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• Dosage of Beclometasone Topical in details
• Beclometasone Topical interactions
• Dosage of Clotrimazole Topical in details
• Clotrimazole Topical interactions
• Dosage of Neomycin Topical in details
• Neomycin Topical interactions
• Beclometasone Topical/Clotrimazole Topical/Neomycin Topical reviews

Consists of Beclometasone Topical, Clotrimazole Topical, Neomycin Topical

Dosage of Beclometasone Topical in details

Management of Chronic Asthma: Adults and Children >12 years: 100-400 mcg twice daily. Maximum: 1000 mcg twice daily.

Children (5-12 years): 100-200 mcg twice daily. Maximum: 200-400 mcg twice daily.

Prophylaxis of Asthma: Adults and Children >12 years: 50-200 mcg twice daily. Increase if necessary to maximum 400 mcg twice daily.

Children (5-12 years): The usual starting dose is 100 mcg twice daily. Depending on the severity of asthma, the daily dose may be increased up to 400 mcg administered in 2-4 divided doses.

When patient's symptoms remain under satisfactory control, the dose should be titrated to the lowest dose at which effective control of asthma is maintained.

Therapy in New Patients: Mild Asthma: 50-100 mcg twice daily.

Moderate Asthma: 100-200 mcg twice daily.

Severe Asthma: 200-400 mcg twice daily.

When switching a patient with well-controlled asthma from another corticosteroid inhaler, initially Beclometasone Topical 100 mcg puff should be prescribed for beclometasone dipropionate (CFC) or budesonide 200-250 mcg; fluticasone propionate 100 mcg.

When switching a patient with poorly-controlled asthma from another corticosteroid inhaler, initially Beclometasone Topical 100 mcg puff should be prescribed for beclometasone dipropionate (CFC) or budesonide or fluticasone propionate 100 mcg. The dose of Beclometasone Topical should be adjusted to response.

Use in the elderly or patients with hepatic or renal impairment: There are no special dosage recommendations for use in the elderly or in patients with hepatic or renal impairment.

What other drugs will affect Beclometasone Topical?

There may be other drugs that can interact with beclomethasone. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Beclometasone Topical interactions

Due to the very low plasma concentration achieved after inhaled dosing, clinically significant drug interactions are in general unlikely. Care should be taken when co-administering with known strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, nelfinavir, ritonavir) as there is a potential for increased systemic exposure to beclometasone.

Dosage of Clotrimazole Topical in details

Usual Adult Dose for Tinea Corporis:

Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Tinea Cruris:

Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Tinea Pedis:

Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 to 8 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Cutaneous Candidiasis:

Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Tinea Versicolor:

Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Vaginal Candidiasis:

Regimen 1: 100 mg (one 100 mg vaginal suppository) intravaginally once a day for 7 consecutive days alone or in combination with topical application of 1% clotrimazole cream to affected area two times daily for 7 consecutive days.

Regimen 2: 200 mg (one 200 mg vaginal suppository) intravaginally once a day for 3 consecutive days alone or in combination with topical application of 1% clotrimazole cream to affected area two times daily for 7 consecutive days.

Regimen 3: 500 mg (one 500 mg vaginal suppository) intravaginally once.

Regimen 4: One applicatorful of 1% clotrimazole vaginal cream intravaginally once daily (preferably at bedtime) for 7 consecutive days.

Regimen 5: One applicatorful of 2% clotrimazole vaginal cream intravaginally once daily (preferably at bedtime) for 3 consecutive days.

Studies have shown the three and seven day courses of clotrimazole to be equally effective. Patient compliance may be increased with a three day course. Patients who fail to achieve a cure with a single 500 mg dose should be treated with a 3 or 7 day course of clotrimazole.

Weekly or monthly clotrimazole vaginal suppositories appear to be effective topical regimens for chronic suppressive therapy in female patients with HIV.

Usual Pediatric Dose for Tinea Corporis:

> 3 years: Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Tinea Cruris:

> 3 years: Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Tinea Pedis:

> 3 years: Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 4 to 8 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Cutaneous Candidiasis:

> 3 years: Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Tinea Versicolor:

> 3 years: Apply clotrimazole topical in a quantity sufficient to cover the affected area and immediately surrounding skin twice a day for 2 to 4 weeks, depending on the nature and severity of the infection.

