Amidol Uses

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What is Amidol?

Amidol is in a group of drugs called radiopaque (RAY dee oh payk) contrast agents. Amidol contains iodine, a substance that absorbs x-rays. Radiopaque contrast agents are used to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on a CT scan or other radiologic (x-ray) examination.

Amidol is used to help diagnose certain disorders of the heart, brain, blood vessels, and nervous system.

Amidol may also be used for purposes not listed in this medication guide.

Amidol indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or Amidol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of Amidol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Intra-arterial

Peripheral arteriography

Adult: Use 300 mg iodine/ml (Amidol inj 61%). Femoral or subclavian artery: 5-40 ml. Aorta for a distal runoff: 25-50 ml. Up to 250 ml has been used.

Intra-arterial

Selective visceral arteriography or aortography

Adult: Use 370 mg iodine/ml (Amidol inj 76%). Larger vessels e.g. aorta or coeliac artery: Up to 50 ml. Renal artery: Up to 10 ml. Lower doses are often sufficient. Total multiple doses up to 225 ml have been used.

Intra-arterial

Cerebral arteriography

Adult: Use 300 mg iodine/ml (Amidol inj 61%). Carotid puncture or transfemoral catheterisation: 8-12 ml. Total multiple doses for procedure up to 90 ml.

Intra-arterial

Coronary arteriography and ventriculography

Adult: Use 370 mg iodine/ml (Amidol inj 76%). Selective coronary artery: 2-10 ml. Ventriculography or nonselective opacification of multiple coronary arteries following inj at the aortic root: 25-50 ml. Total dose for combined procedures up to 200 ml has been used. EKG monitoring is essential.

Intravenous

Angiocardiography

Child: Use 370 mg iodine/ml (Amidol inj 76%). For single inj: <2 yr: 10-15 ml; 2-9 yr: 15-30 ml; 10-18 yr: 20-50 ml. Administer by inj into a large peripheral vein or by direct cardiac catheterisation. For cumulative inj: <2 yr: 40 ml; 2-4 yr: 50 ml; 5-9 yr: 100 ml; 10-18 yr: 125 ml.

Intravenous

Computed tomography imaging

Adult: Head: 250 mg iodine/ml (Amidol inj 51%): 130-240 ml; 300 mg iodine/ml (Amidol inj 61%): 100-200 ml. Administer by IV infusion. Body: 250 mg iodine/ml (Amidol inj 51%): 130-240 ml; 300 mg iodine/ml (Amidol inj 61%): 100-200 ml. Administer by rapid IV infusion or bolus inj. Total dose for procedure should not exceed 60 g of iodine.

Child: 250 mg iodine/ml (Amidol inj 51%): 1.2-3.6 ml/kg; 300 mg iodine/ml (Amidol inj 61%): 1-3 ml/kg. Total dose should not exceed 30 g of iodine.

Intravenous

Excretory urography

Adult: 250 mg iodine/ml (Amidol inj 51%): 50-100 ml; 300 mg iodine/ml (Amidol inj 61%): 50 ml; 370 mg iodine/ml (Amidol inj 76%): 40 ml. Administer by rapid IV inj.

Child: Children: 250 mg iodine/ml (51%): 1.2-3.6 ml/kg; 300 mg iodine/ml (61%): 1-3 ml/kg. Max dose for procedure: 30 g of iodine.

Intravenous

Peripheral venography

Adult: Use 200 mg iodine/ml (Amidol inj 41%). 25-150 ml per lower extremity. Total dose for multiple injections should not exceed 350 ml.

How should I use Amidol?

Amidol is injected into a vein or artery through an IV. A healthcare provider will give you this injection.

You may be given medication to prevent certain side effects while you are receiving Amidol.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Amidol is injected.

Drink extra fluids before and after your radiologic test. Amidol can cause you to get dehydrated, which can lead to dangerous effects on your kidneys. Follow your doctor's instructions about the types and amount of fluids you should drink before and after your test.

Older adults may need special care to avoid becoming dehydrated. Your kidney function may need to be checked after you have received Amidol.

