Betamethasone Dipropionate Uses

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What is Betamethasone Dipropionate?

Betamethasone Dipropionate topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. Betamethasone Dipropionate is a corticosteroid (cortisone-like medicine or steroid).

Betamethasone Dipropionate is available only with your doctor's prescription.

Betamethasone Dipropionate indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Betamethasone Dipropionate gel (augmented) is a super-high potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Treatment beyond two consecutive weeks is not recommended, and the total dose should not exceed 50 g per week because of potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis.

This product is not recommended for use in pediatric patients under 12 years of age.

How should I use Betamethasone Dipropionate?

Use Betamethasone Dipropionate lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Betamethasone Dipropionate lotion.

Uses of Betamethasone Dipropionate in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use: Labeled Indications


Allergic states: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions

Dermatologic diseases: Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome)

Endocrine disorders: Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Note: Hydrocortisone or cortisone is the drug of choice in primary or secondary adrenocortical insufficiency. Synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance

Gastrointestinal diseases: During acute episodes in regional enteritis and ulcerative colitis

Hematologic disorders: Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia

Neoplastic diseases: Palliative management of leukemias and lymphomas

Nervous system: Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy. Note: Treatment guidelines recommend the use of high-dose IV or oral methylprednisolone for acute exacerbations of multiple sclerosis (AAN [Scott 2011]; NICE 2014).

Ophthalmic diseases:

Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids

Renal diseases: To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus

Respiratory diseases: Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis

Rheumatic disorders: Adjunctive therapy for short-term administration in acute gout flares; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus.

Miscellaneous: Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy

Intra-articular or soft tissue administration:

Adjunctive therapy for short-term administration in acute gout flares, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, synovitis of osteoarthritis


Treatment of alopecia areata; discoid lupus erythematosus; keloids; localized hypertrophic, infiltrated, inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus (neurodermatitis), and psoriatic plaques; necrobiosis lipoidica diabeticorum

Off Label Uses

Accelerate fetal lung maturation

According to systematic reviews of randomized controlled trials using Betamethasone Dipropionate or dexamethasone, evidence supports the use of a single course of antenatal corticosteroids to accelerate fetal lung maturation in women at risk for preterm delivery, with no clear advantages found regarding use of one corticosteroid over another.

Betamethasone Dipropionate description


Each gram of Betamethasone Dipropionate (Betamethasone Dipropionate*) Cream* contains: 640 mcg Betamethasone Dipropionate (equivalent to 500 mcg Betamethasone Dipropionate).

Each gram of Betamethasone Dipropionate (Betamethasone Dipropionate*) Ointment* contains: 640 mcg Betamethasone Dipropionate (equivalent to 500 mcg Betamethasone Dipropionate).

Betamethasone Dipropionate (Betamethasone Dipropionate*) Cream and Ointment contain Betamethasone Dipropionate, a synthetic corticosteroid with anti-inflammatory activity to be administered topically.

Betamethasone Dipropionate is a white to creamy white odorless crystalline powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol. It has a molecular weight of 504.16 and the empirical formula C28H37FO7; a chemical name of 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,17,21-dipropionate.

Betamethasone Dipropionate dosage

Apply a thin film of Betamethasone Dipropionate cream, 0.5% (augmented) to the affected skin areas once or twice daily. Therapy should be discontinued when control is achieved. Betamethasone Dipropionate cream, 0.5% (augmented)is a high-potency corticosteroid. Treatment with Betamethasone Dipropionate cream, 0.5% (augmented)should not exceed 50 g per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis.

Betamethasone Dipropionate cream, 0.5% (augmented)should not be used with occlusive dressings unless directed by a physician.

Betamethasone Dipropionate cream, 0.5% (augmented)is for topical use only. It is not for oral, ophthalmic, or intravaginal use.

Avoid use on the face, groin, or axillae, or if skin atrophy is present at the treatment site.

Betamethasone Dipropionate interactions

See also:
What other drugs will affect Betamethasone Dipropionate?


There are no known drug interactions with topical Betamethasone Dipropionate.

Betamethasone Dipropionate side effects

See also:
What are the possible side effects of Betamethasone Dipropionate?

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In controlled clinical trials, involving 242 adult subjects, the adverse reaction associated with the use of Betamethasone Dipropionate cream, 0.5% (augmented)reported at a frequency of 0.4% was stinging. It occurred in 1 subject.

In a controlled clinical trial involving 67 pediatric subjects from 3 months to 12 years of age, the adverse reactions associated with the use of Betamethasone Dipropionate cream, 0.5% (augmented)occurred in 7 of 67 (10%) subjects. Reported reactions included signs of skin atrophy (telangiectasia, bruising, shininess).

Postmarketing Experience

Because adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Postmarketing reports for local adverse reactions to topical corticosteroids may also include: burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, hypertrichosis, skin atrophy, striae, and miliaria.

Hypersensitivity reactions, consisting of predominantly skin signs and symptoms, e.g., contact dermatitis, pruritus, bullous dermatitis, and erythematous rash have been reported.

Betamethasone Dipropionate contraindications

See also:
What is the most important information I should know about Betamethasone Dipropionate?