Usual Pediatric Dose for Vaginal Candidiasis:

> 12 years: Regimen 1: 100 mg (one 100 mg vaginal suppository) intravaginally once a day for 7 consecutive days alone or in combination with topical application of 1% clotrimazole cream to affected area two times daily for 7 consecutive days.

Regimen 2: 200 mg (one 200 mg vaginal suppository) intravaginally once a day for 3 consecutive days alone or in combination with topical application of 1% clotrimazole cream to affected area two times daily for 7 consecutive days.

Regimen 3: 500 mg (one 500 mg vaginal suppository) intravaginally once.

Regimen 4: One applicatorful of 1% clotrimazole vaginal cream intravaginally once daily (preferably at bedtime) for 7 consecutive days.

Studies have shown the three and seven day courses of clotrimazole to be equally effective. Patient compliance may be increased with a three day course. Patients who fail to achieve a cure with a single 500 mg dose should be treated with a 3 or 7 day course of clotrimazole.

Weekly or monthly clotrimazole vaginal suppositories appear to be effective topical regimens for chronic suppressive therapy in female patients with HIV.

What other drugs will affect Clotrimazole Topical?

It is not likely that other drugs you take orally or inject will have an effect on topically applied clotrimazole. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Clotrimazole Topical interactions

Simultaneous administration of Clotrimazole Topical with amphotericin B, nystatin, natamycin activity of clotrimazole decreases.

Dosage of Neomycin Topical in details

Neomycin Topical Dosage

Applies to the following strength(s): 125 mg/5 mL; 500 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

• Bowel Preparation
• Hepatic Encephalopathy
• Hepatic Coma
• Diarrhea

Usual Pediatric Dose for:

• Bowel Preparation
• Hepatic Encephalopathy
• Hepatic Coma
• Diarrhea

Additional dosage information:

• Renal Dose Adjustments
• Liver Dose Adjustments
• Dose Adjustments
• Precautions
• Dialysis

Usual Adult Dose for Bowel Preparation

1 g orally every hour for 4 doses followed by 1 g every 4 hours for 5 doses

Alternate dosing: 6 g/day orally divided every 4 hours for 2 to 3 days

Usual Adult Dose for Hepatic Encephalopathy

4 to 12 g/day orally divided every 4 to 6 hours for 5 to 6 days

Usual Adult Dose for Hepatic Coma

4 to 12 g/day orally divided every 4 to 6 hours for 5 to 6 days

Usual Adult Dose for Diarrhea

3 g/day orally in 4 divided doses

Usual Pediatric Dose for Bowel Preparation

The safety and efficacy of Neomycin Topical in children less than 18 years of age has not been established. However, the use of Neomycin Topical may be appropriate is some situations.

Less than 1 month: 50 mg/kg/day orally divided every 6 hours

1 year to 18 years: 50 to 100 mg/kg/day orally divided every 6 hours

Usual Pediatric Dose for Hepatic Encephalopathy

The safety and efficacy of Neomycin Topical in children less than 18 years of age has not been established. However, the use of Neomycin Topical may be appropriate is some situations.

1 month to 18 years: 50 to 100 mg/kg/day orally divided every 6 to 8 hours for 5 to 6 days

Usual Pediatric Dose for Hepatic Coma

The safety and efficacy of Neomycin Topical in children less than 18 years of age has not been established. However, the use of Neomycin Topical may be appropriate is some situations.

1 month to 18 years: 50 to 100 mg/kg/day orally divided every 6 to 8 hours for 5 to 6 days

Usual Pediatric Dose for Diarrhea

The safety and efficacy of Neomycin Topical in children less than 18 years of age has not been established. However, the use of Neomycin Topical may be appropriate is some situations.

Less than 1 month: 50 mg/kg/day orally divided every 6 hours

1 year to 18 years: 50 mg/kg/day orally divided every 6 hours for 2 to 3 days

Renal Dose Adjustments

Patients with impaired renal function have a high risk of developing nephrotoxicity and ototoxicity with oral Neomycin Topical. Use of a less nephrotoxic medication may be a consideration for this patient.

Liver Dose Adjustments

In chronic hepatic insufficiency, it may be necessary to give Neomycin Topical sulfate 4 g daily for an indefinite period, if less toxic drugs cannot be used.