Some people receiving Amidol have had reactions that did not start until 30 to 60 minutes after the medicine was first given. Your caregivers may want to watch you during this period of time after your injection. This is to make sure you do not have any unwanted side effects or delayed reactions.

This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using Amidol.

Uses of Amidol in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Amidol is used as a radiopaque contrast enhancement medium used in diagnostic procedures such as computed tomography (CT) scans and other radiologic (x-ray) examination to help in the improved visualization of blood vessels and associated abnormalities in heart, kidney and other organs.

Amidol description

Amidol chemically is (S)-N,N'-bis[2-hydroxy-1(hydroxymethyl)-ethyl]-2, 4, 6-triiodo-5-lactamido-isophthalamide.

The 612 mg/mL of Amidol is equivalent to 300 mg iodine/mL.

Each 50 mL vial contains 30.62 g of Amidol.

Each 100 mL vial contains 61.24 g of Amidol.

The 755.3 mg/mL of Amidol is equivalent to 370 mg iodine/mL.

Each 50 mL vial contains 37.76 g of Amidol.

Each 100 mL vial contains: 75.53 g of Amidol.

Amidol dosage

Intravenous

Peripheral venography

Adult: Use 200 mg iodine/ml (Amidol inj 41%). 25-150 ml per lower extremity. Total dose for multiple injections should not exceed 350 ml.

Incompatibility: Do not admix with other drugs.

Intravenous

Angiocardiography

Child: Use 370 mg iodine/ml (Amidol inj 76%). For single inj: <2 yr: 10-15 ml; 2-9 yr: 15-30 ml; 10-18 yr: 20-50 ml. Administer by inj into a large peripheral vein or by direct cardiac catheterisation. For cumulative inj: <2 yr: 40 ml; 2-4 yr: 50 ml; 5-9 yr: 100 ml; 10-18 yr: 125 ml.

Incompatibility: Do not admix with other drugs.

Intravenous

Excretory urography

Adult: 250 mg iodine/ml (Amidol inj 51%): 50-100 ml; 300 mg iodine/ml (Amidol inj 61%): 50 ml; 370 mg iodine/ml (Amidol inj 76%): 40 ml. Administer by rapid IV inj.

Child: Children: 250 mg iodine/ml (51%): 1.2-3.6 ml/kg; 300 mg iodine/ml (61%): 1-3 ml/kg. Max dose for procedure: 30 g of iodine.

Incompatibility: Do not admix with other drugs.

Intravenous

Computed tomography imaging

Adult: Head: 250 mg iodine/ml (Amidol inj 51%): 130-240 ml; 300 mg iodine/ml (Amidol inj 61%): 100-200 ml. Administer by IV infusion. Body: 250 mg iodine/ml (Amidol inj 51%): 130-240 ml; 300 mg iodine/ml (Amidol inj 61%): 100-200 ml. Administer by rapid IV infusion or bolus inj. Total dose for procedure should not exceed 60 g of iodine.

Child: 250 mg iodine/ml (Amidol inj 51%): 1.2-3.6 ml/kg; 300 mg iodine/ml (Amidol inj 61%): 1-3 ml/kg. Total dose should not exceed 30 g of iodine.

Incompatibility: Do not admix with other drugs.

Intra-arterial

Cerebral arteriography

Adult: Use 300 mg iodine/ml (Amidol inj 61%). Carotid puncture or transfemoral catheterisation: 8-12 ml. Total multiple doses for procedure up to 90 ml.

Incompatibility: Do not admix with other drugs.

Intra-arterial

Peripheral arteriography

Adult: Use 300 mg iodine/ml (Amidol inj 61%). Femoral or subclavian artery: 5-40 ml. Aorta for a distal runoff: 25-50 ml. Up to 250 ml has been used.

Incompatibility: Do not admix with other drugs.

Intra-arterial

Selective visceral arteriography or aortography

Adult: Use 370 mg iodine/ml (Amidol inj 76%). Larger vessels e.g. aorta or coeliac artery: Up to 50 ml. Renal artery: Up to 10 ml. Lower doses are often sufficient. Total multiple doses up to 225 ml have been used.

Incompatibility: Do not admix with other drugs.

