Amoxin Uses

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What is Amoxin?

Penicillins are used to treat infections caused by bacteria. They work by killing the bacteria or preventing their growth.

There are several different kinds of penicillins. Each is used to treat different kinds of infections. One kind of penicillin usually may not be used in place of another. In addition, penicillins are used to treat bacterial infections in many different parts of the body. They are sometimes given with other antibacterial medicines (antibiotics). Some of the penicillins may also be used for other problems as determined by your doctor. However, none of the penicillins will work for colds, flu, or other virus infections.

Penicillins are available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, penicillins are used in certain patients with the following medical conditions:

  • Chlamydia infections in pregnant women—Amoxin and ampicillin
  • Gas gangrene—Penicillin G
  • Helicobacter pylori-associated gastritis or peptic ulcer disease—Amoxin
  • Leptospirosis—Ampicillin and penicillin G
  • Lyme disease—Amoxin and penicillin V
  • Typhoid fever—Amoxin and ampicillin

Amoxin indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Infections of the Ear, Nose, and Throat

Amoxin Capsules, Amoxin for oral suspension, Amoxin tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase–negative) isolates of Streptococcus species (α- and β-hemolytic isolates only), Streptococcus pneumoniae, Staphylococcus spp., or Haemophilus influenzae.

Infections of the Genitourinary Tract

Amoxin Capsules, Amoxin for oral suspension, Amoxin tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase–negative) isolates of Escherichia coli, Proteus mirabilis, or Enterococcus faecalis.

Infections of the Skin and Skin Structure

Amoxin Capsules, Amoxin for oral suspension, Amoxin tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase-negative) isolates of Streptococcus spp. (α- and β-hemolytic isolates only), Staphylococcus spp., or E. coli.

Infections of the Lower Respiratory Tract

Amoxin Capsules, Amoxin for oral suspension, Amoxin tablets (chewable) are indicated in the treatment of infections due to susceptible (ONLY β-lactamase-negative) isolates of Streptococcus spp. (α- and β-hemolytic isolates only), S. pneumoniae, Staphylococcus spp., or H. influenzae.

Helicobacter pylori Infection

Triple therapy for Helicobacter pylori with clarithromycin and lansoprazole:

Amoxin, in combination with clarithromycin plus lansoprazole as triple therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or 1 year history of a duodenal ulcer) to eradicate H. pylori. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence.

Dual therapy for H. pylori with lansoprazole:

Amoxin, in combination with lansoprazole delayed-release capsules as dual therapy, is indicated for the treatment of patients with H. pylori infection and duodenal ulcer disease (active or 1 year history of a duodenal ulcer) who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspected. Eradication of H. pylori has been shown to reduce the risk of duodenal ulcer recurrence.

Usage

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Amoxin and other antibacterial drugs, Amoxin should be used only to treat infections that are proven or strongly suspected to be caused by bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How should I use Amoxin?

Use Amoxin suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Amoxin suspension by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Shake well before each use.
  • Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.
  • Amoxin suspension may be mixed with formula, milk, fruit juice, water, ginger ale, or other cold drinks. If you mix Amoxin suspension, take it at once after mixing. Be sure that the entire dose is swallowed.
  • To clear up your infection completely, take Amoxin suspension for the full course of treatment. Keep taking it even if you feel better in a few days.
  • If you miss a dose of Amoxin suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Amoxin suspension.

Uses of Amoxin in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Amoxin belongs to a class of antibiotic medicines called penicillin. It is used to treat bacterial infections of the respiratory tract (bronchitis, pneumonia), genital and urinary tract (gonorrhoea, ), skin and soft tissue, ear (otitis media); nose, sinus, and throat (tonsillitis, sinusitis); heart (endocarditis), kidney, urethra or bladder, blood (septicemia), teeth and gums (abcesses), typhoid and paratyphoid fever.

