Frumex Uses

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What is Frumex?

Frumex belongs to a group of medicines called loop diuretics (also known as water pills). Frumex is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine.

Frumex is also used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Frumex is available only with your doctor's prescription.

Frumex indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Parenteral therapy should be reserved for patients unable to take oral medication or for patients in emergency clinical situations.

Edema: Frumex is indicated in adults and pediatric patients for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Frumex is particularly useful when an agent with greater diuretic potential is desired.

Frumex is indicated as adjunctive therapy in acute pulmonary edema. The intravenous administration of Frumex is indicated when a rapid onset of diuresis is desired, e.g., in acute pulmonary edema.

If gastrointestinal absorption is impaired or oral medication is not practical for any reason, Frumex is indicated by the intravenous or intramuscular route.

Parenteral use should be replaced with oral Frumex as soon as practical.

How should I use Frumex?

Use Frumex solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Frumex solution by mouth with or without food.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • If you take cholestyramine, colestipol, or sucralfate, ask your doctor or pharmacist how to take them with Frumex solution.
  • Frumex solution may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm.
  • If you miss a dose of Frumex solution, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Frumex solution.

Uses of Frumex in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Frumex is used to reduce extra fluid in the body (edema) caused by conditions such as heart failure, liver disease, and kidney disease. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen.

This drug is also used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

Frumex is a "water pill" (diuretic) that causes you to make more urine. This helps your body get rid of extra water and salt.

OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

This medication may also be used to decrease a high level of calcium in the blood (hypercalcemia).

How to use Frumex

Read the Patient Information Leaflet if available from your pharmacist before you start taking Frumex and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, with or without food, usually once or twice daily. It is best to avoid taking this medication within 4 hours of your bedtime to prevent having to get up to urinate.

Dosage is based on your medical condition, age, and response to treatment. For children, the dose is also based on weight. Older adults usually start with a lower dose to decrease the risk of side effects. Do not increase your dose or take it more often than directed.

Take this medication regularly in order to get the most benefit from it. To help you remember, take it at the same time(s) of the day as directed. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

Sucralfate, cholestyramine, and colestipol can decrease the absorption of Frumex. If you are taking any of these drugs, separate the timing of each dose from Frumex by at least 2 hours.

Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings remain high or increase).

Frumex description


A topical anti-infective agent effective against gram-negative and gram-positive bacteria. It is used for superficial wounds, burns, ulcers, and skin infections. Frumex has also been administered orally in the treatment of trypanosomiasis.

Frumex dosage


Therapy should be individualized according to patient response to gain maximal therapeutic response and to determine the minimal dose needed to maintain that response.


The usual initial dose of Frumex is 20 to 80 mg given as a single dose. Ordinarily a prompt diuresis ensues. If needed, the same dose can be administered 6 to 8 hours later or the dose may be increased. The dose may be raised by 20 or 40 mg and given not sooner than 6 to 8 hours after the previous dose until the desired diuretic effect has been obtained. The individually determined single dose should then be given once or twice daily (eg, at 8 am and 2 pm). The dose of Frumex may be carefully titrated up to 600 mg/day in patients with clinically severe edematous states.

Edema may be most efficiently and safely mobilized by giving Frumex on 2 to 4 consecutive days each week.

When doses exceeding 80 mg/day are given for prolonged periods, careful clinical observation and laboratory monitoring are particularly advisable.

Geriatric patients

In general, dose selection for the elderly patient should be cautious, usually starting at the low end of the dosing range.

Pediatric patients

The usual initial dose of oral Frumex in pediatric patients is 2 mg/kg body weight, given as a single dose. If the diuretic response is not satisfactory after the initial dose, dosage may be increased by 1 or 2 mg/kg no sooner than 6 to 8 hours after the previous dose. Doses greater than 6 mg/kg body weight are not recommended. For maintenance therapy in pediatric patients, the dose should be adjusted to the minimum effective level.


Therapy should be individualized according to the patient's response to gain maximal therapeutic response and to determine the minimal dose needed to maintain the therapeutic response.


The usual initial dose of Frumex for hypertension is 80 mg, usually divided into 40 mg twice a day. Dosage should then be adjusted according to response. If response is not satisfactory, add other antihypertensive agents.

Changes in blood pressure must be carefully monitored when Frumex is used with other antihypertensive drugs, especially during initial therapy. To prevent excessive drop in blood pressure, the dosage of other agents should be reduced by at least 50 percent when Frumex is added to the regimen. As the blood pressure falls under the potentiating effect of Frumex, a further reduction in dosage or even discontinuation of other antihypertensive drugs may be necessary.

