Pipolphen is in a group of drugs called phenothiazines (FEEN-oh-THYE-a-zeens). It works by changing the actions of chemicals in your brain. Pipolphen also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.
Pipolphen is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes.
Pipolphen also prevents motion sickness, and treats nausea and vomiting or pain after surgery. It is also used as a sedative or sleep aid.
Pipolphen is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections.
Pipolphen may also be used for other purposes not listed in this medication guide.
Pipolphen indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral
Allergic conditions
Adult: As Pipolphen HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.
Child: As Pipolphen HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses.
Oral
Short-term management of insomnia
Adult: As Pipolphen HCl: 20-50 mg at night.
Child: As Pipolphen HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg.
Oral
Nausea and vomiting
Adult: As Pipolphen teoclate: 25 mg at night, may increase to 50-75 mg at night or to 25 mg 2-3 times daily if necessary. Max: 100 mg daily.
Child: As Pipolphen teoclate: 5-10 yr 12.5-37.5 mg daily.
Oral
Prophylaxis of motion sickness
Adult: As Pipolphen HCl: 20 mg or 25 mg the night before travelling, followed by a similar dose the following morning if necessary. As Pipolphen teoclate: 25 mg given on the night or 1-2 hr before travelling.
Child: As Pipolphen HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary. As Pipolphen teoclate: 5-10 yr 12.5 mg given either on the night or 1-2 hr before travelling.
Oral
Motion sickness
Adult: As Pipolphen teoclate: 25 mg given as soon as possible and repeated in the evening, followed by a 3rd dose the next evening.
Child: As Pipolphen teoclate: 5-10 yr 12.5 mg given as soon as possible and repeated in the evening, followed by a 3rd dose the next evening.
Parenteral
Allergic conditions, Sedation
Adult: As Pipolphen HCl: 25-50 mg, by deep IM, IV inj or IV infusion at a rate of not more than 25 mg/min. Max: 100 mg.
Child: As Pipolphen HCl: 5-10 yr 6.25-12.5 mg by deep IM.
Parenteral
Nausea and vomiting
Adult: As Pipolphen HCl: 12.5-25 mg, repeated at intervals of not less than 4 hr. Max: 100 mg daily.
Rectal
Short-term management of insomnia
Adult: As Pipolphen HCl: 20-50 mg at night.
Child: As Pipolphen HCl: 2-5 yr 15-20 mg; >5-10 yr 20-25 mg.
Rectal
Allergic conditions
Adult: As Pipolphen HCl: 25 mg at night, increase to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily.
Child: As Pipolphen HCl: 2-5 yr 5-15 mg daily in 1 or 2 divided doses; >5-10 yr 10-25 mg daily in 1 or 2 divided doses.
Rectal
Prophylaxis of motion sickness
Adult: As Pipolphen HCl: 20 or 25 mg the night before travelling, followed by a similar dose the following morning if necessary.
Child: As Pipolphen HCl: 2-5 yr 5 mg; >5-10 yr 10 mg. Doses are given the night before the journey and repeated on the following morning (6-8 hr later) if necessary.
How should I use Pipolphen?
Use Pipolphen as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Pipolphen is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Pipolphen at home, a health care provider will teach you how to use it. Be sure you understand how to use Pipolphen. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
Pipolphen should be given as an injection into a muscle or a vein. Do not inject Pipolphen into an artery or under the skin.
Do not use Pipolphen if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
If you are using Pipolphen for motion sickness, take a dose at least 30 to 60 minutes before you begin traveling.
If you miss a dose of Pipolphen and you are using it regularly, use it as soon as possible. If several hours have passed or if it is nearing time for the next dose, do not double the dose to catch up, unless advised by your health care provider. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Pipolphen.
Uses of Pipolphen in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Pipolphen is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). It is also used with other medication to treat severe allergic reactions (anaphylaxis) and reactions to blood products. It may also be used to treat milder allergic reactions when you cannot take Pipolphen by mouth. It may also be used to help you feel sleepy/relaxed before and after surgery, during other procedures, or during labor and delivery. It may also be used to help certain narcotic pain relievers (such as meperidine) work better.
Pipolphen is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain.
This drug is not approved for use in children younger than 2 years due to an increased risk of side effects (such as slow/shallow breathing). See also Warning section.
How to use Pipolphen injection
It is best to inject this medication deep into a muscle. It may also be given by injection slowly into a large vein by a health care professional. Do not inject this medication under the skin or into an artery. For nausea and vomiting, use this medication as directed by your doctor, usually every 4 hours as needed. If you have any questions about the proper use of this medication, ask your doctor or pharmacist.
If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.
The dosage and how often you receive this medication are based on your age, medical condition, and response to treatment. In children, the dosage may also be based on weight. Do not increase your dose or use this medication more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.
Tell your doctor if you do not get better or if you get worse.
Pipolphen description
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A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Pipolphen&
Pipolphen dosage
Adult :POAllergic conditions As Pipolphen HCl: 25 mg at night, increase to 25 mg bid if necessary. Short-term management of insomnia As Pipolphen HCl: 20-50 mg at night. Prophylaxis of motion sickness As Pipolphen HCl: 20 mg or 25 mg the night before travelling, then a similar dose the following morning if necessary. As Pipolphen teoclate: 25 mg given on the night or 1-2hr before travelling. Motion sickness As Pipolphen teoclate: 25 mg given as soon as possible and repeated in the evening, then a 3rd dose the next evening. Nausea and vomiting As Pipolphen teoclate: 25 mg at night, may increase to 50-75 mg at night or to 25 mg 2-3 times/day if necessary. Max: 100 mg/day. RectalAllergic conditions As Pipolphen HCl: 25 mg at night, increase to 25 mg bid if necessary. Short-term management of insomnia As Pipolphen HCl: 20-50 mg at night. Prophylaxis of motion sickness As Pipolphen HCl: 20 mg or 25 mg the night before travelling, then a similar dose the following morning if necessary. IM/IVAllergic conditions; Sedation As Pipolphen HCl: 25-50 mg. Max: 100 mg. Nausea and vomiting As Pipolphen HCl: 12.5-25 mg, repeated at intervals of not less than 4 hr. Max: 100 mg/day.
CNS Depressants – Pipolphen (Pipolphen HCl) Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving Pipolphen HCl. When given concomitantly with Pipolphen (Pipolphen HCl) Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of Pipolphen HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.
Epinephrine – Because of the potential for Pipolphen HCl to reverse epinephrine's vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Pipolphen HCl Suppositories overdose.
Anticholinergics – Concomitant use of other agents with anticholinergic properties should be undertaken with caution.
Monoamine Oxidase Inhibitors (MAOI) – Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Pipolphen (Pipolphen HCl) Suppositories.
Drug/Laboratory Test Interactions
The following laboratory tests may be affected in patients who are receiving therapy with Pipolphen HCl:
Pregnancy Tests
Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.
Glucose Tolerance Test
An increase in blood glucose has been reported in patients receiving Pipolphen HCl.
Drowsiness is the most prominent CNS effect of this drug. Sedation, somnolence, blurred vision, dizziness; confusion, disorientation, and extrapyramidal symptoms such as oculogyric crisis, torticollis, and tongue protrusion; lassitude, tinnitus, incoordination, fatigue, euphoria, nervousness, diplopia, insomnia, tremors, convulsive seizures, excitation, catatonic-like states, hysteria. Hallucinations have also been reported.
Cardiovascular–Increased or decreased blood pressure, tachycardia, bradycardia, faintness.
Other –Angioneurotic edema. Neuroleptic malignant syndrome (potentially fatal) has also been reported.
Paradoxical Reactions
Hyperexcitability and abnormal movements have been reported in patients following a single administration of Pipolphen HCl. Consideration should be given to the discontinuation of Pipolphen HCl and to the use of other drugs if these reactions occur. Respiratory depression, nightmares, delirium, and agitated behavior have also been reported in some of these patients.
Injection: Pipolphen is contraindicated in comatose states, in patients who have received large amounts of central-nervous-system depressants (alcohol, sedative hypnotics, including barbiturates, general anesthetics, narcotics, narcotic analgesics, tranquilizers, etc.), and in patients who have demonstrated an idiosyncrasy or hypersensitivity to Pipolphen.
Under no circumstances should Pipolphen be given by intra-arterial injection due to the likelihood of severe arteriospasm and the possibility of resultant gangrene
Pipolphen HCl injection should not be given by the subcutaneous route; evidence of chemical irritation has been noted, and necrotic lesions have resulted on rare occasions following subcutaneous injection. The preferred parenteral route of administration is by deep intramuscular injection.
Syrup, Tablets and Suppositories: Pipolphen Tablets and Suppositories are contraindicated for use in pediatric patients less than two years of age.
Pipolphen Tablets and Suppositories are contraindicated in comatose states, and in individuals known to be hypersensitive or to have had an idiosyncratic reaction to Pipolphen or to other phenothiazines.
Antihistamines are contraindicated for use in the treatment of lower respiratory tract symptoms including asthma.
Active ingredient matches for Pipolphen:
Promethazine in Georgia, Hungary, Lithuania, Russian Federation.
DTP/NCI. "promethazine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Pipolphen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Pipolphen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
Consumer reported useful
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4 consumers reported age
Users
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16-29
1
25.0%
6-15
1
25.0%
1-5
1
25.0%
< 1
1
25.0%
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