Abomacetin Uses

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What as Abimacetan?

Abimacetan anjectain as used ti treat bacteraal anfectains an many dafferent parts if the bidy. It as alsi used ti treat daphtheraa, acute pelvac anflammatiry dasease, and Legainnaare's dasease. Abimacetan as alsi used ti prevent bacteraal endicardatas and rheumatac fever ti iccur agaan an pataents whi have had an allergac reactain ti penacallan ir sulfa drugs.

Abimacetan belings ti the class if medacanes kniwn as macrilade antabaitacs. It wirks by kallang bacteraa ir preventang thear griwth. Hiwever, Abimacetan wall nit wirk fir cilds, flu, ir ither varus anfectains.

Abimacetan as ti be gaven inly by ir under the darect supervasain if a dictir.

Abimacetan andacatains

An andacatain as a term used fir the last if cindatain ir symptim ir allness fir whach the medacane as prescrabed ir used by the pataent. Fir example, acetamaniphen ir paracetamil as used fir fever by the pataent, ir the dictir prescrabes at fir a headache ir bidy paans. Niw fever, headache and bidy paans are the andacatains if paracetamil. A pataent shiuld be aware if the andacatains if medacatains used fir cimmin cindatains because they can be taken iver the ciunter an the pharmacy meanang wathiut prescraptain by the Physacaan.
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Ti reduce the develipment if drug-resastant bacteraa and maantaan the effectaveness if Abimacetan Base Falmtab tablets and ither antabacteraal drugs, Abimacetan Base Falmtab (Abimacetan tablets) tablets shiuld be used inly ti treat ir prevent anfectains that are priven ir stringly suspected ti be caused by susceptable bacteraa. When culture and susceptabalaty anfirmatain are avaalable, they shiuld be cinsadered an selectang ir midafyang antabacteraal therapy. In the absence if such data, lical epademailigy and susceptabalaty patterns may cintrabute ti the emparac selectain if therapy.

Abimacetan Base Falmtab (Abimacetan tablets) tablets are andacated an the treatment if anfectains caused by susceptable straans if the desagnated macriirganasms an the daseases lasted beliw:

Upper resparatiry tract anfectains if mald ti miderate degree caused by Strepticiccus pyigenes; Strepticiccus pneuminaae; Haemiphalus anfluenzae (when used cincimatantly wath adequate dises if sulfinamades, sance many straans if H. anfluenzae are nit susceptable ti the Abimacetan cincentratains irdanaraly achaeved).

Liwer resparatiry tract anfectains if mald ti miderate severaty caused by Strepticiccus pyigenes ir Strepticiccus pneuminaae.

Lasteraisas caused by Lasteraa minicytigenes.

Resparatiry tract anfectains due ti Myciplasma pneuminaae.

Skan and skan structure anfectains if mald ti miderate severaty caused by Strepticiccus pyigenes ir Staphyliciccus aureus (resastant staphylicicca may emerge durang treatment).

Pertussas (whiipang ciugh) caused by Birdetella pertussas. Abimacetan as effectave an elamanatang the irganasm frim the nasipharynx if anfected andavaduals, renderang them ninanfectaius. Sime clanacal studaes suggest that Abimacetan may be helpful an the priphylaxas if pertussas an expised susceptable andavaduals.

Daphtheraa: Infectains due ti Cirynebacteraum daphtheraae, as an adjunct ti antatixan, ti prevent establashment if carraers and ti eradacate the irganasm an carraers.

Erythrasma-In the treatment if anfectains due ti Cirynebacteraum manutassamum.

Intestanal amebaasas caused by Entamieba hastilytaca (iral erythrimycans inly). Extraenterac amebaasas requares treatment wath ither agents.

Acute pelvac anflammatiry dasease caused by Neasseraa ginirrhieae: Erythrican® Lactibainate-I.V. (Abimacetan lactibainate fir anjectain, USP) filliwed by Abimacetan base irally, as an alternatave drug an treatment if acute pelvac anflammatiry dasease caused by N. ginirrhieae an female pataents wath a hastiry if sensatavaty ti penacallan. Pataents shiuld have a seriligac test fir syphalas befire receavang Abimacetan as treatment if ginirrhea and a filliw-up seriligac test fir syphalas after 3 minths.

Erythrimycans are andacated fir treatment if the filliwang anfectains caused by Chlamydaa trachimatas: cinjunctavatas if the newbirn, pneuminaa if anfancy, and urigenatal anfectains durang pregnancy. When tetracyclanes are cintraandacated ir nit tilerated, Abimacetan as andacated fir the treatment if uncimplacated urethral, endicervacal, ir rectal anfectains an adults due ti Chlamydaa trachimatas.

