Amilamont 5mg / 5ml Oral Solution Uses

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What is Amilamont 5mg / 5ml Oral Solution?

Amilamont 5mg / 5ml Oral Solution is used in combination with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Amilamont 5mg / 5ml Oral Solution is also used to treat water retention (edema) in patients with congestive heart failure.

Amilamont 5mg / 5ml Oral Solution is a type of diuretic (water pill) that helps prevent your body from losing too much potassium. It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.

Amilamont 5mg / 5ml Oral Solution is available only with your doctor's prescription.

Amilamont 5mg / 5ml Oral Solution indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Amilamont 5mg / 5ml Oral Solution HCl is indicated as adjunctive treatment with thiazide diuretics or other kaliureticdiuretic agents in congestive heart failure or hypertension to:

  1. help restore normal serum potassium levels in patients who develop hypokalemia on the kaliuretic diuretic.
  2. prevent development of hypokalemia in patients who would be exposed to particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias.

The use of potassium-conserving agents is often unnecessary in patients receiving diuretics for uncomplicated essential hypertension when such patients have a normal diet. Amilamont 5mg / 5ml Oral Solution HCl has little additive diuretic or antihypertensive effect when added to a thiazide diuretic.

Amilamont 5mg / 5ml Oral Solution HCl should rarely be used alone. It has weak (compared with thiazides) diuretic and antihypertensive effects. Used as single agents, potassium sparing diuretics, including Amilamont 5mg / 5ml Oral Solution HCl, result in an increased risk of hyperkalemia (approximately 10% with Amilamont 5mg / 5ml Oral Solution). Amilamont 5mg / 5ml Oral Solution HCl should be used alone only when persistent hypokalemia has been documented and only with careful titration of the dose and close monitoring of serum electrolytes.

How should I use Amilamont 5mg / 5ml Oral Solution?

Use Amilamont 5mg / 5ml Oral Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Amilamont 5mg / 5ml Oral Solution.

Uses of Amilamont 5mg / 5ml Oral Solution in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Heart failure or hypertension: Counteracts potassium loss induced by other diuretics in the treatment of hypertension or heart failure; usually used in conjunction with more potent diuretics such as thiazides or loop diuretics

Note: Potassium-sparing diuretics are not recommended for the initial treatment of hypertension (ACC/AHA [Whelton 2017]).

Off Label Uses

Ascites

Data from a small randomized controlled trial in patients with nonazotemic cirrhosis treated with Amilamont 5mg / 5ml Oral Solution or potassium canrenoate support use of Amilamont 5mg / 5ml Oral Solution (although less effective than potassium canrenoate) for management of ascites in patients who do not tolerate treatment with spironolactone.

Amilamont 5mg / 5ml Oral Solution description

A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amilamont 5mg / 5ml Oral Solution is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705)

Amilamont 5mg / 5ml Oral Solution dosage

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Amilamont 5mg / 5ml Oral Solution HCl should be administered with food.

Amilamont 5mg / 5ml Oral Solution HCl, one 5 mg tablet daily, should be added to the usual antihypertensive or diuretic dosage of a kaliuretic diuretic. The dosage may be increased to 10 mg per day, if necessary. More than two 5 mg tablets of Amilamont 5mg / 5ml Oral Solution HCl daily usually are not needed, and there is little controlled experience with such doses. If persistent hypokalemia is documented with 10 mg, the dose can be increased to 15 mg, then 20 mg, with careful monitoring of electrolytes.

In treating patients with congestive heart failure after an initial diuresis has been achieved, potassium loss may also decrease and the need for Amilamont 5mg / 5ml Oral Solution HCl should be re-evaluated. Dosage adjustment may be necessary. Maintenance therapy may be on an intermittent basis.

If it is necessary to use Amilamont 5mg / 5ml Oral Solution HCl alone, the starting dosage should be one 5 mg tablet daily. This dosage may be increased to 10 mg per day, if necessary. More than two 5 mg tablets usually are not needed, and there is little controlled experience with such doses. If persistent hypokalemia is documented with 10 mg, the dose can be increased to 15 mg, then 20 mg, with careful monitoring of electrolytes.

How supplied

Each yellow compressed tablet contains 5 mg of anhydrous Amilamont 5mg / 5ml Oral Solution HCl and is debossed “ Par 117”. They are available in bottles of 100's (NDC #49884-117-01), 500's (NDC #49884- 117-05) and 1000's (NDC #49884-117-10).

Store at controlled room temperature 15°-30°C (59°-86°F).

Dispense in a tight, light-resistant container as defined in the USP.

Manufactured by: PAR PHARMACEUTICAL, INC., Spring Valley, NY 10977. Revised: 01/05. FDA revision date: 9/16/2002

Amilamont 5mg / 5ml Oral Solution interactions

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What other drugs will affect Amilamont 5mg / 5ml Oral Solution?

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When Amilamont 5mg / 5ml Oral Solution HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus, the risk of hyperkalemia may be increased. Therefore, if concomitant use of these agents is indicated because of demonstrated hypokalemia, they should be used with caution and with frequent monitoring of serum potassium..

Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy.

In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when Amilamont 5mg / 5ml Oral Solution HCl and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Since indomethacin and potassium-sparing diuretics, including Amilamont 5mg / 5ml Oral Solution HCl, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.

Amilamont 5mg / 5ml Oral Solution side effects

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What are the possible side effects of Amilamont 5mg / 5ml Oral Solution?

