Anaflex Uses

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What is Anaflex?

Anaflex is a nonsteroidal anti-inflammatory drug (NSAID). Anaflex works by reducing hormones that cause inflammation and pain in the body.

Anaflex is used to treat pain or inflammation caused by conditions such as arthritis, ankylosing spondylitis, tendinitis, bursitis, gout, or menstrual cramps.

The delayed-release or extended-release tablets are slower-acting forms of Anaflex that are used only for treating chronic conditions such as arthritis or ankylosing spondylitis. These forms of Anaflex will not work fast enough to treat acute pain.

Anaflex may also be used for purposes not listed in this medication guide.

Anaflex indications

infoAn indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Carefully consider the potential benefits and risks of Anaflex, EC-Anaflex, ANAPROX, ANAPROX DS or Anaflex Suspension and other treatment options before deciding to use Anaflex, EC-Anaflex, ANAPROX, ANAPROX DS or Anaflex Suspension. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.

Anaflex as Anaflex, EC-Anaflex, ANAPROX, ANAPROX DS or Anaflex Suspension is indicated:

  • For the relief of the signs and symptoms of rheumatoid arthritis
  • For the relief of the signs and symptoms of osteoarthritis
  • For the relief of the signs and symptoms of ankylosing spondylitis
  • For the relief of the signs and symptoms of juvenile arthritis

Anaflex as Anaflex Suspension is recommended for juvenile rheumatoid arthritis in order to obtain the maximum dosage flexibility based on the patient's weight.

Anaflex as Anaflex, ANAPROX, ANAPROX DS and Anaflex Suspension is also indicated:

  • For relief of the signs and symptoms of tendonitis
  • For relief of the signs and symptoms of bursitis
  • For relief of the signs and symptoms of acute gout
  • For the management of pain
  • For the management of primary dysmenorrhea

EC-Anaflex is not recommended for initial treatment of acute pain because the absorption of Anaflex is delayed compared to absorption from other Anaflex-containing products.

How should I use Anaflex?

Use Anaflex sustained-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Anaflex sustained-release tablets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Anaflex sustained-release tablets refilled.
  • Swallow Anaflex sustained-release tablets whole. Do not break, crush, or chew before swallowing.
  • Take Anaflex sustained-release tablets by mouth. It may be taken with food if it upsets your stomach. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
  • Take Anaflex sustained-release tablets with a full glass of water (8 oz [240 mL]) as directed by your doctor.
  • If you take antacids, cholestyramine, or sucralfate, ask your doctor or pharmacist how to take them with Anaflex sustained-release tablets.
  • If you miss a dose of Anaflex sustained-release tablets and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose. Go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Anaflex sustained-release tablets.

Uses of Anaflex in details

infoThere are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Anaflex is used to relieve mild to moderate pain from various conditions. It also reduces pain, swelling, and joint stiffness from arthritis. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID). It works by blocking your body's production of certain natural substances that cause inflammation.

If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.

This form of Anaflex is absorbed slowly and should not be used for pain that needs quick relief (such as during a gout attack). Ask your doctor or pharmacist about using a different form of this drug or other medications for quick relief of pain.

How to use EC-Anaflex

Read the Medication Guide provided by your pharmacist before you start using Anaflex and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth as directed by your doctor, usually twice daily with or without food. Swallow this medication whole. Do not break, crush, or chew the tablets. Doing so can release the drug too quickly, increasing the risk of side effects. Take this medication with a full glass of water (8 ounces/240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug.

The dosage is based on your medical condition and response to treatment. To reduce your risk of stomach bleeding and other side effects, take this medication at the lowest effective dose for the shortest possible time. Do not increase your dose or take this drug more often than directed. For ongoing conditions such as arthritis, continue taking this medication as directed by your doctor.

For certain conditions (such as arthritis), it may take up to two weeks of taking this drug regularly until you get the full benefit.

Tell your doctor if your condition does not improve or if it worsens.

Anaflex description

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Each tablet contains Naproxen 200 mg and sodium 20 mg. It also contains the following inactive ingredients: Povidone, microcrystalline cellulose, talc, magnesium stearate, purified water and Opadry (blue) in the coating. It is lactose- and gluten-free.

The sodium content of Anaflex is low, similar to a slice of wheat bread.

