Adolor Actions

How long did you take this medication to work?

Actions of Adolor in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.

Pharmacology: As a nonsteroidal anti-inflammatory drug (NSAID), Adolor possesses analgesic, anti-inflammatory and antipyretic activity. The major mechanism by which Adolor and other NSAIDs exert their pharmacological effects is inhibition of prostaglandin synthesis. NSAIDs are most active in the periphery but recent evidence suggests they may act centrally also.

Pharmacokinetics: Tablet: The oral bioavailability of Adolor is 80-100%. The peak plasma concentrations are reached within about 30-60 min after oral administration. The pharmacokinetics of Adolor is linear over the usual dosage range. Steady-state plasma levels achieved after 1 day of 4 times daily dosing.

As with other NSAIDs, Adolor is almost entirely bound to plasma proteins (>99%). It is extensively metabolised, primarily by conjugation with glucuronic acid and excreted via kidney. The metabolites have no significant analgesic activity. The mean terminal elimination half-life of Adolor in healthy volunteers is about 5 hrs.

Injection: The bioavailability of Adolor after oral administration is about 80-100%. The bioavailability is similar after IV/IM administration. The pharmacokinetics of Adolor is linear over the usual parenteral dosage range. Steady-state plasma drug concentration is about 50% higher than after single-dose administration.

As with other NSAIDs, Adolor is almost entirely bound to plasma proteins (>99%), which results in a small apparent volume of distribution (Vd) <0.3 L/kg. It is extensively metabolised, primarily by conjugation with glucuronic acid and excreted via kidney. The metabolites have no significant analgesic activity. The mean terminal half-life of Adolor in healthy volunteers is about 5 hrs.

How should I take Adolor?

For patients taking Adolor tablets:

For patients using Adolor injection:

For safe and effective use of Adolor, do not use more of it, do not use it more often, and do not use it for more than 5 days. Using too much of Adolor increases the chance of unwanted effects, especially in elderly patients.

Adolor should be used only when it is ordered by your doctor for treating certain kinds of pain. Because of the risk of serious side effects, do not save any leftover Adolor for use in the future, and do not share it with other people.


The dose of Adolor will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Adolor. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of Adolor, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Adolor administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.

Intranasal: For intranasal use only; do not inhale Adolor nasal spray. Each nasal spray bottle contains medication for 1 day of therapy. Before first use of nasal spray, prime by holding the bottle upright and pressing pump 5 times. There is no need to prime again if more doses are administered during the next 24 hours using the same nasal spray bottle. Repeat priming each day prior to first use of each new nasal spray bottle. Blow nose to clear nostrils before using nasal spray.

Sit up straight or stand; tilt head slightly forward. Insert tip of container into nostril, keeping bottle upright, and point bottle toward the back and away from center of the nose. Hold breath and spray once, pressing down evenly on both sides of container. Immediately after administration, resume breathing through mouth to expel the product; pinch nose to help retain spray if dripping begins. Repeat in the opposite nostril if 2 sprays are prescribed per dose.

Discard bottle within 24 hours of priming even if there is unused medication.

Adolor pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.


Adolor Tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits analgesic activity in animal models. The mechanism of action of Adolor, like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition.

The biological activity of Adolor Tromethamine is associated with the S-form. Adolor Tromethamine possesses no sedative or anxiolytic properties.

The peak analgesic effect of Adolor Tromethamine occurs within 2 to 3 hours and is not statistically significantly different over the recommended dosage range of Adolor Tromethamine. The greatest difference between large and small doses of Adolor Tromethamine by either route is in the duration of analgesia.


Adolor Tromethamine is a racemic mixture of [-]S- and [+]R-enantiomeric forms, with the S-form having analgesic activity.

Comparison of IV, IM and

Oral Pharmacokinetics

The pharmacokinetics of Adolor Tromethamine, following IV, IM and oral doses of Adolor Tromethamine are compared in. In adults, the extent of bioavailability following administration of the ORAL and IM forms of Adolor Tromethamine was equal to that following an IV bolus.

Linear Kinetics

In adults, following administration of single ORAL, IM or IV doses of Adolor Tromethamine in the recommended dosage ranges, the clearance of the racemate does not change. This implies that the pharmacokinetics of Adolor Tromethamine in adults, following single or multiple IM, IV or recommended oral doses of Adolor Tromethamine, are linear. At the higher recommended doses, there is a proportional increase in the concentrations of free and bound racemate.


The mean apparent volume (Vß) of Adolor Tromethamine following complete distribution was approximately 13 liters. This parameter was determined from single-dose data.