Intra-arterial

Coronary arteriography and ventriculography

Adult: Use 370 mg iodine/ml (Amidol inj 76%). Selective coronary artery: 2-10 ml. Ventriculography or nonselective opacification of multiple coronary arteries following inj at the aortic root: 25-50 ml. Total dose for combined procedures up to 200 ml has been used. EKG monitoring is essential.

Incompatibility: Do not admix with other drugs.

Amidol interactions

See also:
What other drugs will affect Amidol?

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Renal toxicity has been reported in a few patients with liver dysfunction who were given oral cholecystographic agents followed by intravascular contrast agents. Administration of intravascular agents should therefore be postponed in any patient with a known or suspected hepatic or biliary disorder who has recently received a cholecystographic contrast agent.

Other drugs should not be admixed with Amidol.

Drug/Laboratory Test Interactions

The results of PBI and radioactive iodine uptake studies, which depend on iodine estimations, will not accurately reflect thyroid function for up to 16 days following administration of iodinated contrast media. However, thyroid function tests not depending on iodine estimations, e.g., T3 resin uptake and total or free thyroxine (T4) assays are not affected.

Any test which might be affected by contrast media should be performed prior to administration of the contrast medium.

Laboratory Test Findings

In vitro studies with animal blood showed that many radiopaque contrast agents, including Amidol, produced a slight depression of plasma coagulation factors including prothrombin time, partial thromboplastin time, and fibrinogen, as well as a slight tendency to cause platelet and/or red blood cell aggregation.

Transitory changes may occur in red cell and leucocyte counts, serum calcium, serum creatinine, serum glutamic oxaloacetic transaminase (SGOT), and uric acid in urine; transient albuminuria may occur.

These findings have not been associated with clinical manifestations.

Amidol side effects

See also:
What are the possible side effects of Amidol?

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Applies to Amidol: injection solution

In addition to its needed effects, some unwanted effects may be caused by Amidol (the active ingredient contained in Amidol-370). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking Amidol, check with your doctor or nurse immediately:

Less common:

  • Arm, back, or jaw pain
  • blurred vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast or irregular heartbeat
  • feeling of warmth
  • hives
  • lightheadedness, dizziness, or fainting
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • shortness of breath
  • slow or irregular heartbeat
  • sudden sweating
  • unusual tiredness or weakness
Less common or rare:
  • Blue lips and fingernails
  • changes in skin color
  • chills
  • coughing that sometimes produces a pink frothy sputum
  • decrease in the frequency of urination
  • decrease in urine volume
  • difficult, fast, noisy breathing, sometimes with wheezing
  • difficulty in passing urine (dribbling)
  • dizziness
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • headache
  • hives or welts, itching, or skin rash
  • increased sweating
  • nervousness
  • numbness or tingling in the face, arms, or legs
  • pain or discomfort in the arms, jaw, back, or neck
  • pain, tenderness, or swelling of the foot or leg
  • painful urination
  • pale skin
  • pounding in the ears
  • redness of the skin
  • severe, unusual tiredness or weakness
  • trouble speaking, thinking, or walking
  • vomiting
Rare
  • Double vision
  • inability to move the arms, legs, or facial muscles
  • pain in the chest, groin, or legs, especially the calves
  • severe, sudden headache
  • slow speech
  • slurred speech
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • sudden, unexplained shortness of breath
  • vision changes
Incidence not known:
  • Change in consciousness
  • heart stops
  • loss of consciousness
  • no breathing
  • no pulse or blood pressure
  • no sensation in the legs
  • not able to pass urine
  • pain, redness, or pale skin at the injection site
  • seizures
  • unable to move the legs

Minor Side Effects

Some of the side effects that can occur with Amidol may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common or rare:

  • Bad, unusual, or unpleasant (after) taste
  • change in taste
  • discouragement
  • disturbed color perception
  • feeling sad or empty
  • halos around lights
  • irritability
  • loss of appetite
  • loss of interest or pleasure
  • loss of vision
  • night blindness
  • overbright appearance of lights
  • stuffy nose
  • trouble concentrating
  • trouble sleeping
  • tunnel vision
  • weight loss
Incidence not known:
  • Abdominal or stomach cramps
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • burning, dry, or itching eyes
  • discharge or excessive tearing
  • general feeling of discomfort or illness
  • loss of memory
  • problems with memory
  • redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid
  • runny nose
  • sneezing
  • trembling or shaking of the hands or feet

Amidol contraindications

See also:
What is the most important information I should know about Amidol?

