The dose of a drug and dosage of the drug are two different terminologies. Dose is defined as the quantity or amount of medicine given by the doctor or taken by the patient at a given period. Dosage is the regimen prescribed by the doctor about how many days and how many times per day the drug is to be taken in specified dose by the patient. The dose is expressed in mg for tablets or gm, micro gm sometimes, ml for syrups or drops for kids syrups. The dose is not fixed for a drug for all conditions, and it changes according to the condition or a disease. It also changes on the age of the patient.
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Note: Barbiturates and Anesket Pisa hydrochloride, being chemically incompatible because of precipitate formation, should not be injected from the same syringe.
If the Anesket Pisa hydrochloride dose is augmented with diazepam, the two drugs must be given separately. Do not mix Anesket Pisa hydrochloride and diazepam in syringe or infusion flask. For additional information on the use of diazepam, refer to the WARNINGS and DOSAGE AND ADMINISTRATION Sections of the diazepam insert.
Preoperative Preparations
While vomiting has been reported following Anesket Pisa hydrochloride administration, some airway protection may be afforded because of active laryngeal-pharyngeal reflexes. However, since aspiration may occur with Anesket Pisa hydrochloride and since protective reflexes may also be diminished by supplementary anesthetics and muscle relaxants, the possibility of aspiration must be considered. Anesket Pisa hydrochloride is recommended for use in the patient whose stomach is not empty when, in the judgment of the practitioner, the benefits of the drug outweigh the possible risks.
Atropine, scopolamine, or another drying agent should be given at an appropriate interval prior to induction.
Onset And Duration
Because of rapid induction following the initial intravenous injection, the patient should be in a supported position during administration.
The onset of action of Anesket Pisa hydrochloride is rapid; an intravenous dose of 2 mg/kg (1 mg/lb) of body weight usually produces surgical anesthesia within 30 seconds after injection, with the anesthetic effect usually lasting five to ten minutes. If a longer effect is desired, additional increments can be administered intravenously or intramuscularly to maintain anesthesia without producing significant cumulative effects.
Intramuscular doses, in a range of 9 to 13 mg/kg (4 to 6 mg/lb) usually produce surgical anesthesia within 3 to 4 minutes following injection, with the anesthetic effect usually lasting 12 to 25 minutes.
Dosage
As with other general anesthetic agents, the individual response to Anesket Pisa hydrochloride is somewhat varied depending on the dose, route of administration, and age of patient, so that dosage recommendation cannot be absolutely fixed. The drug should be titrated against the patient's requirements.
Induction
Intravenous Route
The initial dose of Anesket Pisa hydrochloride administered intravenously may range from 1 mg/kg to 4.5 mg/kg (0.5 to 2 mg/lb). The average amount required to produce five to ten minutes of surgical anesthesia has been 2 mg/kg (1 mg/lb).
Alternatively, in adult patients an induction dose of 1 mg to 2 mg/kg intravenous Anesket Pisa at a rate of 0.5 mg/kg/min may be used for induction of anesthesia. In addition, diazepam in 2 mg to 5 mg doses, administered in a separate syringe over 60 seconds, may be used. In most cases, 15 mg of intravenous diazepam or less will suffice. The incidence of psychological manifestations during emergence, particularly dream-like observations and emergence delirium, may be reduced by this induction dosage program.
Note: The 100 mg/mL concentration of Anesket Pisa hydrochloride should not be injected intravenously without proper dilution. It is recommended the drug be diluted with an equal volume of either Sterile Water for injection, USP, Normal Saline, or 5% Dextrose in Water.
Rate of Administration
It is recommended that Anesket Pisa hydrochloride be administered slowly (over a period of 60 seconds). More rapid administration may result in respiratory depression and enhanced pressor response.
Intramuscular Route
The initial dose of Anesket Pisa hydrochloride administered intramuscularly may range from 6.5 to 13 mg/kg (3 to 6 mg/lb). A dose of 10 mg/kg (5 mg/lb) will usually produce 12 to 25 minutes of surgical anesthesia.
Maintenance Of Anesthesia
The maintenance dose should be adjusted according to the patient's anesthetic needs and whether an additional anesthetic agent is employed.
Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia. However, it should be noted that purposeless and tonic-clonic movements of extremities may occur during the course of anesthesia. These movements do not imply a light plane and are not indicative of the need for additional doses of the anesthetic.
It should be recognized that the larger the total dose of Anesket Pisa hydrochloride administered, the longer will be the time to complete recovery.
Adult patients induced with Anesket Pisa hydrochloride augmented with intravenous diazepam may be maintained on Anesket Pisa hydrochloride given by slow microdrip infusion technique at a dose of 0.1 to 0.5 mg/minute, augmented with diazepam 2 to 5 mg administered intravenously as needed. In many cases 20 mg or less of intravenous diazepam total for combined induction and maintenance will suffice. However, slightly more diazepam may be required depending on the nature and duration of the operation, physical status of the patient, and other factors. The incidence of psychological manifestations during emergence, particularly dream-like observations and emergence delirium, may be reduced by this maintenance dosage program.
Dilution
To prepare a dilute solution containing 1 mg of Anesket Pisa per mL, aseptically transfer 10 mL from a 50 mg per mL vial or 5 mL from a 100 mg per mL vial to 500 mL of 5% Dextrose Injection, USP or Sodium Chloride (0.9%) Injection, USP (Normal Saline) and mix well. The resultant solution will contain 1 mg of Anesket Pisa per mL.
