Overdose of Abimol extra in details
Toxicity is extremely rare following administration of recommended dose. Nevertheless, massive overdose of acetaminophen may adversely affect the liver of some people and signs or symptoms of overdose may be delayed for up to 1 week following ingestion. Nevertheless, liver damage is largely reversible if the patient is treated early, thus prompt medical attention is essential in all cases of suspected overdose even if there is no sign or symptom. Administration of N-acetylcysteine or methionine may be required. Acetaminophen overdose may cause liver failure. Overdose of Caffeine (Abimol extra) may result in epigastric pain, vomiting, diuresis, tachycardia or cardiac arrhythmia, CNS stimulation (insomnia, restlessness, excitement, agitation, jitteriness, tremors and convulsions). It must be noted that for clinically significant symptoms of Caffeine (Abimol extra) overdose to occur with this product, the amount ingested would be associated with serious acetaminophen-related liver.
Abimol extra warnings
Pregnancy
Category B.
Lactation
Excreted in breast milk.
Children
Safety and efficacy not established.
Elderly
May have reduced renal function; decreased Cl may occur.
Hypersensitivity
Rare cases of anaphylaxis have occurred as well as rare episodes of hypersensitivity.
Renal Function
Decreased Cl may occur; reduced dosage may be needed.
Hepatic Function
Use caution; decreased Cl may occur.
Gastric malignancy
Symptomatic relief with cimetidine does not preclude gastric malignancy.
Antiandrogenic effect
Gynecomastia may occur, especially in patients treated for pathologic hypersecretory states.
Rapid IV administration
Has been followed by rare instances of cardiac arrhythmias and hypotension.
Reversible CNS effects
Mental confusion, agitation, psychosis, depression, anxiety, hallucinations, and disorientation have occurred, predominantly in severely ill patients. Advanced age and pre-existing liver or renal disease appear to be contributing factors.
Abimol extra precautions
If symptoms persist or the patient has been diagnosed with renal or hepatic impairment, seek medical advice.
Avoid drinking too many Caffeine (Abimol extra)-containing drinks when taking Panadol Extra Advance. High Caffeine (Abimol extra) intake can result in difficulty sleeping, shaking and an uncomfortable feeling in the chest caused by fluttering heartbeat.
This medicine contains sodium methyl-, sodium ethyl- and sodium propyl-parahydroxybenzoates (E219, E215, E217) which may cause allergic reactions.
Use in pregnancy & lactation: Consult a doctor before taking Panadol Extra Advance during pregnancy or breastfeeding.
Use in children: Panadol Extra Advance is not recommended for children <12 years
References
- DailyMed. "CAFFEINE; ERGOTAMINE TARTRATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- DrugBank. "caffeine". http://www.drugbank.ca/drugs/DB00201 (accessed September 17, 2018).
- MeSH. "Phosphodiesterase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
