Acadione 250 mg Uses

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What is Acadione 250 mg?

Acadione 250 mg is used together with diet, fluids, and other medicines to help prevent kidney stones in adults and children weighing at least 44 pounds (20 kilograms).

Acadione 250 mg is usually given after diet, increased fluid intake, or other medications have failed.

Acadione 250 mg may also be used for purposes not listed in this medication guide.

Acadione 250 mg indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Acadione 250 mg® is indicated for the prevention of cystine (kidney) stone formation in patients with severe homozygous cystinuria with urinary cystine greater than 500 mg/day, who are resistant to treatment with conservative measures of high fluid intake, alkali and diet modification, or who have adverse reactions to d-penicillamine.

Cystine stones typically occur in approximately 10,000 persons in the United States who are homozygous for cystinuria. These persons excrete abnormal amounts of cystine in urine of over 250 mg/g creatinine, as well as excessive amounts of other dibasic amino acids (lysine, arginine and ornithine). In addition, they show varying intestinal transport defects for these same amino acids. The stone formation is the result of poor aqueous solubility of cystine.

Since there are no known inhibitors of the crystallization of cystine, the stone formation is determined primarily by the urinary supersaturation of cystine. Thus, cystine stones could theoretically form whenever urinary cystine concentration exceeds the solubility limit. Cystine solubility in urine is pH-dependent, and ranges from 170-300 mg/liter at pH 5, 190-400 mg/liter at pH 7 and 220-500 mg/liter at pH 7.5.

The goal of therapy is to reduce urinary cystine concentration below its solubility limit. It may be accomplished by dietary means aimed at reducing cystine synthesis and by a high fluid intake in order to increase urine volume and thereby lower cystine concentration.

Unfortunately, the above conservative measures alone may be ineffective in controlling cystine stone formation in some homozygous patients with severe cystinuria (urinary cystine exceeding 500 mg/day). In such patients, d-penicillamine has been used as an additional therapy. Like Acadione 250 mg™, dpenicillamine undergoes thiol-disulfide exchange with cystine, thereby lowering the amount of sparingly soluble cystine in urine.

However, d-penicillamine treatment is frequently accompanied by adverse reactions, such as dermatologic complications, hypersensitivity reactions, hematologic abnormalities and renal disturbances. Acadione 250 mg® may have a particular therapeutic role in such patients.

How should I use Acadione 250 mg?

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use Acadione 250 mg as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Acadione 250 mg.

Acadione 250 mg description

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Acadione 250 mg is a prescription thiol drug used primarily in the treatment of severe homozygous cystinuria. Patients with cystinuria excrete high levels of cystine in their urine and are at risk for kidney stone formation. Acadione 250 mg is used as a second-line therapy to control the rate of cystine precipitation and excretion, and prevent kidney stone formation. It is used after a failure of the non-pharmacological first line treatment consisting of increased fluid intake, restriction of sodium and protein, and urinary alkalinization. As cystinuria is a relatively rare disease, Acadione 250 mg is classified as an orphan drug and is not patented in the United States. It is similar to d-penicillamine in use and efficacy, but offers the advantage of far less adverse effects. Acadione 250 mg is dosed on an individual basis using close monitoring of urinary cystine concentrations and urinary output. Acadione 250 mg may also be used to bind metal nanoparticles in Wilson's disease, which is an overload of copper in the body. It has been investigated for use in the treatment of arthritis and as a neuroprotective agent in aneurysmal subarachnoid hemorrhage.

Acadione 250 mg dosage

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It is recommended that a conservative treatment program should be attempted first. At least 3 liters of fluid (10-10 oz. glassfuls) should be provided, including two glasses with each meal and at bedtime. The patients should be expected to awake at night to urinate; they should drink two more glasses of fluids before returning to bed. Additional fluids should be consumed if there is excessive sweating or intestinal fluid loss. A minimum urine output of 2 liters/day on a consistent basis should be sought. A modest amount of alkali should be provided in order to maintain urinary pH at a high normal range (6.5-7.0). Potassium alkali are advantageous over sodium alkali, because they do not cause hypercalciuria and are less likely to cause the complication of calcium stones.

