Amphetamine Sulfate Actions

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Actions of Amphetamine Sulfate in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.

Amphetamines stimulate the release of norepinephrine from central adrenergic receptors. At higher dosages, they cause release of dopamine from the mesocorticolimbic system and the nigrostriatal dopamine systems. Amphetamine Sulfate may also act as a direct agonist on central 5-HT receptors and may inhibit monoamine oxidase (MAO). In the periphery, amphetamines are believed to cause the release of noradrenaline by acting on the adrenergic nerve terminals and alpha- and beta-receptors. Modulation of serotonergic pathways may contribute to the calming affect. The drug interacts with VMAT enzymes to enhance release of DA and 5-HT from vesicles. It may also directly cause the reversal of DAT and SERT.

How should I take Amphetamine Sulfate?

Using Amphetamine Sulfate improperly can cause death or serious side effects on the heart.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use Amphetamine Sulfate in larger or smaller amounts or for longer than recommended.

Amphetamine Sulfate may be habit-forming. Never share Amphetamine Sulfate with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

You may take Amphetamine Sulfate with or without food. It is best to take this medicine first thing in the morning.

If your doctor changes your brand, strength, or type of stimulant medicine, your dosage needs may change. Use only the brand of Amphetamine Sulfate your doctor has prescribed.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

To take the orally disintegrating tablet (Adzenys XR-ODT):

  • Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.

  • Use dry hands to remove the tablet and place it in your mouth.

  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.

While using this medicine, your doctor will need to check your progress at regular visits. Your heart rate, blood pressure, height and weight may also need to be checked often.

Amphetamine Sulfate can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Keep track of the amount of medicine used from each new bottle. Amphetamine Sulfate is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Throw away unused or expired Amphetamine Sulfate in a sealed container or bag. Ask your pharmacist where to locate a community pharmaceutical take back disposal program.

Amphetamine Sulfate administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.


Extended-release orally disintegrating tablet: Administer in the morning with or without food. Do not remove from blister until ready to administer. Using dry hands, peel backing off the blister; do not push tablet through foil. Remove tablet and immediately place on tongue and allow to disintegrate. Swallow with saliva. Do not chew or crush tablet.

Extended-release suspension: Administer in the morning with or without food; use the oral dosing dispenser provided. Administer directly into mouth from dispenser (do not add to food or mix with liquids); wash dispenser after each use. Shake bottle well prior to administration.

Immediate-release tablet: Administer with or without food; for short-term adjunct treatment of exogenous obesity, administer 30 to 60 minutes before meals. Administer the first dose on awakening; administer additional doses at intervals of 4 to 6 hours. Avoid late evening dosing.

Amphetamine Sulfate pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.

Mechanism Of Action

Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. The mode of therapeutic action in ADHD is not known. Amphetamines are thought to block the reuptake of norepinephrine and dopamine into the presynaptic neuron and increase the release of these monoamines into the extraneuronal space.



Following a single, 18.8 mg oral dose of Amphetamine Sulfate in 29 healthy adult subjects in a crossover study under fasting conditions, d-Amphetamine Sulfate and l-Amphetamine Sulfate, the median (range) time to peak plasma concentrations (Tmax) were 4.0 (2 – 7) hours after dosing and peak concentration (Cmax) were 102% and 106%, respectively of the Cmax of immediate-release (IR) mixed Amphetamine Sulfate salts tablets. The relative bioavailability of Amphetamine Sulfate compared to an equal dose of mixed Amphetamine Sulfate salts IR tablets is 106% of d-Amphetamine Sulfate and 111% for l-Amphetamine Sulfate.

Metabolism And Excretion

Amphetamine Sulfate contains d-Amphetamine Sulfate and l-Amphetamine Sulfate in a ratio of 3.2 to 1. Following a single 18.8 mg oral dose of Amphetamine Sulfate in 29 healthy adult subjects under fasting conditions, the mean (± SD) plasma terminal elimination half-life of d-Amphetamine Sulfate was 12.36 (± 2.95 h) hours and the mean (± SD) plasma terminal half-life for l-Amphetamine Sulfate was 15.12 (± 4.40 h) hours. Amphetamine Sulfate is reported to be oxidized at the 4 position of the benzene ring to form 4-hydroxyamphetamine, or on the side chain A or B carbons to form alpha-hydroxy-Amphetamine Sulfate or norephedrine, respectively. Norephedrine and 4-hydroxy-Amphetamine Sulfate are both active and each is subsequently oxidized to form 4-hydroxy-norephedrine. Alpha-hydroxy-Amphetamine Sulfate undergoes deamination to form phenylacetone, which ultimately forms benzoic acid and its glucuronide and the glycine conjugate hippuric acid. Although the enzymes involved in Amphetamine Sulfate metabolism have not been clearly defined, CYP2D6 is known to be involved with formation of 4-hydroxy-Amphetamine Sulfate. Since CYP2D6 is genetically polymorphic, population variations in Amphetamine Sulfate metabolism are a possibility.

