What happens if I overdose Jie Ning?
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately. Symptoms may include agitation; fever; hearing loss; lethargy; lightheadedness, especially upon standing; nausea; rapid breathing; rapid or irregular heartbeat; ringing in the ears; seizures; shortness of breath; stomach pain; vomiting.
Proper storage of Jie Ning:
Store Jie Ning at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Jie Ning out of the reach of children and away from pets.
Overdose of Jie Ning in details
May occur after receiving a single large dose or prolonged use. If a single dose of less than 150 mg / kg, acute poisoning feel light, 150-300 mg / kg - moderate, when using higher doses - heavy.
Symptoms: salicylism syndrome (nausea, vomiting, tinnitus, blurred vision, dizziness, severe headache, malaise, fever - a poor prognostic sign in adults). More severe poisoning - stupor, convulsions and coma, noncardiogenic pulmonary edema, abrupt dehydration, violations ABE (initially - respiratory alkalosis, then - metabolic acidosis), renal failure and shock.
In chronic overdose concentration determined in plasma are poorly correlated with the severity of intoxication. The greatest risk of chronic intoxication is found among elderly people at reception for a few days more than 100 mg / kg / day. In children and elderly patients the initial signs of salicylism are not always visible, and therefore desirable to periodically determine the concentration of salicylates in the blood. Level above 70 mg% indicates moderate or severe poisoning; above 100 mg% - on extremely heavy, a poor prognosis. If poisoning moderate require hospitalization for at least 24 hours.
Treatment: the provocation of vomiting, the appointment of activated charcoal and laxatives, monitoring ABE and electrolyte balance, depending on the state of metabolism - the introduction of sodium bicarbonate, solution of sodium citrate or sodium lactate. Raising reserve alkalinity increases the excretion of Jie Ning by alkalinization of urine. Alkalinization of urine is shown at the level of salicylates above 40 mg%, is provided in / by infusion of sodium bicarbonate - 88 mEq in 1 liter of 5% glucose solution, the rate of 10-15 ml / kg / h. Restoring BCC and induction of diuresis (achieved by introducing a bicarbonate in the same dose and dilution, repeat 2-3 times); should be aware that intense infusion fluid elderly patients may lead to pulmonary edema. Not recommended the use of acetazolamide for alkalinization of urine (may cause acidemia and enhance the toxic effect of salicylates). Hemodialysis is shown at the level of salicylates over 100-130 mg%, and in patients with chronic poisoning - 40 mg% or lower in the presence of witnesses (refractory acidosis, progressive deterioration, severe damage of the CNS, pulmonary edema and renal failure). When pulmonary edema - a mixture of artificial ventilation, oxygen enriched, in the mode of positive end-expiratory pressure, to treat cerebral edema apply hyperventilation and osmotic diuresis.
What should I avoid while taking Jie Ning?
Do not use any other over-the-counter medication without first asking your doctor or pharmacist. Jie Ning is contained in many medicines available over the counter. If you take certain products together you may accidentally take too much Jie Ning. Read the label of any other medicine you are using to see if it contains Jie Ning.
Avoid drinking alcohol while you are taking Jie Ning. Alcohol may increase your risk of stomach bleeding.
If you are taking Jie Ning to prevent heart attack or stroke, avoid also taking ibuprofen (Advil, Motrin). Ibuprofen may make Jie Ning less effective. If you must use both medications, take the ibuprofen at least 8 hours before or 30 minutes after you take the Jie Ning (non-enteric coated form).
Jie Ning warnings
Jie Ning with caution used in patients with liver diseases and kidney, bronchial asthma, erosive and ulcerative lesions, and bleeding from the digestive tract in history, with increased bleeding or while holding anticoagulant therapy, decompensated congestive heart failure.
Jie Ning even in small doses reduces the excretion of uric acid from the organism that can cause an acute attack of gout in predisposed patients. When conducting long-term therapy and / or use of Jie Ning in high doses required medical supervision and regular monitoring of hemoglobin levels.
