Dosage of Arinib in details
Arinib Dosage
Generic name: Arinib 1mg
Dosage form: tablet
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Recommended Dose
The dose of Arinib is one 1 mg tablet taken once a day. For patients with advanced breast cancer, Arinib should be continued until tumor progression. Arinib can be taken with or without food.
For adjuvant treatment of early breast cancer in postmenopausal women, the optimal duration of therapy is unknown. In the ATAC trial, Arinib was administered for five years.
No dosage adjustment is necessary for patients with renal impairment or for elderly patients.
Patients with Hepatic Impairment
No changes in dose are recommended for patients with mild-to-moderate hepatic impairment. Arinib has not been studied in patients with severe hepatic impairment.
More about Arinib (Arinib)
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Consumer resources
- Arinib
- Arinib (Advanced Reading)
Professional resources
- Arinib (AHFS Monograph)
- Arinib (FDA)
Related treatment guides
- Breast Cancer, Metastatic
- Breast Cancer
- McCune-Albright Syndrome
- Pubertal Gynecomastia
What other drugs will affect Arinib?
Arinib may not work as well if you take it together with tamoxifen or an estrogen medication (such as hormone replacement therapy, estrogen creams, or birth control pills, injections, implants, skin patches, and vaginal rings). Before you start taking Arinib, tell your doctor if you also take tamoxifen or estrogen.
There may be other drugs that can interact with Arinib. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
Arinib interactions
Arinib inhibited in vitro metabolic reactions catalyzed by cytochromes P450 1A2, 2C8/9, and 3A4 but only at relatively high concentrations. Arinib did not inhibit P450 2A6 or the polymorphic P450 2D6 in human liver microsomes. Arinib did not alter the pharmacokinetics of antipyrine. Although there have been no formal interaction studies other than with antipyrine, based on these in vivo and in vitro studies, it is unlikely that co-administration of a 1 mg dose of Arinib with other drugs will result in clinically significant drug inhibition of cytochrome P450-mediated metabolism of the other drugs.
An interaction study with warfarin showed no clinically significant effect of Arinib on warfarin pharmacokinetics or anticoagulant activity.
At a median follow-up of 33 months, the combination of Arinib and tamoxifen did not demonstrate any efficacy benefit when compared with tamoxifen in all patients as well as in the hormone receptor-positive subpopulation. This treatment arm was discontinued from the trial. Based on clinical and pharmacokinetic results from the ATAC trial, tamoxifen should not be administered with Arinib (see CLINICAL PHARMACOLOGY ñ Drug Interactions and CLINICAL PHARMACOLOGY - Clinical Studies - Adjuvant Treatment of Breast Cancer in Postmenopausal Women subsections). Co-administration of Arinib and tamoxifen resulted in a reduction of Arinib plasma levels by 27% compared with those achieved with Arinib alone.
Estrogen-containing therapies should not be used with Arinib as they may diminish its pharmacologic action.
Drug/Laboratory Test Interactions
No clinically significant changes in the results of clinical laboratory tests have been observed.
References
- DailyMed. "ANASTROZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- FDA/SPL Indexing Data. "2Z07MYW1AZ: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).
- MeSH. "Aromatase Inhibitors". https://www.ncbi.nlm.nih.gov/mesh/68... (accessed September 17, 2018).
Reviews
The results of a survey conducted on ndrugs.com for Arinib are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Arinib. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.User reports
2 consumers reported frequency of use
How frequently do I need to take Arinib?It was reported by ndrugs.com website users that Arinib should ideally be taken Once in a day as the most common frequency of the Arinib. You should you adhere strictly to the instructions and guidelines provided by your doctor on how frequently this Arinib should be taken. Get another patient's view on how frequent the capsule should be used by clicking here.
| Users | % | ||
|---|---|---|---|
| Once in a day | 2 | 100.0% | |
4 consumers reported doses
What doses of Arinib drug you have used?The drug can be in various doses. Most anti-diabetic, anti-hypertensive drugs, pain killers, or antibiotics are in different low and high doses and prescribed by the doctors depending on the severity and demand of the condition suffered by the patient. In our reports, ndrugs.com website users used these doses of Arinib drug in following percentages. Very few drugs come in a fixed dose or a single dose. Common conditions, like fever, have almost the same doses, e.g., [acetaminophen, 500mg] of drug used by the patient, even though it is available in various doses.
| Users | % | ||
|---|---|---|---|
| 1-5mg | 4 | 100.0% | |
Consumer reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology
