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Antimania Uses |
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This medication is used before an X-ray or similar tests (e.g., tomography) to help your doctor view on film, your throat (esophagus), stomach, and intestines more effectively. It may be used with other injectable products (IV contrast) as determined by your doctor.
Dosage depends on the type & location of the investigation.
Hypersensitivity reactions can be aggravated in patients on beta-blockers, particularly in people with bronchial asthma. Moreover, it should be considered that patients on beta-blockers may be refractory to standard treatment of hypersensitivity reactions with beta-agonists.
The prevalence of delayed reactions (eg fever, rash, flu-like symptoms, joint pain and pruritus) to contrast media is higher in patients who have received interleukin.
The presence of renal damage in diabetic patients is one of the factors predisposing to renal impairment following contrast media administration. This may precipitate lactic acidosis in patients who are taking biguanides. As a precaution, biguanides should be stopped 48 hours prior to the contrast agent examination and reinstated only after control of renal function has been regained.
Interference with diagnostic tests
Following the administration of iodinated contrast media, the capacity of the thyroid tissue to take up radioisotopes for diagnosing disorders of the thyroid is reduced for up to two weeks, and even longer in individual cases.
Pregnancy and lactation
Reproduction-toxicological studies with Antimania- or sodium amidotrizoate gave no indication of a teratogenic or other embryotoxic potential following an inadvertent administration of Urografin during pregnancy.
It has not been sufficiently demonstrated that contrast media are safe for use in pregnant patients. Since, wherever possible, radiation exposure should be avoided during pregnancy, the benefits of any X-ray examination, with or without contrast media, should be carefully weighed against the possible risk.
Renally eliminated contrast media like Urografin enter the breast milk in only very small amounts.
Limited data suggest that the risk to the suckling infant of administering salts of diatrizoic acid to its mother is low. Breastfeeding is probably safe.
Intravascular use
Side effects in association with the use of iodinated contrast media are usually mild to moderate and transient in nature. However, severe and life-threatening reactions as well as deaths have been reported. The prevalence of adverse drug reactions in patients receiving ionic contrast media is reported to be over 12% compared to over 3% for non-ionics.
Nausea, vomiting, a sensation of pain and a general feeling of warmth are the most frequently recorded reactions.
Anaphylactoid reactions/hypersensitivity
Angioedema, conjunctivitis, coughing, pruritus, rhinitis, sneezing and urticaria have been reported commonly. These reactions which can occur irrespective of the amount administered and the mode of administration, may be the first signs of an incipient state of shock. Administration of the contrast medium must be discontinued immediately and –if necessary –specific therapy instituted via a venous access.
Severe reactions requiring emergency treatment can occur in the form of a circulatory reaction accompanied by peripheral vasodilatation and subsequent hypotension, reflex tachycardia, dyspnoea, agitation, confusion and cyanosis possibly leading to unconsciousness.
Hypotension, bronchospasm and laryngeal spasm or oedema occur uncommonly.
Delayed contrast medium reactions are rare.
Body as a whole
Heat sensations and headache have been reported as being common. Malaise, chills or sweating and vasovagal reactions are uncommon.
In rare cases alterations in body temperature and swelling of salivary glands are possible.
Respiratory
Transient disturbance in respiratory rate, dyspnoea and respiratory distress and coughing are common.
Respiratory arrest and pulmonary oedema are rare reactions.
Cardiovascular
Clinically relevant transient disturbance in heart rate, blood pressure, disturbance in cardiac rhythm or function and cardiac arrest are uncommon.
Severe reactions requiring emergency treatment can occur in the form of a circulatory reaction accompanied by peripheral vasodilatation and subsequent hypotension, reflex tachycardia, dyspnoea, agitation, confusion and cyanosis possibly leading to unconsciousness.
Serious thromboembolic events causing myocardial infarction have been reported in rare cases.
Gastrointestinal
Nausea and vomiting are common reactions. Abdominal pain has been reported as being uncommon.
Cerebrovascular
Cerebral angiography and other procedures in which the contrast medium reaches the brain in high concentrations with the arterial blood can be accompanied by transient neurological complications such as: dizziness, headache, agitation or confusion, amnesia, disturbed speech, vision, hearing, convulsions, tremor, paresis/paralysis, photophobia, temporary blindness, coma, and somnolence are uncommon.
Serious, in isolated cases fatal, thromboembolic events causing stroke have been reported on rare occasions.
Renal
In rare cases renal impairment or failure have been reported.
Skin
Mild angioedema, flush reaction with vasodilatation, urticaria, pruritus and erythema have been commonly observed.
Toxic skin reactions such as the mucocutaneous syndrome (eg Stevens-Johnson
Hypersensitivity to antihistamines,
History of agranulocytosis,
Risk of urinary retention due to disorders - Risk of glaucoma angle closure.