The Adolor Tromethamine racemate has been shown to be highly protein bound (99%). Nevertheless, plasma concentrations as high as 10 mcg/mL will only occupy approximately 5% of the albumin binding sites. Thus, the unbound fraction for each enantiomer will be constant over the therapeutic range. A decrease in serum albumin, however, will result in increased free drug concentrations.

Adolor Tromethamine is excreted in human milk.


Adolor Tromethamine is largely metabolized in the liver. The metabolic products are hydroxylated and conjugated forms of the parent drug. The products of metabolism, and some unchanged drug, are excreted in the urine.


The principal route of elimination of Adolor and its metabolites is renal. About 92% of a given dose is found in the urine, approximately 40% as metabolites and 60% as unchanged Adolor. Approximately 6% of a dose is excreted in the feces.

A single-dose study with 10 mg Adolor Tromethamine (n = 9) demonstrated that the S-enantiomer is cleared approximately two times faster than the R-enantiomer and that the clearance was independent of the route of administration. This means that the ratio of S/R plasma concentrations decreases with time after each dose. There is little or no inversion of the R- to S- form in humans. The clearance of the racemate in normal subjects, elderly individuals and in hepatically and renally impaired patients is outlined in.

The half-life of the Adolor Tromethamine S-enantiomer was approximately 2.5 hours (SD ± 0.4) compared with 5 hours (SD ± 1.7) for the R-enantiomer. In other studies, the half-life for the racemate has been reported to lie within the range of 5 to 6 hours.


Adolor Tromethamine administered as an IV bolus, every 6 hours for 5 days to healthy subjects (n = 13), showed no significant difference in Cmax on Day 1 and Day 5. Trough levels averaged 0.29 mcg/mL (SD ± 0.13) on Day 1 and 0.55 mcg/mL (SD ± 0.23) on Day 6. Steady state was approached after the fourth dose.

Accumulation of Adolor Tromethamine has not been studied in special populations (geriatric, pediatric, renal failure patients, or hepatic disease patients).

Kinetics in Special Populations

Geriatric Patients

Based on single-dose data only, the half-life of the Adolor Tromethamine racemate increased from 5 to 7 hours in the elderly (65 to 78 years) compared with young healthy volunteers (24 to 35 years). There was little difference in the Cmax for the two groups (elderly, 2.52 mcg/mL ± 0.77; young, 2.99 mcg/mL ± 1.03).

Pediatric Patients

Limited information is available regarding the pharmacokinetics of dosing of Adolor Tromethamine in the pediatric population.

Following a single intravenous bolus dose of 0.5 mg/kg in 10 children 4 to 8 years old, the half-life was 5.8 ± 1.6 hours, the average clearance was 0.042 ± 0.01 L/hr/kg, the volume of distribution during the terminal phase (Vβ) was 0.34 ± 0.12 L/kg and the volume of distribution at steady state (Vss) was 0.26± 0.08 L/kg. The volume of distribution and clearance of Adolor in pediatric patients was higher than those observed in adult subjects. There are no pharmacokinetic data available for administration of Adolor Tromethamine by the IM route in pediatric patients.

Renal Insufficiency

Based on single-dose data only, the mean half-life of Adolor Tromethamine in renally impaired patients is between 6 and 19 hours, and is dependent on the extent of the impairment. There is poor correlation between creatinine clearance and total Adolor Tromethamine clearance in the elderly and populations with renal impairment (r = 0.5).

In patients with renal disease, the AUC∞ of each enantiomer increased by approximately 100% compared with healthy volunteers. The volume of distribution doubles for the S-enantiomer and increases by 1/5th for the R-enantiomer. The increase in volume of distribution of Adolor Tromethamine implies an increase in unbound fraction.

The AUC∞-ratio of the Adolor Tromethamine enantiomers in healthy subjects and patients remained similar, indicating there was no selective excretion of either enantiomer in patients compared to healthy subjects.

Hepatic Insufficiency

There was no significant difference in estimates of half-life, AUC∞ and Cmax, in 7 patients with liver disease compared to healthy volunteers.


Pharmacokinetic differences due to race have not been identified.

IV-Administration: In normal subjects (n=37), the total clearance of 30 mg IV-administered Adolor Tromethamine was 0.030 (0.017-0.051) L/h/kg. The terminal half-life was 5.6 (4.0-7.9) hours.


  1. EPA DSStox. "Ketorolac: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". (accessed September 17, 2018).


The results of a survey conducted on for Adolor are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Adolor. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported administration

No survey data has been collected yet

Consumer reviews

There are no reviews yet. Be the first to write one!

Your name: 
Spam protection:  < Type 6 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2022 All Rights Reserved