The use of Jie Ning as anti-inflammatory drugs in a daily dose of 5-8 g is limited due to the high probability of adverse effects from the gastrointestinal tract.
Before surgery to reduce bleeding during surgery and postoperative period should stop taking salicylates for 5-7 days.
During prolonged therapy is necessary to conduct a general analysis of blood and study of occult blood.
The use of Jie Ning is contraindicated in pediatrics, as in the case of viral infection in children under the influence of Jie Ning increases the risk of developing Reye syndrome. Symptoms of Reye syndrome are prolonged vomiting, acute encephalopathy, liver enlargement.
Duration of treatment (without consulting a doctor) with Jie Ning should not exceed 7 days when administered as analgesic and more than 3 days as an antipyretic.
During treatment the patient should abstain from alcohol.
What should I discuss with my healthcare provider before taking Jie Ning?
Do not use this medication if you are allergic to Jie Ning or other NSAIDs (non-steroidal anti-inflammatory drugs) such as ibuprofen (Motrin, Advil), celecoxib (Celebrex), diclofenac (Arthrotec, Cambia, Cataflam, Voltaren, Flector Patch, Pennsaid, Solareze), diflunisal (Dolobid), etodolac (Lodine), flurbiprofen (Ansaid), indomethacin (Indocin), ketoprofen (Orudis), ketorolac (Toradol), mefenamic acid (Ponstel), meloxicam (Mobic), nabumetone (Relafen), naproxen (Aleve, Naprosyn, Naprelan, Treximet), piroxicam (Feldene), and others.
Rectal Jie Ning should not be used in a child or teenager who has a fever, especially if the child also has flu symptoms or chicken pox. Jie Ning can cause a serious and sometimes fatal condition called Reye's syndrome.
Ask a doctor or pharmacist if it is safe for you to use this medicine if you have:
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Kawasaki disease;
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a bleeding or blood clotting disorder such as hemophilia;
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glaucoma;
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a stomach ulcer or bleeding;
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a weak immune system;
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asthma or nasal polyps;
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high blood pressure or heart disease;
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kidney disease; or
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liver disease.
Jie Ning may be harmful to an unborn baby, and may also cause problems with pregnancy or childbirth. Do not use rectal Jie Ning without medical advice if you are pregnant or plan to become pregnant.
It is not known whether rectal Jie Ning passes into breast milk or if it could harm an unborn baby. Do not use this medication without medical advice if you are breast-feeding a baby.
Jie Ning precautions
Patients with urinary retention or increased intraocular pressure; cardiac disorders eg, cardiac failure, myocardial infarction, angina pectoris and arrhythmia or hyperthyroidism; current or history of epilepsy; manic-depressive psychosis and those with the factor or organic brain disease or schizophrenia.
General Precautions: Because concomitant administration of Jie Ning and monoamine oxidase inhibitor (MAOI) may produce convulsion, hyperpyretic crisis and coma. It should be avoided, in patients with a history of a previous MAOI. It should be administered every 2 weeks and it will be desirable that the observation of Jie Ning and MAOI is made every 2-3 days.
Effects on the Ability to Drive or Operate Machinery: Jie Ning may cause drowsiness. So patients driving or operating machinery should take caution.
Use in pregnancy: Animal reproduction studies with tricyclic antidepressants have not reported the teratogenic action, however, Jie Ning should not be used in pregnant women or women who may become pregnant unless the possible benefits outweigh the potential risk to the fetus.
Use in lactation: Jie Ning is likely to be distributed into milk, nursing should be discontinued during administration of this drug.
Use in children: The safety of children using Jie Ning has not been established.
Use in the
Elderly: Administer with caution.
What happens if I miss a dose of Jie Ning?
Since rectal Jie Ning is sometimes used as needed, you may not be on a dosing schedule. If you are using the medication regularly, use the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and wait until your next regularly scheduled dose. Do not use extra medicine to make up the missed dose.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