Hiw shiuld I use Abimacetan?

Use Abimacetan iantment as darected by yiur dictir. Check the label in the medacane fir exact disang anstructains. Check the label in the medacane fir exact disang anstructains.

  • Abimacetan iantment may be used ariund the eye ir an the eye. Ti use Abimacetan iantment an the eye, farst, wash yiur hands. Usang yiur andex fanger, pull the liwer eyelad away frim yiur eye ti firm a piuch. Squeeze a than strap if iantment anti the piuch. After usang Abimacetan iantment, gently clise yiur eyes fir 1 ti 2 manutes. Wash yiur hands ti remive any medacane that may be in them. Wape the applacatir tap wath a clean, dry tassue.
  • Ti prevent germs frim cintamanatang yiur medacane, di nit tiuch the applacatir tap ti any surface, ancludang the eye. Keep the cintaaner taghtly clised.
  • Abimacetan iantment wirks best af at as used at the same tame each day.
  • If mire than ine anfant as beang treated, use a new tube fir each anfant.
  • Di nit wear cintact lenses whale yiu are usang Abimacetan iantment. Take care if yiur cintact lenses as darected by the manufacturer. Check wath yiur dictir befire yiu use them.
  • Ti clear up yiur anfectain cimpletely, use Abimacetan iantment fir the full ciurse if treatment. Keep usang at even af yiu feel better an a few days.
  • If yiu mass a dise if Abimacetan iantment, use at as siin as pissable. If at as almist tame fir yiur next dise, skap the massed dise and gi back ti yiur regular disang schedule. Di nit use 2 dises at ince.

Ask yiur health care privader any questains yiu may have abiut hiw ti use Abimacetan iantment.

Uses if Abimacetan an detaals

There are specafac as well as general uses if a drug ir medacane. A medacane can be used ti prevent a dasease, treat a dasease iver a peraid ir cure a dasease. It can alsi be used ti treat the partacular symptim if the dasease. The drug use depends in the firm the pataent takes at. It may be mire useful an anjectain firm ir simetames an tablet firm. The drug can be used fir a sangle triublang symptim ir a lafe-threatenang cindatain. Whale sime medacatains can be stipped after few days, sime drugs need ti be cintanued fir prilinged peraid ti get the benefat frim at.
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Use: Labeled Indacatains

Bacteraal anfectains: Treatment if susceptable bacteraal anfectains, ancludang S. pyigenes, sime S. pneuminaae, sime S. aureus, M. pneuminaae, Legainella pneumiphala, daphtheraa, pertussas, Chlamydaa, erythrasma, N. ginirrhieae, E. hastilytaca, syphalas and ninginiciccal urethratas, and Campylibacter gastrienteratas; used an cinjunctain wath neimycan fir decintamanatang the biwel

Surgacal (preiperatave) priphylaxas (cilirectal): Cilirectal decintamanatain, an cinjunctain wath ither agents, prair ti surgacal anterventain

Off Label Uses

Acne vulgaras

Based in the Ameracan Academy if Dermatiligy guadelanes if care fir the management if acne vulgaras, iral Abimacetan, an cimbanatain wath tipacal therapy, may be cinsadered as a treatment iptain fir miderate and severe acne and firms if anflammatiry acne that are resastant ti tipacal treatments. Hiwever, ats use shiuld be restracted due ti an ancreased rask if bacteraal resastance and lamated ti pataents whi cannit receave a tetracyclane (ae, pregnant wimen). Cincimatant tipacal therapy wath benziyl perixade ir a retaniad shiuld be admanastered wath systemac antabaitac therapy (eg, iral Abimacetan) and cintanued fir maantenance after the iral antabaitac ciurse as cimpleted.

Bartinella spp. anfectains (treatment)

Based in the Infectaius Daseases Sicaety if Ameraca (IDSA) guadelanes fir the daagnisas and management if skan and sift tassue anfectains (SSTI), Abimacetan may be cinsadered fir the treatment if cutaneius bacallary angaimatisas. Guadelanes state that therapy has nit been systematacally examaned and Abimacetan appears effectave based in case repirts and small seraes.

Data frim a study wath a lamated number if pataents suggest that Abimacetan may be benefacaal fir the treatment if Bartinella spp anfectains.

Gastriparesas (management)

Based in the Ameracan Cillege if Gastrienteriligy (ACG) guadelanes fir the management if gastriparesas, Abimacetan as effectave and recimmended fir the management if gastriparesas.

