What is Aztreonam Farmalogica?
Aztreonam Farmalogica inhalation is an antibiotic that is used to treat lung infections in patients with cystic fibrosis. The medicine is breathed into the lungs through the mouth to treat infections caused by the Pseudomonas aeruginosa bacteria.
Aztreonam Farmalogica works by killing bacteria or preventing their growth. However, Aztreonam Farmalogica will not work for colds, flu, or other virus infections.
Aztreonam Farmalogica is available only with your doctor's prescription.
Aztreonam Farmalogica indications
To reduce the development of drug-resistant bacteria and maintain the effectiveness of Aztreonam Farmalogica (Aztreonam Farmalogica for injection, USP) and other antibacterial drugs, Aztreonam Farmalogica should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.
Aztreonam Farmalogica is indicated for the treatment of the following infections caused by susceptible Gram-negative microorganisms:
Urinary Tract Infections (complicated and uncomplicated), including pyelonephritis and cystitis (initial and recurrent) caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Enterobacter cloacae, Klebsiella oxytoca*, Citrobacter species*, and Serratia marcescens*.
Lower Respiratory Tract Infections, including pneumonia and bronchitis caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Haemophilus influenzae, Proteus mirabilis, Enterobacter species, and Serratia marcescens*.
Septicemia caused by Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis*, Serratia marcescens*, and Enterobacter species.
Skin and Skin-Structure Infections, including those associated with postoperative wounds, ulcers, and burns, caused by Escherichia coli, Proteus mirabilis, Serratia marcescens, Enterobacter species, Pseudomonas aeruginosa, Klebsiella pneumoniae, and Citrobacter species*.
Intra-abdominal Infections, including peritonitis caused by Escherichia coli, Klebsiella species including K. pneumoniae, Enterobacter species including E. cloacae*, Pseudomonas aeruginosa, Citrobacter species* including C. freundii*, and Serratia species* including S. marcescens*.
Gynecologic Infections, including endometritis and pelvic cellulitis caused by Escherichia coli, Klebsiella pneumoniae*, Enterobacter species* including E. cloacae*, and Proteus mirabilis*.
Aztreonam Farmalogica is indicated for adjunctive therapy to surgery in the management of infections caused by susceptible organisms, including abscesses, infections complicating hollow viscus perforations, cutaneous infections, and infections of serous surfaces. Aztreonam Farmalogica is effective against most of the commonly encountered Gram-negative aerobic pathogens seen in general surgery.
————————————
* Efficacy for this organism in this organ system was studied in fewer than 10 infections.
Concurrent Therapy
Concurrent initial therapy with other antimicrobial agents and Aztreonam Farmalogica is recommended before the causative organism(s) is known in seriously ill patients who are also at risk of having an infection due to Gram-positive aerobic pathogens. If anaerobic organisms are also suspected as etiologic agents, therapy should be initiated using an anti-anaerobic agent concurrently with Aztreonam Farmalogica. Certain antibiotics (eg, cefoxitin, imipenem) may induce high levels of beta-lactamase in vitro in some Gram-negative aerobes such as Enterobacter and Pseudomonas species, resulting in antagonism to many beta-lactam antibiotics including Aztreonam Farmalogica. These in vitro findings suggest that such beta-lactamase-inducing antibiotics not be used concurrently with Aztreonam Farmalogica. Following identification and susceptibility testing of the causative organism(s), appropriate antibiotic therapy should be continued.
How should I use Aztreonam Farmalogica?
Use Aztreonam Farmalogica Inhalation as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Aztreonam Farmalogica Inhalation. Talk to your pharmacist if you have questions about this information.
- You should use a bronchodilator (eg, albuterol) before you use Aztreonam Farmalogica Inhalation. Contact your doctor for instructions on how and when to use a bronchodilator before using Aztreonam Farmalogica Inhalation.
- If you are taking several inhaled medicines, talk to your doctor about the best order for taking your medicines.
- Aztreonam Farmalogica Inhalation should be used with a certain nebulizer (Altera Nebulizer System). Do not use other medicines with this nebulizer. Be sure you know which nebulizer to use Aztreonam Farmalogica Inhalation with.
- Do not mix Aztreonam Farmalogica Inhalation with other medicines before using it.
- Do not use Aztreonam Farmalogica Inhalation if it is cloudy, contains particles, or if it has been stored at room temperature for more than 28 days.
- To clear up your infection completely, use Aztreonam Farmalogica Inhalation for the full course of treatment. Keep using it even if you feel better in a few days.
- Aztreonam Farmalogica Inhalation must be mixed with the provided diluent that comes with it before you use it. Follow your doctor's instructions on how to mix Aztreonam Farmalogica Inhalation.
