Actions of Jamp ASA in details
The analgesic, antipyretic, and anti-inflammatory effects of Jamp ASA are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Jamp ASA directly and irreversibly inhibits the activity of both types of cyclooxygenase (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. This makes Jamp ASA different from other NSAIDS (such as diclofenac and ibuprofen) which are reversible inhibitors. Salicylate may competitively inhibit prostaglandin formation. Jamp ASA's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms; the therapeutic effects are not due to pituitary-adrenal stimulation. The platelet aggregation-inhibiting effect of Jamp ASA specifically involves the compound's ability to act as an acetyl donor to cyclooxygenase; the nonacetylated salicylates have no clinically significant effect on platelet aggregation. Irreversible acetylation renders cyclooxygenase inactive, thereby preventing the formation of the aggregating agent thromboxane A2 in platelets. Since platelets lack the ability to synthesize new proteins, the effects persist for the life of the exposed platelets (7-10 days). Jamp ASA may also inhibit production of the platelet aggregation inhibitor, prostacyclin (prostaglandin I2), by blood vessel endothelial cells; however, inhibition prostacyclin production is not permanent as endothelial cells can produce more cyclooxygenase to replace the non-functional enzyme.
How should I take Jamp ASA?
Take Jamp ASA only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Take the capsule with a full glass of water at the same time each day.
Swallow the extended-release capsule whole. Do not crush, break, or chew it.
Do not take Durlaza™ 2 hours before or 1 hour after drinking alcohol.
Dosing
The dose of Jamp ASA will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Jamp ASA. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (extended-release capsules):
- To lower risk of heart attack and stroke:
- Adults—162.5 milligrams (mg) (one capsule) once a day.
- Children—Use and dose must be determined by your doctor.
- To lower risk of heart attack and stroke:
Missed Dose
If you miss a dose of Jamp ASA, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Jamp ASA administration
Oral:
IR tablets: Administer with food or a full glass of water to minimize GI distress. In situations for which a rapid onset of action is required (eg, acute treatment of myocardial infarction), have patient chew IR tablet.
Preeclampsia (prevention): Administration as an evening dose may be more beneficial than administration in the morning (Ayala 2013; Rolnik 2017)
ER capsules: Do not cut, crush, or chew. Administer with a full glass of water at the same time each day. Do not administer 2 hours before or 1 hour after alcohol consumption.
Bariatric surgery: Some institutions may have specific protocols that conflict with these recommendations; refer to institutional protocols as appropriate. Switch to IR formulation.
Rectal: Remove suppository from plastic packet and insert into rectum as far as possible.
Jamp ASA pharmacology
The analgesic, antipyretic, and anti-inflammatory effects of Jamp ASA are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Jamp ASA directly and irreversibly inhibits the activity of both types of cyclo-oxygenase (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. This makes Jamp ASA different from other NSAIDS (such as diclofenac and ibuprofen) which are reversible inhibitors. Salicylate may competitively inhibit prostaglandin formation. Jamp ASA's antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms; the therapeutic effects are not due to pituitary-adrenal stimulation. The platelet aggregation–inhibiting effect of Jamp ASA specifically involves the compound's ability to act as an acetyl donor to the platelet membrane; the nonacetylated salicylates have no clinically significant effect on platelet aggregation. Jamp ASA affects platelet function by inhibiting the enzyme prostaglandin cyclooxygenase in platelets, thereby preventing the formation of the aggregating agent thromboxane A2. This action is irreversible; the effects persist for the life of the platelets exposed. Jamp ASA may also inhibit formation of the platelet aggregation inhibitor prostacyclin (prostaglandin I2) in blood vessels; however, this action is reversible.
Reviews
The results of a survey conducted on ndrugs.com for Jamp ASA are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Jamp ASA. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported administration
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Information checked by Dr. Sachin Kumar, MD Pharmacology
