Bactoprim Combi Uses

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Bactoprim Combi indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Infectious-inflammatory diseases caused by sensitive to Bactoprim Combi microorganisms: respiratory tract infections (including acute and chronic bronchitis, empyema, bronchiectasis, lung abscess, pneumonia, tonsillitis, pharyngitis); urinary tract infections (including gonococcal urethritis), cystitis, pyelonephritis, prostatitis; gastrointestinal infections (including enteritis, typhoid, paratyphoid, dysentery, cholecystitis, cholangitis); infections of skin and soft tissue (including pyoderma, furunculosis, wound infection), septicemia, brucellosis.

Bactoprim Combi dosage

Individual. Doses of Bactoprim Combi are given on the basis of Sulfamethoxazole (Bactoprim Combi). For oral administration for adults and children older than 12 years the average dose is 0.4-2 g every 12 hours (2 times / day), course of treatment - 5-14 days.

Orally for children aged 2-5 months - 100 mg 2 times / day; 1-2 years - 100 mg 2 times / day; 3-6 years - 200 mg 2 times / day; 6-12 years at 200-400 mg 2 times / day.

Parenterally administered only in the absence of the possibility of oral administration. IM for adults and children over 12 years - 800 mg every 12 hours; for children aged 6-12 years - 30 mg / kg / day, interval between each dose - 12 hours.

If necessary prescribed IV as drops at 0.8-1.6 g every 12 hours (2 times / day) within 5 days. For children aged 6-12 years are prescribed at 15 mg / kg every 12 hours. Average duration of Bactoprim Combi injection - 30-60 minutes but no more than 1.5 hours. The course of treatment is average 5 days, then if necessary go to oral administration. The maximum oral daily dose for adults is 3.6 g.

Bactoprim Combi interactions

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With the simultaneous application of Bactoprim Combi effect of anticoagulants of indirect action is greatly enhanced due to slow inactivation of the latter, as well as their release from binding with plasma proteins.

In an application with some sulfonylureas may increase hypoglycemic effect which is associated with an increased concentration of free fraction of Bactoprim Combi.

The simultaneous use of Bactoprim Combi and methotrexate may increase the toxicity of the latter (in particular to the appearance of pancytopenia) due to its release from binding to plasma proteins.

Influenced butadion, indomethacin, naproxen, salicylates and other NSAIDs may increase the action Bactoprim Combi with the development of undesirable effects, since there release of active substances from binding with blood proteins and increase their concentration.

Simultaneous treatment with diuretics and Bactoprim Combi increases the risk of thrombocytopenia caused by the latter especially in elderly patients.

In the case of co-administration chloridine with Bactoprim Combi antimicrobial effect is enhanced because chloridine inhibits the formation of tetrahydrofolic acid required for the synthesis of nucleic acids and proteins. In turn sulfonamides inhibit the formation of dihydrofolic acid, a precursor of tetrahydrofolic acid. This combination is widely used in the treatment of toxoplasmosis.

Absorption of Sulfamethoxazole (Bactoprim Combi) and trimethoprim at their joint reception with cholestyramine decreases the formation of insoluble complexes, which leads to a decrease in their concentration in the blood.

Bactoprim Combi side effects

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Digestive system: nausea, vomiting, diarrhea, glossitis, pseudomembranous colitis, cholestatic hepatitis.

Allergic reactions: skin rash, angioedema, Stevens-Johnson syndrome, Lyell's syndrome.

Hemopoietic system: leukopenia, neutropenia, thrombocytopenia, agranulocytosis, megaloblastic anemia.

Urinary system: crystalluria, hematuria, interstitial nephritis.

Local reactions: phlebitis (when IV injected).

Other: purpura, impaired thyroid function.

Bactoprim Combi contraindications

Expressed disorders of liver and kidney function, blood diseases, deficiency of glucose-6-phosphate dehydrogenase, pregnancy, lactation (breastfeeding), hypersensitivity to sulfonamides and trimethoprim.

Active ingredient matches for Bactoprim Combi:

Co-trimoxazole: Trimethoprim/sulfamethoxazole in Indonesia.

Co-trimoxazole in Indonesia.


Unit description / dosage (Manufacturer)Price, USD
Bactoprim Combi 10 x 10's$ 4.03
Bactoprim Combi 50 mL$ 0.81
Bactoprim Combi Forte 10 x 10's$ 7.25

List of Bactoprim Combi substitutes (brand and generic names):

Tablet; Oral; Sulfamethoxazole 800 mg; Trimethoprim 160 mg (Universal Drug House Pvt Ltd)
Suspension; Oral; Sulfamethoxazole 200 mg; Trimethoprim 40 mg / 5 ml (Universal Drug House Pvt Ltd)
Tablet; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg (Universal Drug House Pvt Ltd)
500's (Universal Drug House Pvt Ltd)$ 10.71
Tablets; Oral; Sulfamethoxazole 800 mg; Trimethoprim 160 mg (Universal Drug House Pvt Ltd)
Tablets; Oral; Sulfamethoxazole 400 mg; Trimethoprim 80 mg (Universal Drug House Pvt Ltd)
Cotrimoxazole Sulphamethoxazole 800 mg, Trimethoprim 160 mg. TAB / 500 (Universal Drug House Pvt Ltd)$ 10.71
Cotrimoxazole 400+80 Tablet (Universal Drug House Pvt Ltd)$ 0.01
Cotrimoxazole 50 ml Syrup (Universal Drug House Pvt Ltd)$ 0.02
COTRIMOXAZOLE 800MG/160MG TABLET 1 strip / 10 tablets each (Universal Drug House Pvt Ltd)$ 0.23
COTRIMOXAZOLE / CLARIS tab 10's (Universal Drug House Pvt Ltd)$ 0.21
Cotrimoxazole Tablet (Universal Drug House Pvt Ltd)$ 0.02
COTRIMOXAZOLE 160MG TABLET 1 strip / 10 tablets each (Cadila Pharmaceuticals Ltd)$ 0.18
Lykaprime-DS 10 Blister x 10 Tablet
Mano-Trim cap 500's (Lam Thong)
Mano-Trim Forte tab 1000's (Lam Thong)
Mano-Trim tab 1000's (Lam Thong)
Metrim syr 60 mL x 1's (Siam Bheasach)
Metrim tab 500's (Siam Bheasach)
Metrim-F tab 500's (Siam Bheasach)

References

  1. DailyMed. "SULFAMETHOXAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "sulfamethoxazole". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "sulfamethoxazole". http://www.drugbank.ca/drugs/DB01015 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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