Amoxin description

A broad-spectrum semisynthetic antibiotic similar to ampicillin except that its resistance to gastric acid permits higher serum levels with oral administration. Amoxin is commonly prescribed with clauvanic acid (a beta lactamase inhibitor) as it is susceptible to beta-lacatamase degradation. [PubChem]

Amoxin dosage

Dosing For Adult And Pediatric Patients > 3 Months Of Age

Treatment should be continued for a minimum of 48 to 72 hours beyond the time that the patient becomes asymptomatic or evidence of bacterial eradication has been obtained. It is recommended that there be at least 10 days' treatment for any infection caused by Streptococcus pyogenes to prevent the occurrence of acute rheumatic fever. In some infections, therapy may be required for several weeks. It may be necessary to continue clinical and/or bacteriological follow-up for several months after cessation of therapy.

Table 1: Dosing Recommendations for Adult and Pediatric Patients > 3 Months of Age

Infection SeverityThe children's dosage is intended for individuals whose weight is less than 40 kg. Children weighing 40 kg or more should be dosed according to the adult recommendations.

Dosing In Neonates And Infants Aged ≤ 12 Weeks ( ≤ 3 Months)

Treatment should be continued for a minimum of 48 to 72 hours beyond the time that the patient becomes asymptomatic or evidence of bacterial eradication has been obtained. It is recommended that there be at least 10 days' treatment for any infection caused by Streptococcus pyogenes to prevent the occurrence of acute rheumatic fever. Due to incompletely developed renal function affecting elimination of Amoxin in this age group, the recommended upper dose of Amoxin is 30 mg/kg/day divided every 12 hours. There are currently no dosing recommendations for pediatric patients with impaired renal function.

Dosing For H. Pylori Infection

Triple therapy

The recommended adult oral dose is 1 gram Amoxin, 500 mg clarithromycin, and 30 mg lansoprazole, all given twice daily (every 12 hours) for 14 days.

Dual therapy

The recommended adult oral dose is 1 gram Amoxin and 30 mg lansoprazole, each given three times daily (every 8 hours) for 14 days. Please refer to clarithromycin and lansoprazole full prescribing information.

Dosing In Renal Impairment

  • Patients with impaired renal function do not generally require a reduction in dose unless the impairment is severe.
  • Severely impaired patients with a glomerular filtration rate of < 30 mL/min. should not receive a 875-mg dose.
  • Patients with a glomerular filtration rate of 10 to 30 mL/min should receive 500 mg or 250 mg every 12 hours, depending on the severity of the infection.
  • Patients with a glomerular filtration rate less than 10 mL/min should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection.
  • Hemodialysis patients should receive 500 mg or 250 mg every 24 hours, depending on severity of the infection. They should receive an additional dose both during and at the end of dialysis.

Directions For Mixing

Oral Suspension

Tap bottle until all powder flows freely. Add approximately 1/3 of the total amount of water for reconstitution and shake vigorously to wet powder. Add remainder of the water and again shake vigorously.

Table 2: Amount of Water for Mixing

Oral Suspension

Strength Bottle Size Amount of Water Reauired for Reconstitution

Oral Suspension 125 mg/5 mL

80 mL 62 mL
100 mL 78 mL
150 mL 116 mL

Oral Suspension 200 mg/5 mL

50 mL 39 mL
75 mL 57 mL
100 mL 76 mL

Oral Suspension 250 mg/5 mL

80 mL 59 mL
100 mL 74 mL
150 mL 111 mL

Oral Suspension 400 mg/5 mL

50 mL 36 mL
75 mL 54 mL
100 mL 71 mL

After reconstitution, the required amount of suspension should be placed directly on the child's tongue for swallowing. Alternate means of administration are to add the required amount of suspension to formula, milk, fruit juice, water, ginger ale, or cold drinks. These preparations should then be taken immediately.

NOTE: SHAKE ORAL SUSPENSION WELL BEFORE USING. Keep bottle tightly closed. Any unused portion of the reconstituted suspension must be discarded after 14 days. Refrigeration is preferable, but not required.

How supplied

Dosage Forms And Strengths

Capsules

250 mg, 500 mg. Each capsule of Amoxin, with royal blue opaque cap and pink opaque body, contains 250 mg or 500 mg Amoxin as the trihydrate. The cap and body of the 250-mg capsule are imprinted with the product name Amoxin and 250; the cap and body of the 500 mg capsule are imprinted with Amoxin and 500.