Dose Adjustments

Caution should be used when administering Neomycin Topical to patients with renal impairment. Dose reduction should be considered in these patients.

Precautions

To minimize the risk of toxicity use the lowest possible dose and the shortest possible treatment period to control the condition. Treatment periods of longer than 2 weeks are not recommended.

Do not use in patients with intestinal obstruction.

Do not use in patients with inflammatory or ulcerative gastrointestinal disease due to the potential for increased gastrointestinal absorption of the drug.

Patients should be monitored for nephrotoxicity and ototoxicity.

Neomycin Topical should be used with caution in patients with hearing impairment, renal impairment or neuromuscular disorders.

Dialysis

Patients with impaired renal function have a high risk of developing nephrotoxicity and ototoxicity with oral Neomycin Topical. Use of a less nephrotoxic medication may be a consideration for this patient.

More about Neomycin Topical

• Side Effects
• During Pregnancy or Breastfeeding
• Dosage Information
• Drug Images
• Drug Interactions
• Support Group
• En Espanol
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Consumer resources

• Neomycin Topical
• Neomycin Topical solution
• Neomycin Topical (Advanced Reading)

• Other brands: Neo-Tab, Neo-Fradin

Professional resources

• Neomycin Topical Sulfate (AHFS Monograph)
• More (2) »

Related treatment guides

• Bowel Preparation
• Diarrhea
• Hepatic Coma
• Hepatic Encephalopathy

What other drugs will affect Neomycin Topical?

Neomycin Topical can harm your kidneys, and this effect is increased when you also use certain other medicines harmful to the kidneys. Before using Neomycin Topical, tell your doctor about all other medicines you use. Many other drugs (including some over-the-counter medicines) can be harmful to the kidneys.

Before you take Neomycin Topical, tell your doctor if you are using any other antibiotics, such as

• amikacin (Amikin)

• amphotericin-B (Amphotec);

• bacitracin (Baci IM);

• colistimethate (Coly Mycin M);

• gentamicin (Garamycin);

• kanamycin (Kantrex);

• paromomycin (Humatin, Paromycin);

• polymyxin B sulfate;

• penicillin V (PC Pen VK);

• streptomycin;

• tobramycin (Nebcin, Tobi); or

• vancomycin (Vancocin, Vancoled).

Tell your doctor about all other medicines you use, especially:

• cisplatin (Platinol);

• digoxin (digitalis, Lanoxin, Lanoxicaps);

• methotrexate (Rheumatrex, Trexall);

• vitamin B-12;

• antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or tenofovir (Viread);

• a blood thinner such as warfarin (Coumadin, Jantoven);

• a botulism toxin medication (Botox, Dysport, Myobloc, Xeomin, and others); or

• a diuretic (water pill) such as bumetanide (Bumex), ethacrynic acid (Edecrin), furosemide (Lasix), or torsemide (Demadex).

This list is not complete and other drugs may interact with Neomycin Topical. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Neomycin Topical interactions

Caution should be taken in concurrent or serial use of other neurotoxic and/ or nephrotoxic drugs because of possible enhancement of the nephrotoxicity and/or ototoxicity of Neomycin Topical.

Caution should also be taken in concurrent or serial use of other aminoglycosides and polymyxins because they may enhance Neomycin Topicalís nephrotoxicity and/or ototoxicity and potentiate Neomycin Topical sulfateís neuromuscular blocking effects.

Oral Neomycin Topical inhibits the gastrointestinal absorption of penicillin V, oral vitamin B-12, methotrexate and 5-fluorouracil. The gastrointestinal absorption of digoxin also appears to be inhibited. Therefore, digoxin serum levels should be monitored.

Oral Neomycin Topical sulfate may enhance the effect of coumarin in anticoagulants by decreasing vitamin K availability.

References

1. DailyMed. "HYDROCORTISONE; NEOMYCIN SULFATE; POLYMYXIN B SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
2. DailyMed. "BETAMETHASONE DIPROPIONATE; CLOTRIMAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
3. FDA/SPL Indexing Data. "G07GZ97H65: The UNique Ingredient Identifier (UNII) is an alphanumeric substance identifier from the joint FDA/USP Substance Registration System (SRS).". https://www.fda.gov/ForIndustry/Data... (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology