Ansuzole Uses

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What is Ansuzole?

Ansuzole is used to treat certain types of breast cancer in women who have already stopped menstruating (postmenopausal). It is also used for women who have already had other cancer treatments (e.g., tamoxifen).

Many breast cancer tumors grow in response to estrogen. Ansuzole interferes with the production of estrogen in the body. As a result, the amount of estrogen that the tumor is exposed to is reduced, limiting the growth of the tumor.

Ansuzole is available only with your doctor's prescription.

Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Ansuzole is used in certain patients with the following medical conditions:

Ansuzole indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Adjuvant Treatment

Ansuzole tablets are indicated for adjuvant treatment of postmenopausal women with hormone receptor-positive early breast cancer.

First-Line Treatment

Ansuzole tablets are indicated for the first-line treatment of postmenopausal women with hormone receptor-positive or hormone receptor unknown locally advanced or metastatic breast cancer.

Second-Line Treatment

Ansuzole tablets are indicated for the treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy. Patients with ER-negative disease and patients who did not respond to previous tamoxifen therapy rarely responded to Ansuzole tablets.

How should I use Ansuzole?

Use Ansuzole as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Ansuzole.

Uses of Ansuzole in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Breast cancer:

First-line treatment of locally-advanced or metastatic breast cancer (hormone receptor-positive or unknown) in postmenopausal women

Adjuvant treatment of early hormone receptor-positive breast cancer in postmenopausal women

Treatment of advanced breast cancer in postmenopausal women with disease progression following tamoxifen therapy

Off Label Uses

Endometrial or uterine cancers (recurrent or metastatic)

Hormonal agents such as progestational agents or tamoxifen may be used in the management of recurrent or metastatic endometrial cancer; in select patients, aromatase inhibitors, including Ansuzole, may be considered. A small phase II trial evaluated Ansuzole in a group of unselected patients with advanced recurrent or persistent endometrial cancer; the results showed minimal activity of Ansuzole.

Ansuzole description

Ansuzole is a drug indicated in the treatment of breast cancer in post-menopausal women. It is used both in adjuvant therapy (i.e. following surgery) and in metastatic breast cancer. It decreases the amount of estrogens that the body makes. Ansuzole belongs in the class of drugs known as aromatase inhibitors. It inhibits the enzyme aromatase, which is responsible for converting androgens (produced by women in the adrenal glands) to estrogens.

Ansuzole dosage

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Ansuzole Dosage

Generic name: Ansuzole 1mg

Dosage form: tablet

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Recommended Dose

The dose of Ansuzole is one 1 mg tablet taken once a day. For patients with advanced breast cancer, Ansuzole should be continued until tumor progression. Ansuzole can be taken with or without food.

For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial, Ansuzole was administered for five years.

No dosage adjustment is necessary for patients with renal impairment or for elderly patients.

Patients with Hepatic Impairment

No changes in dose are recommended for patients with mild-to-moderate hepatic impairment. Ansuzole has not been studied in patients with severe hepatic impairment.

More about Ansuzole (Ansuzole)

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Ansuzole interactions

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What other drugs will affect Ansuzole?

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Ansuzole inhibited in vitro metabolic reactions catalyzed by cytochromes P450 1A2, 2C8/9, and 3A4 but only at relatively high concentrations. Ansuzole did not inhibit P450 2A6 or the polymorphic P450 2D6 in human liver microsomes. Ansuzole did not alter the pharmacokinetics of antipyrine. Although there have been no formal interaction studies other than with antipyrine, based on these in vivo and in vitro studies, it is unlikely that co-administration of a 1 mg dose of Ansuzole with other drugs will result in clinically significant drug inhibition of cytochrome P450-mediated metabolism of the other drugs.

An interaction study with warfarin showed no clinically significant effect of Ansuzole on warfarin pharmacokinetics or anticoagulant activity.

At a median follow-up of 33 months, the combination of Ansuzole and tamoxifen did not demonstrate any efficacy benefit when compared with tamoxifen in all patients as well as in the hormone receptor-positive subpopulation. This treatment arm was discontinued from the trial. Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with Ansuzole (see CLINICAL PHARMACOLOGY ñ Drug Interactions and CLINICAL PHARMACOLOGY - Clinical Studies - Adjuvant Treatment of Breast Cancer in Postmenopausal Women subsections). Co-administration of Ansuzole and tamoxifen resulted in a reduction of Ansuzole plasma levels by 27% compared with those achieved with Ansuzole alone.

Estrogen-containing therapies should not be used with Ansuzole as they may diminish its pharmacologic action.

Drug/Laboratory Test Interactions

No clinically significant changes in the results of clinical laboratory tests have been observed.

Ansuzole side effects

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What are the possible side effects of Ansuzole?

Unless specified, the following frequency categories were calculated from the number of adverse events reported in a large phase III study conducted in 9,366 postmenopausal women with operable breast cancer treated for 5 years (ATAC Study).

The table below presents the frequency of pre-specified adverse events in the ATAC study, irrespective of causality, reported in patients receiving trial therapy and up to 14 days after cessation of trial therapy.

