Dosage of Acetaminophen Infant's in details
General Dosing Information
Acetaminophen Infant's Injection may be given as a single or repeated dose for the treatment of acute pain or fever. No dose adjustment is required when converting between oral Acetaminophen Infant's and Acetaminophen Infant's Injection dosing in adults and adolescents who weigh 50 kg and above. Calculated maximum daily dose of Acetaminophen Infant's is based on all routes of administration (i.e., intravenous, oral, and rectal) and all products containing Acetaminophen Infant's. Exceeding the maximum mg/kg daily dose of Acetaminophen Infant's as described in Tables 1 to 3 may result in hepatic injury, including the risk of liver failure and death. To avoid the risk of overdose, ensure that the total amount of Acetaminophen Infant's from all routes and from all sources does not exceed the maximum recommended dose.
Recommended
Dosage: Adults and Adolescents
Adults and adolescents weighing 50 kg and over: the recommended dosage of Acetaminophen Infant's Injection is 1,000 mg every 6 hours or 650 mg every 4 hours, with a maximum single dose of Acetaminophen Infant's Injection of 1,000 mg, a minimum dosing interval of 4 hours, and a maximum daily dose of Acetaminophen Infant's of 4,000 mg per day (includes all routes of administration and all Acetaminophen Infant's-containing products including combination products).
Adults and adolescents weighing under 50 kg: the recommended dosage of Acetaminophen Infant's Injection is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Acetaminophen Infant's Injection of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Acetaminophen Infant's of 75 mg/kg per day (includes all routes of administration and all Acetaminophen Infant's-containing products including combination products).
| Age group | Dose given every 4 hours | Dose given every 6 hours | Maximum single dose | Maximum total daily dose of Acetaminophen Infant's (by all routes) |
|---|---|---|---|---|
| Adults and adolescents (13 years and older) weighing ≥ 50 kg | 650 mg | 1,000 mg | 1,000 mg | 4,000 mg in 24 hours |
| Adults and adolescents (13 years and older) weighing < 50 kg | 12.5 mg/kg | 15 mg/kg | 15 mg/kg (up to 750 mg) | 75 mg/kg in 24 hours (up to 3,750 mg) |
Recommended
Dosage: Children
Children 2 to 12 years of age: the recommended dosage of Acetaminophen Infant's Injection is 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours, with a maximum single dose of Acetaminophen Infant's Injection of 15 mg/kg, a minimum dosing interval of 4 hours, and a maximum daily dose of Acetaminophen Infant's of 75 mg/kg per day.
| Age group | Dose given every 4 hours | Dose given every 6 hours | Maximum single dose | Maximum total daily dose of Acetaminophen Infant's (by all routes) |
| Children 2 to 12 years of age | 12.5 mg/kg | 15 mg/kg | 15 mg/kg (up to 750 mg) | 75 mg/kg in 24 hours (up to 3,750 mg) |
Recommended Dosage for Treatment of Fever in Neonates and Infants
Neonates, including premature neonates born at ≥ 32 weeks gestational age, up to 28 days chronological age: the recommended dosage of Acetaminophen Infant's is 12.5 mg/kg every 6 hours, to a maximum daily dose of Acetaminophen Infant's of 50 mg/kg per day, with a minimum dosing interval of 6 hours.
Infants 29 days to 2 years of age: the recommended dosage of Acetaminophen Infant's is 15 mg/kg every 6 hours, to a maximum daily dose of Acetaminophen Infant's of 60 mg/kg per day, with a minimum dosing interval of 6 hours.
| Age group | Dose given every 6 hours | Maximum total daily dose of Acetaminophen Infant's (by all routes) |
| Neonates (birth to 28 days) | 12.5 mg/kg | 50 mg/kg |
| Infants (29 days to 2 years) | 15 mg/kg | 60 mg/kg |
Instructions for
Intravenous Administration
For adult and adolescent patients weighing ≥ 50 kg requiring 1,000 mg doses of Acetaminophen Infant's Injection, administer the dose by inserting a vented intravenous set through the septum of the 100 mL vial. Acetaminophen Infant's Injection may be administered without further dilution. Examine the container contents before dose preparation or administering. DO NOT USE if particulate matter or discoloration is observed. Administer the contents of the vial intravenously over 15 minutes. Use aseptic technique when preparing Acetaminophen Infant's Injection for intravenous infusion. Do not add other medications to the Acetaminophen Infant's Injection vial or infusion device.