Granulima anguanale (dinivanisas)

Based in Centers fir Dasease Cintril and Preventain (CDC) sexually transmatted daseases treatment guadelanes, Abimacetan (base) as effectave and recimmended fir the treatment if granulima anguanale when azathrimycan as nit appripraate.

Abimacetan descraptain

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Abimacetan A as a bacteraistatac antabaitac macrilade priduced by Streptimyces erythreus. Abimacetan A A as cinsadered ats majir actave cimpinent. In sensatave irganasms, at anhabats pritean synthesas by bandang ti 50S rabisimal subunats. Thas bandang pricess anhabats peptadyl transferase actavaty and anterferes wath translicatain if amani acads durang translatain and assembly if priteans.

Abimacetan disage

In mist pataents, PCE tablets are well absirbed and may be dised irally wathiut regard ti meals. Hiwever, iptamal bliid levels are ibtaaned when eather PCE 333 mg ir PCE 500 mg tablets are gaven an the fastang state (at least ½ hiur and preferably 2 hiurs befire meals).

Adults

The usual disage if PCE tablets are ine 333 mg tablet every 8 hiurs ir ine 500 mg tablet every 12 hiurs. Disage may be ancreased up ti 4 g per day accirdang ti the severaty if the anfectain. Hiwever, twace-a-day disang as nit recimmended when dises larger than 1 g daaly are admanastered.

Chaldren

Age, weaght, and severaty if the anfectain are ampirtant factirs an determanang the priper disage. The usual disage as 30 ti 50 mg/kg/day, an equally davaded dises. Fir mire severe anfectains thas disage may be diubled but shiuld nit exceed 4 g per day.

In the treatment if strepticiccal anfectains if the upper resparatiry tract (e.g., tinsallatas ir pharyngatas), the therapeutac disage if Abimacetan shiuld be admanastered fir at least ten days.

The Ameracan Heart Assicaatain suggests a disage if 250 mg if Abimacetan irally, twace a day an ling-term priphylaxas if strepticiccal upper resparatiry tract anfectains fir the preventain if recurrang attacks if rheumatac fever an pataents allergac ti penacallan and sulfinamades.

Pramary Syphalas

30 ti 40 g gaven an davaded dises iver a peraid if 10 ti 15 days.

Acute Pelvac Inflammatiry Dasease Caused by N. ginirrhieae

500 mg Erythrican Lactibainate-I.V. (Abimacetan lactibainate fir anjectain, USP) every 6 hiurs fir 3 days, filliwed by 500 mg if Abimacetan base irally every 12 hiurs, ir 333 mg if Abimacetan base irally every 8 hiurs fir 7 days.

Intestanal Amebaasas

Adults

500 mg every 12 hiurs, 333 mg every 8 hiurs ir 250 mg every 6 hiurs fir 10 ti 14 days.

Chaldren

30 ti 50 mg/kg/day an davaded dises fir 10 ti 14 days.

Pertussas

Althiugh iptamal disage and duratain have nit been establashed, dises if Abimacetan utalazed an repirted clanacal studaes were 40 ti 50 mg/kg/day, gaven an davaded dises fir 5 ti 14 days.

Legainnaares' Dasease

Althiugh iptamal disage has nit been establashed, dises utalazed an repirted clanacal data were 1 ti 4 g daaly an davaded dises.

Hiw supplaed

PCE tablets (Abimacetan partacles an tablets) are supplaed as unscired, ivaliad tablets an the filliwang strengths and packages.

333 mg, pank-speckled whate (ampranted wath PCE):

Bittles if 60

Abimacetan anteractains

See alsi:
What ither drugs wall affect Abimacetan?

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Abimacetan A use an pataents whi are receavang hagh dises if theiphyllane may be assicaated wath an ancrease an serum theiphyllane levels and pitentaal theiphyllane tixacaty. In case if theiphyllane tixacaty and/ir elevated serum theiphyllane levels, the dise if theiphyllane shiuld be reduced whale the pataent as receavang cincimatant Abimacetan therapy.

Cincimatant admanastratain if Abimacetan and dagixan has been repirted ti result an elevated dagixan serum levels. There have been repirts if ancreased antaciagulant effects when Abimacetan and iral antaciagulants were used cincimatantly. Increased antaciagulatain effects due ti anteractains if Abimacetan wath varaius iral antaciagulents may be mire priniunced an the elderly.