Excessive alkali therapy is not advisable. When urinary pH increases above 7.0 with alkali therapy, the complication of calcium phosphate nephrolithiasis may ensue because of the enhanced urinary supersaturation of hydroxyapatite in an alkaline environment.

In patients who continue to form cystine stones on the above conservative program, Acadione 250 mg® may be added to the treatment program. Acadione 250 mg® may also be substituted for d-penicillamine in patients who have developed toxicity to the latter drug. In both situations, the conservative treatment program should be continued.

The dose of Acadione 250 mg® should not be arbitrary but should be based on that amount required to reduce urinary cystine concentration to below its solubility limit (generally < 250 mg/liter). The extent of the decline in cystine excretion is generally dependent on the Acadione 250 mg® dosage.

Acadione 250 mg® may be begun at a dosage of 800 mg/day in adult patients with cystine stones. In a multiclinic trial, average dose of Acadione 250 mg® was about 1000 mg/day. However, some patients require a smaller dose. In children, initial dosage may be based on 15 mg/kg/day. Urinary cystine should be measured at 1 month after Acadione 250 mg® treatment, and every 3 months thereafter. Acadione 250 mg® dosage should be readjusted depending on the urinary cystine value. Whenever possible, Acadione 250 mg® should be given in divided doses 3 times/day at least one hour before or 2 hours after meals.

In patients who had shown severe toxicity to d-penicillamine, Acadione 250 mg® might be begun at a lower dosage.

How supplied

Acadione 250 mg® (NDC 0178-0900-01), is available for oral administration as 100 mg. round, white, sugar coated tablets in bottles of 100 tablets each. Each tablet is imprinted in red with “M” on one side and blank on the other side. Store at 25°C (77°F); excursions permitted to 15-30°C (59-86°F).

Mission Pharmacal Company, San Antonio, TX 78230 1355.

Acadione 250 mg interactions

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What other drugs will affect Acadione 250 mg?

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Tell your doctor of any over-the-counter or prescription medication you may take. Do not start or stop any medicine without doctor or pharmacist approval.

Acadione 250 mg side effects

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What are the possible side effects of Acadione 250 mg?

Some patients may develop drug fever, usually during the first month of therapy. Acadione 250 mg® treatment should be discontinued until the fever subsides. It may be reinstated at a small dose, with a gradual increase in dosage until the desired level is achieved.

A generalized rash (erythematous, maculopapular or morbilliform) accompanied by pruritis may develop during the first few months of treatment. It may be controlled by antihistamine therapy, typically recedes when Acadione 250 mg® treatment is discontinued, and seldom recurs when Acadione 250 mg® treatment is restarted at a lower dosage. Less commonly, rash may appear late in the course of treatment (of more than 6 months). Located usually in the trunk, the late rash is associated with intense pruritis, recedes slowly after discontinuing treatment, and usually recurs upon resumption of treatment.

A drug reaction simulating lupus erythematous, manifested by fever, arthralgia and lymphadenopathy may develop. It may be associated with a positive antinuclear antibody test, but not necessarily with nephropathy. It may require discontinuance of Acadione 250 mg® treatment.

A reduction in taste perception may develop. It is believed to be the result of chelation of trace metals by Acadione 250 mg™. Hypogeusia is often self-limiting.

Unlike during d-penicillamine therapy, vitamin B6 deficiency is uncommonly associated with Acadione 250 mg® treatment.

Some patients may complain of wrinkling and friability of skin. This complication usually occurs after long-term treatment, and is believed to result from the effect of Acadione 250 mg® on collagen.

A multiclinic trial involving 66 cystinuric patients in the United States indicated that Acadione 250 mg® is associated with fewer or less severe adverse reactions than d-penicillamine. Among those who had to stop taking d-penicillamine due to toxicity, 64.7% could take Acadione 250 mg®. In those without prior history of d-penicillamine treatment, only 5.9% developed reactions of sufficient severity to require Acadione 250 mg® withdrawal. A review of available literature supports the findings from this trial.