Amilamont 5mg / 5ml Oral Solution HCl is usually well tolerated and, except for hyperkalemia (serum potassium levels greater than 5.5 mEq liter - see WARNINGS), significant adverse effects have been reported infrequently. Minor adverse reactions were reported relatively frequently (about 20%) but the relationship of many of the reports to Amilamont 5mg / 5ml Oral Solution HCl is uncertain and the overall frequency was similar in hydrochlorothiazide treated groups. Nausea/anorexia, abdominal pain, flatulence, and mild skin rash have been reported and probably are related to Amilamont 5mg / 5ml Oral Solution. Other adverse experiences that have been reported with Amilamont 5mg / 5ml Oral Solution are generally those known to be associated with diuresis, or with the underlying disease being treated.

The adverse reactions for Amilamont 5mg / 5ml Oral Solution HCl listed in the following table have been arranged into two groups: (1) incidence greater than one percent; and (2) incidence one percent or less. The incidence for group (1) was determined from clinical studies conducted in the United States (837 patients treated with Amilamont 5mg / 5ml Oral Solution HCl). The adverse effects listed in group (2) include reports from the same clinical studies and voluntary reports since marketing. The probability of a causal relationship exists between Amilamont 5mg / 5ml Oral Solution HCl and these adverse reactions, some of which have been reported only rarely.

Incidence > 1% Incidence ≤ 1%
Body as a Whole
Headache* Back pain
Weakness Chest pain
Fatigability Neck/shoulder ache
Pain, extremities
Cardiovascular
None Angina pectoris
Orthostatic hypotension
Arrhythmia
Palpitation
Digestive
Nausea/anorexia* Jaundice
Diarrhea* GI bleeding
Vomiting* Abdominal fullness
Abdominal pain GI disturbance
Gas pain Thirst
Appetite changes Heartburn
Constipation Flatulence
Dyspepsia
Metabolic
Elevated serum potassium levels ( > 5.5 mEq per liter)** None
Skin
None Skin rash
Itching
Dryness of mouth
Pruritus
Alopecia
Musculoskeletal
Muscle cramps Joint pain
Leg ache
Nervous
Dizziness Paresthesia
Encephalopathy Tremors
Vertigo
Psychiatric
None Nervousness
Mental confusion
Insomnia
Decreased libido
Depression
Somnolence
Respiratory
Cough Shortness of breath
Dyspnea
Special Senses
None Visual disturbances
Nasal congestion
Tinnitus
Increased intraocular pressure
Urogenital
Impotence Polyuria
Dysuria
Urinary frequency
Bladder spasms
Gynecomastia
*Reactions occurring in 3% to 8% of patients treated with Amilamont 5mg / 5ml Oral Solution HCl. (Those reactions occurring in less than 3% of the patients are unmarked.)

**See WARNINGS.

Causal Relationship Unknown

Other reactions have been reported but occurred under circumstances where a causal relationship could not be established. However, in these rarely reported events, that possibility cannot be excluded. Therefore, these observations are listed to serve as alerting information to physicians.

Activation of probable pre-existing peptic ulcer

Aplastic anemia

Neutropenia

Abnormal liver function

Amilamont 5mg / 5ml Oral Solution contraindications

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What is the most important information I should know about Amilamont 5mg / 5ml Oral Solution?

Hyperkalemia

Amilamont 5mg / 5ml Oral Solution HCl should not be used in the presence of elevated serum potassium levels (greater than 5.5 mEq per liter).

Antikaliuretic Therapy or Potassium Supplementation

Amilamont 5mg / 5ml Oral Solution HCl should not be given to patients receiving other potassium-conserving agents, such as spironolactone or triamterene. Potassium supplementation in the form of medication, potassium-containing salt substitutes or a potassium-rich diet should not be used with Amilamont 5mg / 5ml Oral Solution HCl except in severe and/or refractory cases of hypokalemia. Such concomitant therapy can be associated with rapid increases in serum potassium levels. If potassium supplementation is used, careful monitoring of the serum potassium level is necessary.

Impaired Renal Function

Anuria, acute or chronic renal insufficiency, and evidence of diabetic nephropathy are contraindications to the use of Amilamont 5mg / 5ml Oral Solution HCl. Patients with evidence of renal functional impairment (blood urea nitrogen [BUN] levels over 30 mg per 100 mL or serum creatinine levels over 1.5 mg per 100 mL) or diabetes mellitus should not receive the drug without careful, frequent and continuing monitoring of serum electrolytes, creatinine, and BUN levels. Potassium retention associated with the use of an antikaliuretic agent is accentuated in the presence of renal impairment and may result in the rapid development of hyperkalemia.

Hypersensitivity

Amilamont 5mg / 5ml Oral Solution HCl is contraindicated in patients who are hypersensitive to this product.



Active ingredient matches for Amilamont 5mg / 5ml Oral Solution:

Amiloride hydrochloride in United Kingdom.


List of Amilamont 5mg / 5ml Oral Solution substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
100 tablet in 1 bottle
1000 tablet in 1 bottle
500 tablet in 1 bottle
Amiloride Hydrochloride tablet 5 mg/1 (Physicians Total Care, Inc. (US))

References

  1. PubChem. "AMILORIDE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  2. DrugBank. "AMILORIDE". http://www.drugbank.ca/drugs/DB00594 (accessed September 17, 2018).
  3. MeSH. "Diuretics". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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