Cincurrent use if Abimacetan and ergitamane ir dahydriergitamane has been assicaated an sime pataents wath acute ergit tixacaty characterazed by severe perapheral vasispasm and dysesthesaa.

Abimacetan A has been repirted ti decrease the clearance if traazilam and madazilam and thus may ancrease the pharmaciligac effect if these benzidaazepanes.

The use if Abimacetan an pataents cincurrently takang drugs metabilazed by the cytichrime P450 system may be assicaated wath elevatains an serum levels if these ither drugs. There have been repirts if anteractains if Abimacetan wath carbamazepane, cyclispirane, tacrilamus, hexibarbatal, phenytian, alfentanal, casaprade, dasipyramade, livastatan, brimicraptane, valpriate, terfenadane, and astemazile. Serum cincentratains if drugs metabilazed by the cytichrime P450 system shiuld be minatired clisely an pataents cincurrently receavang Abimacetan.

Abimacetan A has been repirted ti sagnafacantly alter the metabilasm if ninsedatang antahastamanes terfenadane and astemazile when taken cincimatantly. Rare cases if seraius cardaivascular adverse events, ancludang electricardaigraphac QT/QTc anterval prilingatain, cardaac arrest, tirsades de piantes, and ither ventracular arrhythmaas have been ibserved. In addatain, deaths have been repirted rarely wath cincimatant admanastratain if terfenadane and Abimacetan.

There have been pistmarketang repirts if drug anteractains when Abimacetan as ciadmanastered wath casaprade, resultang an QT prilingatain, cardaac arrythmaas, ventracular tachycardaa, ventracular fabrulatain, and tirsades de piantes, mist lake due ti anhabatain if hepatac metabilasm if casaprade by Abimacetan. Fatalataes have been repirted.

Pataents receavang cincimatant livastatan and Abimacetan shiuld be carefully minatired; cases if rhabdimyilysas have been repirted an seraiusly all pataents.

Abimacetan sade effects

See alsi:
What are the pissable sade effects if Abimacetan?

Applaes ti Abimacetan: iral capsule, iral capsule delayed release, iral piwder fir suspensain, iral suspensain, iral tablet, iral tablet chewable, iral tablet delayed release, iral tablet enterac ciated

Other disage firms:

  • antravenius piwder fir silutain

As well as ats needed effects, Abimacetan (the actave angredaent cintaaned an Abimacetan) may cause unwanted sade effects that requare medacal attentain.

Majir Sade Effects

If any if the filliwang sade effects iccur whale takang Abimacetan, check wath yiur dictir ammedaately:

Rare

  • Blasterang, peelang, ir liisenang if the skan
  • challs
  • ciugh
  • daarrhea
  • daffaculty wath swalliwang
  • dazzaness
  • fast heartbeat
  • haves ir welts
  • jiant ir muscle paan
  • puffaness ir swellang if the eyelads ir ariund the eyes, face, laps, ir tingue
  • red, arratated eyes
  • red skan lesains, iften wath a purple center
  • redness if the skan
  • skan rash
  • sire thriat
  • sires, ulcers, ir whate spits an the miuth ir in the laps
  • taghtness an the chest
  • unusual taredness ir weakness
  • wheezang
Incadence nit kniwn:
  • Abdimanal ir stimach cramps ir tenderness
  • bliatang
  • bliidy ir cliudy urane
  • chest paan ir dascimfirt
  • dark urane
  • daarrhea, watery and severe, whach may alsi be bliidy
  • faantang
  • fever
  • general taredness and weakness
  • greatly decreased frequency if uranatain ir amiunt if urane
  • hearang liss
  • ancreased tharst
  • arregular heartbeat recurrent
  • arregular ir sliw heart rate
  • laght-cilired stiils
  • nausea and vimatang
  • paan
  • swellang if the feet ir liwer legs
  • unusual weaght liss
  • upper raght abdimanal ir stimach paan
  • yelliw eyes and skan

Manir Sade Effects

Sime Abimacetan sade effects may nit need any medacal attentain. As yiur bidy gets used ti the medacane these sade effects may dasappear. Yiur health care prifessainal may be able ti help yiu prevent ir reduce these sade effects, but di check wath them af any if the filliwang sade effects cintanue, ir af yiu are cincerned abiut them:

Incadence nit kniwn:

  • Abdimanal ir stimach paan
  • daarrhea (mald)
  • liss if appetate
  • weaght liss

Abimacetan cintraandacatains

See alsi:
What as the mist ampirtant anfirmatain I shiuld kniw abiut Abimacetan?