Anaflex dosage

Usual Adult Dose for Ankylosing Spondylitis:

Initial: 250 mg to 500 mg (Anaflex) or 275 mg to 550 mg (Anaflex sodium) orally twice a day. The initial dose for Anaflex sodium controlled-release is two 375 mg tablets (750 mg) orally once a day, one 750 mg tablet orally once a day, or two 500 mg tablets (1000 mg) orally once a day.

Maintenance: May be increased to a daily maximum of 1500 mg (Anaflex) or 1650 mg (Anaflex sodium) in 2 divided doses, for limited periods up to 6 months. In patients who tolerate lower doses well, the dose of Anaflex sodium controlled-release may be increased to two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) orally once a day for limited periods.

Usual Adult Dose for Osteoarthritis:

Initial: 250 mg to 500 mg (Anaflex) or 275 mg to 550 mg (Anaflex sodium) orally twice a day. The initial dose for Anaflex sodium controlled-release is two 375 mg tablets (750 mg) orally once a day, one 750 mg tablet orally once a day, or two 500 mg tablets (1000 mg) orally once a day.

Maintenance: May be increased to a daily maximum of 1500 mg (Anaflex) or 1650 mg (Anaflex sodium) in 2 divided doses, for limited periods up to 6 months. In patients who tolerate lower doses well, the dose of Anaflex sodium controlled-release may be increased to two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) orally once a day for limited periods.

Usual Adult Dose for Rheumatoid Arthritis:

Initial: 250 mg to 500 mg (Anaflex) or 275 mg to 550 mg (Anaflex sodium) orally twice a day. The initial dose for Anaflex sodium controlled-release is two 375 mg tablets (750 mg) orally once a day, one 750 mg tablet orally once a day, or two 500 mg tablets (1000 mg) orally once a day.

Maintenance: May be increased to a daily maximum of 1500 mg (Anaflex) or 1650 mg (Anaflex sodium) in 2 divided doses, for limited periods up to 6 months. In patients who tolerate lower doses well, the dose of Anaflex sodium controlled-release may be increased to two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) orally once a day for limited periods.

Usual Adult Dose for Acute Gout:

750 mg (Anaflex) or 825 mg (Anaflex sodium) orally one time, followed by 250 mg (Anaflex) or 275 mg (Anaflex sodium) every 8 hours until the gouty attack has resolved, usually 2 to 3 days. The recommended dose of Anaflex sodium controlled-release is two to three 500 mg tablets (1000 to 1500 mg) orally on the first day, followed by two 500 mg tablets (1000 mg) orally daily until the attack has subsided.

Usual Adult Dose for Bursitis:

550 mg Anaflex sodium orally once, followed by 550 mg Anaflex sodium every 12 hours, or 275 mg (Anaflex sodium)/250 mg (Anaflex) every 6 to 8 hours as needed. Titrate to a maximum daily dose of 1100 mg Anaflex sodium or 1000 mg Anaflex. The recommended initial dose of Anaflex sodium controlled-release is two 500 mg tablets (1000 mg) orally once a day. For patients requiring greater analgesic benefit, two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) may be used for a limited period. Thereafter, the total daily dose should not exceed two 500 mg tablets (1000 mg).

Usual Adult Dose for Tendonitis:

550 mg Anaflex sodium orally once, followed by 550 mg Anaflex sodium every 12 hours, or 275 mg (Anaflex sodium)/250 mg (Anaflex) every 6 to 8 hours as needed. Titrate to a maximum daily dose of 1100 mg Anaflex sodium or 1000 mg Anaflex. The recommended initial dose of Anaflex sodium controlled-release is two 500 mg tablets (1000 mg) orally once a day. For patients requiring greater analgesic benefit, two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) may be used for a limited period. Thereafter, the total daily dose should not exceed two 500 mg tablets (1000 mg).

Usual Adult Dose for Dysmenorrhea:

550 mg Anaflex sodium orally once, followed by 550 mg Anaflex sodium every 12 hours, or 275 mg (Anaflex sodium)/250 mg (Anaflex) every 6 to 8 hours as needed. Titrate to a maximum daily dose of 1100 mg Anaflex sodium or 1000 mg Anaflex.

Over-the-counter preparation: Anaflex sodium 220 mg orally every 8 hours as needed. Do not exceed 2 caplets in any 8- to 12-hour period.