Betamethasone Dipropionate cream, 0.5% (augmented)is contraindicated in patients who are hypersensitive to Betamethasone Dipropionate, to other corticosteroids, or to any ingredient in this preparation.

Active ingredient matches for Betamethasone Dipropionate:

Betamethasone Dipropionate

Unit description / dosage (Manufacturer)Price, USD
15 gram in 1 tube
50 gram in 1 tube
Betamethasone Dipropionate ointment .5 mg/g (A S Medication Solutions Llc (US))
Betamethasone Dipropionate cream .5 mg/g (A S Medication Solutions (US))
Betamethasone Dipropionate lotion .5 mg/mL (G&W Laboratories, Inc. (US))
Betamethasone Dipropionate ointment, augmented .5 mg/g (Actavis Mid Atlantic LLC (US))
Betamethasone Dipropionate lotion, augmented .5 mg/mL (Taro Pharmaceuticals U.S.A., Inc. (US))
Betamethasone Dipropionate lotion .5 mg/g (Perrigo New York Inc (US))
Betamethasone Dipropionate cream .64 mg/g (Rebel Distributors Corp. (US))
Betamethasone Dipropionate cream, augmented .5 mg/g (Taro Pharmaceuticals U.S.A., Inc. (US))
Betamethasone Dipropionate gel .5 mg/g (E. Fougera & Co. a division of Fougera Pharmaceuticals Inc. (US))
Betamethasone Dipropionate gel .64 mg/g (Physicians Total Care, Inc. (US))
Betamethasone Dipropionate ointment .05 mg/g (Rebel Distributors Corp. (US))

List of Betamethasone Dipropionate substitutes (brand and generic names):

Betametlife 0.5 mg x 10 Blister x 10 Tablet
BETAMIL Cream/ Gel/ Ointment / 0.05/ % / 10gm units (Merck (India) Ltd (Merck Ltd))$ 0.28
Betamil 0.05% w/w CRM / 10g (Merck (India) Ltd (Merck Ltd))$ 0.28
0.05 % w/w x 10g (Merck (India) Ltd (Merck Ltd))$ 0.28
Betamil Skin 10 gm Cream (Merck (India) Ltd (Merck Ltd))$ 0.18
BETAMIL 0.05% W/W CREAM 1 tube / 20 GM cream each (Merck (India) Ltd (Merck Ltd))$ 0.17
BETAMIL cream 0.05 % w/w x 10g (Merck (India) Ltd (Merck Ltd))$ 0.28
Betamil 0.05% w/w Cream (Merck (India) Ltd (Merck Ltd))$ 0.18
Betamil N Skin 10 gm Cream (Merck (India) Ltd (Merck Ltd))$ 0.29
BETAMIL N 0.05%/0.5% CREAM 1 tube / 20 GM cream each (Merck (India) Ltd (Merck Ltd))$ 0.22
Betamil N 0.05%/5% Cream (Merck (India) Ltd (Merck Ltd))$ 0.24
Betamil-GM Betamethasone dipropionate0.05 % w/w, Gentamicin sulfate0.1 % w/w, Miconazole nitrate2 % w/w. CRM / 10g (Merck)$ 0.31
10g (Merck)$ 0.31
Betamil-GM Betamethasone Dipropionate0.05% w/w, Gentamicin Sulfate0.1% w/w, Miconazole Nitrate2% w/w CRM / 10g (Merck)$ 0.31
BETAMIL-GM cream 20g (Merck)$ 0.22
Betamine Forte 1mg TAB / 10 (Unimarck Pharma (India) Limited)$ 0.14
1 mg x 10's (Unimarck Pharma (India) Limited)$ 0.14
Betamine Forte 1 mg Tablet (Unimarck Pharma (India) Limited)$ 0.01
BETAMINE FORTE tab 1 mg x 10's (Unimarck Pharma (India) Limited)$ 0.14
Betamycin N Skin 20 gm Cream (Modhike Pvt Ltd.)$ 0.27
Betamycin-N Betamethasone 0.1 % w/w, Neomycin sulphate 0.5 % w/w. CRM / 20g (ModHike)$ 0.27
20g (ModHike)$ 0.27
BETAMYCIN-N cream 20g (ModHike)$ 0.27
Betanij 0.5 mg Tablet (Sunij Pharma Pvt Ltd)$ 0.01
BETANIJ 0.5MG TABLET 1 strip / 10 tablets each (Sunij Pharma Pvt Ltd)$ 0.06
Betanij 0.5mg Tablet (Sunij Pharma Pvt Ltd)$ 0.01
Betanin N Eye Drop (Sunways India Pvt. Ltd.)$ 0.04
Betaphos 0.5 mg Tablet (Pharma Synth Formulations Ltd.)$ 0.01
Betapro 0.5 mg/1 g x 1 g (Consern Pharma Pvt Ltd.)
Betapro 0.5 mg/1 g x 5 g (Consern Pharma Pvt Ltd.)
Betapro 0.5 mg/1 g x 10 g (Consern Pharma Pvt Ltd.)
Betapro 0.5 mg/1 g x 450 g (Consern Pharma Pvt Ltd.)


  1. DailyMed. "BETAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "betamethasone". (accessed September 17, 2018).
  3. DrugBank. "betamethasone". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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