Tablets

500 mg, 875 mg. Each tablet contains 500 mg or 875 mg Amoxin as the trihydrate. Each film-coated, capsule-shaped, pink tablet is debossed with Amoxin centered over 500 or 875, respectively. The 875-mg tablet is scored on the reverse side.

Powder for

Oral Suspension

125 mg/5 mL, 200 mg/5 mL, 250 mg/5 mL, 400 mg/5 mL. Each 5 mL of reconstituted strawberry-flavored suspension contains 125 mg Amoxin as the trihydrate. Each 5 mL of reconstituted bubble-gumflavored suspension contains 200 mg, 250 mg or 400 mg Amoxin as the trihydrate.

Storage And Handling

Capsules: Each capsule of Amoxin, with royal blue opaque cap and pink opaque body, contains 250 mg or 500 mg Amoxin as the trihydrate. The cap and body of the 250-mg capsule are imprinted with the product name Amoxin and 250; the cap and body of the 500 mg capsule are imprinted with Amoxin and 500.

250-mg Capsule

NDC 43598-025-01 Bottles of 100

NDC 43598-025-05 Bottles of 500

500-mg Capsule

NDC 43598-005-01 Bottles of 100

NDC 43598-005-05 Bottles of 500

Tablets: Each tablet contains 500 mg or 875 mg Amoxin as the trihydrate. Each film-coated, capsule-shaped, pink tablet is debossed with Amoxin centered over 500 or 875, respectively. The 875-mg tablet is scored on the reverse side.

500-mg Tablet

NDC 43598-024-01 Bottles of 100

NDC 43598-024-05 Bottles of 500

875-mg Tablet

NDC 43598-019-01 Bottles of 100

NDC 43598-019-14 Bottles of 20

Powder for

Oral Suspension:

Each 5 mL of reconstituted strawberry-flavored suspension contains 125 mg Amoxin as the trihydrate. Each 5 mL of reconstituted bubble-gum-flavored suspension contains 200 mg, 250 mg or 400 mg Amoxin as the trihydrate.

125 mg/5 mL

NDC 43598-022-80 80-mL bottle

NDC 43598-022-52 100-mL bottle

NDC 43598-022-53 150-mL bottle

200 mg/5 mL

NDC 43598-023-50 50-mL bottle

NDC 43598-023-51 75-mL bottle

NDC 43598-023-52 100-mL bottle

250 mg/5 mL

NDC 43598-009-80 80-mL bottle

NDC 43598-009-52 100-mL bottle

NDC 43598-009-53 150-mL bottle

400 mg/5 mL

NDC 43598-007-50 50-mL bottle

NDC 43598-007-51 75-mL bottle

NDC 43598-007-52 100-mL bottle

Store at or below 20° C (68° F) -250 mg and 500 mg Capsules and 125 mg and 250 mg unreconstituted powder.

Store at or below 25° C (77° F) -500 mg and 875 mg Tablets and 200 mg and 400 mg unreconstituted powder.

Dispense in a tight container.

Manufactured. By: Dr. Reddy's Laboratories Tennessee,LLC. Bristol, TN 37620. Revised: Sep 2015

Amoxin interactions

See also:
What other drugs will affect Amoxin?

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Probenecid

Probenecid decreases the renal tubular secretion of Amoxin. Concurrent use of Amoxin and probenecid may result in increased and prolonged blood levels of Amoxin.

Oral Anticoagulants

Abnormal prolongation of prothrombin time (increased international normalized ratio [INR]) has been reported in patients receiving Amoxin and oral anticoagulants. Appropriate monitoring should be undertaken when anticoagulants are prescribed concurrently. Adjustments in the dose of oral anticoagulants may be necessary to maintain the desired level of anticoagulation.

Allopurinol

The concurrent administration of allopurinol and Amoxin increases the incidence of rashes in patients receiving both drugs as compared to patients receiving Amoxin alone. It is not known whether this potentiation of Amoxin rashes is due to allopurinol or the hyperuricemia present in these patients.

