Avetiser Pregnancy

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Pregnancy of Avetiser in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.

Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters).

Avetiser breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

There are no data on the excretion of Avetiser into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. Khir AS, How J, Bewsher PD "Successful pregnancy after Avetiser treatment for Cushing's disease." Eur J Obstet Gynecol Reprod Biol 13 (1982): 343-7
  2. "Product Information. Periactin (Avetiser)." Merck & Co, Inc, West Point, PA.
  3. Kasperlik-Zaluska A, Migdalska B, Hartwig W, Wilczynska J, Marianowski L, Stopinska-Gluszak U, Lozinska D "Two pregnancies in a woman with Cushing's syndrome treated with Avetiser. Case report." Br J Obstet Gynaecol 87 (1980): 1171-3
  4. Sadovsky E, Pfeifer Y, Polishuk WA, Sulman FG "The use of antiserotonin-Avetiser HCL in pregnancy: an experimental and clinical study." Adv Exp Med Biol 27: (1972): 399-405

References for breastfeeding information

  1. "Product Information. Periactin (Avetiser)." Merck & Co, Inc, West Point, PA.



  1. Human Metabolome Database (HMDB). "Cyproheptadine: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
  2. LiverTox. "Cyproheptadine: LIVERTOX provides up-to-date, accurate, and easily accessed information on the diagnosis, cause, frequency, patterns, and management of liver injury attributable to prescription and nonprescription medications, herbals and dietary supplements. ". https://livertox.nlm.nih.gov//Cyproh... (accessed September 17, 2018).
  3. FDA Orange Book. "CYPROHEPTADINE HYDROCHLORIDE: The publication, Approved Drug Products with Therapeutic Equivalence Evaluations (the List, commonly known as the Orange Book), identifies drug products approved on the basis of safety and effectiveness by the Food and Drug Administration (FDA) under the Federal Food, Drug, and Cosmetic Act (the Act).". https://www.fda.gov/Drugs/Informatio... (accessed September 17, 2018).


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