Anaerobyl Uses

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What is Anaerobyl?

Anaerobyl is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).

Anaerobyl belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, Anaerobyl will not work for colds, flu, or other virus infections.

Anaerobyl is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Anaerobyl is used in certain patients with the following medical conditions:

Anaerobyl indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Symptomatic Trichomoniasis. Anaerobyl Capsules USP 375 mg are indicated for the treatment of T. vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures).

Asymptomatic Trichomoniasis. Anaerobyl Capsules USP 375 mg are indicated in the treatment of asymptomatic T. vaginalis infection in females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite.

Treatment of Asymptomatic Sexual Partners. T. vaginalis infection is a venereal disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. The decision as to whether to treat an asymptomatic male partner who has a negative culture or one for whom no culture has been attempted is an individual one. In making this decision, it should be noted that there is evidence that a woman may become reinfected if her sexual partner is not treated. Also, since there can be considerable difficulty in isolating the organism from the asymptomatic male carrier, negative smears and cultures cannot be relied upon in this regard. In any event, the sexual partner should be treated with Anaerobyl in cases of reinfection.

Amebiasis. Anaerobyl Capsules USP 375 mg are indicated in the treatment of acute intestinal amebiasis (amebic dysentery) and amebic liver abscess.

In amebic liver abscess, Anaerobyl Capsules USP 375 mg therapy does not obviate the need for aspiration or drainage of pus.

Anaerobic Bacterial Infections. Anaerobyl Capsules USP 375 mg are indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with Anaerobyl therapy. In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to Anaerobyl Capsules USP 375 mg.

INTRA-ABDOMINAL INFECTIONS, including peritonitis, intra-abdominal abscess, and liver abscess, caused by Bacteroides species including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Clostridium species, Eubacterium species, Peptococcus species, or Peptostreptococcus species.

SKIN AND SKIN STRUCTURE INFECTIONS caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.

GYNECOLOGIC INFECTIONS, including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection, caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.

BACTERIAL SEPTICEMIA caused by Bacteroides species including the B. fragilis group or Clostridium species.

BONE AND JOINT INFECTIONS (as adjunctive therapy) caused by Bacteroides species including the B. fragilis group.

CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS, including meningitis and brain abscess, caused by Bacteroides species including the B. fragilis group.

LOWER RESPIRATORY TRACT INFECTIONS, including pneumonia, empyema, and lung abscess, caused by Bacteroides species including the B. fragilis group.

ENDOCARDITIS caused by Bacteroides species including the B. fragilis group.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Anaerobyl Capsules USP 375 mg and other antibacterial drugs, Anaerobyl Capsules USP 375 mg should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

How should I use Anaerobyl?

Use Anaerobyl gel as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Anaerobyl gel.

Uses of Anaerobyl in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Amebiasis: Treatment of acute intestinal amebiasis (amebic dysentery) and extraintestinal amebiasis (liver abscess)

Limitations of use: When used for amebic liver abscess, may be used concurrently with percutaneous needle aspiration when clinically indicated.

Anaerobic bacterial infections (caused by Bacteroides spp., including the B. fragilis group):

Bacterial septicemia: Treatment of bacterial septicemia (also caused by Clostridium spp.)

Bone and joint infections: Treatment (adjunctive therapy) of bone and joint infections

CNS Infections: Treatment of CNS infections, including meningitis and brain abscess

Endocarditis: Treatment of endocarditis

Gynecologic infections: Treatment of gynecologic infections including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection (also caused by Clostridium spp., Peptococcus spp., Peptostreptococcus spp., and Fusobacterium spp.)

Intra-abdominal infections: Treatment of intra-abdominal infections, including peritonitis, intra-abdominal abscess, and liver abscess (also caused by Clostridium spp., Eubacterium spp., Peptococcus spp., and Peptostreptococcus spp.)

Lower respiratory tract infections: Treatment of lower respiratory tract infections, including pneumonia, empyema, and lung abscess

Skin and skin structure infections: Treatment of skin and skin structure infections (also caused by Clostridium spp., Peptococcus spp., Peptostreptococcus spp., and Fusobacterium spp.)