Oral Contraceptives

Amoxin may affect the gut flora, leading to lower estrogen reabsorption and reduced efficacy of combined oral estrogen/progesterone contraceptives.

Other Antibacterials

Chloramphenicol, macrolides, sulfonamides, and tetracyclines may interfere with the bactericidal effects of penicillin. This has been demonstrated in vitro; however, the clinical significance of this interaction is not well documented.

Effects on Laboratory Tests

High urine concentrations of ampicillin may result in false-positive reactions when testing for the presence of glucose in urine using CLINITEST®, Benedict' s Solution, or Fehling's Solution. Since this effect may also occur with Amoxin, it is recommended that glucose tests based on enzymatic glucose oxidase reactions (such as CLINISTIX®) be used.

Following administration of ampicillin or Amoxin to pregnant women, a transient decrease in plasma concentration of total conjugated estriol, estriol-glucuronide, conjugated estrone, and estradiol has been noted.

Amoxin side effects

See also:
What are the possible side effects of Amoxin?

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As with other penicillins, it may be expected that untoward reactions will be essentially limited to sensitivity phenomena. They are more likely to occur in individuals who have previously demonstrated hypersensitivity to penicillins and in those with a history of allergy, asthma, hay fever, or urticaria. The following adverse reactions have been reported as associated with the use of penicillins:

Gastrointestinal: nausea, vomiting, diarrhea, and hemorrhagic/pseudomembranous colitis.

Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment.

Hypersensitivity Reactions: Serum sickness like reactions, erythematous maculopapular rashes, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalized exanthematous pustulosis, hypersensitivity vasculitis and urticaria have been reported.

NOTE: These hypersensitivity reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, Amoxin should be discontinued unless, in the opinion of the physician, the condition being treated is life-threatening and amenable only to Amoxin therapy.

Liver: A moderate rise in AST (SGOT) and/or ALT (SGPT) has been noted, but the significance of this finding is unknown. Hepatic dysfunction including cholestatic jaundice, hepatic cholestasis, and acute cytolytic hepatitis have been reported.

Renal: Crystalluria has also been reported.

Hemic and Lymphatic Systems: Anemia, including hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena.

Central Nervous System: Reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, and/or dizziness have been reported rarely.

Miscellaneous: Tooth discoloration (brown, yellow, or gray staining) has been rarely reported. Most reports occurred in pediatric patients. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases.

Combination therapy with clarithromycin and lansoprazole

In clinical trials using combination therapy with Amoxin plus clarithromycin and lansoprazole, and Amoxin plus lansoprazole, no adverse reactions peculiar to these drug combinations were observed. Adverse reactions that have occurred have been limited to those that had been previously reported with Amoxin, clarithromycin, or lansoprazole.

Triple therapy: Amoxin/clarithromycin/lansoprazole

The most frequently reported adverse events for patients who received triple therapy were diarrhea (7%), headache (6%), and taste perversion (5%). No treatment-emergent adverse events were observed at significantly higher rates with triple therapy than with any dual therapy regimen.

Dual therapy: Amoxin/lansoprazole

The most frequently reported adverse events for patients who received Amoxin t.i.d. plus lansoprazole t.i.d. dual therapy were diarrhea (8%) and headache (7%). No treatment-emergent adverse events were observed at significantly higher rates with Amoxin t.i.d. plus lansoprazole t.i.d. dual therapy than with lansoprazole alone.

For more information on adverse reactions with clarithromycin or lansoprazole, refer to their package inserts, ADVERSE REACTIONS.

Amoxin contraindications

See also:
What is the most important information I should know about Amoxin?

Do not use this medication if you are allergic to Amoxin or to any other penicillin antibiotic, such as ampicillin (Principen, Unasyn), dicloxacillin (Dycill, Dynapen), oxacillin (Bactocill), or penicillin (Bicillin L-A, PC Pen VK, Pfizerpen), and others.

Before using Amoxin, tell your doctor if you are allergic to cephalosporins such as Omnicef, Cefzil, Ceftin, Keflex, and others. Also tell your doctor if you have asthma, liver or kidney disease, a bleeding or blood clotting disorder, mononucleosis (also called "mono"), or any type of allergy.