Geriatric Patients

In general, dose selection and dose adjustment for the elderly patient should be cautious, usually starting at the low end of the dosing range.

How supplied

Frumex (Frumex) Tablets 20 mg are supplied as white, oval, monogrammed tablets in Bottles of 100 (NDC 0039-0067-10) and 1000 (NDC 0039-0067-70). The 20 mg tablets are imprinted with “Frumex®” on one side.

Frumex Tablets 40 mg are supplied as white, round, monogrammed, scored tablets in Bottles of 100 (NDC 0039-0060-13), 500 (NDC 0039-0060-50), and 1000 (NDC 0039-0060-70). The 40 mg tablets are imprinted with “Frumex® 40” on one side.

Frumex Tablets 80 mg are supplied as white, round, monogrammed, facetted edge tablets in Bottles of 50 (NDC 0039-0066-05) and 500 (NDC 0039-0066-50). The 80 mg tablets are imprinted with “Frumex® 80” on one side.

Note: Dispense in well-closed, light-resistant containers. Exposure to light might cause a slight discoloration. Discolored tablets should not be dispensed.

Tested by USP Dissolution Test 2

Store at 25° C (77° F); excursions permitted to 15 -30° C (59 -86° F).

Manufactured for: sanofi-aventis U.S. LLC Bridgewater, NJ 08807. A Sanofi Company.. Revised: Mar 2016

Frumex interactions

See also:
What other drugs will affect Frumex?


Apo-Frumex may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in life-threatening situations, avoid this combination.

Apo-Frumex should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. Patients receiving high doses of salicylates concomitantly with Frumex, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.

Apo-Frumex has a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine.

Lithium generally should not be given with diuretics because they reduce lithiums renal clearance and add a high risk of lithium toxicity.

Apo-Frumex may add to or potentiate the therapeutic effect of other antihypertensive drugs. Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs.

Apo-Frumex may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used effectively.


Simultaneous administration of sucralfate and Frumex tablets may reduce the natriuretic and antihypertensive effects of Frumex. Patients receiving both drugs should be observed closely to determine if the desired diuretic and/or antihypertensive effect of Frumex is achieved. The intake of Frumex and sucralfate should be separated by at least two hours.

Tablets, Injection, and

Oral Solution

One study in six subjects demonstrated that the combination of Frumex and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency. There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when Frumex was used in conjunction with NSAIDs.

Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of Frumex in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma renin levels, aldosterone excretion, and renin profile evaluation. Patients receiving both indomethacin and Frumex should be observed closely to determine if the desired diuretic and/or antihypertensive effect of Frumex is achieved.

Frumex side effects

See also:
What are the possible side effects of Frumex?

Applies to Frumex: oral solution, oral tablet

Other dosage forms:

  • injection injectable, injection solution

In addition to its needed effects, some unwanted effects may be caused by Frumex (the active ingredient contained in Frumex). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Frumex:


  • Chest pain
  • chills
  • cough or hoarseness
  • fever
  • general feeling of tiredness or weakness
  • headache
  • lower back or side pain
  • painful or difficult urination
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen or painful glands
  • tightness in the chest
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • wheezing
Incidence not known:
  • Back or leg pains
  • black, tarry stools
  • bleeding gums
  • blistering, peeling, or loosening of the skin
  • bloating
  • blood in the urine or stools
  • blurred vision
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • changes in skin color, pain, tenderness, or swelling of the foot or leg
  • clay-colored stools
  • cloudy urine
  • cold sweats
  • confusion
  • constipation
  • continuing ringing or buzzing or other unexplained noise in the ears
  • coughing up blood
  • cracks in the skin
  • darkened urine
  • diarrhea
  • difficulty breathing
  • dizziness, faintness, or lightheadedness when getting up from a lying or sitting position
  • dry mouth
  • fast heartbeat
  • flushed, dry skin
  • fruit-like breath odor
  • greatly decreased frequency of urination or amount of urine
  • hearing loss
  • increased hunger
  • increased thirst
  • indigestion
  • itching
  • loss of appetite
  • nausea or vomiting
  • nosebleeds
  • pain in the joints or muscles
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • pinpoint red spots on the skin
  • red, irritated eyes
  • red, swollen skin
  • skin rash
  • spots on your skin resembling a blister or pimple
  • sweating
  • swelling of the feet or lower legs
  • trouble breathing with exertion
  • unusual weight loss
  • vomiting of blood
  • yellow eyes or skin