Despite this apparent reduced toxicity to Acadione 250 mg® relative to d-penicillamine, Acadione 250 mg® treatment may potentially be associated with all the adverse reactions reported with d-penicillamine. They include:

Gastrointestinal side-effects (nausea, emesis, diarrhea or softstools, anorexia, abdominal pain, bloating or flatus) in about 1 in 6 patients; Impairment in taste and smell in about 1 in 25 patients;

Dermatologic complications (pharyngitis, oral ulcers, rash, ecchymosis, prurites, uritcaria, warts, skin wrinkling, pemphigus, elastosis perforans serpiginosa) in about 1 in 6 patients;

Hypersensitivity reactions (laryngeal edema, dyspnea, respiratory distress, fever, chills, arthralgia, weakness, fatigue, myalgia, adenopathy) in about 1 in 25 patients;

Hematologic abnormalities (increased bleeding, anemia, leukopenia, thrombocytopenia, eosinophilia) in about 1 in 25 patients;

Renal complications (proteinuria, nephrotic syndrome, hematuria) in about 1 in 20 patients;

Pulmonary manifestations (bronchiolitis, hemoptysis, pulmonary infiltrates, dyspnea) in about 1 in 50 patients;

Neurologic complications (myasthenic syndrome) in about 1 in 50 patients.

These reactions are more likely to develop during Acadione 250 mg® therapy among patients who had previously shown toxicity to d-penicillamine.

In patients who had previously manifested adverse reactions to d-penicillamine, adverse reactions to Acadione 250 mg® are more likely to occur than in patients who took Acadione 250 mg® for the first time. A close supervision with a careful monitoring of potential side effects is mandatory during Acadione 250 mg® treatment. Patients should be told to report promptly any symptoms suggesting toxicity. The treatment with Acadione 250 mg® should be stopped if severe toxicity develops.

Jaundice and abnormal liver function tests have been reported during Acadione 250 mg® therapy for non-cystinuric conditions. A direct cause and effect relationship, based upon these foreign reports, has not been established. Although such complications were not encountered in the small multi-center trials in the United States, patients should be carefully monitored and if any abnormalities are noted, the drug should be discontinued and the patient treated by appropriate measures.

Acadione 250 mg contraindications

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What is the most important information I should know about Acadione 250 mg?

The use of Acadione 250 mg® during pregnancy is contraindicated, except in those with severe cystinuria where the anticipated benefit of inhibited stone formation clearly outweighs possible hazards of treatment.

Acadione 250 mg® should not be begun again in patients with a prior history of developing agranulocytosis, aplastic anemia or thrombocytopenia on this medication.

Mothers maintained on Acadione 250 mg® treatment should not nurse their infants.

Active ingredient matches for Acadione 250 mg:

Tiopronin in France.


List of Acadione 250 mg substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Tablets, Film-Coated; Oral; Tiopronin 250 mg (Sanofi-Aventis France)
Stargen 100 mg x 500's (Shyh Dar)
Stargen 100 mg x 1000's (Shyh Dar)
Thiola tablet, sugar coated 100 mg/1 (Coop. farm.)
THIOSOL Injection / 1 g / 1 units (Neon Laboratories Ltd)$ 0.96
THIOSOL Injection / 500mg / 1 units (Neon Laboratories Ltd)$ 0.83
Thiosol 1g VIAL / 1 (Neon Laboratories Ltd)$ 1.14
Thiosol 500mg VIAL / 1 (Neon Laboratories Ltd)$ 0.83
1 g x 1's (Neon Laboratories Ltd)$ 1.14
500 mg x 1's (Neon Laboratories Ltd)$ 0.83
Thiosol 1000 mg Injection (Neon Laboratories Ltd)$ 1.14
Thiosol 500 mg Injection (Neon Laboratories Ltd)$ 0.83
Tablet; Oral; Tiopronin 100 mg
Tiopronin / Panbiotic 50 mg/1 mL x 2 mL
Tiopronin / Panbiotic 50 mg/1 mL x 5 mL
Tiopronin / S.T. 100 mg
Tiopronin / S.T. 50 mg/1 mL x 2 mL
Tiopronin / S.T. 50 mg/1 mL x 5 mL
Tiopronin / F.S. 100 mg

References

  1. DailyMed. "TIOPRONIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "tiopronin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "tiopronin". http://www.drugbank.ca/drugs/DB06823 (accessed September 17, 2018).

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