Opedroxil Pregnancy

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Pregnancy of Opedroxil in details

infoPregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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The Michigan Medicaid surveillance study does not reveal an association between Opedroxil and congenital defects. This report is a summary of information from two studies, one in which 99 of 104,000 pregnant women from 1980 to 1983, and one in which 722 of 229,000 pregnant women from 1985 to 1992 received Opedroxil. In the first study, eight total defects and one cardiovascular defect were observed (six and one were expected, respectively). In the second study, fewer total and cardiovascular defects were observed than expected. Cleft palate was not observed in either study.

Opedroxil has been assigned to pregnancy category B by the FDA. Animal studies failed to reveal evidence of fetal harm. There are no controlled data in human pregnancy. Opedroxil should only be given during pregnancy when need has been clearly established.

See references

Opedroxil breastfeeding

infoWhen a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

Following a single 1 gram oral dose to six lactating women, peak milk Opedroxil levels were observed at six to seven hours, averaging 1.83 mcg per mL. These levels are low and are not expected to cause adverse effects in nursing infants.

Opedroxil is excreted into human milk in small amounts. However, no adverse effects in nursing infants have been reported. Opedroxil is considered compatible with breast-feeding by the American Academy of Pediatrics.

See references

References for pregnancy information

  1. "Product Information. Duricef (Opedroxil)." Bristol-Myers Squibb, Princeton, NJ.
  2. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):

References for breastfeeding information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  2. "Product Information. Duricef (Opedroxil)." Bristol-Myers Squibb, Princeton, NJ.
  3. Kafetzi D, Siafas C, Georgakopoulos P, Papdatos C "Passage of cephalosporins and amoxicillin into the breast milk." Acta Paediatr Scand 70 (1981): 285-8


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References

  1. DailyMed. "CEFADROXIL/CEFADROXIL HEMIHYDRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubMed Health. "Cefadroxil (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  3. Human Metabolome Database (HMDB). "Cefadroxil: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).

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