearance of GKS, lengthens T1/2 and their therapeutic and toxic effects. The appearance of hirsutism and acne promotes the simultaneous use of other steroid hormone funds - androgens, estrogens, anabolic steroids, oral contraceptives.

Tricyclic antidepressants may increase the severity of depression caused by GCS (not shown for the treatment of these side effects).

The risk of developing cataracts increases with the application against other GCS antipsychotic funds (neuroleptics), carbutamide and azathioprine. Simultaneous of Hydrocortisone Xepa-Soul Pattinson with the appointment of m-cholinoblockers, as well as with means having m-anticholinergic action (including antihistamines, tricyclic antidepressants), with nitrates improves the intraocular pressure.

With simultaneous application of SCS with live vaccines and antiviral compared to other types of immunization increases the risk of activation of viruses and development of infections.

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Reviews

The results of a survey conducted on nDrugs.com for Hydrocortisone are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Hydrocortisone. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported frequency of use

How frequently do I need to take Hydrocortisone?
It was reported by nDrugs.com website users that Hydrocortisone should ideally be taken Once in a day as the most common frequency of the Hydrocortisone. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Hydrocortisone should be taken. Get other patientsí view on how frequent the capsule should be used by clicking here.
Users%
Once in a day1
100.0%


2 consumers reported doses

What doses of Hydrocortisone drug you have used?
The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, nDrugs.com website users used these doses of Hydrocortisone drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Users%
11-50mg2
100.0%


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