Amphetamine is used to treat narcolepsy (sleep disorder). It is also used to treat attention-deficit hyperactivity disorder (ADHD). It belongs to the group of medicines called central nervous system (CNS) stimulants.
Amphetamine is also used for weight reduction in obese patients.
Amphetamine works in the treatment of ADHD by increasing attention and decreasing restlessness in children and adults who are overactive, cannot concentrate for very long, or are easily distracted and impulsive. Amphetamine is used as part of a total treatment program that also includes social, educational, and psychological treatment.
Amphetamine is available only with a doctor's prescription.
Amphetamine indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Amphetamine is a central nervous system (CNS) stimulant indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in patients 6 years and older.
How should I use Amphetamine?
Use Amphetamine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Amphetamine comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Amphetamine refilled.
Take Amphetamine by mouth with or without food.
Take your doses of Amphetamine 4 to 6 hours apart unless your doctor tells you otherwise.
Do not drink fruit juice at the same time that you take Amphetamine. Certain fruit juices (eg, grapefruit, apple, orange) may decrease Amphetamine's effectiveness.
Take Amphetamine on a regular schedule to get the most benefit from it. Taking Amphetamine at the same time each day will help you remember to take it.
If you miss a dose of Amphetamine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Amphetamine.
Uses of Amphetamine in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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This medication is used to treat attention deficit hyperactivity disorder - ADHD. It works by changing the amounts of certain natural substances in the brain. Amphetamine belongs to a class of drugs known as stimulants. It can help increase your ability to pay attention, stay focused on an activity, and control behavior problems. It may also help you to organize your tasks and improve listening skills.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This drug may also be used to treat a certain sleeping disorder (narcolepsy). It should not be used to treat tiredness or to hold off sleep in people who do not have a sleep disorder.
How to use Amphetamine
Read the Medication Guide provided by your pharmacist before you start taking Amphetamine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with or without food as directed by your doctor, usually once daily in the morning. Taking this medication after noon may cause trouble sleeping (insomnia).
Keep the medication in the original package until you are ready to take a dose. Dry your hands before handling the medication. Peel back the foil layer of the blister pack to remove a tablet. Do not push the tablet through the foil because it may get damaged. Place the tablet on your tongue, allow it to dissolve, and swallow with your saliva. You do not need to take this medication with water or other liquid. Do not crush or chew the tablet.
The dosage is based on your medical condition and response to treatment. Your doctor may adjust your dose to find the dose that is best for you. Follow your doctor's instructions carefully.
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.
During treatment, your doctor may sometimes stop the medication for a short time to see if the medication is still needed.
This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. In such cases, withdrawal symptoms (including severe tiredness, sleep problems, mental/mood changes such as depression) may occur if you suddenly stop using this medication. To prevent withdrawal reactions, your doctor may reduce your dose gradually. Consult your doctor or pharmacist for more details, and report any withdrawal reactions right away.
When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.
Along with its benefits, this medication may rarely cause abnormal drug-seeking behavior (addiction). This risk may be increased if you have abused alcohol or drugs in the past. Take this medication exactly as prescribed to lessen the risk of addiction.
Tell your doctor if your condition does not get better or if it gets worse.
Amphetamine description
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Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. By mimicking the structures of the catecholamine neurotransmitters, noradrenaline and dopamine, amphetamines modulate monoamine release, reuptake, and signalling within the brain. Although "Amphetamine" is used as a descriptor of its own structural class, Amphetamine properly refers to a racemic free base composed of equal parts of its two optical antipodes: levo-Amphetamine and dextro-Amphetamine. Used in the past for the treatment of depression, stress, and for concentration improvement, it is currently available as a prescription drug for the treatment of attention hyperactivity disorder (ADHD), narcolepsy, and as an adjunct in the treatment of exogenous obesity. Amphetamine is also available in a mixed salt/mixed enantiomer form (Adderall), where d-Amphetamine and l-Amphetamine are available in a ratio of 3:1. It is also available in a prodrug form as lisdexamfetamine.
Amphetamine dosage
Amphetamine Dosage
Generic name: Amphetamine 2.5mg in 1mL
Dosage form: suspension, extended release
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
2.1 Important Information Prior to Initiating Treatment
Prior to treating children, adolescents, and adults with CNS stimulants, including Amphetamine, assess for the presence of cardiac disease (i.e., perform a careful history, family history of sudden death or ventricular arrhythmia, and physical exam).