If any of the following symptoms of overdose occur while taking Frumex, get emergency help immediately:

Symptoms of overdose:

  • Decreased urination
  • drowsiness
  • increase in heart rate
  • irregular heartbeat
  • irritability
  • mood changes
  • muscle cramps
  • numbness, tingling, pain, or weakness in the hands, feet, or lips
  • rapid breathing
  • seizures
  • sunken eyes
  • thirst
  • trembling
  • weak pulse
  • weakness and heaviness of the legs
  • wrinkled skin

Minor Side Effects

Some of the side effects that can occur with Frumex may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:

  • Feeling of constant movement of self or surroundings
  • hives or welts
  • increased sensitivity of the skin to sunlight
  • muscle spasm
  • redness or other discoloration of the skin
  • restlessness
  • sensation of spinning
  • severe sunburn
  • weakness

Frumex contraindications

See also:
What is the most important information I should know about Frumex?

You should not use this medication if you are unable to urinate.

Before using this medication, tell your doctor if you have kidney disease, enlarged prostate, urination problems, cirrhosis or other liver disease, an electrolyte imbalance, high cholesterol, gout, lupus, diabetes, or an allergy to sulfa drugs.

Tell your doctor if you have recently had an MRI (magnetic resonance imaging) or any type of scan using a radioactive dye that is injected into your veins.

Do not take more of this medication than is recommended. High doses of Frumex may cause irreversible hearing loss.

If you are being treated for high blood pressure, keep using this medication even if you feel fine. High blood pressure often has no symptoms.

Active ingredient matches for Frumex:


List of Frumex substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Frumid / amp 10 mg/1 mL x 2 mL x 10's
Frumide 40+5 Tablet (Gnosis Pharmaceuticals (P) Ltd)$ 0.02
FRUMIDE 40MG/5MG TABLET 1 strip / 10 tablets each (Gnosis Pharmaceuticals (P) Ltd)$ 0.09
Frumide 40 mg/5 mg Tablet (Gnosis Pharmaceuticals (P) Ltd)$ 0.01
FRUMIDE 40MG/5MG TABLET (Gnosis Pharmaceuticals (P) Ltd)$ 0.02
Tablet; Oral; Furosemide 40 mg (Hexal)
Tablets; Oral; Furosemide 40 mg (Hexal)
Injectable; Injection; Furosemide 10 mg / ml (Korea United Pharma)
Tablets; Oral; Furosemide 20 mg (Korea United Pharma)
Tablets; Oral; Furosemide 40 mg (Korea United Pharma)
Frusema 20 mg x 100's (Korea United Pharma)$ 0.13
Frusema 40 mg x 100's (Korea United Pharma)$ 0.23
Frusema / amp 20 mg/2 mL x 100's (Korea United Pharma)$ 144.76
Frusema tab 20 mg 100's (Korea United Pharma)
Frusema tab 40 mg 100's (Korea United Pharma)
Frusemide 40 mg x 1, 000's (Kokad Pharmaceutical Laboratories Ltd)
Frusemide 10 mg Injection (Kokad Pharmaceutical Laboratories Ltd)$ 0.05
Injectable; Injection; Furosemide 10 mg / ml
Injectable; Injection; Furosemide 10 mg / ml
FRUSEMIDE 40MG TABLET 1 strip / 10 tablets each (Jan Aushadhi)$ 0.07
Frusemide DHA 40 mg x 1000's (DHA)
Frusemide DHA tab 40 mg 10 x 10 x 10's (DHA)
Tablet; Oral; Furosemide 40 mg
Tablets; Oral; Furosemide 40 mg
Frusemide-Hameln 20 mg/2 mL x 2 mL x 10's (Hameln Pharma Plus)$ 90.00
Frusemide-Hameln inj 20 mg/2 mL 2 mL x 10 x 1's (Hameln Pharma Plus)
40 mg x 10's (Geno Pharmaceuticals Ltd.)$ 0.06
100 mg x 10's (Geno Pharmaceuticals Ltd.)$ 0.07
Tablets; Oral; Furosemide 40 mg (Geno Pharmaceuticals Ltd.)
Tablets; Oral; Furosemide 100 mg (Geno Pharmaceuticals Ltd.)
Frusenex 100 mg Tablet (Geno Pharmaceuticals Ltd.)$ 0.01
Frusenex 40 mg Tablet (Geno Pharmaceuticals Ltd.)$ 0.01


  1. DailyMed. "FUROSEMIDE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "furosemide". (accessed September 17, 2018).
  3. DrugBank. "furosemide". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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