Amrixen 125 Uses

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What is Amrixen 125?

Amrixen 125 is a nonsteroidal anti-inflammatory drug (NSAID). Amrixen 125 works by reducing hormones that cause inflammation and pain in the body.

Amrixen 125 is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps.

The delayed-release or extended-release tablets are slower-acting forms of Amrixen 125 that are used only for treating chronic conditions such as arthritis or ankylosing spondylitis. These forms of Amrixen 125 will not work fast enough to treat acute pain.

Amrixen 125 may also be used for purposes not listed in this medication guide.

Amrixen 125 indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Carefully consider the potential benefits and risks of Amrixen 125, EC-Amrixen 125 or Amrixen 125 Suspension and other treatment options before deciding to use Amrixen 125, EC-Amrixen 125 or Amrixen 125 Suspension. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

Amrixen 125 as Amrixen 125, EC-Amrixen 125 or Amrixen 125 Suspension is indicated:

  • For the relief of the signs and symptoms of rheumatoid arthritis
  • For the relief of the signs and symptoms of osteoarthritis
  • For the relief of the signs and symptoms of ankylosing spondylitis
  • For the relief of the signs and symptoms of juvenile arthritis

Amrixen 125 as Amrixen 125 Suspension is recommended for juvenile rheumatoid arthritis in order to obtain the maximum dosage flexibility based on the patient's weight.

Amrixen 125 as Amrixen 125 and Amrixen 125 Suspension is also indicated:

  • For relief of the signs and symptoms of tendonitis
  • For relief of the signs and symptoms of bursitis
  • For relief of the signs and symptoms of acute gout
  • For the management of pain
  • For the management of primary dysmenorrhea

EC-Amrixen 125 is not recommended for initial treatment of acute pain because the absorption of Amrixen 125 is delayed compared to absorption from other Amrixen 125-containing products.

How should I use Amrixen 125?

Use Amrixen 125 sustained-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Amrixen 125 sustained-release tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Amrixen 125 sustained-release tablets refilled.
  • Swallow Amrixen 125 sustained-release tablets whole. Do not break, crush, or chew before swallowing.
  • Take Amrixen 125 sustained-release tablets by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
  • Take Amrixen 125 sustained-release tablets with a full glass of water (8 oz [240 mL]) as directed by your doctor.
  • If you take antacids, cholestyramine, or sucralfate, ask your doctor or pharmacist how to take them with Amrixen 125 sustained-release tablets.
  • If you miss a dose of Amrixen 125 sustained-release tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Amrixen 125 sustained-release tablets.

Uses of Amrixen 125 in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Amrixen 125 is used to relieve mild to moderate pain from various conditions. It also reduces pain, swelling, and joint stiffness from arthritis. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation.

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

This form of Amrixen 125 is absorbed slowly and should not be used for pain that needs quick relief (such as during a gout attack). Ask your doctor or pharmacist about using a different form of this drug or other medications for quick relief of pain.

How to use EC-Amrixen 125

Read the Medication Guide provided by your pharmacist before you start using Amrixen 125 and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually twice daily with or without food. Swallow this medication whole. Do not break, crush, or chew the tablets. Doing so can release the drug too quickly, increasing the risk of side effects. Take this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug.

The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take this drug more often than directed. For ongoing conditions such as arthritis, continue taking this medication as directed by your doctor.

For certain conditions (such as arthritis), it may take up to two weeks of taking this drug regularly until you get the full benefit.

Tell your doctor if your condition does not improve or if it worsens.

Amrixen 125 description

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Each tablet contains Naproxen 200 mg and sodium 20 mg. It also contains the following inactive ingredients: Povidone, microcrystalline cellulose, talc, magnesium stearate, purified water and Opadry (blue) in the coating. It is lactose- and gluten-free.

The sodium content of Amrixen 125 is low, similar to a slice of wheat bread.

Amrixen 125 dosage

Usual Adult Dose for Ankylosing Spondylitis:

Initial: 250 mg to 500 mg (Amrixen 125) or 275 mg to 550 mg (Amrixen 125 sodium) orally twice a day. The initial dose for Amrixen 125 sodium controlled-release is two 375 mg tablets (750 mg) orally once a day, one 750 mg tablet orally once a day, or two 500 mg tablets (1000 mg) orally once a day.