Amphetamine Sulfate is known to inhibit monoamine oxidase, whereas the ability of Amphetamine Sulfate and its metabolites to inhibit various P450 isozymes and other enzymes has not been adequately elucidated. In vitro experiments with human microsomes indicate minor inhibition of CYP2D6 by Amphetamine Sulfate and minor inhibition of CYP1A2, 2D6, and 3A4 by one or more metabolites. However, due to the probability of auto-inhibition and the lack of information on the concentration of these metabolites relative to in vivo concentrations, no predications regarding the potential for Amphetamine Sulfate or its metabolites to inhibit the metabolism of other drugs by CYP isozymes in vivo can be made.

With normal urine pHs approximately half of an administered dose of Amphetamine Sulfate is recoverable in urine as derivatives of alpha-hydroxy-Amphetamine Sulfate and approximately another 30% to 40% of the dose is recoverable in urine as Amphetamine Sulfate itself. Since Amphetamine Sulfate has a pKa of 9.9, urinary recovery of Amphetamine Sulfate is highly dependent on pH and urine flow rates. Alkaline urine pHs result in less ionization and reduced renal elimination, and acidic pHs and high flow rates result in increased renal elimination with clearances greater than glomerular filtration rates, indicating the involvement of active secretion. Urinary recovery of Amphetamine Sulfate has been reported to range from 1% to 75%, depending on urinary pH, with the remaining fraction of the dose hepatically metabolized. Consequently, both hepatic and renal dysfunctions have the potential to inhibit the elimination of Amphetamine Sulfate and result in prolonged exposures. In addition, drugs that affect urinary pH are known to alter the elimination of Amphetamine Sulfate, and any decrease in Amphetamine Sulfate's metabolism that might occur due to drug interactions or genetic polymorphisms is more likely to be clinically significant when renal elimination is decreased.

Food Effect

In a study in adult volunteers to investigate the effects of a high-fat meal on the bioavailability of Amphetamine Sulfate at a dose of 18.8 mg, the presence of food delayed the time to peak concentration of both d- and l-Amphetamine Sulfate by approximately 1 hour (fed: median [range] 5 [3 – 8] hours vs. fasted: 4 [2 – 7] hours). Overall, a high-fat meal increased the average Cmax of both isomers of Amphetamine Sulfate by about 2% and decreased the AUC by 5-7% (5.7% decrease for d-Amphetamine Sulfate and 7.4% for l-Amphetamine Sulfate). These changes are not considered clinically significant.

Specific Populations


Following a single 10 mg oral dose of Amphetamine Sulfate in 12 pediatric subjects with ADHD (aged 6-12 years) under fasting conditions, d-Amphetamine Sulfate and l-Amphetamine Sulfate peak plasma concentrations occurred at a median time of 3.9 and 4.5 hours after dosing, respectively. The mean plasma terminal elimination half-life of d-Amphetamine Sulfate was 10.43 (± 2.01 h) hours and the mean plasma terminal half-life for l-Amphetamine Sulfate was 12.14 (± 3.15 h) hours.

Alcohol Effect

There is no in vivo study conducted for the effect of alcohol on drug exposure. An in vitro dissolution study showed alcohol-induced dose dumping potential in the presence of 40% alcohol. Dose dumping was not observed in the presence of lower alcohol concentrations.

