Apresoline Pregnancy

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Pregnancy of Apresoline in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Apresoline crosses the placenta (Lamont 1986; Liedholm 1982).

Due to pregnancy-induced physiologic changes and maternal acetylator status (NAT2 genotype), some pharmacokinetic properties of oral Apresoline may be altered. Larger studies are needed to evaluate if or how these changes influence safety or efficacy during pregnancy (Han 2019).

Chronic maternal hypertension may increase the risk of birth defects, low birth weight, preterm delivery, stillbirth, and neonatal death. Actual fetal/neonatal risks may be related to duration and severity of maternal hypertension. Untreated hypertension may also increase the risks of adverse maternal outcomes, including gestational diabetes, myocardial infarction, preeclampsia, stroke, and delivery complications (ACOG 203 2019).

Agents other than oral Apresoline are more commonly used to treat chronic hypertension in pregnancy (ACOG 203 2019; ESC [Regitz-Zagrosek 2018]). Females with preexisting hypertension may continue their medication during pregnancy unless contraindications exist (ESC [Regitz-Zagrosek 2018]).

Intravenous Apresoline is recommended for use in the management of acute onset, severe hypertension (systolic BP ≥160 mm Hg or diastolic BP ≥110 mm Hg) with preeclampsia or eclampsia in pregnant and postpartum women (ACOG 767 2019).

Apresoline breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!
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During the first week postpartum, 10 lactating women had blood and breast milk samples analyzed 24 hours after receiving a dose between 10 and 40 mg. The average concentration of this drug plus its pharmacologically active acid-labile metabolites in breast milk was 240 nmol/L (about half of the simultaneous concentration in maternal plasma). It was further estimated that the daily dose to a breastfed infant was unlikely to exceed 25 mcg. Serum drug concentrations were measured in 2 infants 2 hours after feeding in this study and were determined to be 557 and 293 nmol/L.

Use is considered acceptable; according to some experts, use only if the benefit outweighs the potential risk. Excreted into human milk: Yes Comments: This drug has been used without apparent harmful effects in the nursing infant.

See references

References for pregnancy information

  1. "Product Information. Apresoline (Apresoline)." Ciba Pharmaceuticals, Summit, NJ.
  2. Cerner Multum, Inc. "Australian Product Information." O 0
  3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  4. "Product Information. Apresoline." Akorn Inc, Buffalo Grove, IL.

References for breastfeeding information

  1. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  2. "Product Information. Apresoline." Akorn Inc, Buffalo Grove, IL.
  3. "Product Information. Apresoline (Apresoline)." Ciba Pharmaceuticals, Summit, NJ.
  4. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
  5. Cerner Multum, Inc. "Australian Product Information." O 0


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References

  1. PubMed Health. "Hydralazine (Oral route): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  2. Human Metabolome Database (HMDB). "Hydralazine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
  3. FDA Pharm Classes. "FDA Pharmacological Classification: FDA published a final rule that amended the requirements for the content and format of approved labeling (prescribing information) for human prescription drug and biological products in January 2006.". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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