Assess the risk of abuse prior to prescribing, and monitor for signs of abuse and dependence while on therapy. Maintain careful prescription records, educate patients about abuse, monitor for signs of abuse and overdose, and periodically re-evaluate the need for Amphetamine use.
2.2 General Dosing Information
Amphetamine should be orally administered once daily in the morning with or without food. The dose should be individualized according to the needs and responses of the patient. Before administering the dose, shake the bottle of Amphetamine.
In children 6 years of age and older, start with 2.5 mg or 5 mg once daily in the morning. The dose may be increased in increments of 2.5 mg to 10 mg per day every 4 to 7 days up to a maximum dose of 20 mg per day.
Pharmacological treatment of ADHD may be needed for extended periods. Healthcare providers should periodically re-evaluate the long-term use of Amphetamine, and adjust dosage as needed.
2.3 Switching from other Amphetamine Products
If switching from other Amphetamine products, discontinue that treatment, and titrate with Amphetamine using the above titration schedule.
Do not substitute for other Amphetamine products on a milligram-per-milligram basis, because of different Amphetamine base compositions and differing pharmacokinetic profiles.
2.4 Dosage Modifications due to Drug Interactions
Agents that alter urinary pH can impact urinary excretion and alter blood levels of Amphetamine. Acidifying agents (e.g., ascorbic acid) decrease blood levels, while alkalinizing agents (e.g., sodium bicarbonate) increase blood levels. Adjust Amphetamine dosage accordingly.
Drugs Having Clinically Important Interactions With Amphetamines
Table 5: Drugs having clinically important interactions with amphetamines.
MAO Inhibitors (MAOI)
Clinical Impact
MAOI antidepressants slow Amphetamine metabolism, increasing amphetamines effect on the release of norepinephrine and other monoamines from adrenergic nerve endings causing headaches and other signs of hypertensive crisis. Toxic neurological effects and malignant hyperpyrexia can occur, sometimes with fatal results.
Intervention
Do not administer Amphetamine during or within 14 days following the administration of MAOI.
May enhance the activity of tricyclic or sympathomimetic agents causing striking and sustained increases in the concentration of d-Amphetamine in the brain; cardiovascular effects can be potentiated.
Intervention
Monitor frequently and adjust or use alternative therapy based on clinical response.
Examples
desipramine, protriptyline
Proton Pump Inhibitors
Clinical Impact
Time to maximum concentration (Tmax) of Amphetamine is increased compared to when administered alone.
Intervention
Monitor patients for changes in clinical effect and adjust therapy based on clinical response.
Example
omeprazole
Drug/Laboratory Test Interactions
Amphetamines can cause a significant elevation in plasma corticosteroid levels. This increase is greatest in the evening. Amphetamines may interfere with urinary steroid determinations.
Drug Abuse And Dependence
Controlled Substance
Amphetamine contains Amphetamine, which is a Schedule II controlled substance in the U.S. Controlled Substance Act (CSA).
Abuse
Amphetamine, is a CNS stimulant that contains Amphetamine which has a high potential for abuse. Abuse is characterized by impaired control of drug use, compulsive use despite harm, and craving.
Signs and symptoms of Amphetamine abuse may include increased heart rate, respiratory rate, blood pressure, and/or sweating, dilated pupils, hyperactivity, restlessness, insomnia, decreased appetite, loss of coordination, tremors, flushed skin, vomiting, and/or abdominal pain. Anxiety, psychosis, hostility, aggression, suicidal or homicidal ideation have also been observed. Abusers of amphetamines may use other unapproved routes of administration which can result in overdose and death.
To reduce the abuse of Amphetamine, assess the risk of abuse prior to prescribing. After prescribing, keep careful prescription records, educate patients and their families about abuse and proper storage and disposal of CNS stimulants, monitor for signs of abuse while on therapy, and re-evaluate the need for Amphetamine use.
Dependence
Tolerance
Tolerance (a state of adaptation in which exposure to a drug results in a reduction of the drug’s desired and/or undesired effects over time) may occur during the chronic therapy of CNS stimulants including Amphetamine.
Dependence
Physical dependence (which is manifested by a withdrawal syndrome produced by abrupt cessation, rapid dose reduction, or administration of an antagonist) may occur in patients treated with CNS stimulants including Amphetamine. Withdrawal symptoms after abrupt cessation following prolonged high dosage administration of CNS stimulants include dysphoric mood; fatigue; vivid, unpleasant dreams; insomnia or hypersomnia; increased appetite; and psychomotor retardation or agitation.