Maintenance: May be increased to a daily maximum of 1500 mg (Amrixen 125) or 1650 mg (Amrixen 125 sodium) in 2 divided doses, for limited periods up to 6 months. In patients who tolerate lower doses well, the dose of Amrixen 125 sodium controlled-release may be increased to two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) orally once a day for limited periods.

Usual Adult Dose for Osteoarthritis:

Initial: 250 mg to 500 mg (Amrixen 125) or 275 mg to 550 mg (Amrixen 125 sodium) orally twice a day. The initial dose for Amrixen 125 sodium controlled-release is two 375 mg tablets (750 mg) orally once a day, one 750 mg tablet orally once a day, or two 500 mg tablets (1000 mg) orally once a day.

Maintenance: May be increased to a daily maximum of 1500 mg (Amrixen 125) or 1650 mg (Amrixen 125 sodium) in 2 divided doses, for limited periods up to 6 months. In patients who tolerate lower doses well, the dose of Amrixen 125 sodium controlled-release may be increased to two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) orally once a day for limited periods.

Usual Adult Dose for Rheumatoid Arthritis:

Initial: 250 mg to 500 mg (Amrixen 125) or 275 mg to 550 mg (Amrixen 125 sodium) orally twice a day. The initial dose for Amrixen 125 sodium controlled-release is two 375 mg tablets (750 mg) orally once a day, one 750 mg tablet orally once a day, or two 500 mg tablets (1000 mg) orally once a day.

Maintenance: May be increased to a daily maximum of 1500 mg (Amrixen 125) or 1650 mg (Amrixen 125 sodium) in 2 divided doses, for limited periods up to 6 months. In patients who tolerate lower doses well, the dose of Amrixen 125 sodium controlled-release may be increased to two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) orally once a day for limited periods.

Usual Adult Dose for Acute Gout:

750 mg (Amrixen 125) or 825 mg (Amrixen 125 sodium) orally one time, followed by 250 mg (Amrixen 125) or 275 mg (Amrixen 125 sodium) every 8 hours until the gouty attack has resolved, usually 2 to 3 days. The recommended dose of Amrixen 125 sodium controlled-release is two to three 500 mg tablets (1000 to 1500 mg) orally on the first day, followed by two 500 mg tablets (1000 mg) orally daily until the attack has subsided.

Usual Adult Dose for Bursitis:

550 mg Amrixen 125 sodium orally once, followed by 550 mg Amrixen 125 sodium every 12 hours, or 275 mg (Amrixen 125 sodium)/250 mg (Amrixen 125) every 6 to 8 hours as needed. Titrate to a maximum daily dose of 1100 mg Amrixen 125 sodium or 1000 mg Amrixen 125. The recommended initial dose of Amrixen 125 sodium controlled-release is two 500 mg tablets (1000 mg) orally once a day. For patients requiring greater analgesic benefit, two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) may be used for a limited period. Thereafter, the total daily dose should not exceed two 500 mg tablets (1000 mg).

Usual Adult Dose for Tendonitis:

550 mg Amrixen 125 sodium orally once, followed by 550 mg Amrixen 125 sodium every 12 hours, or 275 mg (Amrixen 125 sodium)/250 mg (Amrixen 125) every 6 to 8 hours as needed. Titrate to a maximum daily dose of 1100 mg Amrixen 125 sodium or 1000 mg Amrixen 125. The recommended initial dose of Amrixen 125 sodium controlled-release is two 500 mg tablets (1000 mg) orally once a day. For patients requiring greater analgesic benefit, two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) may be used for a limited period. Thereafter, the total daily dose should not exceed two 500 mg tablets (1000 mg).

Usual Adult Dose for Dysmenorrhea:

550 mg Amrixen 125 sodium orally once, followed by 550 mg Amrixen 125 sodium every 12 hours, or 275 mg (Amrixen 125 sodium)/250 mg (Amrixen 125) every 6 to 8 hours as needed. Titrate to a maximum daily dose of 1100 mg Amrixen 125 sodium or 1000 mg Amrixen 125.