- After you mix Aztreonam Farmalogica Inhalation with the diluent, use it immediately. Do not mix more than one dose at a time.
- Aztreonam Farmalogica Inhalation is usually used for 28 days on the medicine followed by at least 28 days off the medicine. Follow the dosing schedule given to you by your doctor carefully.
- If you miss a dose of Aztreonam Farmalogica Inhalation, use it as soon as possible. If it is less than 4 hours until your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Aztreonam Farmalogica Inhalation.
Uses of Aztreonam Farmalogica in details
Use: Labeled Indications
Treatment of patients with urinary tract infections, lower respiratory tract infections, septicemia, skin/skin structure infections, intra-abdominal infections, and gynecological infections caused by susceptible gram-negative bacilli
Off Label Uses
Meningitis, bacterial
Based on the Infectious Diseases Society of America (IDSA) guidelines for the management of bacterial meningitis and health care-associated ventriculitis and meningitis, Aztreonam Farmalogica is an effective and recommended alternative therapy for meningitis due to beta-lactamase positive Haemophilus influenzae, Enterobacteriaceae, or Pseudomonas aeruginosa, and for health care-associated meningitis or ventriculitis requiring empiric therapy for gram-negative pathogens in patients with anaphylaxis to beta-lactams, in combination with other appropriate agents.
Osteomyelitis, native vertebral
Based on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and treatment of native vertebral osteomyelitis in adults, Aztreonam Farmalogica is an effective and recommended alternative treatment option for the treatment of native vertebral osteomyelitis due to Pseudomonas aeruginosa in patients with severe penicillin allergy and quinolone-resistant strains.
Surgical prophylaxis (perioperative)
Based on the American Society of Health-System Pharmacists (ASHP), the Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the Society of Healthcare Epidemiology of America (SHEA) guidelines for antimicrobial prophylaxis in surgery, Aztreonam Farmalogica is an effective and recommended alternative agent (in combination with other antibiotics) for patients with beta-lactam allergy for a number of surgical procedures (eg, gastroduodenal, biliary tract, appendectomy, hysterectomy, urologic involving implanted prosthesis, liver transplantation, or pancreas and pancreas-kidney transplantation) and may be used first-line in combination with cefazolin for procedures involving implanted prosthetic material (eg, penile prosthesis).
Aztreonam Farmalogica description
A monocyclic beta-lactam antibiotic originally isolated from Chromobacterium violaceum. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms. [PubChem]
Aztreonam Farmalogica dosage
Aztreonam Farmalogica Dosage
Generic name: Aztreonam Farmalogica 1g
Dosage form: injection, powder, for solution
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Dosage in Adult Patients
Aztreonam Farmalogica may be administered intravenously or by intramuscular injection. Dosage and route of administration should be determined by susceptibility of the causative organisms, severity and site of infection, and the condition of the patient.
Type of Infection | Dose | Frequency (hours) |
---|---|---|
* Maximum recommended dose is 8 g per day. | ||
Urinary tract infections | 500 mg or 1 g | 8 or 12 |
Moderately severe systemic infections | 1 g or 2 g | 8 or 12 |
Severe systemic or life-threatening infections | 2 g | 6 or 8 |
Because of the serious nature of infections due to Pseudomonas aeruginosa, dosage of 2 g every six or eight hours is recommended, at least upon initiation of therapy, in systemic infections caused by this organism.
The intravenous route is recommended for patients requiring single doses greater than 1 g or those with bacterial septicemia, localized parenchymal abscess (eg, intra-abdominal abscess), peritonitis, or other severe systemic or life-threatening infections.
The duration of therapy depends on the severity of infection. Generally, Aztreonam Farmalogica should be continued for at least 48 hours after the patient becomes asymptomatic or evidence of bacterial eradication has been obtained. Persistent infections may require treatment for several weeks. Doses smaller than those indicated should not be used.
Renal Impairment in Adult Patients
Prolonged serum levels of Aztreonam Farmalogica may occur in patients with transient or persistent renal insufficiency. Therefore, the dosage of Aztreonam Farmalogica should be halved in patients with estimated creatinine clearances between 10 and 30 mL/min/1.73 m2 after an initial loading dose of 1 or 2 g.