Clinical Studies

The efficacy of Amphetamine Sulfate was evaluated in a laboratory classroom study conducted in 108 pediatric patients (aged 6 to 12 years) with ADHD. The study began with an open-label dose optimization period (5 weeks) with an initial Amphetamine Sulfate dose of 2.5 or 5 mg once daily in the morning. The dose could be titrated weekly in increments of 2.5 to 10 mg until an optimal dose or the maximum dose of 20 mg/day was reached. Subjects then entered a 1-week randomized, double-blind treatment with the individually optimized dose of Amphetamine Sulfate or placebo. At the end of the week, school teachers and raters evaluated the attention and behavior of the subjects in a laboratory classroom using the Swanson, Kotkin, Agler, M-Flynn, and Pelham (SKAMP) rating scale. SKAMP is a 13-item teacher-rated scale that assesses manifestations of ADHD in a classroom setting. Each item is rated on a 7-point impairment scale.

The primary efficacy endpoint was change from pre-dose in the SKAMP-Combined score at 4 hours post-dosing. The key secondary efficacy parameters were onset and duration of clinical effect. The change scores from pre-dose SKAMP-Combined scores at post-dose time points (1, 2, 4, 6, 8, 10, 12 and 13 hours) were used to evaluate the key secondary efficacy. Results from the double-blind, placebo-controlled week of the study are summarized in Table 3 and Figure 1.

SKAMP-Combined change scores from pre-dose demonstrated a statistically significant improvement at all time points (1, 2, 4, 6, 8, 10, 12, 13 hours) post-dosing with Amphetamine Sulfate compared to placebo.

Table 3: Primary efficacy result.

Patient Counseling Information

Advise the patient to read the FDA-approved patient labeling (Medication Guide).

Controlled Substance Status/Potential For Abuse, Misuse, And Dependence

Advise patients that Amphetamine Sulfate is a federally controlled substance because it can be abused or lead to dependence. Advise patients to store Amphetamine Sulfate in a safe place, preferably locked, to prevent abuse. Advise patients to comply with laws and regulations on drug disposal. Advise patients to dispose of remaining, unused, or expired Amphetamine Sulfate by a medicine take-back program if available.

Dosage And Administration Instructions

Provide the following instructions on administration to the patient:

  • Use with an oral dosing device or other suitable measuring device.
  • Shake the bottle of Amphetamine Sulfate before each dose.
  • Measure the appropriate dose as prescribed by the physician.
  • Using the filled oral dosing syringe or measuring device, dispense Amphetamine Sulfate directly into mouth.
  • Replace bottle cap and store bottle as directed.
  • Wash oral dosing syringe or measuring device after each use.
Serious Cardiovascular Risks

Advise patients of serious cardiovascular risk (including sudden death, myocardial infarction, stroke, and hypertension) with Amphetamine Sulfate. Instruct patients to contact a healthcare provider immediately if they develop symptoms such as exertional chest pain, unexplained syncope, or other symptoms suggestive of cardiac disease.

Blood Pressure And Heart Rate Increases

Instruct patients that Amphetamine Sulfate can cause elevations of their blood pressure and pulse rate.

Psychiatric Risks

Advise patients that Amphetamine Sulfate, at recommended doses, may cause psychotic or manic symptoms, even in patients without a prior history of psychotic symptoms or mania.

Long-Term Suppression Of Growth

Advise patients that Amphetamine Sulfate may cause slowing of growth and weight loss.

Circulation Problems In Fingers And Toes [Peripheral vasculopathy, including Raynaud's phenomenon]

Instruct patients beginning treatment with Amphetamine Sulfate about the risk of peripheral vasculopathy, including Raynaud's phenomenon, and associated signs and symptoms: fingers or toes may feel numb, cool, painful, and/or may change color from pale, to blue, to red.

Instruct patients to report to their physician any new numbness, pain, skin color change, or sensitivity to temperature in fingers or toes.

Instruct patients to call their physician immediately with any signs of unexplained wounds appearing on fingers or toes while taking Amphetamine Sulfate.

Further clinical evaluation (e.g., rheumatology referral) may be appropriate for certain patients.


Advise patients to notify their healthcare provider if they become pregnant or intend to become pregnant during treatment with Amphetamine Sulfate. Advise patients of the potential fetal effects from the use of Amphetamine Sulfate during pregnancy.


Patients should be advised not to breastfeed if they are taking Amphetamine Sulfate.


Advise patients to avoid alcohol while taking Amphetamine Sulfate. Consumption of alcohol while taking

Amphetamine Sulfate may result in a more rapid release of the dose of Amphetamine Sulfate.



  1. DailyMed. "AMPHETAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. NCIt. "Amphetamine: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". (accessed September 17, 2018).
  3. EPA DSStox. "Amphetamine: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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