Over-the-counter preparation: Amrixen 125 sodium 220 mg orally every 8 hours as needed. Do not exceed 2 caplets in any 8- to 12-hour period.

The recommended initial dose of Amrixen 125 sodium controlled-release is two 500 mg tablets (1000 mg) orally once a day. For patients requiring greater analgesic benefit, two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) may be used for a limited period. Thereafter, the total daily dose should not exceed two 500 mg tablets (1000 mg).

Usual Adult Dose for Pain:

550 mg Amrixen 125 sodium orally once, followed by 550 mg Amrixen 125 sodium every 12 hours, or 275 mg (Amrixen 125 sodium)/250 mg (Amrixen 125) every 6 to 8 hours as needed. Titrate to a maximum daily dose of 1100 mg Amrixen 125 sodium or 1000 mg Amrixen 125.

Over-the-counter preparation: Amrixen 125 sodium 220 mg orally every 8 hours as needed. Do not exceed 2 caplets in any 8- to 12-hour period.

The recommended initial dose of Amrixen 125 sodium controlled-release is two 500 mg tablets (1000 mg) orally once a day. For patients requiring greater analgesic benefit, two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) may be used for a limited period. Thereafter, the total daily dose should not exceed two 500 mg tablets (1000 mg).

Usual Geriatric Dose for Pain:

Over-the-counter preparation - 220 mg (Amrixen 125 sodium) orally every 12 hours or 250 mg (Amrixen 125) orally every 8 hours as needed.

Usual Pediatric Dose for Fever:

Dosage guidelines are based on Amrixen 125:

Greater than 2 years: 2.5 to 10 mg/kg/dose. Maximum daily dose is 10 mg/kg, given every 8 to 12 hours.

Usual Pediatric Dose for Pain:

Dosage guidelines are based on Amrixen 125:

Greater than 2 years: 2.5 to 10 mg/kg/dose. Maximum daily dose is 10 mg/kg, given every 8 to 12 hours.

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis:

Dosage guidelines are based on Amrixen 125:

Greater than or equal to 2 years: 5 mg/kg orally twice a day. Maximum dose: 1000 mg/day.

Amrixen 125 interactions

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What other drugs will affect Amrixen 125?

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The use of NSAIDs in patients who are receiving ACE inhibitors may potentiate renal disease states.

In vitro studies have shown that Amrixen 125 anion, because of its affinity for protein, may displace from their binding sites other drugs which are also albumin-bound.

Theoretically, the Amrixen 125 anion itself could likewise be displaced. Short-term controlled studies failed to show that taking the drug significantly affects prothrombin times when administered to individuals on coumarin-type anticoagulants. Caution is advised nonetheless, since interactions have been seen with other nonsteroidal agents of this class. Similarly, patients receiving the drug and a hydantoin, sulfonamide or sulfonylurea should be observed for signs of toxicity to these drugs.

Concomitant administration of Amrixen 125 and aspirin is not recommended because Amrixen 125 is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations and peak plasma levels.

The natriuretic effect of furosemide has been reported to be inhibited by some drugs of this class. Inhibition of renal lithium clearance leading to increases in plasma lithium concentrations has also been reported. DL Amrixen 125 and other NSAIDs can reduce the antihypertensive effect of propranolol and other beta-blockers.

Probenecid given concurrently increases Amrixen 125 anion plasma levels and extends its plasma half-life significantly.

Caution should be used if Amrixen 125 is administered concomitantly with methotrexate. DL Amrixen 125, Amrixen 125 sodium and other NSAIDs have been reported to reduce the tubular secretion of methotrexate in an animal model, possibly increasing the toxicity of methotrexate.

