Avogain Actions

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Actions of Avogain in details

The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Avogain Sunward Pharmaceutical is a drugs for the treatment of hair loss. This medication has a stimulating effect on hair growth in men and women with androgenetic alopecia (male pattern baldness). The appearance of signs of hair growth observed after 4 months or more of taking the drug 2 times / day. The beginning and the severity of the effect may vary in different patients. After the abolition of Avogain new hair growth stops, and after 3-4 months may restore the original appearance.

The exact mechanism of action of Avogain Sunward Pharmaceutical as a hair growth stimulant in patients with androgenic alopecia is unknown.

When used systemically this medicine has a vasodilating action. In controlled clinical studies after topical usage Avogain in patients with normal as well as with high blood pressure was not observed systemic side effects associated with systemic absorption of this drug.

How should I take Avogain?

Avogain usually comes with patient instructions. It is important that you read the instructions carefully.

It is very important that you use Avogain only as directed. Do not use more of it and do not use it more often than your doctor ordered. To do so may increase the chance of it being absorbed through the skin. For the same reason, do not apply Avogain to other parts of your body. Absorption into the body may affect the heart and blood vessels and cause unwanted effects.

Do not use any other skin products on the same skin area on which you use Avogain. Hair coloring, hair permanents, and hair relaxers may be used during Avogain therapy as long as the scalp is washed just before applying the hair coloring, permanent, or relaxer. Avogain should not be used 24 hours before and after the hair treatment procedure. Be sure to not double your doses of Avogain to make up for any missed doses.

To apply Avogain topical solution:

  • Make sure your hair and scalp are completely dry before applying Avogain.
  • Apply the amount prescribed to the area of the scalp being treated, beginning in the center of the area. Follow your doctor's instructions on how to apply the solution, using the applicator provided.
  • Do not shampoo your hair for 4 hours after applying Avogain.
  • Immediately after using Avogain, wash your hands to remove any medicine that may be on them.
  • Do not use a hairdryer to dry the scalp after you apply Avogain solution. Blowing with a hairdryer on the scalp may make the treatment less effective.
  • Allow the Avogain to completely dry for 2 to 4 hours after applying it, including before going to bed. Avogain can stain clothing, hats, or bed linen if your hair or scalp is not fully dry after using the medicine.
  • Avoid transferring the medicine while wet to other parts of the body. This can occur if the medicine gets on your pillowcase or bed linens or if your hands are not washed after applying Avogain.

To apply Avogain topical foam:

  • Open the container by matching the arrow on can ring with the arrow on cap. Pull off the cap.
  • Part the hair into one or more rows to expose the hair thinning area on the scalp.
  • Hold the can upside down and press the nozzle to put foam on your fingers.
  • Use your fingers to spread the foam over the hair loss area and gently massage into your scalp.
  • Immediately after using Avogain, wash your hands to remove any medicine that may be on them.

If your scalp becomes abraded, irritated, or sunburned, check with your doctor before applying Avogain.

Avogain topical foam or solution is for use on the scalp only. Keep Avogain away from the eyes, nose, and mouth. If you should accidentally get some in your eyes, nose, or mouth, flush the area thoroughly with cool tap water. If you are using the pump spray, be careful not to breathe in the spray.

Do not use the foam near heat or open flame, or while smoking. Do not puncture, break, or burn the aerosol can.

Dosing

The dose of Avogain will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Avogain. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For hair growth:
    • For topical solution dosage form:
      • Adults—Apply 1 milliliter (mL) to the scalp two times a day.
      • Children—Use and dose must be determined by the doctor.
    • For topical foam dosage form:
      • Adults—Apply half a capful to the scalp two times a day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of Avogain, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Flammable: Keep away from fire or flame.

Avogain administration

Administration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
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You may need to receive your first few doses of Avogain in a hospital setting where your heart and blood pressure can be monitored in case the medication causes serious side effects.

Take Avogain exactly as it was prescribed for you. Do not take the medication in larger amounts or for longer than recommended by your doctor. Follow the directions on your prescription label.

Your doctor may occasionally change your dose to make sure you get the best results from this medication.

To be sure this medication is helping your condition and not causing harmful effects, your weight and blood pressure will need to be checked on a regular basis. You may also need blood tests. Do not miss any scheduled visits to your doctor.

Avogain is usually given together with other medications. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms, so you may not know when your blood pressure is high. You may need to use blood pressure medication for the rest of your life.

Store Avogain at room temperature away from moisture and heat.

Avogain pharmacology

Pharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
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General Pharmacologic Properties

Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) is an orally effective direct acting peripheral vasodilator that reduces elevated systolic and diastolic blood pressure by decreasing peripheral vascular resistance. Microcirculatory blood flow in animals is enhanced or maintained in all systemic vascular beds. In man, forearm and renal vascular resistance decline; forearm blood flow increases while renal blood flow and glomerular filtration rate are preserved.

Because it causes peripheral vasodilation, Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) elicits a number of predictable reactions. Reduction of peripheral arteriolar resistance and the associated fall in blood pressure trigger sympathetic, vagal inhibitory, and renal homeostatic mechanisms, including an increase in renin secretion, that lead to increased cardiac rate and output and salt and water retention. These adverse effects can usually be minimized by concomitant administration of a diuretic and a beta-adrenergic blocking agent or other sympathetic nervous system suppressant.

Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) does not interfere with vasomotor reflexes and therefore does not produce orthostatic hypotension. The drug does not enter the central nervous system in experimental animals in significant amounts, and it does not affect CNS function in man.

