Consists of Chlorphenamine, Ibuprofen, Pseudoephedrine
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Aseptobron Antigripal Forte Actions |
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Consists of Chlorphenamine, Ibuprofen, Pseudoephedrine
Chlorphenamine (Aseptobron Antigripal Forte) Citadel Fine Pharmaceuticals is a broad-spectrum antimicrobial drug of fluoroquinolone group with bactericidal action. Inhibits DNA gyrase and inhibits the synthesis of bacterial DNA. Highly active against most gram-negative bacteria: Pseudomonas aeruginosa, Haemophilus influenzae, Escherichia coli, Shigella spp., Salmonella spp., Neisseria meningitidis, Neisseria gonorrhoeae.
Chlorphenamine (Aseptobron Antigripal Forte) Citadel Fine Pharmaceuticals is active against Staphylococcus spp. (including strains producing and not producing penicillinase, methicillin-resistant strains), some strains of Enterococcus spp., Campylobacter spp., Legionella spp., Mycoplasma spp., Chlamydia spp., Mycobacterium spp.
ciprofloxacin is active against bacteria producing beta-lactamases.
Ureaplasma urealyticum, Clostridium difficile, Nocardia asteroides resistant to ciprofloxacin. The effect on Treponema pallidum is studied not enough.
May be taken with or without food.
Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations. Chlorphenamine (Aseptobron Antigripal Forte) is cell cycle phase-nonspecific.
Ibuprofen (Aseptobron Antigripal Forte) is a nonsteroidal anti-inflammatory agent with analgesic and antipyretic action.
Pharmacology: While the precise mechanism of action is not known, it is thought that Ibuprofen (Aseptobron Antigripal Forte), like other nonsteroidal anti-inflammatory drugs, produces an anti-inflammatory effect at least in part by inhibiting prostaglandin synthetase. Ibuprofen (Aseptobron Antigripal Forte) also has been shown to have analgesic and antipyretic activity.
Pharmacodynamics: Ibuprofen (Aseptobron Antigripal Forte) is a nonsteroidal anti-inflammatory drug (NSAID) belonging to propionic acid derivative. In common with other NSAIDs, it possesses analgesic, antipyretic and anti-inflammatory activities. Ibuprofen (Aseptobron Antigripal Forte) exerts its effect mainly by inhibiting prostaglandin synthetase and thereby prevents the formation of prostaglandins, thromboxanes and other cyclooxygenase products. These properties provide symptomatic relief of inflammation and pain in rheumatoid arthritis and osteoarthritis. Ibuprofen (Aseptobron Antigripal Forte) does not possess glucocorticoid- or adrenocorticoid-stimulating properties and has no uricosuric action. Like other nonsteroidal anti-inflammatory agents, Ibuprofen (Aseptobron Antigripal Forte) inhibits platelet aggregation and prolongs bleeding time (although within normal range) but does not affect prothrombin time or whole blood-clotting time.
Ibuprofen (Aseptobron Antigripal Forte) also inhibits the renal prostacycline synthesis and may cause risk of water retention by reducing the renal blood flow. This effect must be taken in account when using Ibuprofen (Aseptobron Antigripal Forte) in patients with renal insufficiency, cardiac failure, liver impairment and conditions altering the plasma volume.
Pharmacokinetics: Ibuprofen (Aseptobron Antigripal Forte) is well absorbed after oral administration. Single dose of 200 mg taken on an empty stomach by volunteers produced peak serum levels after approximately 45 min. When taken after food, absorption was slower, peak levels appearing at 1.5-3 hrs. Ibuprofen (Aseptobron Antigripal Forte) is extensively bound to plasma proteins. About 95% of Ibuprofen (Aseptobron Antigripal Forte) is metabolized to 2 major metabolites (A and B), both of which are devoid of anti-inflammatory and analgesic activity. Excretion is rapid, serum levels showing no evidence of accumulation. The excretion of Ibuprofen (Aseptobron Antigripal Forte) is virtually complete 24 hrs after the last dose. The serum half-life of Ibuprofen (Aseptobron Antigripal Forte) is approximately 2 hrs. Studies have shown that following ingestion of the drug, approximately 95% of the dose was recovered in the urine within 24 hrs as metabolites (A and B). The percentages of unchanged and conjugated Ibuprofen (Aseptobron Antigripal Forte) were approximately 1% and 14%, respectively.
For safe and effective use of Ibuprofen (Aseptobron Antigripal Forte), do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of Ibuprofen (Aseptobron Antigripal Forte) may increase the chance of unwanted effects, especially in elderly patients.