Drug/Laboratory Test Interactions

DL Amrixen 125 may decrease platelet aggregation and prolong bleeding time. This effect should be kept in mind when bleeding times are determined. The administration of Amrixen 125 may result in increased urinary values for 17-ketogenic steroids because of an interaction between the drug and/or its metabolites with m-dinitrobenzene used in this assay. Although 17-hydroxy-corticosteroid measurements (Porter-Silber test) do not appear to be artifactually altered, it is suggested that therapy with Amrixen 125 be temporarily discontinued 72 hours before adrenal function tests are performed if the Porter-Silber test is to be used.

DL Amrixen 125 may interfere with some urinary assays of 5-hydroxy indoleacetic acid (5HIAA).

Amrixen 125 side effects

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What are the possible side effects of Amrixen 125?

Adverse reactions reported in controlled clinical trials in 960 patients treated for rheumatoid arthritis or osteoarthritis are listed below. In general, reactions in patients treated chronically were reported 2 to 10 times more frequently than they were in short-term studies in the 962 patients treated for mild to moderate pain or for dysmenorrhea. The most frequent complaints reported related to the gastrointestinal tract.

A clinical study found gastrointestinal reactions to be more frequent and more severe in rheumatoid arthritis patients taking daily doses of 1500 mg Amrixen 125 compared to those taking 750 mg Amrixen 125.

In controlled clinical trials with about 80 pediatric patients and in well-monitored, open-label studies with about 400 pediatric patients with juvenile arthritis treated with Amrixen 125, the incidence of rash and prolonged bleeding times were increased, the incidence of gastrointestinal and central nervous system reactions were about the same, and the incidence of other reactions were lower in pediatric patients than in adults.

In patients taking Amrixen 125 in clinical trials, the most frequently reported adverse experiences in approximately 1% to 10% of patients are:

Gastrointestinal (GI) Experiences, including: heartburn*, abdominal pain*, nausea*, constipation*, diarrhea, dyspepsia, stomatitis

Central Nervous System: headache*, dizziness*, drowsiness*, lightheadedness, vertigo

Dermatologic: pruritus (itching)*, skin eruptions*, ecchymoses*, sweating, purpura

Special Senses: tinnitus*, visual disturbances, hearing disturbances

Cardiovascular: edema*, palpitations

General: dyspnea*, thirst

*Incidence of reported reaction between 3% and 9%. Those reactions occurring in less than 3% of the patients are unmarked.

In patients taking NSAIDs, the following adverse experiences have also been reported in approximately 1% to 10% of patients.

Gastrointestinal (GI) Experiences, including: flatulence, gross bleeding/perforation, GI ulcers (gastric/duodenal), vomiting

General: abnormal renal function, anemia, elevated liver enzymes, increased bleeding time, rashes

The following are additional adverse experiences reported in <1% of patients taking Amrixen 125 during clinical trials and through postmarketing reports. Those adverse reactions observed through postmarketing reports are italicized.

Body as a Whole: anaphylactoid reactions, angioneurotic edema, menstrual disorders, pyrexia (chills and fever)

Cardiovascular: congestive heart failure, vasculitis, hypertension, pulmonary edema

Gastrointestinal: inflammation, bleeding (sometimes fatal, particularly in the elderly), ulceration, perforation and obstruction of the upper and lower gatrointestinal tract. Esophagitis, stomatitis, hematemesis, pancreatitis, vomiting, colitis, exacerbation of inflammatory bowel disease (ulcerative colitis, Crohn’s disease)

Hepatobiliary: jaundice, abnormal liver function tests, hepatitis (some causes have been fatal)

Hemic and Lymphatic: eosinophilia, leucopenia, melena, thrombocytopenia, agranulocytosis, granulocytopenia, hemolytic anemia, aplastic anemia

Metabolic and Nutritional: hyperglycemia, hypoglycemia

Nervous System: inability to concentrate, depression, dream abnormalities, insomnia, malaise, myalgia, muscle weakness, aseptic meningitis, cognitive dysfunction, convulsions

Respiratory: eosinophilic pneumonitis, asthma

Dermatologic: alopecia, urticaria, skin rashes, toxic epidermal necrolysis, erythema multiforme, erythema nodosum, fixed drug eruption, lichen planus, pustular reaction, systemic lupus erythematoses, Stevens-Johnson syndrome, photosensitive dermatitis, photosensitivity reactions, including rare cases resembling porphyria cutanea tarda (pseudoporphyria) or epidermolysis bullosa. If skin fragility, blistering or other symptoms suggestive of pseudoporphyria occur, treatment should be discontinued and the patient monitored.

Special Senses: hearing impairment, corneal opacity, papillitis, retrobulbar optic neuritis, papilledema

Urogenital: glomerular nephritis, hematuria, hyperkalemia, interstitial nephritis, nephrotic syndrome, renal disease, renal failure, renal papillary necrosis, raised serum creatinine

Reproduction (Female): infertility

In patients taking NSAIDs, the following adverse experiences have also been reported in <1% of patients.

Body as a Whole: fever, infection, sepsis, anaphylactic reactions, appetite changes, death

Cardiovascular: hypertension, tachycardia, syncope, arrhythmia, hypotension, myocardial infarction

Gastrointestinal: dry mouth, esophagitis, gastric/peptic ulcers, gastritis, glossitis, eructation

Hepatobiliary: hepatitis, liver failure

Hemic and Lymphatic: rectal bleeding, lymphadenopathy, pancytopenia

Metabolic and Nutritional: weight changes

Nervous System: anxiety, asthenia, confusion, nervousness, paresthesia, somnolence, tremors, convulsions, coma, hallucinations

Respiratory: asthma, respiratory depression, pneumonia

Dermatologic: exfoliative dermatitis

Special Senses: blurred vision, conjunctivitis

Urogenital: cystitis, dysuria, oliguria/polyuria, proteinuri

Amrixen 125 contraindications

See also:
What is the most important information I should know about Amrixen 125?

Amrixen 125, EC-Amrixen 125 and Amrixen 125 Suspension are contraindicated in patients with known hypersensitivity to Amrixen 125 and Amrixen 125 sodium.

Amrixen 125, EC-Amrixen 125 and Amrixen 125 Suspension should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.

Amrixen 125, EC-Amrixen 125 and Amrixen 125 Suspension are contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

Active ingredient matches for Amrixen 125:

Naproxen


List of Amrixen 125 substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
AmeProxen 220 mg x 1 Bottle 200 Tablet
Anaflex 10 % x 30 g x 1's (Bago)
Anaflex 10 % x 10 g x 1's (Bago)
Tablet; Oral; Naproxen Sodium 220 mg (Liomont)
Analgen 25 g (Liomont)
Tablets; Oral; Naproxen Sodium 220 mg (Liomont)
Anapran 275 mg x 20 Tablet/Box (Polfa pabianice)
Anapran 550 mg x 20 Tablet/Box (Polfa pabianice)
Tablet; Oral; Naproxen Sodium 250 mg (Minerva)
Tablet; Oral; Naproxen Sodium 550 mg (Minerva)
Anaprox 275 mg x 100's (Minerva)
Anaprox 275 mg x 500's (Minerva)
Tablets; Oral; Naproxen Sodium 250 mg (Minerva)
Tablets; Oral; Naproxen Sodium 550 mg (Minerva)
Anaprox tablet 275 mg (Minerva)
Anaprox tablet 275 mg/1 (Minerva)
Anaprox tablet 550 mg/1 (Minerva)
Tablet; Oral; Naproxen Sodium 500 mg
Tablets; Oral; Naproxen Sodium 500 mg
Anaprox DS tablet 550 mg/1 (Canton Laboratories (US))
Anaprox DS tablet 550 mg (Atnahs Pharma Uk Limited (Canada))
Anex 50mg x 5mL DRY SYR / 30ml (Andic)
Anex 50mg DT-TAB / 10 (Andic)
Anex 100mg TAB / 10 (Andic)
Anex 200mg TAB / 10x10 (Andic)
ANEX dry syr 50 mg x 5 mL x 30ml (Andic)
ANEX dispertab 50 mg x 10's (Andic)
ANEX tab 100 mg x 10's (Andic)

References

  1. DailyMed. "NAPROXEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "NAPROXEN". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "NAPROXEN". http://www.drugbank.ca/drugs/DB00788 (accessed September 17, 2018).

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