Intrathecal administration of corticosteroids with Amidol is contraindicated. Because of overdosage considerations, immediate repeat myelography in the event of technical failure is contraindicated. Myelography should not be performed in the presence of significant local or systemic infection where bacteremia is likely.

Active ingredient matches for Amidol:

Iopamidol in Bangladesh.

Paracetamol

Amikacin in India.


Unit description / dosage (Manufacturer)Price, USD
Amidol 500mg INJ / 2ml
Amidol 250mg INJ / 2ml
Amidol 100mg INJ / 2ml
AMIDOL TABLET 1 strip / 10 tablets each (Logos Pharma)$ 0.35
AMIDOL inj 100 mg x 2ml (Impact)
AMIDOL inj 250 mg x 2ml (Impact)
AMIDOL inj 500 mg x 2ml (Impact)
Amidol NA Tablet (Logos Pharma)$ 0.03

List of Amidol substitutes (brand and generic names):

AMID inj 500 mg x 2ml (Epitome)$ 0.92
Amifact 100mg VIAL / 1 (Medico HC)$ 0.28
Amifact 250mg VIAL / 1 (Medico HC)$ 0.62
Amifact 500mg VIAL / 2ml (Medico HC)$ 0.95
100 mg x 1's (Medico HC)$ 0.28
250 mg x 1's (Medico HC)$ 0.62
500 mg x 2 mL x 1's (Medico HC)$ 0.95
Injectable; Injection; Amikacin Sulfate 100 mg (Medico HC)
Injectable; Injection; Amikacin Sulfate 250 mg (Medico HC)
Injectable; Injection; Amikacin Sulfate 500 mg (Medico HC)
AMIFACT inj 100 mg x 2 mL x 2ml (Medico HC)$ 0.28
AMIFACT inj 250 mg x 2 mL x 2ml (Medico HC)$ 0.62
AMIFACT inj 500 mg x 2 mL x 2ml (Medico HC)$ 0.95
Solution; Intrauterine; Amikacin Sulfate 250 mg / ml
Amijay 100mg INJ / 2ml (Allen Dale)$ 0.33
Amijay 500mg INJ / 2ml (Allen Dale)$ 0.95
AMIJAY inj 100 mg x 2ml (Allen Dale)$ 0.33
AMIJAY inj 500 mg x 2ml (Allen Dale)$ 0.95
Amiject 50mg x 1mL INJ / 2ml (Alkem)$ 0.34
Amiject 125mg x 1mL INJ / 2ml (Alkem)$ 0.66
AMIJECT 100MG INJECTION 1 vial / 2 ML injection each (Alkem)$ 0.43
AMIJECT 250MG INJECTION 1 vial / 2 ML injection each (Alkem)$ 0.51
AMIJECT 500MG INJECTION 1 vial / 2 ML injection each (Alkem)$ 1.51
AMIJECT inj 50 mg x 1 mL x 2ml (Alkem)$ 0.43
AMIJECT inj 125 mg x 1 mL x 2ml (Alkem)$ 0.50
AMIJECT inj 250 mg x 1 mL x 2ml (Alkem)$ 1.51
Amiject 100mg Injection (Alkem)$ 0.21
Amiject 250mg Injection (Alkem)$ 0.26
Amiject 500mg Injection (Alkem)$ 0.75
Amijet 500mg INJ / 1 (Hanburys)$ 0.89
500 mg x 1's (Hanburys)$ 0.89
Injectable; Injection; Amikacin Sulfate 500 mg (Hanburys)
AMIJET inj 500 mg x 2ml (Hanburys)$ 0.89

References

  1. DailyMed. "IOPAMIDOL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "AMIKACIN SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "iopamidol". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Amidol are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Amidol. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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