Betamethasone Dipropionate Cream Uses

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What is Betamethasone Dipropionate Cream?

Betamethasone Dipropionate Cream topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. Betamethasone Dipropionate Cream is a corticosteroid (cortisone-like medicine or steroid).

Betamethasone Dipropionate Cream is available only with your doctor's prescription.

Betamethasone Dipropionate Cream indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Betamethasone Dipropionate Cream gel (augmented) is a super-high potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Treatment beyond two consecutive weeks is not recommended, and the total dose should not exceed 50 g per week because of potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis.

This product is not recommended for use in pediatric patients under 12 years of age.

How should I use Betamethasone Dipropionate Cream?

Use Betamethasone Dipropionate Cream lotion as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Betamethasone Dipropionate Cream lotion.

Uses of Betamethasone Dipropionate Cream in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Intramuscular:

Allergic states: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions

Dermatologic diseases: Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome)

Endocrine disorders: Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Note: Hydrocortisone or cortisone is the drug of choice in primary or secondary adrenocortical insufficiency. Synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance

Gastrointestinal diseases: During acute episodes in regional enteritis and ulcerative colitis

Hematologic disorders: Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia

Neoplastic diseases: Palliative management of leukemias and lymphomas

Nervous system: Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy. Note: Treatment guidelines recommend the use of high-dose IV or oral methylprednisolone for acute exacerbations of multiple sclerosis (AAN [Scott 2011]; NICE 2014).

Ophthalmic diseases:

Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids

Renal diseases: To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus

Respiratory diseases: Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis

Rheumatic disorders: Adjunctive therapy for short-term administration in acute gout flares; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus.

Miscellaneous: Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy

Intra-articular or soft tissue administration:

Adjunctive therapy for short-term administration in acute gout flares, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, synovitis of osteoarthritis

Intralesional:

Treatment of alopecia areata; discoid lupus erythematosus; keloids; localized hypertrophic, infiltrated, inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus (neurodermatitis), and psoriatic plaques; necrobiosis lipoidica diabeticorum

Off Label Uses

Accelerate fetal lung maturation

According to systematic reviews of randomized controlled trials using Betamethasone Dipropionate Cream or dexamethasone, evidence supports the use of a single course of antenatal corticosteroids to accelerate fetal lung maturation in women at risk for preterm delivery, with no clear advantages found regarding use of one corticosteroid over another.

Betamethasone Dipropionate Cream description

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Each gram of Betamethasone Dipropionate Cream (Betamethasone Dipropionate Cream*) Cream* contains: 640 mcg Betamethasone Dipropionate Cream (equivalent to 500 mcg Betamethasone Dipropionate Cream).

Each gram of Betamethasone Dipropionate Cream (Betamethasone Dipropionate Cream*) Ointment* contains: 640 mcg Betamethasone Dipropionate Cream (equivalent to 500 mcg Betamethasone Dipropionate Cream).

Betamethasone Dipropionate Cream (Betamethasone Dipropionate Cream*) Cream and Ointment contain Betamethasone Dipropionate Cream, a synthetic corticosteroid with anti-inflammatory activity to be administered topically.

Betamethasone Dipropionate Cream is a white to creamy white odorless crystalline powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol. It has a molecular weight of 504.16 and the empirical formula C28H37FO7; a chemical name of 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,17,21-dipropionate.

Betamethasone Dipropionate Cream dosage

Apply a thin film of Betamethasone Dipropionate Cream cream, 0.5% (augmented) to the affected skin areas once or twice daily. Therapy should be discontinued when control is achieved. Betamethasone Dipropionate Cream cream, 0.5% (augmented)is a high-potency corticosteroid. Treatment with Betamethasone Dipropionate Cream cream, 0.5% (augmented)should not exceed 50 g per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis.

Betamethasone Dipropionate Cream cream, 0.5% (augmented)should not be used with occlusive dressings unless directed by a physician.

Betamethasone Dipropionate Cream cream, 0.5% (augmented)is for topical use only. It is not for oral, ophthalmic, or intravaginal use.

Avoid use on the face, groin, or axillae, or if skin atrophy is present at the treatment site.

Betamethasone Dipropionate Cream interactions

See also:
What other drugs will affect Betamethasone Dipropionate Cream?

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There are no known drug interactions with topical Betamethasone Dipropionate Cream.

Betamethasone Dipropionate Cream side effects

See also:
What are the possible side effects of Betamethasone Dipropionate Cream?

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In controlled clinical trials, involving 242 adult subjects, the adverse reaction associated with the use of Betamethasone Dipropionate Cream cream, 0.5% (augmented)reported at a frequency of 0.4% was stinging. It occurred in 1 subject.