When only the serum creatinine concentration is available, the following formula (based on sex, weight, and age of the patient) may be used to approximate the creatinine clearance (Clcr). The serum creatinine should represent a steady state of renal function.
weight (kg) × (140−age)
Males: Clcr = ———————————————
72 × serum creatinine (mg/dL)
Females: 0.85 × above value
In patients with severe renal failure (creatinine clearance less than 10 mL/min/1.73 m2), such as those supported by hemodialysis, the usual dose of 500 mg, 1 g, or 2 g should be given initially. The maintenance dose should be one-fourth of the usual initial dose given at the usual fixed interval of 6, 8, or 12 hours. For serious or life-threatening infections, in addition to the maintenance doses, one-eighth of the initial dose should be given after each hemodialysis session.
Dosage in the Elderly
Renal status is a major determinant of dosage in the elderly; these patients in particular may have diminished renal function. Serum creatinine may not be an accurate determinant of renal status. Therefore, as with all antibiotics eliminated by the kidneys, estimates of creatinine clearance should be obtained and appropriate dosage modifications made if necessary.
Dosage in Pediatric Patients
Aztreonam Farmalogica should be administered intravenously to pediatric patients with normal renal function. There are insufficient data regarding intramuscular administration to pediatric patients or dosing in pediatric patients with renal impairment.
Type of Infection | Dose | Frequency (hours) |
---|---|---|
* Maximum recommended dose is 120 mg/kg/day. | ||
Mild to moderate infections | 30 mg/kg | 8 |
Moderate to severe infections | 30 mg/kg | 6 or 8 |
CLINICAL STUDIES
A total of 612 pediatric patients aged 1 month to 12 years were enrolled in uncontrolled clinical trials of Aztreonam Farmalogica in the treatment of serious Gram-negative infections, including urinary tract, lower respiratory tract, skin and skin-structure, and intra-abdominal infections.
Preparation of
Parenteral Solutions
General
Upon the addition of the diluent to the container, contents should be shaken immediately and vigorously. Constituted solutions are not for multiple-dose use; should the entire volume in the container not be used for a single dose, the unused solution must be discarded.
Depending upon the concentration of Aztreonam Farmalogica and diluent used, constituted Aztreonam Farmalogica yields a colorless to light straw yellow solution which may develop a slight pink tint on standing (potency is not affected).
Parenteral drug products should be inspected visually for particulate matter and discoloration whenever solution and container permit.
Admixtures with Other Antibiotics
Intravenous infusion solutions of Aztreonam Farmalogica not exceeding 2% w/v prepared with Sodium Chloride Injection, USP 0.9% or Dextrose Injection, USP 5%, to which clindamycin phosphate, gentamicin sulfate, tobramycin sulfate, or cefazolin sodium have been added at concentrations usually used clinically, are stable for up to 48 hours at room temperature or 7 days under refrigeration. Ampicillin sodium admixtures with Aztreonam Farmalogica in Sodium Chloride Injection, USP 0.9% are stable for 24 hours at room temperature and 48 hours under refrigeration; stability in Dextrose Injection, USP 5% is 2 hours at room temperature and 8 hours under refrigeration.
Aztreonam Farmalogica-cloxacillin sodium and Aztreonam Farmalogica-vancomycin hydrochloride admixtures are stable in Dianeal 137 (Peritoneal Dialysis Solution) with 4.25% Dextrose for up to 24 hours at room temperature.
Aztreonam Farmalogica is incompatible with nafcillin sodium, cephradine, and metronidazole.
Other admixtures are not recommended since compatibility data are not available.
Intravenous Solutions
For Bolus Injection: The contents of an Aztreonam Farmalogica 15 mL capacity vial should be constituted with 6 to 10 mL Sterile Water for Injection, USP.
For Infusion: If the contents of a 15 mL capacity vial are to be transferred to an appropriate infusion solution, each gram of Aztreonam Farmalogica should be initially constituted with at least 3 mL Sterile Water for Injection, USP. Further dilution may be obtained with one of the following intravenous infusion solutions:
- Sodium Chloride Injection, USP, 0.9%
- Ringer’s Injection, USP
- Lactated Ringer’s Injection, USP
- Dextrose Injection, USP, 5% or 10%
- Dextrose and Sodium Chloride Injection, USP, 5%:0.9%, 5%:0.45%, or 5%:0.2%
- Sodium Lactate Injection, USP (M/6 Sodium Lactate)
- Ionosol® B and 5% Dextrose
- Isolyte® E
- Isolyte® E with 5% Dextrose
- Isolyte® M with 5% Dextrose
- Normosol®-R
- Normosol®-R and 5% Dextrose
- Normosol®-M and 5% Dextrose
- Mannitol Injection, USP, 5% or 10%
- Lactated Ringer’s and 5% Dextrose Injection
- Plasma-Lyte M and 5% Dextrose
Intramuscular Solutions
The contents of an Aztreonam Farmalogica 15 mL capacity vial should be constituted with at least 3 mL of an appropriate diluent per gram Aztreonam Farmalogica. The following diluents may be used:
- Sterile Water for Injection, USP
- Sterile Bacteriostatic Water for Injection, USP (with benzyl alcohol or with methyl- and propylparabens)
- Sodium Chloride Injection, USP, 0.9%
- Bacteriostatic Sodium Chloride Injection, USP (with benzyl alcohol)
Stability of
Intravenous and
Intramuscular Solutions
Aztreonam Farmalogica solutions for intravenous infusion at concentrations not exceeding 2% w/v must be used within 48 hours following constitution if kept at controlled room temperature (59°F-86°F/15°C-30°C) or within 7 days if refrigerated (36°F-46°F/2°C-8°C).