The following adverse reactions are discussed in greater detail in other sections of the labeling:
Drug Dependence
Hypersensitivity to Amphetamine, or other components of Amphetamine
Hypertensive Crisis When Used Concomitantly with Monoamine Oxidase Inhibitors
Serious Cardiovascular Reactions
Blood Pressure and Heart Rate Increases
Psychiatric Adverse Reactions
Long-Term Suppression of Growth
Peripheral Vasculopathy, including Raynaud's phenomenon
Clinical Trial Experience
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.
Clinical Trials Experience With Other Amphetamine Products In Pediatric Patients And Adults With ADHD
Cardiovascular: Palpitations, tachycardia, elevation of blood pressure, sudden death, myocardial infarction. There have been isolated reports of cardiomyopathy associated with chronic Amphetamine use.
Central Nervous System: Psychotic episodes at recommended doses, overstimulation, restlessness, irritability, euphoria, dyskinesia, dysphoria, depression, tremor, tics, aggression, anger, logorrhea.
Eye Disorders: Vision blurred, mydriasis.
Gastrointestinal: Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances. Anorexia and weight loss may occur as undesirable effects.
Allergic: Urticaria, rash, hypersensitivity reactions including angioedema and anaphylaxis. Serious skin rashes, including Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported.
Endocrine: Impotence, changes in libido.
Skin: Alopecia.
Clinical Trials Experience With Amphetamine In Pediatric Patients With ADHD
There is limited experience with Amphetamine in controlled trials. Based on this limited experience, the adverse reaction profile of Amphetamine appears similar to other Amphetamine extended-release products. The most common ( ≥ 2% in the Amphetamine group and greater than placebo) adverse reactions reported in the Phase 3 controlled study conducted in 108 patients with ADHD (aged 6–12 years) were: epistaxis, allergic rhinitis and upper abdominal pain.
Table 1: Common adverse reactions occurring in ≥ 2% of Subjects on Amphetamine and greater than Placebo during the double blind phase.
Preferred Term
DYANAVELXR
(N=52)
Placebo
(N=48)
Respiratory, thoracic and mediastinal disorders
Epistaxis
3.8%
0%
Rhinitis allergic
3.8%
0%
Gastrointestinal disorders
Abdominal pain upper
3.8%
2.1%
Postmarketing Experience
The following adverse reactions have been identified during post approval use of other Amphetamine products. Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Endocrine: frequent or prolonged erections.
Musculoskeletal, Connective Tissue, and Bone Disorders: rhabdomyolysis.
Amphetamine extended-release oral suspension is contraindicated:
In patients known to be hypersensitive to Amphetamine, or other components of Amphetamine extended-release oral suspension. Hypersensitivity reactions such as angioedema and anaphylactic reactions have been reported in patients treated with other Amphetamine products.
In patients taking monoamine oxidase inhibitors (MAOIs), or within 14 days of stopping MAOIs (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis.
Active ingredient matches for Amphetamine:
Amphetamine
Unit description / dosage (Manufacturer)
Price, USD
Desoxyn 5 mg tablet
$ 5.10
Dexedrine 15 mg 24 Hour Capsule
$ 4.22
Dexedrine 10 mg 24 Hour Capsule
$ 3.23
Dexedrine 5 mg 24 Hour Capsule
$ 3.00
Dexedrine spansule 15 mg
$ 2.45
Dexedrine spansule 10 mg
$ 1.91
Dexedrine spansule 5 mg
$ 1.91
Amphetamine salts 12.5 mg tablet
$ 1.43
Amphetamine salts 15 mg tablet
$ 1.43
Amphetamine salts 7.5 mg tablet
$ 1.43
Amphetamine salts 10 mg tablet
$ 1.37
Amphetamine salts 20 mg tablet
$ 1.37
Amphetamine salts 30 mg tablet
$ 1.37
Amphetamine salts 5 mg tablet
$ 1.37
Amphetamine Salt Combo 7.5 mg tablet
$ 1.30
List of Amphetamine substitutes (brand and generic names):
DailyMed. "AMPHETAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
The results of a survey conducted on ndrugs.com for Amphetamine are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Amphetamine. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
Consumer reported useful
No survey data has been collected yet
Consumer reported price estimates
No survey data has been collected yet
1 consumer reported time for results
To what extent do I have to use Amphetamine before I begin to see changes in my health conditions? As part of the reports released by ndrugs.com website users, it takes 3 days and a few days before you notice an improvement in your health conditions. Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Amphetamine. To get the time effectiveness of using Amphetamine drug by other patients, please click here.
Users
%
3 days
1
100.0%
1 consumer reported age
Users
%
30-45
1
100.0%
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