Amiloride Hydrochloride Dosage

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Dosage of Amiloride Hydrochloride in details

The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Amiloride Hydrochloride HCl should be administered with food.

Amiloride Hydrochloride HCl, one 5 mg tablet daily, should be added to the usual antihypertensive or diuretic dosage of a kaliuretic diuretic. The dosage may be increased to 10 mg per day, if necessary. More than two 5 mg tablets of Amiloride Hydrochloride HCl daily usually are not needed, and there is little controlled experience with such doses. If persistent hypokalemia is documented with 10 mg, the dose can be increased to 15 mg, then 20 mg, with careful monitoring of electrolytes.

In treating patients with congestive heart failure after an initial diuresis has been achieved, potassium loss may also decrease and the need for Amiloride Hydrochloride HCl should be re-evaluated. Dosage adjustment may be necessary. Maintenance therapy may be on an intermittent basis.

If it is necessary to use Amiloride Hydrochloride HCl alone, the starting dosage should be one 5 mg tablet daily. This dosage may be increased to 10 mg per day, if necessary. More than two 5 mg tablets usually are not needed, and there is little controlled experience with such doses. If persistent hypokalemia is documented with 10 mg, the dose can be increased to 15 mg, then 20 mg, with careful monitoring of electrolytes.

How supplied

Each yellow compressed tablet contains 5 mg of anhydrous Amiloride Hydrochloride HCl and is debossed “ Par 117”. They are available in bottles of 100's (NDC #49884-117-01), 500's (NDC #49884- 117-05) and 1000's (NDC #49884-117-10).

Store at controlled room temperature 15°-30°C (59°-86°F).

Dispense in a tight, light-resistant container as defined in the USP.

Manufactured by: PAR PHARMACEUTICAL, INC., Spring Valley, NY 10977. Revised: 01/05. FDA revision date: 9/16/2002

What other drugs will affect Amiloride Hydrochloride?

Before taking this medication, tell your doctor if you are using any of the following drugs:

This list is not complete and there may be other drugs that can interact with Amiloride Hydrochloride. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Amiloride Hydrochloride interactions

Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Amiloride Hydrochloride, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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When Amiloride Hydrochloride HCl is administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus, the risk of hyperkalemia may be increased. Therefore, if concomitant use of these agents is indicated because of demonstrated hypokalemia, they should be used with caution and with frequent monitoring of serum potassium..

Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy.

In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when Amiloride Hydrochloride HCl and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Since indomethacin and potassium-sparing diuretics, including Amiloride Hydrochloride HCl, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.


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References

  1. FDA/SPL Indexing Data. "7DZO8EB0Z3: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
  2. MeSH. "Diuretics". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
  3. European Chemicals Agency - ECHA. "Amiloride: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Amiloride Hydrochloride are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Amiloride Hydrochloride. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported frequency of use

How frequently do I need to take Amiloride Hydrochloride?
It was reported by ndrugs.com website users that Amiloride Hydrochloride should ideally be taken Once in a day as the most common frequency of the Amiloride Hydrochloride. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Amiloride Hydrochloride should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
Users%
Once in a day1
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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