Actions of Trihexyphen in details
Trihexyphen is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphen partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.
How should I take Trihexyphen?
Take Trihexyphen every day exactly as ordered by your doctor in order to improve your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
You may take Trihexyphen before or after food, although it is usually taken with meals.
Dosing
The dose of Trihexyphen will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Trihexyphen. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (elixir or tablets):
- For Parkinson's disease:
- Adults—At first, 1 milligram (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 15 mg per day, given in divided doses 3 or 4 times per day.
- Children—Use and dose must be determined by your doctor.
- For side effects caused by other medicines:
- Adults—5 to 15 milligrams (mg) per day, given in divided doses 3 or 4 times per day.
- Children—Use and dose must be determined by your doctor.
- For Parkinson's disease:
Missed Dose
If you miss a dose of Trihexyphen, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Trihexyphen administration
Take Trihexyphen exactly as directed by your doctor. If you do not understand these directions, ask your pharmacist, nurse, or doctor to explain them to you.
Take each dose with a full glass of water.
Trihexyphen may be taken with or without meals. Taking Trihexyphen with food may lessen stomach upset.
To ensure that you get a correct dose, measure the liquid form of Trihexyphen with a special dose-measuring spoon or cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.
Store Trihexyphen at room temperature away from moisture and heat.
Trihexyphen pharmacology
PMS Trihexyphen is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). PMS Trihexyphen partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.
References
- EPA DSStox. "Trihexyphenidyl: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Trihexyphen are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Trihexyphen. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
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Information checked by Dr. Sachin Kumar, MD Pharmacology