Aztreonam Farmalogica solutions at concentrations exceeding 2% w/v, except those prepared with Sterile Water for Injection, USP or Sodium Chloride Injection, USP, should be used promptly after preparation; the 2 excepted solutions must be used within 48 hours if stored at controlled room temperature or within 7 days if refrigerated.
Intravenous Administration
Bolus Injection: A bolus injection may be used to initiate therapy. The dose should be slowly injected directly into a vein, or the tubing of a suitable administration set, over a period of 3 to 5 minutes.
Infusion: With any intermittent infusion of Aztreonam Farmalogica and another drug with which it is not pharmaceutically compatible, the common delivery tube should be flushed before and after delivery of Aztreonam Farmalogica with any appropriate infusion solution compatible with both drug solutions; the drugs should not be delivered simultaneously. Any Aztreonam Farmalogica infusion should be completed within a 20- to 60-minute period. With use of a Y-type administration set, careful attention should be given to the calculated volume of Aztreonam Farmalogica solution required so that the entire dose will be infused. A volume control administration set may be used to deliver an initial dilution of Aztreonam Farmalogica into a compatible infusion solution during administration; in this case, the final dilution of Aztreonam Farmalogica should provide a concentration not exceeding 2% w/v.
Intramuscular Administration
The dose should be given by deep injection into a large muscle mass (such as the upper outer quadrant of the gluteus maximus or lateral part of the thigh). Aztreonam Farmalogica is well tolerated and should not be admixed with any local anesthetic agent.
More about Aztreonam Farmalogica (Aztreonam Farmalogica)
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Consumer resources
- Aztreonam Farmalogica
- Aztreonam Farmalogica injection
- Aztreonam Farmalogica (Advanced Reading)
- Other brands: Cayston
Professional resources
- Aztreonam Farmalogica (AHFS Monograph)
- Aztreonam Farmalogica (FDA)
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Aztreonam Farmalogica interactions
See also:
What other drugs will affect Aztreonam Farmalogica?
Your healthcare professionals (e.g., doctor or pharmacist) may already be aware of any possible drug interactions and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first. Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: cefoxitin, imipenem, live bacterial vaccines. Aztreonam Farmalogica may cause false positive results with some diabetic urine testing products (cupric sulfate-type). Consult your doctor or pharmacist for recommendations. Make sure laboratory personnel and your doctors know you use this drug.
Aztreonam Farmalogica side effects
See also:
What are the possible side effects of Aztreonam Farmalogica?
Applies to Aztreonam Farmalogica: inhalation powder for solution
Other dosage forms:
- powder for solution, solution
In addition to its needed effects, some unwanted effects may be caused by Aztreonam Farmalogica (the active ingredient contained in Aztreonam Farmalogica). In the event that any of these side effects do occur, they may require medical attention.
Major Side Effects
You should check with your doctor immediately if any of these side effects occur when taking Aztreonam Farmalogica:
More common:
- Chest discomfort
- cough
- difficulty with breathing or troubled breathing
- fever
- Noisy breathing
- shortness of breath
- tightness in the chest
Minor Side Effects
Some of the side effects that can occur with Aztreonam Farmalogica may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:
More common:
- Abdominal or stomach pain
- sore throat
- stuffy nose
- vomiting
- Rash
Aztreonam Farmalogica contraindications
See also:
What is the most important information I should know about Aztreonam Farmalogica?
You should not use this medication if you are allergic to Aztreonam Farmalogica or to a penicillin antibiotic such as amoxicillin (Amoxil, Augmentin), ampicillin (Omnipen, Principen), penicillin (Beepen-VK, Ledercillin VK, Pen-V, Pen-Vee K, Pfizerpen, V-Cillin K, Veetids), and others.
Before using Aztreonam Farmalogica, tell your doctor if you are allergic to cephalosporins such as Ceftin, Cefzil, Keflex, Omnicef, and others, or if you have liver or kidney disease, or a history of any type of allergy.