In a controlled clinical trial involving 67 pediatric subjects from 3 months to 12 years of age, the adverse reactions associated with the use of Betamethasone Dipropionate Cream cream, 0.5% (augmented)occurred in 7 of 67 (10%) subjects. Reported reactions included signs of skin atrophy (telangiectasia, bruising, shininess).

Postmarketing Experience

Because adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Postmarketing reports for local adverse reactions to topical corticosteroids may also include: burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, hypertrichosis, skin atrophy, striae, and miliaria.

Hypersensitivity reactions, consisting of predominantly skin signs and symptoms, e.g., contact dermatitis, pruritus, bullous dermatitis, and erythematous rash have been reported.

Betamethasone Dipropionate Cream contraindications

See also:
What is the most important information I should know about Betamethasone Dipropionate Cream?

Betamethasone Dipropionate Cream cream, 0.5% (augmented)is contraindicated in patients who are hypersensitive to Betamethasone Dipropionate Cream, to other corticosteroids, or to any ingredient in this preparation.

Active ingredient matches for Betamethasone Dipropionate Cream:

Betamethasone Dipropionate


Unit description / dosage (Manufacturer)Price, USD
15 gram in 1 tube
45 gram in 1 tube

List of Betamethasone Dipropionate Cream substitutes (brand and generic names):

C.G.B. 10 g
Caditrigel 1 tube x 10 g
Demacot 1 tube 10 g
Dermal SA 1 tube 15 g
Diproderma Cream (Universal Twin Labs)$ 0.54
Diprosone-OV 0.05 % x 5 g x 1's (Schering-plough)$ 3.99
Diprosone-OV 0.05 % x 10 g x 1's (Schering-plough)$ 6.42
20g$ 1.43
Ointment; Topical; Betamethasone Dipropionate 0.5 mg; Calcipotriol 50 mcg / g (Formenti)
DR.PI.A.F 1 g
DR.PI.A.F 5 g
DR.PI.A.F 10 g
DR.PI.A.F 16 g
DR.PI.A.F 20 g
DR.PI.A.F 100 g
Forever 1 g
Gentizone 1 tube 10 g
10g (Lupin)$ 0.30
Lupiderm-M Betamethasone dipropionate0.05 % w/w, Miconazole nitrate2 % w/w. T-SOLN / 10g (Lupin)$ 0.30
LUPIDERM-M cream 10g (Lupin)$ 0.30
Lupiderm-M Betamethasone dipropionate0.05 % w/w, Miconazole nitrate2 % w/w. T-SOLN / 10g (Lupin)$ 0.30
Philgenta 1 tube 10 g
15g (Ind-Swift Limited)$ 0.78
5g (Ind-Swift Limited)$ 0.37
Quadrimix Betamethasone dipropionate0.05 % w/w, gentamicinsulphate 0.1 % w/w, tolnaftate1 % w/w, iodochlorhydroxyquinoline 1 %w/w, chlorocresol 0.1 % w/w. CRM / 15g (Ind-Swift Limited)$ 0.78
Quadrimix Betamethasone dipropionate0.05 % w/w, gentamicinsulphate 0.1 % w/w, tolnaftate1 % w/w, iodochlorhydroxyquinoline 1 %w/w, chlorocresol 0.1 % w/w. CRM / 5g (Ind-Swift Limited)$ 0.37
Quadrimix Skin 15 gm Cream (Ind-Swift Limited)$ 0.78
Quadrimix Skin 5 gm Cream (Ind-Swift Limited)$ 0.37
QUADRIMIX cream 15g (Ind-Swift Limited)$ 0.78
QUADRIMIX cream 5g (Ind-Swift Limited)$ 0.37
Quadrimix Betamethasone dipropionate0.05 % w/w, gentamicinsulphate 0.1 % w/w, tolnaftate1 % w/w, iodochlorhydroxyquinoline 1 %w/w, chlorocresol 0.1 % w/w. CRM / 15g (Ind-Swift Limited)$ 0.78
Quadrimix Betamethasone dipropionate0.05 % w/w, gentamicinsulphate 0.1 % w/w, tolnaftate1 % w/w, iodochlorhydroxyquinoline 1 %w/w, chlorocresol 0.1 % w/w. CRM / 5g (Ind-Swift Limited)$ 0.37
Scanderma Plus 10 g x 1's (Tempo scan pacific)$ 2.29
Temprosone 0.05 % x 1 tube 30 g

References

  1. DailyMed. "BETAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubChem. "betamethasone". https://pubchem.ncbi.nlm.nih.gov/com... (accessed September 17, 2018).
  3. DrugBank. "betamethasone". http://www.drugbank.ca/drugs/DB00443 (accessed September 17, 2018).

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Information checked by Dr. Sachin Kumar, MD Pharmacology

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