The recommended initial dose of Anaflex sodium controlled-release is two 500 mg tablets (1000 mg) orally once a day. For patients requiring greater analgesic benefit, two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) may be used for a limited period. Thereafter, the total daily dose should not exceed two 500 mg tablets (1000 mg).

Usual Adult Dose for Pain:

550 mg Anaflex sodium orally once, followed by 550 mg Anaflex sodium every 12 hours, or 275 mg (Anaflex sodium)/250 mg (Anaflex) every 6 to 8 hours as needed. Titrate to a maximum daily dose of 1100 mg Anaflex sodium or 1000 mg Anaflex.

Over-the-counter preparation: Anaflex sodium 220 mg orally every 8 hours as needed. Do not exceed 2 caplets in any 8- to 12-hour period.

The recommended initial dose of Anaflex sodium controlled-release is two 500 mg tablets (1000 mg) orally once a day. For patients requiring greater analgesic benefit, two 750 mg tablets (1500 mg) or three 500 mg tablets (1500 mg) may be used for a limited period. Thereafter, the total daily dose should not exceed two 500 mg tablets (1000 mg).

Usual Geriatric Dose for Pain:

Over-the-counter preparation - 220 mg (Anaflex sodium) orally every 12 hours or 250 mg (Anaflex) orally every 8 hours as needed.

Usual Pediatric Dose for Fever:

Dosage guidelines are based on Anaflex:

Greater than 2 years: 2.5 to 10 mg/kg/dose. Maximum daily dose is 10 mg/kg, given every 8 to 12 hours.

Usual Pediatric Dose for Pain:

Dosage guidelines are based on Anaflex:

Greater than 2 years: 2.5 to 10 mg/kg/dose. Maximum daily dose is 10 mg/kg, given every 8 to 12 hours.

Usual Pediatric Dose for Juvenile Rheumatoid Arthritis:

Dosage guidelines are based on Anaflex:

Greater than or equal to 2 years: 5 mg/kg orally twice a day. Maximum dose: 1000 mg/day.

Anaflex interactions

See also:
What other drugs will affect Anaflex?

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The use of NSAIDs in patients who are receiving ACE inhibitors may potentiate renal disease states.

In vitro studies have shown that Anaflex anion, because of its affinity for protein, may displace from their binding sites other drugs which are also albumin-bound.

Theoretically, the Anaflex anion itself could likewise be displaced. Short-term controlled studies failed to show that taking the drug significantly affects prothrombin times when administered to individuals on coumarin-type anticoagulants. Caution is advised nonetheless, since interactions have been seen with other nonsteroidal agents of this class. Similarly, patients receiving the drug and a hydantoin, sulfonamide or sulfonylurea should be observed for signs of toxicity to these drugs.

Concomitant administration of Anaflex and aspirin is not recommended because Anaflex is displaced from its binding sites during the concomitant administration of aspirin, resulting in lower plasma concentrations and peak plasma levels.

The natriuretic effect of furosemide has been reported to be inhibited by some drugs of this class. Inhibition of renal lithium clearance leading to increases in plasma lithium concentrations has also been reported. Anaflex and other NSAIDs can reduce the antihypertensive effect of propranolol and other beta-blockers.

Probenecid given concurrently increases Anaflex anion plasma levels and extends its plasma half-life significantly.

Caution should be used if Anaflex is administered concomitantly with methotrexate. Anaflex, Anaflex sodium and other NSAIDs have been reported to reduce the tubular secretion of methotrexate in an animal model, possibly increasing the toxicity of methotrexate.

Drug/Laboratory Test Interactions

Anaflex may decrease platelet aggregation and prolong bleeding time. This effect should be kept in mind when bleeding times are determined. The administration of Anaflex may result in increased urinary values for 17-ketogenic steroids because of an interaction between the drug and/or its metabolites with m-dinitrobenzene used in this assay. Although 17-hydroxy-corticosteroid measurements (Porter-Silber test) do not appear to be artifactually altered, it is suggested that therapy with Anaflex be temporarily discontinued 72 hours before adrenal function tests are performed if the Porter-Silber test is to be used.

Anaflex may interfere with some urinary assays of 5-hydroxy indoleacetic acid (5HIAA).

Anaflex side effects

See also:
What are the possible side effects of Anaflex?

