An1 Uses

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How times a day do you take this medicine?

What is An1?

An1 is used to treat narcolepsy (sleep disorder). It is also used to treat attention-deficit hyperactivity disorder (ADHD). It belongs to the group of medicines called central nervous system (CNS) stimulants.

An1 is also used for weight reduction in obese patients.

An1 works in the treatment of ADHD by increasing attention and decreasing restlessness in children and adults who are overactive, cannot concentrate for very long, or are easily distracted and impulsive. An1 is used as part of a total treatment program that also includes social, educational, and psychological treatment.

An1 is available only with a doctor's prescription.

An1 indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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An1 is indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) in pediatric patients 6 to 17 years of age.

How should I use An1?

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use An1 as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An1 comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get An1 refilled.
  • Take An1 by mouth with or without food.
  • Take your doses of An1 4 to 6 hours apart unless your doctor tells you otherwise.
  • Do not drink fruit juice at the same time that you take An1. Certain fruit juices (eg, grapefruit, apple, orange) may decrease An1's effectiveness.
  • Take An1 on a regular schedule to get the most benefit from it. Taking An1 at the same time each day will help you remember to take it.
  • If you miss a dose of An1, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use An1.

An1 description

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Amphetamines are non-catecholamine sympathomimetic amines with CNS stimulant activity. By mimicking the structures of the catecholamine neurotransmitters, noradrenaline and dopamine, amphetamines modulate monoamine release, reuptake, and signalling within the brain. Although "An1" is used as a descriptor of its own structural class, An1 properly refers to a racemic free base composed of equal parts of its two optical antipodes: levo-An1 and dextro-An1. Used in the past for the treatment of depression, stress, and for concentration improvement, it is currently available as a prescription drug for the treatment of attention hyperactivity disorder (ADHD), narcolepsy, and as an adjunct in the treatment of exogenous obesity. An1 is also available in a mixed salt/mixed enantiomer form (Adderall), where d-An1 and l-An1 are available in a ratio of 3:1. It is also available in a prodrug form as lisdexamfetamine.

An1 dosage

Pre-treatment Screening

Prior to treating patients with An1, assess for the presence of cardiac disease (i.e., perform a careful history, family history of sudden death or ventricular arrhythmia, and physical exam).

Assess the risk of abuse prior to prescribing and monitor for signs of abuse and dependence while on therapy. Maintain careful prescription records, educate patients about abuse, monitor for signs of abuse and overdose, and periodically re-evaluate the need for An1 use.

Dosing Information

Administer An1 orally in the morning with or without food or liquid.

The recommended starting dose of An1 for patients 6 to 17 years of age is 5 mg once or twice daily. If necessary, administer an additional dose after 4 to 6 hours. Titrate the dosage in increments of 5 mg at weekly intervals until optimal response is obtained. Only in rare cases will it be necessary to exceed a total of 40 mg daily.

Where possible, drug administration should be interrupted occasionally to determine if there is a recurrence of behavioral symptoms sufficient to require continued therapy.

An1 should be administered at the lowest effective dosage and dosage should be individually adjusted.

Administration Instructions

Instruct the patient or caregiver on the following administration instructions:

  • Do not remove the tablet from the blister pack until just prior to dosing. Do not store the tablet for future use.
  • Use dry hands to open the blister.
  • Remove the tablet by pushing it through the back of the foil-lined blister pack.
  • As soon as the blister is opened, remove the tablet and place the tablet on the patient's tongue.
  • Place the whole tablet on the tongue and allow it to disintegrate without chewing or crushing.
  • The tablet will disintegrate in saliva so that it can be swallowed. No liquid is needed to take the tablet. The tablet can be actively moved around between the tongue and the roof of the mouth until it disintegrates.

Switching from Other An1 Products

Switching from EVEKEO to An1 can be done on a milligram-per-milligram basis.

When switching from other An1 products, discontinue treatment and titrate with An1 using the titration schedule above. Do not substitute for other An1 products on a milligram-per-milligram basis because of different An1 salt compositions and differing pharmacokinetic profiles.

Dosage Modifications due to Drug Interactions

Agents that alter urinary pH can impact urinary excretion and alter blood levels of An1. Acidifying agents (e.g., ascorbic acid) decrease blood levels, while alkalinizing agents (e.g., sodium bicarbonate) increase blood levels. Adjust An1 dosage accordingly.

An1 interactions

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What other drugs will affect An1?

