Amiloride Hydrochloride Pregnancy

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Pregnancy of Amiloride Hydrochloride in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.

Three cases of Amiloride Hydrochloride exposure during pregnancy have been reported. In one, gross fetal malformations were reported following a voluntary abortion in a woman who had received Amiloride Hydrochloride, captopril and propranolol during her first trimester. Since angiotensin converting enzyme inhibitors are known teratogens, the defects were attributed to captopril. In two other cases a normal pregnancy and mild intrauterine growth retardation were reported in women treated for Bartter's syndrome and atrial fibrillation, respectively. Both infants were healthy and normal at birth.

Amiloride Hydrochloride has been assigned to pregnancy category B by the FDA. Animal studies have revealed no evidence of teratogenicity or impaired fertility, although a decrease in rat pup growth and survival was observed at doses 5 or more times the expected maximum daily dose for humans. There are no controlled data in human pregnancy. Amiloride Hydrochloride should only be given during pregnancy when need has been clearly established.

See references

Amiloride Hydrochloride breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

Animal studies have shown that Amiloride Hydrochloride is excreted into rat milk in concentrations higher than those found in blood.

There are no data on the excretion of Amiloride Hydrochloride into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. Almeida O, Spinnato J "Maternal Bartter's syndrome and pregnancy." Am J Obstet Gynecol 160 (1989): 1225-6
  2. "Product Information. Midamor (Amiloride Hydrochloride)." Merck & Co, Inc, West Point, PA.

References for breastfeeding information

  1. "Product Information. Midamor (Amiloride Hydrochloride)." Merck & Co, Inc, West Point, PA.


  1. PubMed Health. "Amiloride (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". (accessed September 17, 2018).
  2. Human Metabolome Database (HMDB). "Amiloride: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". (accessed September 17, 2018).
  3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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