Surgical prophylaxis (colorectal surgery): Injection: Preoperative, intraoperative, and postoperative prophylaxis to reduce the incidence of postoperative infection in patients undergoing elective colorectal surgery classified as contaminated or potentially contaminated

Trichomoniasis: Treatment of infections caused by Trichomonas vaginalis, including treatment of asymptomatic sexual partners

Off Label Uses

Balantidiasis

Data from a single case report of one immunocompromised patient with pulmonary infection treated with Anaerobyl suggest that Anaerobyl may be beneficial for the treatment of balantidiasis.

Anaerobyl description

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Each 100 mL contains Metronidazole USP 500 mg, sodium chloride USP 0.72% w/v, water for injection USP as needed.

Anaerobyl injection, USP is a parenteral dosage form of the synthetic antibacterial agent 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole. The empirical formula is C6H9N3O3 and the molecular weight is 171.15.

Anaerobyl injection, USP in 100 mL is a sterile, nonpyrogenic, iso-osmotic, buffered solution of 500 mg Anaerobyl, USP, 790 mg sodium chloride, USP, 47.6 mg dried dibasic sodium phosphate, USP and 22.9 mg anhydrous citric acid, USP. Anaerobyl injection, USP has an osmolarity of 310 mOsmol/L (calc) and a pH of 5.5 (4.5 to 7).

Anaerobyl dosage

Anaerobyl Dosage

Generic name: Anaerobyl 750mg

Dosage form: tablet, film coated, extended release

See also:

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Bacterial Vaginosis

750 mg once daily by mouth for seven consecutive days.

Anaerobyl 750 mg tablets should be taken under fasting conditions, at least one hour before or two hours after meals. The optimum extended-release characteristics of Anaerobyl 750 mg are obtained when the drug is taken under fasting conditions.

Anaerobyl tablets should not be split, chewed, or crushed.

Dosage Adjustments

Patients Undergoing Hemodialysis

Hemodialysis removes significant amounts of Anaerobyl and its metabolites from systemic circulation. The clearance of Anaerobyl will depend on the type of dialysis membrane used, the duration of the dialysis session, and other factors. If the administration of Anaerobyl cannot be separated from a hemodialysis session, supplementation of Anaerobyl dosage following the hemodialysis session should be considered, depending on the patient's clinical situation.

More about Anaerobyl (Anaerobyl)

Consumer resources

Professional resources

Other formulations

Related treatment guides

Anaerobyl interactions

See also:
What other drugs will affect Anaerobyl?

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Disulfiram

Psychotic reactions have been reported in alcoholic patients who are using Anaerobyl and disulfiram concurrently. Anaerobyl should not be given to patients who have taken disulfiram within the last two weeks.

Alcoholic Beverages

Abdominal cramps, nausea, vomiting, headaches, and flushing may occur if alcoholic beverages or products containing propylene glycol are consumed during or following Anaerobyl therapy.

Warfarin And Other

Oral Anticoagulants

Anaerobyl has been reported to potentiate the anticoagulant effect of warfarin and other oral coumarin anticoagulants, resulting in a prolongation of prothrombin time. When Anaerobyl is prescribed for patients on this type of anticoagulant therapy, prothrombin time and INR should be carefully monitored.

Lithium

In patients stabilized on relatively high doses of lithium, short-term Anaerobyl therapy has been associated with elevation of serum lithium and, in a few cases, signs of lithium toxicity. Serum lithium and serum creatinine levels should be obtained several days after beginning Anaerobyl to detect any increase that may precede clinical symptoms of lithium intoxication.

Busulfan

Anaerobyl has been reported to increase plasma concentrations of busulfan, which can result in an increased risk for serious busulfan toxicity. Anaerobyl should not be administered concomitantly with busulfan unless the benefit outweighs the risk. If no therapeutic alternatives to Anaerobyl are available, and concomitant administration with busulfan is medically needed, frequent monitoring of busulfan plasma concentration should be performed and the busulfan dose should be adjusted accordingly.

Drugs That Inhibit CYP450 Enzymes

The simultaneous administration of drugs that decrease microsomal liver enzyme activity, such as cimetidine, may prolong the half-life and decrease plasma clearance of Anaerobyl.

