Aprezolin is used to treat high blood pressure (hypertension). It is also used to control high blood pressure in a mother during pregnancy (pre-eclampsia or eclampsia) or in emergency situations when blood pressure is extremely high (hypertensive crisis).
High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure can increase the risk of heart attacks and strokes.
Aprezolin works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its workload.
Aprezolin is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although this use is not specifically included in product labeling, Aprezolin is used in certain patients with the following medical condition:
Congestive heart failure.
Aprezolin indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Oral
Hypertension
Adult: 40-50 mg daily in divided doses, increased according to response. Max: 200 mg/day.
Renal impairment: Reduce dose or prolong dosage interval.
Hepatic impairment: Reduce dose or prolong dosage interval.
Intravenous
Hypertensive crisis
Adult: 5-10 mg via slow IV inj, repeated if necessary after 20-30 min. Alternatively, as continuous IV, initial dose is 200-300 mcg/min.
Maintenance: 50-150 mcg/min.
How should I use Aprezolin?
Use Aprezolin injection as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Aprezolin injection is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Aprezolin injection at home, a health care provider will teach you how to use it. Be sure you understand how to use Aprezolin injection. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
Do not use Aprezolin injection if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
If you miss a dose of Aprezolin injection, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Aprezolin injection.
Uses of Aprezolin in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications
Hypertension: Management of moderate to severe hypertension. Note: Not recommended for the initial treatment of hypertension (ACC/AHA [Whelton 2017])
Off Label Uses
Heart failure with reduced ejection fraction
Data from a randomized, double-blind trial comparing enalapril and Aprezolin plus isosorbide dinitrate in patients with chronic heart failure with reduced ejection fraction (HFrEF) support the use of Aprezolin (in combination with isosorbide dinitrate) in patients with intolerance to angiotensin-converting enzyme (ACE) inhibitor therapy.
Aprezolin description
A direct-acting vasodilator that is used as an antihypertensive agent. [PubChem]
Aprezolin dosage
Aprezolin Dosage
Generic name: Aprezolin hydrochloride
Dosage form: Tablets
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Initiate therapy in gradually increasing dosages; adjust according to individual response. Start with 10 mg four times daily for the first 2-4 days, increase to 25 mg four times daily for the balance of the first week. For the second and subsequent weeks, increase dosage to 50 mg four times daily. For maintenance, adjust dosage to the lowest effective levels.
The incidence of toxic reactions, particularly the L.E. cell syndrome, is high in the group of patients receiving large doses of Aprezolin.
In a few resistant patients, up to 300 mg of Aprezolin daily may be required for a significant antihypertensive effect. In such cases, a lower dosage of Aprezolin combined with a thiazide and/or reserpine or a beta blocker may be considered. However, when combining therapy, individual titration is essential to ensure the lowest possible therapeutic dose of each drug.
MAO inhibitors should be used with caution in patients receiving Aprezolin.
When other potent parenteral antihypertensive drugs, such as diazoxide, are used in combination with Aprezolin, patients should be continuously observed for several hours for any excessive fall in blood pressure. Profound hypotensive episodes may occur when diazoxide injection and Aprezolin (Aprezolin) are used concomitantly.
In addition to its needed effects, some unwanted effects may be caused by Aprezolin (the active ingredient contained in Aprezolin). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Aprezolin:
More common:
Arm, back, or jaw pain
chest pain or discomfort
chest tightness or heaviness
fast, pounding, or irregular heartbeat or pulse
nausea
shortness of breath
sweating
Less common:
Black, tarry stools
blindness or vision changes
blisters on the skin
blurred vision
burning of the face or mouth
burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
chills
clumsiness or unsteadiness
confusion
cough
difficult or labored breathing
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
fever and sore throat
general feeling of discomfort or illness or weakness
joint pain
lower back or side pain
muscle pain
numbness, tingling, pain, or weakness in the hands or feet
painful or difficult urination
pale skin
shakiness in the legs, arms, hands, or feet
skin rash or itching
swelling of the feet or lower legs
swollen, painful, or tender lymph glands in the neck, armpit, or groin
tightness in the chest
trembling or shaking of the hands or feet
ulcers, sores, or white spots in the mouth
unusual bleeding or bruising
unusual tiredness or weakness
weakness in hands or feet
Rare
Dark urine
light-colored stools
upper right abdominal or stomach pain
yellow eyes and skin
If any of the following symptoms of overdose occur while taking Aprezolin, get emergency help immediately:
Symptoms of overdose:
Feeling of warmth
headache
redness of the face, neck, arms, and occasionally, upper chest
Minor Side Effects
Some of the side effects that can occur with Aprezolin may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
You should not use this medication if you are allergic to Aprezolin, or if you have coronary artery disease, or rheumatic heart disease affecting the mitral valve.
Before taking Aprezolin, tell your doctor if you have kidney disease, lupus, angina pectoris (chest pain), or if you have ever had a stroke.
While taking Aprezolin, avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Call your doctor at once if you have a serious side effect such as fast or pounding heartbeats, swelling, numbness or tingling, dark-colored urine, joint pain or swelling with fever, chest pain, weakness or tired feeling, and urinating less than usual or not at all.
To be sure this medication is helping your condition and is not causing harmful effects, your blood pressure will need to be checked often. You may also need occasional blood tests. Do not miss any scheduled appointments.
Keep using Aprezolin as directed, even if you feel well. High blood pressure often has no symptoms, so you may not know when your blood pressure is high. You may need to use blood pressure medication for the rest of your life.
DTP/NCI. "hydralazine: The NCI Development Therapeutics Program (DTP) provides services and resources to the academic and private-sector research communities worldwide to facilitate the discovery and development of new cancer therapeutic agents.". https://dtp.cancer.gov/dtpstandard/s... (accessed September 17, 2018).
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