Adverse reactions reported in controlled clinical trials in 960 patients treated for rheumatoid arthritis or osteoarthritis are listed below. In general, reactions in patients treated chronically were reported 2 to 10 times more frequently than they were in short-term studies in the 962 patients treated for mild to moderate pain or for dysmenorrhea. The most frequent complaints reported related to the gastrointestinal tract.

A clinical study found gastrointestinal reactions to be more frequent and more severe in rheumatoid arthritis patients taking daily doses of 1500 mg Anaflex compared to those taking 750 mg Anaflex.

In controlled clinical trials with about 80 pediatric patients and in well-monitored, open-label studies with about 400 pediatric patients with juvenile arthritis treated with Anaflex, the incidence of rash and prolonged bleeding times were increased, the incidence of gastrointestinal and central nervous system reactions were about the same, and the incidence of other reactions were lower in pediatric patients than in adults.

In patients taking Anaflex in clinical trials, the most frequently reported adverse experiences in approximately 1% to 10% of patients are:

Gastrointestinal (GI) Experiences, including: heartburn*, abdominal pain*, nausea*, constipation*, diarrhea, dyspepsia, stomatitis

Central Nervous System: headache*, dizziness*, drowsiness*, lightheadedness, vertigo

Dermatologic: pruritus (itching)*, skin eruptions*, ecchymoses*, sweating, purpura

Special Senses: tinnitus*, visual disturbances, hearing disturbances

Cardiovascular: edema*, palpitations

General: dyspnea*, thirst

*Incidence of reported reaction between 3% and 9%. Those reactions occurring in less than 3% of the patients are unmarked.

In patients taking NSAIDs, the following adverse experiences have also been reported in approximately 1% to 10% of patients.

Gastrointestinal (GI) Experiences, including: flatulence, gross bleeding/perforation, GI ulcers (gastric/duodenal), vomiting

General: abnormal renal function, anemia, elevated liver enzymes, increased bleeding time, rashes

The following are additional adverse experiences reported in <1% of patients taking Anaflex during clinical trials and through postmarketing reports. Those adverse reactions observed through postmarketing reports are italicized.

Body as a Whole: anaphylactoid reactions, angioneurotic edema, menstrual disorders, pyrexia (chills and fever)

Cardiovascular: congestive heart failure, vasculitis, hypertension, pulmonary edema

Gastrointestinal: inflammation, bleeding (sometimes fatal, particularly in the elderly), ulceration, perforation and obstruction of the upper and lower gatrointestinal tract. Esophagitis, stomatitis, hematemesis, pancreatitis, vomiting, colitis, exacerbation of inflammatory bowel disease (ulcerative colitis, Crohn’s disease)

Hepatobiliary: jaundice, abnormal liver function tests, hepatitis (some causes have been fatal)

Hemic and Lymphatic: eosinophilia, leucopenia, melena, thrombocytopenia, agranulocytosis, granulocytopenia, hemolytic anemia, aplastic anemia

Metabolic and Nutritional: hyperglycemia, hypoglycemia

Nervous System: inability to concentrate, depression, dream abnormalities, insomnia, malaise, myalgia, muscle weakness, aseptic meningitis, cognitive dysfunction, convulsions

Respiratory: eosinophilic pneumonitis, asthma

Dermatologic: alopecia, urticaria, skin rashes, toxic epidermal necrolysis, erythema multiforme, erythema nodosum, fixed drug eruption, lichen planus, pustular reaction, systemic lupus erythematoses, Stevens-Johnson syndrome, photosensitive dermatitis, photosensitivity reactions, including rare cases resembling porphyria cutanea tarda (pseudoporphyria) or epidermolysis bullosa. If skin fragility, blistering or other symptoms suggestive of pseudoporphyria occur, treatment should be discontinued and the patient monitored.

Special Senses: hearing impairment, corneal opacity, papillitis, retrobulbar optic neuritis, papilledema

Urogenital: glomerular nephritis, hematuria, hyperkalemia, interstitial nephritis, nephrotic syndrome, renal disease, renal failure, renal papillary necrosis, raised serum creatinine

Reproduction (Female): infertility

In patients taking NSAIDs, the following adverse experiences have also been reported in <1% of patients.