When used for severe or continuing arthritis, Ibuprofen (Aseptobron Antigripal Forte) must be taken regularly as ordered by your doctor in order for it to help you. Ibuprofen (Aseptobron Antigripal Forte) usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of Ibuprofen (Aseptobron Antigripal Forte).
To lessen stomach upset, you may take Ibuprofen (Aseptobron Antigripal Forte) with food or milk.
The dose of Ibuprofen (Aseptobron Antigripal Forte) will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Ibuprofen (Aseptobron Antigripal Forte). If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of Ibuprofen (Aseptobron Antigripal Forte), take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended.
Do not take more of this medication than is recommended. An overdose of Ibuprofen (Aseptobron Antigripal Forte) can cause damage to your stomach or intestines. The maximum amount of Ibuprofen (Aseptobron Antigripal Forte) for adults is 800 milligrams per dose or 3200 mg per day (4 maximum doses). Use only the smallest amount of Ibuprofen (Aseptobron Antigripal Forte) needed to get relief from your pain, swelling, or fever.
Take Ibuprofen (Aseptobron Antigripal Forte) with food or milk to lessen stomach upset.
Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.
The Ibuprofen (Aseptobron Antigripal Forte) chewable tablet must be chewed before you swallow it.
If you take Ibuprofen (Aseptobron Antigripal Forte) for a long period of time, your doctor may want to check you on a regular basis to make sure this medication is not causing harmful effects. Do not miss any scheduled visits to your doctor.
Store at room temperature away from moisture and heat. Do not allow the liquid medicine to freeze.
Ibuprofen (Aseptobron Antigripal Forte) tablets contain Ibuprofen (Aseptobron Antigripal Forte) which possesses analgesic and antipyretic activities. Its mode of action, like that of other NSAIDs, is not completely understood, but may be related to prostaglandin synthetase inhibition.
In clinical studies in patients with rheumatoid arthritis and osteoarthritis, Ibuprofen (Aseptobron Antigripal Forte) tablets have been shown to be comparable to aspirin in controlling pain and inflammation and to be associated with a statistically significant reduction in the milder gastrointestinal side effects. Ibuprofen (Aseptobron Antigripal Forte) tablets may be well tolerated in some patients who have had gastrointestinal side effects with aspirin, but these patients when treated with Ibuprofen (Aseptobron Antigripal Forte) tablets should be carefully followed for signs and symptoms of gastrointestinal ulceration and bleeding. Although it is not definitely known whether Ibuprofen (Aseptobron Antigripal Forte) tablets causes less peptic ulceration than aspirin, in one study involving 885 patients with rheumatoid arthritis treated for up to one year, there were no reports of gastric ulceration with Ibuprofen (Aseptobron Antigripal Forte) tablets whereas frank ulceration was reported in 13 patients in the aspirin group (statistically significant p<.001).
Gastroscopic studies at varying doses show an increased tendency toward gastric irritation at higher doses. However, at comparable doses, gastric irritation is approximately half that seen with aspirin. Studies using 51Cr-tagged red cells indicate that fecal blood loss associated with Ibuprofen (Aseptobron Antigripal Forte) tablets in doses up to 2400 mg daily did not exceed the normal range, and was significantly less than that seen in aspirin-treated patients.
In clinical studies in patients with rheumatoid arthritis, Ibuprofen (Aseptobron Antigripal Forte) tablets have been shown to be comparable to indomethacin in controlling the signs and symptoms of disease activity and to be associated with a statistically significant reduction of the milder gastrointestinal and CNS side effects.
Ibuprofen (Aseptobron Antigripal Forte) tablets may be used in combination with gold salts and/or corticosteroids.
Controlled studies have demonstrated that Ibuprofen (Aseptobron Antigripal Forte) tablets are a more effective analgesic than propoxyphene for the relief of episiotomy pain, pain following dental extraction procedures, and for the relief of the symptoms of primary dysmenorrhea.
In patients with primary dysmenorrhea, Ibuprofen (Aseptobron Antigripal Forte) tablets have been shown to reduce elevated levels of prostaglandin activity in the menstrual fluid and to reduce resting and active intrauterine pressure, as well as the frequency of uterine contractions. The probable mechanism of action is to inhibit prostaglandin synthesis rather than simply to provide analgesia.
The Ibuprofen (Aseptobron Antigripal Forte) in Ibuprofen (Aseptobron Antigripal Forte) tablets is rapidly absorbed. Peak serum Ibuprofen (Aseptobron Antigripal Forte) levels are generally attained one to two hours after administration. With single doses up to 800 mg, a linear relationship exists between amount of drug administered and the integrated area under the serum drug concentration vs time curve. Above 800 mg, however, the area under the curve increases less than proportional to increases in dose. There is no evidence of drug accumulation or enzyme induction.