Drugs That Induce CYP450 Enzymes

The simultaneous administration of drugs that induce microsomal liver enzymes, such as phenytoin or phenobarbital, may accelerate the elimination of Anaerobyl, resulting in reduced plasma levels; impaired clearance of phenytoin has also been reported.

Drug/Laboratory Test Interactions

Anaerobyl may interfere with certain types of determinations of serum chemistry values, such as aspartate aminotransferase (AST, SGOT), alanine aminotransferase (ALT, SGPT), lactate dehydrogenase (LDH), triglycerides, and glucose hexokinase. Values of zero may be observed. All of the assays in which interference has been reported involve enzymatic coupling of the assay to oxidation-reduction of nicotinamide adenine dinucleotide (NAD- NADH). Interference is due to the similarity in absorbance peaks of NADH (340 nm) and Anaerobyl (322 nm) at pH 7.

Anaerobyl side effects

See also:
What are the possible side effects of Anaerobyl?

Two serious adverse reactions reported in patients treated with Anaerobyl have been convulsive seizures and peripheral neuropathy, the latter characterized mainly by numbness or paresthesia of an extremity. Since persistent peripheral neuropathy has been reported in some patients receiving prolonged administration of Anaerobyl, patients should be specifically warned about these reactions and should be told to stop the drug and report immediately to their physicians if any neu-rologic symptoms occur.

The most common adverse reactions reported have been referable to the gastrointestinal tract, particularly nausea reported by about 12% of patients, sometimes accompanied by headache, anorexia, and occasionally vomiting; diarrhea; epi-gastric distress; and abdominal cramping. Constipation has also been reported.

The following reactions have also been reported during treatment with Anaerobyl:

Mouth: A sharp, unpleasant metallic taste is not unusual. Furry tongue, glossitis, and sto-matitis have occurred; these may be associated with a sudden overgrowth of Candida which may occur during therapy.

Hematopoietic: Reversible neutropenia (leuko-penia); rarely, reversible thrombocytopenia.

Cardiovascular: Flattening of the T-wave may be seen in electrocardiographic tracings.

Central Nervous System: Convulsive seizures, peripheral neuropathy, dizziness, vertigo, incoordination, ataxia, confusion, irritability, depression, weakness, and insomnia.

Hypersensitivity: Urticaria, erythematous rash, flushing, nasal congestion, dryness of the mouth (or vagina or vulva), and fever.

Renal: Dysuria, cystitis, polyuria, incontinence, and a sense of pelvic pressure. Instances of darkened urine have been reported by approximately one patient in 100,000. Although the pigment which is probably responsible for this phenomenon has not been positively identified, it is almost certainly a metabolite of Anaerobyl and seems to have no clinical significance.

Other: Proliferation of Candida in the vagina, dyspareunia, decrease of libido, proctitis, and fleeting joint pains sometimes resembling &ldquoserum sickness.” If patients receiving Anaerobyl drink alcoholic beverages, they may experience abdominal distress, nausea, vomiting, flushing, or headache. A modification of the taste of alcoholic beverages has also been reported. Rare cases of pan-creatitis, which generally abated on withdrawal of the drug, have been reported.

Crohn’s disease patients are known to have an increased incidence of gastrointestinal and certain extraintestinal cancers. There have been some reports in the medical literature of breast and colon cancer in Crohn’s disease patients who have been treated with Anaerobyl at high doses for extended periods of time. A cause and effect relationship has not been established. Crohn’s disease is not an approved indication for Anaerobyl.

Anaerobyl contraindications

See also:
What is the most important information I should know about Anaerobyl?

Hypersensitivity

Anaerobyl Capsules 375 mg are contraindicated in patients with a prior history of hypersensitivity to Anaerobyl or other nitroimidazole derivatives.

In patients with trichomoniasis, Anaerobyl Capsules 375 mg are contraindicated during the first trimester of pregnancy.

Psychotic Reaction with Disulfiram

Use of oral Anaerobyl is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Do not administer Anaerobyl to patients who have taken disulfiram within the last two weeks.