Effects on Blood Pressure and Target Organs

The extent and time-course of blood pressure reduction by Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) do not correspond closely to its concentration in plasma. After an effective single oral dose, blood pressure usually starts to decline within one-half hour, reaches a minimum between 2 and 3 hours and recovers at an arithmetically linear rate of about 30%/day. The total duration of effect is approximately 75 hours. When Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) is administered chronically, once or twice a day, the time required to achieve maximum effect on blood pressure with a given daily dose is inversely related to the size of the dose. Thus, maximum effect is achieved on 10 mg/day within 7 days, on 20 mg/day within 5 days, and on 40 mg/day within 3 days.

The blood pressure response to Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) is linearly related to the logarithm of the dose administered. The slope of this log-linear dose-response relationship is proportional to the extent of hypertension and approaches zero at a supine diastolic blood pressure of approximately 85 mm Hg.

When used in severely hypertensive patients resistant to other therapy, frequently with an accompanying diuretic and beta-blocker, Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) tablets usually decreased the blood pressure and reversed encephalopathy and retinopathy.

Absorption and Metabolism

Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) is at least 90% absorbed from the Gl tract in experimental animals and man. Plasma levels of the parent drug reach maximum within the first hour and decline rapidly thereafter. The average plasma half-life in man is 4.2 hours. Approximately 90% of the administered drug is metabolized, predominantly by conjugation with glucuronic acid at the N-oxide position in the pyrimidine ring, but also by conversion to more polar products. Known metabolites exert much less pharmacologic effect than Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) itself; all are excreted principally in the urine. Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) does not bind to plasma proteins, and its renal clearance corresponds to the glomerular filtration rate. In the absence of functional renal tissue, Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) and its metabolites can be removed by hemodialysis.

Cardiac Lesions in Animals

Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) produces several cardiac lesions in animals. Some are characteristic of agents that cause tachycardia and diastolic hypotension (beta-agonists like isoproterenol, arterial dilators like hydralazine) while others are produced by a narrower range of agents with arterial dilating properties. The significance of these lesions for humans is not clear, as they have not been recognized in patients treated with oral Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) at systemically active doses, despite formal review of over 150 autopsies of treated patients.

Papillary muscle/subendocardial necrosis

The most characteristic lesion of Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets), seen in rat, dog, and minipig (but not monkeys) is focal necrosis of the papillary muscle and subendocardial areas of the left ventricle. These lesions appear rapidly, within a few days of treatment with doses of 0.5 to 10 mg/kg/day in the dog and minipig, and are not progressive, although they leave residual scars. They are similar to lesions produced by other peripheral arterial dilators, by theobromine, and by beta-adrenergic receptor agonists such as isoproterenol, epinephrine, and albuterol. The lesions are thought to reflect ischemia provoked by increased oxygen demand (tachycardia, increased cardiac output) and relative decrease in coronary flow (decreased diastolic pressure and decreased time in diastole) caused by the vasodilatory effects of these agents coupled with reflex or directly induced tachycardia.

Hemorrhagic lesions

After acute oral Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) treatment (0.5 to 10 mg/kg/day) in dogs and minipigs, hemorrhagic lesions are seen in many parts of the heart, mainly in the epicardium, endocardium, and walls of small coronary arteries and arterioles. In minipigs the lesions occur primarily in the left atrium while in dogs they are most prominent in the right atrium, frequently appearing as grossly visible hemorrhagic lesions. With exposure of 1-20 mg/kg/day in the dog for 30 days or longer, there is replacement of myocardial cells by proliferating fibroblasts and angioblasts, hemorrhage and hemosiderin accumulation. These lesions can be produced by topical Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) administration that gives systemic absorption of 0.5 to 1 mg/kg/day. Other peripheral dilators, including an experimental agent, nicorandil, and theobromine, have produced similar lesions.

Epicarditis

A less fully studied lesion is focal epicarditis, seen in dogs after 2 days of oral Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets). More recently, chronic proliferative epicarditis was observed in dogs treated topically twice a day for 90 days. In a one year oral dog study, serosanguinous pericardial fluid was seen.

Hypertrophy and Dilation

Oral and topical studies in rats, dogs, monkeys (oral only), and rabbits (dermal only) show cardiac hypertrophy and dilation. This is presumed to represent the consequences of prolonged fluid overload; there is preliminary evidence in monkeys that diuretics partly reverse these effects.

Autopsies of over 150 patients who died of various causes after receiving Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) for hypertension have not revealed the characteristic hemorrhagic (especially atrial) lesions seen in dogs and minipigs. While areas of papillary muscle and subendocardial necrosis were occasionally seen, they occurred in the presence of known pre-existing coronary artery disease and were also seen in patients never exposed to Avogain (Avogain (Avogain (Avogain tablets) tablets) tablets) in another series using similar, but not identical, autopsy methods.



References

  1. DailyMed. "MINOXIDIL: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. NCIt. "Minoxidil: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  3. EPA DSStox. "Minoxidil: DSSTox provides a high quality public chemistry resource for supporting improved predictive toxicology.". https://comptox.epa.gov/dashboard/ds... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Avogain are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Avogain. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

1 consumer reported administration

When best can I take Avogain, on an empty stomach, before or after food?
ndrugs.com website users have also released a report stating that Avogain should be taken Before food. In any case, this may not be the right description on how you ought to take this Avogain. Kindly visit your doctor for more medical advice in this regard. Click here to see other users view on when best the Avogain can be taken.
Users%
Before food1
100.0%


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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