Aristogyl is used to treat bacterial infections in different areas of the body. The extended-release tablets are used to treat women with vaginal infections (bacterial vaginosis).
Aristogyl belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, Aristogyl will not work for colds, flu, or other virus infections.
Aristogyl is available only with your doctor's prescription.
Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. Although these uses are not included in product labeling, Aristogyl is used in certain patients with the following medical conditions:
Clostridium difficile diarrhea or colitis (antibiotic-associated colitis).
Crohn's disease (inflammatory bowel disease).
Gastritis or stomach ulcers due to Helicobacter pylori.
Giardiasis (parasite infection in the intestines).
Aristogyl indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Symptomatic Trichomoniasis. Aristogyl Capsules USP 375 mg are indicated for the treatment of T. vaginalis infection in females and males when the presence of the trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures).
Asymptomatic Trichomoniasis. Aristogyl Capsules USP 375 mg are indicated in the treatment of asymptomatic T. vaginalis infection in females when the organism is associated with endocervicitis, cervicitis, or cervical erosion. Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite.
Treatment of Asymptomatic Sexual Partners. T. vaginalis infection is a venereal disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. The decision as to whether to treat an asymptomatic male partner who has a negative culture or one for whom no culture has been attempted is an individual one. In making this decision, it should be noted that there is evidence that a woman may become reinfected if her sexual partner is not treated. Also, since there can be considerable difficulty in isolating the organism from the asymptomatic male carrier, negative smears and cultures cannot be relied upon in this regard. In any event, the sexual partner should be treated with Aristogyl in cases of reinfection.
Amebiasis. Aristogyl Capsules USP 375 mg are indicated in the treatment of acute intestinal amebiasis (amebic dysentery) and amebic liver abscess.
In amebic liver abscess, Aristogyl Capsules USP 375 mg therapy does not obviate the need for aspiration or drainage of pus.
Anaerobic Bacterial Infections. Aristogyl Capsules USP 375 mg are indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with Aristogyl therapy. In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to Aristogyl Capsules USP 375 mg.
INTRA-ABDOMINAL INFECTIONS, including peritonitis, intra-abdominal abscess, and liver abscess, caused by Bacteroides species including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Clostridium species, Eubacterium species, Peptococcus species, or Peptostreptococcus species.
SKIN AND SKIN STRUCTURE INFECTIONS caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.
GYNECOLOGIC INFECTIONS, including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection, caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus species, Peptostreptococcus species, or Fusobacterium species.
BACTERIAL SEPTICEMIA caused by Bacteroides species including the B. fragilis group or Clostridium species.
BONE AND JOINT INFECTIONS (as adjunctive therapy) caused by Bacteroides species including the B. fragilis group.
CENTRAL NERVOUS SYSTEM (CNS) INFECTIONS, including meningitis and brain abscess, caused by Bacteroides species including the B. fragilis group.
LOWER RESPIRATORY TRACT INFECTIONS, including pneumonia, empyema, and lung abscess, caused by Bacteroides species including the B. fragilis group.
ENDOCARDITIS caused by Bacteroides species including the B. fragilis group.
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Aristogyl Capsules USP 375 mg and other antibacterial drugs, Aristogyl Capsules USP 375 mg should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
How should I use Aristogyl?
Use Aristogyl cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Wash and completely dry the affected area. Be sure the area is completely dry before applying Aristogyl cream.
Apply a thin layer of Aristogyl cream to the affected area. Gently rub the medicine in until it is evenly distributed.
Wash your hands immediately after using Aristogyl cream.
You may apply cosmetics after you use Aristogyl cream. If you are using the lotion, wait 5 minutes after you use Aristogyl cream before you apply cosmetics so that the lotion has time to dry.
Use Aristogyl cream on a regular schedule to get the most benefit from it. Using it at the same time(s) each day will help you remember to use it.
Continue to use Aristogyl cream even if your condition improves, unless a doctor tells you otherwise. Do not miss any doses.
If you miss a dose of Aristogyl cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Aristogyl cream.
Uses of Aristogyl in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Aristogyl is an antibiotic that is used to treat a wide variety of infections. It works by stopping the growth of certain bacteria and parasites.
This antibiotic treats only certain bacterial and parasitic infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.
Aristogyl may also be used with other medications to treat certain stomach/intestinal ulcers caused by a bacteria (H. pylori).
How to use Aristogyl
Take this medication by mouth as directed by your doctor. To prevent stomach upset, take this medication with food or a full glass of water or milk. The dosage is based on your medical condition and response to treatment.
Antibiotics work best when the amount of medicine in your body is kept at a constant level. Take this drug at evenly spaced intervals.
Continue to take this medication until the full prescribed amount is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.
Tell your doctor if your condition lasts or gets worse.