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Acidifying agents - Gastrointestinal acidifying agents (guanethidine,reserpine, glutamic acid HCl,ascorbic acid, fruit juices, etc.) lower absorption of amphetamines Urinary acidifying agents -(ammonium chloride, sodium acid phosphate, etc.) Increase the concentration of the ionized species of the An1 Primary excretion - Both Groups of agents lower blood levels and efficacy of amphetamines Adrenergic blockers - Adrenergic blockers are inhibited by amphetamines Alkalinizing agents -Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.)increase absorption of amphetamines. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the An1 molecule, thereby decreasing urinary excretion. Both groups of agents increase blood levels and therefore potentate the actions of amphetamines Antidepressants, tricyclic - Adipans may enhance the activity of tricyclic or sympathomimetic agents; d-An1 with desipramine or protriptyline and possibly other tricyclics cause striking and sustained increases in the concentration of d-An1 in the brain; cardiovascular effects can be potentiated MAO inhibitors - MAO antidepressants, as well as a metabolite of furazolidone, slow An1 metabolism. This slowing potentiates amphetamines, increasing their effect on the release of norepinephrine and other monoamines from adrenergic nerve endings, this can cause headaches and other signs of hypertensive crisis. A variety of neurological toxic effects and malignant hyperpyrexia can occur, sometimes with fatal results Antihistamines - Adipans may counteract the sedative effect of antihistamines Antihypertensives - Adipans may antagonize the hypotensive effects of antihypertensives Chlorpromazine - Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central stimulant effects of amphetamines, and can be used to treat An1 poisoning Ethosuximide - Adipans may delay intestinal absorption of ethosuximide Haloperidol - Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of amphetamines Lithium carbonate - The anorectic and stimulatory effects of amphetamines may be inhibited by lithium carbonate Meperidine - Adipans pone the analgesic effect of meperidine Methenamine therapy - Urinary excretion of amphetamines is increased, and efficacy is reduced, by acidifying agents used in methenamine therapy Norepinephrine - Adipans enhance the adrenergic effect of norepinephrine Phenobarbital - Adipans may delay intestinal absorption of phenobarbital; co-administration of phenobarbital may produce a synergistic anticonvulsant action Phenytoin - Adipans may delay intestinal absorption of phenytoin; co-administration of phenytoin may produce a synergistic anticonvulsant action Propoxyphene - In cases of propoxyphene overdose, An1 CNS stimulation is potentiated and fatal convulsions can occur Veratrum alkaloids - Adipans inhibit the hypotensive effect of veratrum alkaloids Drug/Laboratory Test Interaction Adipans can cause a significant elevation in plasma corticosteroid levels. This increase is greatest in the evening Adipans may interfere with urinary steroid determinations.

An1 side effects

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What are the possible side effects of An1?

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Applies to An1: oral suspension extended release, oral tablet, oral tablet extended release disintegrating

Along with its needed effects, An1 (the active ingredient contained in An1) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking An1:

Rare

  • Seeing, hearing, or feeling things that are not there
  • severe mental changes
Incidence not known
  • Agitation
  • blurred vision
  • confusion
  • diarrhea
  • dizziness
  • false or unusual sense of well-being
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • headache
  • nervousness
  • overactive reflexes
  • pounding in the ears
  • restlessness
  • shakiness in the legs, arms, hands, or feet
  • shivering
  • slow or fast heartbeat
  • sweating
  • talking or acting with excitement you cannot control
  • trouble sleeping
  • twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs
  • uncontrolled vocal outbursts or tics (uncontrolled repeated body movements)

Get emergency help immediately if any of the following symptoms of overdose occur while taking An1:

Symptoms of overdose

  • Abdominal or stomach cramps
  • dark-colored urine
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • muscle cramps or spasms
  • muscle pain or stiffness
  • nausea
  • seizures
  • sweating
  • unusual tiredness or weakness
  • vomiting

Some side effects of An1 may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Decreased interest in sexual intercourse
  • difficulty having a bowel movement (stool)
  • dry mouth
  • hives or welts, itching, or skin rash
  • inability to have or keep an erection
  • loss in sexual ability, desire, drive, or performance
  • loss of appetite
  • redness of the skin
  • unpleasant taste
  • weight loss

An1 contraindications

See also:
What is the most important information I should know about An1?

An1 is contraindicated in patients:

  • With known hypersensitivity to An1, or other components of An1. Hypersensitivity reactions such as angioedema and anaphylactic reactions have been reported in patients treated with other An1 products.
  • Receiving concomitant treatment with monoamine oxidase inhibitors (MAOIs), or within 14 days following discontinuation of treatment with an MOAI (including MAOIs such as linezolid or intravenous methylene blue), because of an increased risk of hypertensive crisis.

Active ingredient matches for An1:

Amphetamine


List of An1 substitutes (brand and generic names)

Sort by popularity
Unit description / dosage (Manufacturer)Price, USD
Amphetamine salts 5 mg tablet$ 1.37
Amphetamine Salt Combo 7.5 mg tablet$ 1.30
Tablet; Oral; Amphetamine 10 mg
Tablet; Oral; Amphetamine Sulfate 5 mg
Tablet; Oral; Amphetamine Sulfate 10 mg

References

  1. DailyMed. "AMPHETAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "AMPHETAMINE". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "AMPHETAMINE". http://www.drugbank.ca/drugs/DB00182 (accessed September 17, 2018).

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The results of a survey conducted on ndrugs.com for An1 are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking An1. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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