Body as a Whole: fever, infection, sepsis, anaphylactic reactions, appetite changes, death

Cardiovascular: hypertension, tachycardia, syncope, arrhythmia, hypotension, myocardial infarction

Gastrointestinal: dry mouth, esophagitis, gastric/peptic ulcers, gastritis, glossitis, eructation

Hepatobiliary: hepatitis, liver failure

Hemic and Lymphatic: rectal bleeding, lymphadenopathy, pancytopenia

Metabolic and Nutritional: weight changes

Nervous System: anxiety, asthenia, confusion, nervousness, paresthesia, somnolence, tremors, convulsions, coma, hallucinations

Respiratory: asthma, respiratory depression, pneumonia

Dermatologic: exfoliative dermatitis

Special Senses: blurred vision, conjunctivitis

Urogenital: cystitis, dysuria, oliguria/polyuria, proteinuri

Anaflex contraindications

See also:
What is the most important information I should know about Anaflex?

Anaflex, EC-Anaflex, ANAPROX, ANAPROX DS and Anaflex Suspension are contraindicated in patients with known hypersensitivity to Anaflex and Anaflex sodium.

Anaflex, EC-Anaflex, ANAPROX, ANAPROX DS and Anaflex Suspension should not be given to patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, rarely fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.

Anaflex, EC-Anaflex, ANAPROX, ANAPROX DS and Anaflex Suspension are contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.

Active ingredient matches for Anaflex:

Naproxen in Argentina, Bangladesh.

Diclofenac in Argentina, Bangladesh.

Diclofenac diethylamine or diclofenac sodium in Argentina.

Polynoxylin in United Kingdom, Switzerland, Singapore, Hungary.

Salsalate


Unit description / dosage (Manufacturer)Price, USD
Anaflex 10 % x 30 g x 1's
Anaflex 10 % x 10 g x 1's

List of Anaflex substitutes (brand and generic names):

Anac 100mg TAB / 10$ 0.41
Tablet; Oral; Naproxen Sodium 220 mg (Liomont)
Analgen 25 g (Liomont)
Tablets; Oral; Naproxen Sodium 220 mg (Liomont)
Analpan 75 mg/3 mL x 20's (CCM Duopharma BioTech)
Analpan 25 mg/1 mL x 10 x 25's (CCM Duopharma BioTech)
Injectable; Injection; Diclofenac Sodium 25 mg / ml (CCM Duopharma BioTech)
Analpan 25 mg/1 mL x 1's (CCM Duopharma BioTech)
Analpan inj / amp 75 mg/3 mL 10 x 1's (CCM Duopharma BioTech)
Analpan inj / vial 25 mg/mL 25 x 1's (CCM Duopharma BioTech)
Anapran 275 mg x 20 Tablet/Box (Polfa pabianice)
Anapran 550 mg x 20 Tablet/Box (Polfa pabianice)
Tablet; Oral; Naproxen Sodium 250 mg (Minerva)
Tablet; Oral; Naproxen Sodium 550 mg (Minerva)
Anaprox 275 mg x 100's (Minerva)
Anaprox 275 mg x 500's (Minerva)
Tablets; Oral; Naproxen Sodium 250 mg (Minerva)
Tablets; Oral; Naproxen Sodium 550 mg (Minerva)
Anaprox tablet 275 mg (Minerva)
Anaprox tablet 275 mg/1 (Minerva)
Anaprox tablet 550 mg/1 (Minerva)
Tablet; Oral; Naproxen Sodium 500 mg
Tablets; Oral; Naproxen Sodium 500 mg
Anaprox DS tablet 550 mg/1 (Canton Laboratories (US))
Anaprox DS tablet 550 mg (Atnahs Pharma Uk Limited (Canada))

References

  1. DailyMed. "NAPROXEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. PubChem. "Salsalate". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Anaflex are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Anaflex. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

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The below mentioned numbers have been reported by ndrugs.com website users about whether the Anaflex drug is expensive or inexpensive. There is a mixed opinion among users. The rating about the cost of the drug depends on factors like which brand drug the patient purchased, how effective it was for the price paid, the country or place the drug is marketed, and the economic condition of the patient. The users who feel the drug is expensive can look for an alternative brand drug or a generic drug to save the cost.
Users%
Expensive1
100.0%


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1 consumer reported age

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46-601
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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