Meglumine in Italy.
List of Antimania substitutes (brand and generic names) | Sort by popularity |
Unit description / dosage (Manufacturer) | Price, USD |
ANGIOGRAFIN 65% INJ (India) | |
20ml (Zydus (G.Rem)) | $ 2.35 |
50ml (Zydus (G.Rem)) | $ 6.70 |
ANGIOGRAFIN 65% INJ inj 0.65 g x 1 mL x 20ml (Zydus (G.Rem)) | $ 2.36 |
ANGIOGRAFIN 65% INJ inj 0.65 g x 1 mL x 50ml (Zydus (G.Rem)) | $ 6.70 |
Biliscopine (France) | |
Injectable; IV / Infusion; Meglumine Iotroxate 105 mg / ml (Schering) | |
Bilisegrol (Spain) | |
Chologram (Italy) | |
CONTRASTIN INJ (India) | |
60 % x 20ml (Dabur) | $ 1.89 |
60 % x 50ml (Dabur) | $ 4.73 |
76 % x 100ml (Dabur) | $ 11.54 |
76 % x 20ml (Dabur) | $ 2.33 |
76 % x 50ml (Dabur) | $ 6.06 |
Contrastin Inj Meglumine 125.46 mg, sodiumdiatrizoate 471.48 mg, iodine5.84 g. INJ / 20ml (Dabur) | $ 1.89 |
Contrastin Inj Meglumine 125.46 mg, sodiumdiatrizoate 471.48 mg, iodine5.84 g. INJ / 50ml (Dabur) | $ 4.73 |
Contrastin Inj Meglumine 159.24 mg, sodiumdiatrizoate 597.3 mg, iodine7.4 g. INJ / 100ml (Dabur) | $ 11.54 |
Contrastin Inj Meglumine 159.24 mg, sodiumdiatrizoate 597.3 mg, iodine7.4 g. INJ / 20ml (Dabur) | $ 2.33 |
Contrastin Inj Meglumine 159.24 mg, sodiumdiatrizoate 597.3 mg, iodine7.4 g. INJ / 50ml (Dabur) | $ 6.06 |
CONTRASTIN INJ inj 20ml (Dabur) | $ 2.33 |
CONTRASTIN INJ inj 50ml (Dabur) | $ 6.06 |
CONTRASTIN INJ inj 100ml (Dabur) | $ 11.54 |
Contrastin Inj Meglumine 125.46 mg, sodiumdiatrizoate 471.48 mg, iodine5.84 g. INJ / 20ml (Dabur) | $ 1.89 |
Contrastin Inj Meglumine 125.46 mg, sodiumdiatrizoate 471.48 mg, iodine5.84 g. INJ / 50ml (Dabur) | $ 4.73 |
Contrastin Inj Meglumine 159.24 mg, sodiumdiatrizoate 597.3 mg, iodine7.4 g. INJ / 100ml (Dabur) | $ 11.54 |
Contrastin Inj Meglumine 159.24 mg, sodiumdiatrizoate 597.3 mg, iodine7.4 g. INJ / 20ml (Dabur) | $ 2.33 |
Contrastin Inj Meglumine 159.24 mg, sodiumdiatrizoate 597.3 mg, iodine7.4 g. INJ / 50ml (Dabur) | $ 6.06 |
Fluisedal (Paraguay) | |
Syrup; Oral; Meglumine Benzoate 390 mg; Polysorbate 20 45 mg; Promethazine Hydrochloride 7.5 mg | |
Glucantime (Brazil, Costa Rica, Dominican Republic, Ecuador, El Salvador, France, Georgia, Guatemala, Honduras, Italy, Nicaragua, Panama, Portugal, Spain, Tunisia, Venezuela) | |
Injectable; Injection; Meglumine Antimoniate 300 mg / ml (Sanofi-aventis) | |
Glucantrix (Peru) | |
Kai Ji Mai (China) | |
Meglumine (Brazil, Costa Rica, Dominican Republic, Ecuador, El Salvador, France, Georgia, Guatemala, Honduras, Italy, Nicaragua, Panama, Portugal, Spain, Tunisia, Venezuela) | |
Meglumine 500 mg | |
Méglumine | |
Meglumine 500 mg | |
Meglumine 500 mg | |
Reamberin (Georgia, Russian Federation) | |
Injectable; Injection; Meglumine Sodium Succinate 15 mg / ml (Polisan) | |
Reamberin 1 Bottle 400 mL (Polisan) | |
Reambisar | |
Injectable; Injection; Meglumine Sodium Succinate 15 mg / ml | |
Telebrix 30 Meglumina | |
Injectable; Injection; Meglumine Ioxitalamate 66.03% | |
Telebrix N 180 | |
Telebrix N 30 G | |
Telebrix N 45 G |
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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