The fluid requirements of the patient and duration of anesthesia must be considered when selecting the appropriate dilution of Anesket Pisa hydrochloride injection. If fluid restriction is required, Anesket Pisa hydrochloride injection can be added to a 250 mL infusion as described above to provide a Anesket Pisa hydrochloride concentration of 2 mg/mL. Anesket Pisa hydrochloride injection 10 mg/mL vials are not recommended for dilution.
Supplementary Agents
Anesket Pisa hydrochloride is clinically compatible with the commonly used general and local anesthetic agents when an adequate respiratory exchange is maintained.
The regimen of a reduced dose of Anesket Pisa hydrochloride supplemented with diazepam can be used to produce balanced anesthesia by combination with other agents such as nitrous oxide and oxygen.
How supplied
Anesket Pisa hydrochloride injection is supplied as the hydrochloride in concentrations equivalent to Anesket Pisa base.
NDC 42023-137-10 - Each 20-mL multi-dose vial contains 10 mg/mL. Supplied in cartons of 10.
NDC 42023-138-10 - Each 10-mL multi-dose vial contains 50 mg/mL. Supplied in cartons of 10.
NDC 42023-139-10 - Each 5-mL multi-dose vial contains 100 mg/mL. Supplied in cartons of 10.
Store between 20° to 25°C (68° to 77°F).
Protect from light.
Manufactured and Distributed by: JHP Pharmaceuticals, LLC, Rochester, MI 48307. Revised: Feb 2013
What other drugs will affect Anesket Pisa?
Tell your doctor about all other medicines you use, especially:
a barbiturate such as butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), pentobarbital (Nembutal), or phenobarbital (Solfoton); or
narcotic medication such as codeine (Tylenol #3), hydrocodone (Lortab, Vicodin, Vicoprofen), hydromorphone (Dilaudid, Palladone), oxycodone (OxyContin, Combunox, Roxicodone, Percocet), fentanyl (Abstral, Actiq, Fentora, Duragesic, Lazanda, Onsolis), methadone (Methadose, Dolophine), morphine (Kadian, MS Contin, Oramorph), and many others.
If you are using any of these drugs, it may take you longer to recover from anesthesia with Anesket Pisa.
This list is not complete and other drugs may interact with Anesket Pisa. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Anesket Pisa interactions
Interactions are the effects that happen when the drug is taken along with the food or when taken with other medications. Suppose if you are taking a drug Anesket Pisa, it may have interactions with specific foods and specific medications. It will not interact with all foods and medications. The interactions vary from drug to drug. You need to be aware of interactions of the medicine you take. Most medications may interact with alcohol, tobacco, so be cautious.
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Prolonged recovery time may occur if barbiturates and/or narcotics are used concurrently with Anesket Pisa.
Anesket Pisa is chemically incompatible with barbiturates and diazepam because of precipitate formation. Therefore, these should not be mixed in the same syringe or infusion fluid.
Anesket Pisa may potentiate the neuromuscular-blocking effects of atracurium and tubocurarine including respiratory depression with apnoea.
The use of halogenated anaesthetics concomitantly with Anesket Pisa can lengthen the elimination half-life of Anesket Pisa and delay recovery from anaesthesia. Concurrent use of Anesket Pisa (especially in high doses or when rapidly administered) with halogenated anaesthetics can increase the risk of developing bradycardia, hypotension or decreased cardiac output.
The use of Anesket Pisa with other CNS depressants (eg, ethanol, phenothiazines, sedating H1-blockers or skeletal muscle relaxants) can potentiate CNS depression and/or increase risk of developing respiratory depression. Reduced doses of Anesket Pisa may be required with concurrent administration of other anxiolytics, sedatives and hypnotics.
Anesket Pisa has been reported to antagonise the hypnotic effect of thiopental.
Patients taking thyroid hormones have an increased risk of developing hypertension and tachycardia when given Anesket Pisa.
Concomitant use of antihypertensive agents and Anesket Pisa increases the risk of developing hypotension.
When Anesket Pisa and theophylline are given concurrently, a clinically significant reduction in the seizure threshold is observed. Unpredictable extensor-type seizures have been reported with concurrent administration of these agents.
Incompatibilities: Anesket Pisa is chemically incompatible with barbiturates and diazepam because of precipitate formation. Therefore, these should not be mixed in the same syringe or infusion fluid.
European Chemicals Agency - ECHA. "Ketamine: The information provided here is aggregated from the "Notified classification and labelling" from ECHA's C&L Inventory. ". https://echa.europa.eu/information-o... (accessed September 17, 2018).
PubMed Health. "Ketamine (By injection) (Ketalar): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Anesket Pisa are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Anesket Pisa. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
1 consumer reported frequency of use
How frequently do I need to take Anesket Pisa? It was reported by ndrugs.com website users that Anesket Pisa should ideally be taken Once in a day as the most common frequency of the Anesket Pisa. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Anesket Pisa should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
Users
%
Once in a day
1
100.0%
3 consumers reported doses
What doses of Anesket Pisa drug you have used? The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Anesket Pisa drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
Users
%
501mg-1g
3
100.0%
Consumer reviews
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