Aristogyl description
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Each 100 mL contains Metronidazole USP 500 mg, sodium chloride USP 0.72% w/v, water for injection USP as needed.
Aristogyl injection, USP is a parenteral dosage form of the synthetic antibacterial agent 1-(β-hydroxyethyl)-2-methyl-5-nitroimidazole. The empirical formula is C6H9N3O3 and the molecular weight is 171.15.
Aristogyl injection, USP in 100 mL is a sterile, nonpyrogenic, iso-osmotic, buffered solution of 500 mg Aristogyl, USP, 790 mg sodium chloride, USP, 47.6 mg dried dibasic sodium phosphate, USP and 22.9 mg anhydrous citric acid, USP. Aristogyl injection, USP has an osmolarity of 310 mOsmol/L (calc) and a pH of 5.5 (4.5 to 7).
Aristogyl dosage
Aristogyl Dosage
Generic name: Aristogyl 750mg
Dosage form: tablet, film coated, extended release
See also:
Aristogyl tablet, film coated
Aristogyl Capsules capsule
Aristogyl Injection injection, solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Bacterial Vaginosis
750 mg once daily by mouth for seven consecutive days.
Aristogyl 750 mg tablets should be taken under fasting conditions, at least one hour before or two hours after meals. The optimum extended-release characteristics of Aristogyl 750 mg are obtained when the drug is taken under fasting conditions.
Aristogyl tablets should not be split, chewed, or crushed.
Dosage Adjustments
Patients Undergoing Hemodialysis
Hemodialysis removes significant amounts of Aristogyl and its metabolites from systemic circulation. The clearance of Aristogyl will depend on the type of dialysis membrane used, the duration of the dialysis session, and other factors. If the administration of Aristogyl cannot be separated from a hemodialysis session, supplementation of Aristogyl dosage following the hemodialysis session should be considered, depending on the patient's clinical situation.
antacids that contain aluminum hydroxide, with kolestiraminom slightly decreases absorption of Aristogyl from the gastrointestinal tract;
Aristogyl potentiates the effect of indirect anticoagulants;
disulfiram may develop acute psychosis and impaired consciousness;
lansoprazole possible glossitis, stomatitis and / or the appearance of dark color language; with lithium carbonate - may increase the concentration of lithium in blood plasma and the development of symptoms of intoxication with prednisone - increased excretion of Aristogyl from the body by accelerating its metabolism in the liver under the influence of prednisone. It is possible a decrease the effectiveness of Zol.
rifampicin increased the clearance of Aristogyl from the body, with phenytoin - it is perhaps a slight increase in the concentration of phenytoin in blood plasma, described the case of toxic action;
phenobarbital significantly increased excretion of Aristogyl from the body, apparently due to acceleration of its metabolism in the liver under the influence of phenobarbital. It is possible a decrease the effectiveness of Zol;
fluorouracil enhanced the toxic effect but not the effectiveness of fluorouracil;
cimetidine may inhibit the metabolism of Aristogyl in the liver that can lead to slow its elimination and increase the concentration in blood plasma. It can not be excluded the increase in the concentration of carbamazepine in plasma and increased risk of toxicity with concomitant use of Zol. There was described a case of acute dystonia after a single dose of chloroquine in patients treated with Aristogyl.
In a controlled clinical trial, safety data from 141 patients who used Aristogyl Lotion
Topical Lotion (n=71), or the lotion vehicle (n=70), twice daily and experienced a local cutaneous adverse event which may or may not have been related to the treatments include: local allergic reaction, Aristogyl
Topical Lotion 0, lotion vehicle 1 (1%); and worsening of rosacea, Aristogyl Lotion
Topical Lotion 1 (1%), lotion vehicle 7 (10%).
The following additional adverse experiences have been reported with the topical use of Aristogyl: skin irritation, transient redness, metallic taste, tingling or numbness of extremities, and nausea.
Aristogyl Capsules 375 mg are contraindicated in patients with a prior history of hypersensitivity to Aristogyl or other nitroimidazole derivatives.
In patients with trichomoniasis, Aristogyl Capsules 375 mg are contraindicated during the first trimester of pregnancy.
Psychotic Reaction with Disulfiram
Use of oral Aristogyl is associated with psychotic reactions in alcoholic patients who were using disulfiram concurrently. Do not administer Aristogyl to patients who have taken disulfiram within the last two weeks.
Interaction with Alcohol
Use of oral Aristogyl is associated with a disulfiram-like reaction to alcohol, including abdominal cramps, nausea, vomiting, headaches, and flushing. Discontinue consumption of alcohol or products containing propylene glycol during and for at least three days after therapy with Aristogyl.
DailyMed. "BISMUTH SUBCITRATE POTASSIUM; METRONIDAZOLE; TETRACYCLINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
The results of a survey conducted on ndrugs.com for Aristogyl are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Aristogyl. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
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