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Aceloflam XP Actions |
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Aceclofenac (Aceloflam XP) is a phenylacetic acid derivative that inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. It increases glycosaminoglycans (GAG) synthesis, the principal macromolecule of the extracellular matrix, which aids in repair and regeneration of articular cartilage. Thus, Aceclofenac (Aceloflam XP) has +ve effects on cartilage anabolism combined with modulating effect of matrix catabolism. Paracetamol (Aceloflam XP) has analgesic and antipyretic action with weak anti-inflammatory activity. It produces analgesia by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating centre.
Absorption: Aceclofenac (Aceloflam XP): Rapidly absorbed; almost 100% bioavailability; peak plasma levels reached about 1.25-3 hr after oral admin.
Distribution: Aceclofenac (Aceloflam XP): >99.7% bound to plasma proteins; distributes into synovial fluid. Paracetamol (Aceloflam XP): Distributes throughout most fluids of the body.
Metabolism: Aceclofenac (Aceloflam XP): Probably metabolised by CYP2C9; average plasma elimination half-life: 4-4.3 hr. Paracetamol (Aceloflam XP): Mainly metabolised hepatically; plasma elimination half-life: 1-4 hr.
Excretion: Aceclofenac (Aceloflam XP): About two-thirds of the administered dose is removed in the urine, mainly as conjugated hydroxymetabolites. Paracetamol (Aceloflam XP): Most metabolites are removed in the urine within 24 hr.
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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