The administration of Ibuprofen (Aseptobron Antigripal Forte) tablets either under fasting conditions or immediately before meals yields quite similar serum Ibuprofen (Aseptobron Antigripal Forte) concentration-time profiles. When Ibuprofen (Aseptobron Antigripal Forte) tablets are administered immediately after a meal, there is a reduction in the rate of absorption but no appreciable decrease in the extent of absorption. The bioavailability of the drug is minimally altered by the presence of food.
A bioavailability study has shown that there was no interference with the absorption of Ibuprofen (Aseptobron Antigripal Forte) when Ibuprofen (Aseptobron Antigripal Forte) tablets were given in conjunction with an antacid containing both aluminum hydroxide and magnesium hydroxide.
Ibuprofen (Aseptobron Antigripal Forte) is rapidly metabolized and eliminated in the urine. The excretion of Ibuprofen (Aseptobron Antigripal Forte) is virtually complete 24 hours after the last dose. The serum half-life is 1.8 to 2.0 hours.
Studies have shown that following ingestion of the drug, 45% to 79% of the dose was recovered in the urine within 24 hours as metabolite A (25%), (+)-2-[p-(2hydroxymethyl-propyl) phenyl] propionic acid and metabolite B (37%), (+)-2-[p-(2carboxypropyl)phenyl] propionic acid; the percentages of free and conjugated Ibuprofen (Aseptobron Antigripal Forte) were approximately 1% and 14%, respectively.
Pseudoephedrine (Aseptobron Antigripal Forte) acts directly on both alpha- and, to a lesser degree, beta-adrenergic receptors. Through direct action on alpha-adrenergic receptors in the mucosa of the respiratory tract, Pseudoephedrine (Aseptobron Antigripal Forte) produces vasoconstriction. Pseudoephedrine (Aseptobron Antigripal Forte) relaxes bronchial smooth muscle by stimulating beta2-adrenergic receptors. Like ephedrine, Pseudoephedrine (Aseptobron Antigripal Forte) releasing norepinephrine from its storage sites, an indirect effect. This is its main and direct mechanism of action. The displaced noradrenaline is released into the neuronal synapse where it is free to activate the postsynaptic adrenergic receptors.
For patients taking Pseudoephedrine (Aseptobron Antigripal Forte) extended-release capsules:
For patients taking Pseudoephedrine (Aseptobron Antigripal Forte) extended-release tablets:
To help prevent trouble in sleeping, take the last dose of Pseudoephedrine (Aseptobron Antigripal Forte) for each day a few hours before bedtime. If you have any questions about this, check with your doctor.
Take Pseudoephedrine (Aseptobron Antigripal Forte) only as directed. Do not take more of it, do not take it more often, and do not take it for a longer period of time than recommended on the label (usually 7 days), unless otherwise directed by your doctor. To do so may increase the chance of side effects.
The dose of Pseudoephedrine (Aseptobron Antigripal Forte) will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Pseudoephedrine (Aseptobron Antigripal Forte). If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
If you miss a dose of Pseudoephedrine (Aseptobron Antigripal Forte), take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Do not crush ER drug product, swallow whole. May administer with or without food. Sudafed 24 Hour tablet may not completely dissolve and appear in stool.
Bariatric surgery: Tablet, extended release: Some institutions may have specific protocols that conflict with these recommendations; refer to institutional protocols as appropriate. ER tablets should be swallowed whole. Do not crush or chew. IR tablet, chewable tablet, capsule, oral solution, syrup, and suspension formulations are available. If safety and efficacy can be effectively monitored, no change in formulation or administration is required after bariatric surgery.
Pseudoephedrine (Aseptobron Antigripal Forte) is a sympathomimetic agent, structurally similar to ephedrine, used to relieve nasal and sinus congestion and reduce air-travel-related otalgia in adults. The salts Pseudoephedrine (Aseptobron Antigripal Forte) hydrochloride and Pseudoephedrine (Aseptobron Antigripal Forte) sulfate are found in many over-the-counter preparations either as single-ingredient preparations, or more commonly in combination with antihistamines and/or paracetamol/Pseudoephedrine (Aseptobron Antigripal Forte). Unlike antihistamines, which modify the systemic histamine-mediated allergic response, Pseudoephedrine (Aseptobron Antigripal Forte) only serves to relieve nasal congestion commonly associated with colds or allergies. The advantage of oral Pseudoephedrine (Aseptobron Antigripal Forte) over topical nasal preparations, such as oxymetazoline, is that it does not cause rebound congestion (rhinitis medicamentosa).
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Information checked by Dr. Sachin Kumar, MD Pharmacology
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