Use this medication for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Aztreonam Farmalogica will not treat a viral infection such as the common cold or flu.
Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking Aztreonam Farmalogica and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.
Active ingredient matches for Aztreonam Farmalogica:
Aztreonam in Colombia.
List of Aztreonam Farmalogica substitutes (brand and generic names) | Sort by popularity |
Unit description / dosage (Manufacturer) | Price, USD |
Aztreonam Vitalis (Colombia, Guatemala, Nicaragua) | |
Aztreotic (Greece) | |
AZTRONE | |
AZTRONE 1GM INJECTION 1 vial / 1 injection each (Neon Laboratories Ltd) | $ 5.65 |
AZTRONE 2GM INJECTION 1 vial / 1 injection each (Neon Laboratories Ltd) | $ 10.41 |
AZTRONE 500MG INJECTION 1 vial / 1 injection each (Neon Laboratories Ltd) | $ 3.34 |
Aztrone 2gm Injection (Neon Laboratories Ltd) | $ 10.41 |
Aztrone 500mg Injection (Neon Laboratories Ltd) | $ 3.34 |
Bencipen (Peru) | |
Cayston 75mg (Austria, Germany, Switzerland) | |
Cayston inhalation | |
Corus 1020 | |
Dynabiotic | |
FRIXA | |
FRIXA 0.5MG INJECTION 1 vial / 1 injection each (Gold Line) | $ 2.41 |
FRIXA 1GM INJECTION 1 vial / 1 injection each (Gold Line) | $ 6.27 |
Frixa 1gm Injection (Gold Line) | $ 6.27 |
Monobactam | |
Namy (India) | |
Namy 1g POWD / 1 (Alna (H&I)) | $ 9.04 |
NISTREO (India) | |
Primbactam (Italy) | |
PROAZ (India) | |
Qualitreo (India) | |
Qualitreo 1g VIAL / 1 (Qualitron (Neiss Labs Pvt Ltd)) | $ 7.59 |
1 g x 1's (Qualitron (Neiss Labs Pvt Ltd)) | $ 7.59 |
Qualitreo 1000 mg Injection (Qualitron (Neiss Labs Pvt Ltd)) | $ 7.59 |
REONAM | |
REONAM 1GM INJECTION 1 vial / 1 injection each (Unimark Remedies Ltd) | $ 5.10 |
REONAM 2GM INJECTION 1 vial / 1 injection each (Unimark Remedies Ltd) | $ 9.73 |
Reonam 2gm Injection (Unimark Remedies Ltd) | $ 9.73 |
Rez (India) | |
Rez 1g POWD / 1 (Rezicure) | |
Treonam (Peru) | |
Treonam 1g VIAL / 1 (Aurobindo) | |
1 g x 1's (Aurobindo) | |
TREONAM 1GM INJECTION 1 vial / 1 injection each (Aurobindo) | $ 5.34 |
TREONAM 500MG INJECTION 1 vial / 1 injection each (Aurobindo) | $ 3.23 |
Treonam 1000mg Injection (Aurobindo) | $ 5.34 |
Treonam 500mg Injection (Aurobindo) | $ 3.23 |
Trezam (India) | |
Trezam 1gm VIAL / 1 (Majesta (Glenmark Pharmaceuticals Ltd.)) | $ 5.42 |
Trezam 2gm VIAL / 1 (Majesta (Glenmark Pharmaceuticals Ltd.)) | $ 10.24 |
Trezam 500mg VIAL / 1 (Majesta (Glenmark Pharmaceuticals Ltd.)) | $ 3.47 |
1 g x 1's (Majesta (Glenmark Pharmaceuticals Ltd.)) | $ 5.42 |
2 g x 1's (Majesta (Glenmark Pharmaceuticals Ltd.)) | $ 10.24 |
500 mg x 1's (Majesta (Glenmark Pharmaceuticals Ltd.)) | $ 3.47 |
Trezam 500 mg Injection (Majesta (Glenmark Pharmaceuticals Ltd.)) | $ 3.47 |
Trezam 1000 mg Injection (Majesta (Glenmark Pharmaceuticals Ltd.)) | $ 5.42 |
Trezam 2000 mg Injection (Majesta (Glenmark Pharmaceuticals Ltd.)) | $ 10.24 |
See 164 substitutes for Aztreonam Farmalogica |
References
- DailyMed. "AZTREONAM: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
- PubChem. "aztreonam". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
- DrugBank. "aztreonam". http://www.drugbank.ca/drugs/DB00355 (accessed September 17, 2018).
Reviews
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Information checked by Dr. Sachin Kumar, MD Pharmacology