Aknederm Ery Gel Actions

How do you administer this medicine?
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Actions of Aknederm Ery Gel in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Pharmacology: Pharmacokinetics:

Orally administered Aknederm Ery Gel stearate is readily and reliably absorbed. Optimal serum levels of Aknederm Ery Gel are reached when the drug is taken in the fasting state or immediately before meals.

Aknederm Ery Gel diffuses readily into most body fluids. Only low concentrations are normally achieved in the spinal fluid, but passage of the drug across the blood-brain barrier increases in meningitis. In the presence of normal hepatic function, Aknederm Ery Gel is concentrated in the liver and excreted in the bile; the effect of hepatic dysfunction on excretion of Aknederm Ery Gel by the liver into the bile is not known. Less than 5% of the orally administered dose of Aknederm Ery Gel is excreted in active form in the urine.

Microbiology: Biochemical tests demonstrate Aknederm Ery Gel inhibits protein synthesis of the pathogen without directly affecting nucleic acid synthesis. Antagonism has been demonstrated between clindamycin and Aknederm Ery Gel.

Aknederm Ery Gel binds to the 50S ribosomal subunits of susceptible bacteria and suppresses protein synthesis.

Aknederm Ery Gel is usually active against most strains of the following organisms both in vitro and in clinical infections: Gram-Positive Organisms: Corynebacterium diphtheriae, Corynebacterium minutissimum, Listeria monocytogenes, Staphylococcus aureus (resistant organisms may emerge during treatment), Streptococcus pneumoniae, Streptococcus pyogenes.

Gram-Negative Organisms: Bordetella pertussis, Legionella pneumophilia, Neisseria gonorrhoeae.

Other Microorganisms: Chlamydia trachomatis, Entamoeba histolytica, Mycoplasma pneumoniae, Ureaplasma urealyticum.

Aknederm Ery Gel has been shown to be active in vitro against most strains of the following organisms; however, the safety and efficacy of Aknederm Ery Gel in treating infections due to these organisms have not been established in adequate and well-controlled trials: Gram-Positive Organisms: Alpha hemolytic streptococci (viridans group).

Gram-Negative Organisms: Moraxella (Branhamella) catarrhalis.

Other Microorganisms: Entamoeba histolytica, Treponema pallidum.

Disc Susceptibility Tests: Quantitative methods require measurement of zone diameters give the most precise estimates of antibiotic susceptibility. One recommended procedure uses Aknederm Ery Gel class discs for testing susceptibility; interpretations correlate zone diameters of this disc test with MIC values for Aknederm Ery Gel. With this procedure, a report from the laboratory of "susceptible" indicates the infecting organism is likely to respond to therapy. A report of "resistant" indicates the infective organism is not likely to respond to therapy. A report of "intermediate susceptibility" indicates the result be considered equivocal, and if, the pathogen is not fully susceptible to alternative clinically feasible drugs, the test should be repeated. This category provides a buffer zone, which prevents small, uncontrolled technical factors from causing major discrepancies in interpretation.

Note: Many strains of Haemophilus influenzae are resistant to Aknederm Ery Gel alone, but are susceptible to Aknederm Ery Gel and sulfonamides together. Staphylococci resistant to Aknederm Ery Gel may emerge during a course of Aknederm Ery Gel therapy. Culture and susceptibility testing should be performed.

How should I take Aknederm Ery Gel?

Before applying Aknederm Ery Gel, thoroughly wash the affected area with warm water and soap, rinse well, and pat dry. After washing or shaving, it is best to wait 30 minutes before applying the pledget (swab), topical gel, or topical liquid form. The alcohol in them may irritate freshly washed or shaved skin.

For patients using the pledget (swab), topical gel, or topical liquid form of Aknederm Ery Gel:

Aknederm Ery Gel will not cure your acne. However, to help keep your acne under control, keep using Aknederm Ery Gel for the full time of treatment, even if your symptoms begin to clear up after a few days. You may have to continue using Aknederm Ery Gel every day for months or even longer in some cases. If you stop using Aknederm Ery Gel too soon, your symptoms may return. It is important that you do not miss any doses.