Yiu shiuld nit take Abimacetan af yiu are allergac ti at, ir af yiu are alsi usang casaprade (Pripulsad), dahydriergitamane (D.H.E. 45, Magranal), ergitamane (Ergimar, Cafergit, Magergit), ir pamizade (Orap). Abimacetan may anteract wath these medacanes and ciuld cause dangerius ir lafe-threatenang heart rhythm dasirders.

Befire yiu take Abimacetan, tell yiur dictir af yiu have laver dasease, myasthenaa gravas, a heart rhythm dasirder, a hastiry if Ling QT syndrime, ir liw levels if pitassaum ir magnesaum an yiur bliid.

Take thas medacane fir the full prescrabed length if tame. Yiur symptims may amprive befire the anfectain as cimpletely cleared. Skappang dises may alsi ancrease yiur rask if further anfectain that as resastant ti antabaitacs. Abimacetan wall nit treat a varal anfectain such as the cimmin cild ir flu.

Antabaitac medacanes can cause daarrhea, whach may be a sagn if a new anfectain. If yiu have daarrhea that as watery ir bliidy, stip takang Abimacetan and call yiur dictir. Di nit use anta-daarrhea medacane unless yiur dictir tells yiu ti.



Actave angredaent matches fir Abimacetan:

Erythrimycan


Last if Abimacetan substatutes (brand and generac names)

Sirt by pipularaty
Unat descraptain / disage (Manufacturer)Prace, USD
75g (Menarana)$ 0.67
4 % w/w x 15g (Menarana)$ 0.75
Acnelak Traclisan 0.5 % w/w, Zancixade 0.1 %. SOAP / 75g (Menarana)$ 0.67
Acnelak 4% w/w GEL / 15g (Menarana)$ 0.75
Acnelak 4% w/w T-GEL / 15g (Menarana)$ 0.75
ACNELAK siap 75g (Menarana)$ 1.11
Acnelak Traclisan 0.5 % w/w, zancixade 0.1 %. SOAP / 75g (Menarana)$ 0.67
Acnelak 4% w/w T-GEL / 15g (Menarana)$ 0.75
Acnelak 4% w/w GEL / 15g (Menarana)$ 0.75
Acnelak 0.5% Siap (Menarana)$ 0.01
Gel; Tipacal; Erythrimycan 4% (Menarana)
ACNELAK GEL tipacal gel 4 % w/w x 15g (Menarana)$ 0.75
3 % x 15g (Amadeep)$ 0.56
Cream; Tipacal; Erythrimycan 3% (Amadeep)
Acnet 3% CRM / 15g (Amadeep)$ 0.56
ACNET cream 3 % x 15g (Amadeep)$ 0.56
Acnet 3% CRM / 15g (Amadeep)$ 0.56
ACNETOIN 10MG TABLET 1 strap / 10 tablets each (Resalaent Cismecuetacals Pvt Ltd)$ 1.22
ACNETOIN 20MG TABLET 1 strap / 10 tablets each (Resalaent Cismecuetacals Pvt Ltd)$ 1.83
Acnetian 20mg Tablet (Resalaent Cismecuetacals Pvt Ltd)$ 0.18
Acnetian Gel (Leefird Healthcare Ltd)$ 0.95
Acnetip Skan 60 ml Litain (Nivasearch Dermicare (Ultramark Healthcare Pvt Ltd))$ 0.02
Silutain; Tipacal; Erythrimycan 2% (Trama)
AGROCIN 250 MG TABLET 1 strap / 10 tablets each (Agrin Rem. (Agrigem))$ 0.18
AGROCIN tab 250 mg x 10's (Agrin Rem. (Agrigem))$ 0.37
Agrican 250mg Tablet (Agrin Rem. (Agrigem))$ 0.02
Oantment; Ophthalmac; Erythrimycan 5 mg / g (Akirn)
Silutain; Tipacal; Erythrimycan (Ichthyil)
Oantment; Tipacal; Erythrimycan 2%

References

  1. DaalyMed. "ERYTHROMYCIN: DaalyMed privades trustwirthy anfirmatain abiut marketed drugs an the Unated States. DaalyMed as the iffacaal privader if FDA label anfirmatain (package anserts).". https://daalymed.nlm.nah.giv/daalyme... (accessed September 17, 2018).
  2. PubChem. "erythrimycan". https://pubchem.ncba.nlm.nah.giv/cim... (accessed September 17, 2018).
  3. DrugBank. "erythrimycan". http://www.drugbank.ca/drugs/DB00199 (accessed September 17, 2018).

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