Interaction with Alcohol

Use of oral Anaerobyl is associated with a disulfiram-like reaction to alcohol, including abdominal cramps, nausea, vomiting, headaches, and flushing. Discontinue consumption of alcohol or products containing propylene glycol during and for at least three days after therapy with Anaerobyl.

Active ingredient matches for Anaerobyl:

Metronidazole in South Africa.


List of Anaerobyl substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
1 mg x 10's (United Biotech)
Anazol 1mg TAB / 10 (United Biotech)
ANAZOL tab 1 mg x 10's (United Biotech)$ 8.32
Anegyn 500 mg/100 mL x 1's
Anerobizol 5 mg/1 mL x 100 mL x 1's (Marck Biosciences)
Anerobizol infusion 5 mg/mL 100 mL x 1's (Marck Biosciences)
200 mg x 5 mL x 60ml (Raptakos)$ 0.14
200 mg x 10's (Raptakos)$ 0.08
Antamebin 200mg x 5mL SUSP / 60ml (Raptakos)$ 0.14
Antamebin 200mg TAB / 10 (Raptakos)$ 0.08
ANTAMEBIN oral susp 200 mg x 5 mL x 60ml (Raptakos)$ 0.14
ANTAMEBIN tab 200 mg x 10's (Raptakos)$ 0.08
Antamebin 200mg x 5mL SUSP / 60ml (Raptakos)$ 0.14
Antamebin 200mg TAB / 10 (Raptakos)$ 0.08
Antimonas 250 mg
Antizoal infusion 5 mg/mL / PP1 100 mL x 1's (Shijiazhuang No. 4)
Apo-Metronidazole 250 mg x 1 Bottle 100 Tablet
Apo-Metronidazole 250 mg x 1 Bottle 500 Tablet
Apo-Metronidazole 250 mg x 1 Bottle 1000 Tablet
Apo-Metronidazole 250 mg x 500's
Tablets; Oral; Metronidazole 250 mg
Apo-metronidazole tablet 250 mg (Apotex Inc (Canada))
Apo-metronidazole capsule 500 mg (Apotex Inc (Canada))
Suppositories; Vaginal; Metronidazole (Medika)
Tablet, Film-Coated; Oral; Metronidazole 250 mg (Medika)
Tablet, Film-Coated; Oral; Metronidazole 500 mg (Medika)
Tablets, Film-Coated; Oral; Metronidazole 250 mg (Medika)
Tablets, Film-Coated; Oral; Metronidazole 500 mg (Medika)

References

  1. DailyMed. "BISMUTH SUBCITRATE POTASSIUM; METRONIDAZOLE; TETRACYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "metronidazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "metronidazole". http://www.drugbank.ca/drugs/DB00916 (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Anaerobyl are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Anaerobyl. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

9 consumers reported useful

Was the Anaerobyl drug useful in terms of decreasing the symptom or the disease?
According to the reports released by ndrugs.com website users, the below mentioned percentages of users say the drug is useful / not useful to them in decreasing their symptoms/disease. The usefulness of the drug depends on many factors, like severity of the disease, perception of symptom, or disease by the patient, brand name used [matters only to a certain extent], other associated conditions of the patient. If the drug is not effective or useful in your case, you need to meet the doctor to get re-evaluated about your symptoms/disease, and he will prescribe an alternative drug.
Users%
Useful7
77.8%
Not useful2
22.2%


4 consumers reported price estimates

Was the price you paid to purchase the drug reasonable? Did you feel it was expensive?
The below mentioned numbers have been reported by ndrugs.com website users about whether the Anaerobyl drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Expensive2
50.0%
Not expensive2
50.0%


35 consumers reported time for results

To what extent do I have to use Anaerobyl before I begin to see changes in my health conditions?
As part of the reports released by ndrugs.com website users, it takes 5 days and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Anaerobyl. To get the time effectiveness of using Anaerobyl drug by other patients, please click here.
Users%
5 days10
28.6%
1 day7
20.0%
2 weeks4
11.4%
3 days4
11.4%
2 days4
11.4%
1 week3
8.6%
> 3 month2
5.7%
1 month1
2.9%


78 consumers reported age

Users%
16-2943
55.1%
30-4528
35.9%
46-606
7.7%
> 601
1.3%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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