Dosing

The dose of Aknederm Ery Gel will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Aknederm Ery Gel. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of Aknederm Ery Gel, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Aknederm Ery Gel administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
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Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

You may take Aknederm Ery Gel with or without food.

Do not crush, chew, break, or open an Aknederm Ery Gel tablet or capsule. Swallow it whole.

Shake the oral suspension (liquid) well just before you measure a dose. Measure the liquid with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

This medication can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Aknederm Ery Gel.

Take this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Aknederm Ery Gel will not treat a viral infection such as the common cold or flu.

Store at room temperature away from moisture and heat, unless otherwise directed on the medicine label.

Aknederm Ery Gel pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
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Orally administered Aknederm Ery Gel ethylsuccinate suspensions and Filmtab tablets are readily and reliably absorbed. Comparable serum levels (Aknederm Ery Gel ethylsuccinate) of Aknederm Ery Gel are achieved in the fasting and nonfasting states.

Aknederm Ery Gel diffuses readily into most body fluids. Only low concentrations are normally achieved in the spinal fluid, but passage of the drug across the blood-brain barrier increases in meningitis. In the presence of normal hepatic function, Aknederm Ery Gel is concentrated in the liver and excreted in the bile; the effect of hepatic dysfunction on excretion of Aknederm Ery Gel by the liver into the bile is not known. Less than 5 percent of the orally administered dose of Aknederm Ery Gel is excreted in active form in the urine.

Aknederm Ery Gel crosses the placental barrier, but fetal plasma levels (Aknederm Ery Gel ethylsuccinate) are low. The drug is excreted in human milk.

Microbiology

Aknederm Ery Gel acts by inhibition of protein synthesis by binding 50 S ribosomal subunits of susceptible organisms. It does not affect nucleic acid synthesis. Antagonism has been demonstrated in vitro between Aknederm Ery Gel and clindamycin, lincomycin, and chloramphenicol.

Many strains of Haemophilus influenzae are resistant to Aknederm Ery Gel alone but are susceptible to Aknederm Ery Gel and sulfonamides used concomitantly.

Staphylocci resistant to Aknederm Ery Gel may emerge during a course of therapy.

Aknederm Ery Gel has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section.

Gram-positive Organisms

Corynebacterium diphtheriae

Corynebacterium minutissimum

Listeria monocytogenes

Staphylococcus aureus(resistant organisms may emerge during treatment)

Streptococcus pneumoniae

Streptococcus pyogenes

Gram-negative Organisms

Bordetella pertussis

Legionella pneumophila

Neisseria gonorrhoeae

Other Microorganisms

Chlamydia trachomatis

Entamoeba histolytica

Mycoplasma pneumoniae

Treponema pallidum

Ureaplasma urealyticum

The following in vitro data are available, but their clinical significance is unknown.

Aknederm Ery Gel exhibits in vitro minimal inhibitory concentrations (MIC's) of 0.5 μg/mL or less against most ( ≥ 90%) strains of the following microorganisms; however, the safety and effectiveness (Aknederm Ery Gel ethylsuccinate) of Aknederm Ery Gel in treating clinical infections due to these microorganisms have not been established in adequate and well controlled clinical trials.

Gram-positive Organisms

Viridans group streptococci

Gram-negative Organisms

Moraxella catarrhalis

Susceptibility Tests

Dilution Techniques

Quantitative methods are used to determine antimicrobial minimum inhibitory concentrations (MIC's). These MIC's provide estimates of the susceptibility of bacteria to antimicrobial compounds. The MIC's should be determined using a standardized procedure. Standardized procedures are based on a dilution methodrequires the use of standardized inoculum concentrations. This procedure uses paper disks impregnated with 15-μg Aknederm Ery Gel to test the susceptibility of microorganisms to Aknederm Ery Gel.

Reports from the laboratory providing results of the standard single-disk susceptibility test with a 15



References

  1. DailyMed. "ERYTHROMYCIN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. NCIt. "Erythromycin: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  3. EPA DSStox. "Erythromycin: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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