For doses less than 1,000 mg, the appropriate dose must be withdrawn from the container and placed into a separate container prior to administration. Using aseptic technique, withdraw the appropriate dose (650 mg or weight-based) from an intact sealed Acetaminophen Infant's Injection container and place the measured dose in a separate empty, sterile container (e.g., glass bottle, plastic intravenous container, or syringe) for intravenous infusion to avoid the inadvertent delivery and administration of the total volume of the commercially available container. The entire 100 mL container of Acetaminophen Infant's Injection is not intended for use in patients weighing less than 50 kg. Acetaminophen Infant's Injection is supplied in a single-dose container and the unused portion must be discarded.
Place small volume pediatric doses up to 60 mL in volume in a syringe and administer over 15 minutes using a syringe pump.
Monitor the end of the infusion in order to prevent the possibility of an air embolism, especially in cases where the Acetaminophen Infant's Injection infusion is the primary infusion.
Once the container seal has been penetrated, or the contents transferred to another container, administer the dose of Acetaminophen Infant's Injection within 6 hours.
Do not add other medications to the Acetaminophen Infant's Injection solution. Diazepam and chlorpromazine hydrochloride are physically incompatible with Acetaminophen Infant's Injection, therefore do not administer simultaneously.
What other drugs will affect Acetaminophen Infant's?
Ask a doctor or pharmacist if it is safe for you to use Acetaminophen Infant's if you are also using any of the following drugs:
- an antibiotic, antifungal medicine, sulfa drug, or tuberculosis medicine;
- birth control pills or hormone replacement therapy;
- blood pressure medication;
- cancer medications;
- cholesterol-lowering medications such as Lipitor, Niaspan, Zocor, Vytorin, and others;
- gout or arthritis medications (including gold injections);
- HIV/AIDS medications;
- medicines to treat psychiatric disorders;
- an NSAID such as Advil, Aleve, Arthrotec, Cataflam, Celebrex, Indocin, Motrin, Naprosyn, Treximet, Voltaren, others; or
- seizure medications.
This list is not complete and there may be other drugs that can interact with Acetaminophen Infant's. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Acetaminophen Infant's interactions
Acetaminophen Infant's is metabolized (eliminated by conversion to other chemicals) by the liver. Therefore drugs that increase the action of liver enzymes that metabolize Acetaminophen Infant's [for example, carbamazepine (Tegretol), isoniazid (INH, Nydrazid, Laniazid), rifampin (Rifamate, Rifadin, Rimactane)] reduce the levels of Acetaminophen Infant's and may decrease the action of Acetaminophen Infant's. Doses of Acetaminophen Infant's greater than the recommended doses are toxic to the liver and may result in severe liver damage. The potential for Acetaminophen Infant's to harm the liver is increased when it is combined with alcohol or drugs that also harm the liver.
Cholestyramine (Questran) reduces the effect of Acetaminophen Infant's by decreasing its absorption into the body from the intestine. Therefore, Acetaminophen Infant's should be administered 3 to 4 hours after cholestyramine or one hour before cholestyramine.
Acetaminophen Infant's doses greater than 2275 mg per day may increase the blood thinning effect of warfarin (Coumadin) by an unknown mechanism. Therefore, prolonged administration or large doses of Acetaminophen Infant's should be avoided during warfarin therapy
References
- DailyMed. "ACETAMINOPHEN; ASPIRIN; CAFFEINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "362O9ITL9D: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "Antipyretics". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Acetaminophen Infant's are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Acetaminophen Infant's. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
Consumer reported frequency of use
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Information checked by Dr. Sachin Kumar, MD Pharmacology