The ATAC trial data showed that patients receiving Ansuzole had an increase in joint disorders (including arthritis, arthrosis, and arthralgia) compared with patients receiving tamoxifen. Patients receiving Ansuzole had an increase in the incidence of fractures (including fractures of spine, hip and wrist) compared with patients receiving tamoxifen. These differences were statistically significant. Fracture rates of 22 per 1,000 patient-years and 15 per 1000 patient-years were observed for the Ansuzole and tamoxifen groups, respectively, after a median follow up of 68 months. The observed fracture rate for Ansuzole is similar to the range reported in age-matched postmenopausal populations. It has not been determined whether the rates of fracture and osteoporosis seen in ATAC in patients on Ansuzole treatment reflect a protective effect of tamoxifen, a specific effect of Ansuzole, or both.

The incidence of osteoporosis was 10.5% in patients treated with Ansuzole and 7.3% in patients treated with tamoxifen.

Patients receiving Ansuzole had a decrease in hot flushes, vaginal bleeding, vaginal discharge, endometrial cancer, venous thromboembolic events (including deep venous thrombosis) and ischaemic cerebrovascular events compared with patients receiving tamoxifen. These differences were statistically significant.

Results from the ATAC trial bone substudy, at 12 and 24 months demonstrated that patients receiving Ansuzole had a mean decrease in both lumbar spine and total hip bone mineral density (BMD) compared to baseline. Patients receiving tamoxifen had a mean increase in both lumbar spine and total hip BMD compared to baseline.

Slight increases in total cholesterol have also been observed in clinical trials with Ansuzole, although the clinical significance has not been determined.

Ansuzole contraindications

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What is the most important information I should know about Ansuzole?

Do not use Ansuzole if you are pregnant. It could harm the unborn baby.

You may need to take a pregnancy test before using Ansuzole, to make sure you are not pregnant.

You should not use this medication if you are allergic to Ansuzole, if you are breast-feeding a baby, or if you have not yet completed menopause. Ansuzole is not for use in men or children.

Before using Ansuzole, tell your doctor if you have heart disease, circulation problems, a history of stroke or blood clot, severe liver disease, high cholesterol, osteoporosis, or low bone mineral density.

Ansuzole may not work as well if you take it together with tamoxifen or an estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings). Before you start taking Ansuzole, tell your doctor if you also take tamoxifen or estrogen.

You may need to keep taking Ansuzole for up to 5 years. Follow your doctor's instructions.



Active ingredient matches for Ansuzole:

Anastrozole in Taiwan.


Unit description / dosage (Manufacturer)Price, USD
Ansuzole 1 mg
Ansuzole film-coated tab 1 mg 28's (Lotus)

List of Ansuzole substitutes (brand and generic names):

Anzol 1 mg x 28's
ANZOL 30MG CAPSULE 1 strip / 10 capsules each (Scott Edil Pharmacia Ltd)$ 0.71
Anzol 30mg Capsule (Scott Edil Pharmacia Ltd)$ 0.07
Anzucia 1mg TAB / 10 (United Biotech)
1 mg x 10's (United Biotech)
ANZUCIA tab 1 mg x 10's (United Biotech)
Apo-anastrozole tablet 1 mg (Apotex Inc (Canada))
Aremed 1 mg x 1000's (Remedica)
Aremed 1 mg x 2 x 14's (Remedica)
Aremed film-coated tab 1 mg 2 x 14's (Remedica)
Aremed 1 FC tab 1 mg 2 x 14's (Remedica)
Tablet, Film-Coated; Oral; Anastrozole 1 mg (AstraZeneca)
1 mg x 2x14 (AstraZeneca)$ 51.94
Arimidex 1 mg x 28's (AstraZeneca)$ 1380.00
Arimidex 1 mg x 2 x 14's (AstraZeneca)$ 196.53
Arimidex 1mg x 2 TAB / 14 (AstraZeneca)$ 51.94
Arimidex 1 mg x 2 Blister x 14 Tablet (AstraZeneca)
30 tablet in 1 bottle, plastic (AstraZeneca)
Arimidex 1 mg x 28's Price upon request (AstraZeneca)
ARIMIDEX 1 MG TABLET 1 strip / 14 tablets each (AstraZeneca)$ 109.05
Arimidex FC tab 1 mg 28's (AstraZeneca)$ 307.91
Arimidex tab 1 mg 28's (AstraZeneca)
ARIMIDEX tab 1 mg x 14's (AstraZeneca)$ 54.52
Arimidex tablet 1 mg/1 (AstraZeneca)
Arimidex 1mg Tablet (AstraZeneca)$ 3.89
Arimidex film-coated tab 1 mg 28's (AstraZeneca)
Arinib FC tab 1 mg 28's (Salutas)
Arinib FC tab 1 mg 30's (Salutas)
Armilon 1mg TAB / 10 (Celon (Vivilon))$ 7.70
1 mg x 10's (Celon (Vivilon))$ 7.70

References

  1. DailyMed. "ANASTROZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "anastrozole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "anastrozole". http://www.drugbank.ca/drugs/DB01217 (accessed September 17, 2018).

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