Amoxin can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom or diaphragm with spermicide) to prevent pregnancy while taking Amoxin.

Take this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Amoxin will not treat a viral infection such as the common cold or flu.

Do not share this medication with another person, even if they have the same symptoms you have.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Amoxin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.



Active ingredient matches for Amoxin:

Amoxicillin in Ethiopia, Finland, Germany, Kenya.

Amoxicillin trihydrate in Finland.

Amoxycillin trihydrate in Thailand.


Unit description / dosage (Manufacturer)Price, USD
Amoxin 250 mg x 500's
Amoxin 250 mg x 1, 000's
Amoxin 500 mg x 500's
Amoxin 500 mg x 1, 000's
Amoxin 125 mg/5 mL x 60 mL

List of Amoxin substitutes (brand and generic names):

Tablet, Film-Coated; Oral; Amoxicillin Trihydrate 750 mg (Cimex)
AMOXINGA Capsule/ Tablet / 500mg / 6 units (Inga)$ 0.59
AMOXINGA Liquid / 125mg per 5ml / 60ml units (Inga)$ 0.44
AMOXINGA Capsule/ Tablet / 250mg / 6 units (Inga)$ 0.34
AMOXINGA Capsule/ Tablet / 125mg / 10 units (Inga)$ 0.34
AMOXINGA Dispersible Tablet / 250mg / 15 units (Inga)$ 0.90
Amoxinga 250mg CAP / 6 (Inga)$ 0.36
Amoxinga 500mg CAP / 6 (Inga)$ 0.59
Amoxinga 125mg P-TAB / 10 (Inga)$ 0.34
Amoxinga 250mg DT-TAB / 15 (Inga)$ 0.90
250 mg x 6's (Inga)$ 0.36
500 mg x 6's (Inga)$ 0.59
125 mg x 10's (Inga)$ 0.34
250 mg x 15's (Inga)$ 0.90
AMOXINGA cap 250 mg x 6's (Inga)$ 0.36
AMOXINGA cap 500 mg x 6's (Inga)$ 0.59
AMOXINGA P- tab 125 mg x 10's (Inga)$ 0.34
AMOXINGA dispertab 250 mg x 15's (Inga)$ 0.90
Amoxinga SYR 125mg SYR / 60ml (Inga)$ 0.44
125 mg x 60ml (Inga)$ 0.44
AMOXINGA SYR syr 125 mg x 60ml (Inga)$ 0.44
Capsule; Oral; Amoxicillin Trihydrate 250 mg (Novag)
Capsule; Oral; Amoxicillin Trihydrate 500 mg (Novag)
Suspension; Oral; Amoxicillin Trihydrate 250 mg / 5 ml (Novag)
Suspension; Oral; Amoxicillin Trihydrate 500 mg / 5 ml (Novag)
AMOXIPEN Capsule/ Tablet / 250mg / 10 units (PCI)$ 0.62
AMOXIPEN Liquid / 125mg per 5ml / 60ml units (PCI)$ 0.52
AMOXIPEN Capsule/ Tablet / 500mg / 10 units (PCI)$ 1.16
AMOXIPEN Liquid / 250mg per 5ml / 30ml units (PCI)$ 0.45
AMOXIPEN Liquid / 125mg per 5ml / 30ml units (PCI)$ 0.28
Amoxipen 250mg CAP / 10 (PCI)$ 0.62
Amoxipen 500mg CAP / 10 (PCI)$ 1.16
Amoxipen 125mgx5mL SYR / 30ml (PCI)$ 0.28
Amoxipen 125mgx5mL SYR / 60ml (PCI)$ 0.52

References

  1. DailyMed. "AMOXICILLIN; CLAVULANATE POTASSIUM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "amoxicillin". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "amoxicillin". http://www.drugbank.ca/drugs/DB01060 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Amoxin are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Amoxin. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported useful

Was the Amoxin drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful1
100.0%


1 consumer reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Amoxin drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Expensive1
100.0%


Consumer reported time for results

No survey data has been collected yet


2 consumers reported age

Users%
30-451
50.0%
> 601
50.0%


Consumer reviews


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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