Betamethasone dipropionate/gentamicin sulfate/miconazole nitrate Uses

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Consists of betamethasone dipropionate, gentamicin sulfate, miconazole nitrate

What is Betamethasone dipropionate?

Betamethasone dipropionate topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. Betamethasone dipropionate dipropionate is a corticosteroid (cortisone-like medicine or steroid).

Betamethasone dipropionate dipropionate is available only with your doctor's prescription.

Betamethasone dipropionate indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Betamethasone dipropionate dipropionate gel (augmented) is a super-high potency corticosteroid indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Treatment beyond two consecutive weeks is not recommended, and the total dose should not exceed 50 g per week because of potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis.

This product is not recommended for use in pediatric patients under 12 years of age.

How should I use Betamethasone dipropionate?

Use Betamethasone dipropionate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Betamethasone dipropionate.

Uses of Betamethasone dipropionate in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Use: Labeled Indications

Intramuscular:

Allergic states: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions

Dermatologic diseases: Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome)

Endocrine disorders: Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Note: Hydrocortisone or cortisone is the drug of choice in primary or secondary adrenocortical insufficiency. Synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance

Gastrointestinal diseases: During acute episodes in regional enteritis and ulcerative colitis

Hematologic disorders: Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia

Neoplastic diseases: Palliative management of leukemias and lymphomas

Nervous system: Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy. Note: Treatment guidelines recommend the use of high-dose IV or oral methylprednisolone for acute exacerbations of multiple sclerosis (AAN [Scott 2011]; NICE 2014).

Ophthalmic diseases:

Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids

Renal diseases: To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus

Respiratory diseases: Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis

Rheumatic disorders: Adjunctive therapy for short-term administration in acute gout flares; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus.

Miscellaneous: Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy

Intra-articular or soft tissue administration:

Adjunctive therapy for short-term administration in acute gout flares, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, synovitis of osteoarthritis

Intralesional:

Treatment of alopecia areata; discoid lupus erythematosus; keloids; localized hypertrophic, infiltrated, inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus (neurodermatitis), and psoriatic plaques; necrobiosis lipoidica diabeticorum

Off Label Uses

Accelerate fetal lung maturation

According to systematic reviews of randomized controlled trials using Betamethasone dipropionate or dexamethasone, evidence supports the use of a single course of antenatal corticosteroids to accelerate fetal lung maturation in women at risk for preterm delivery, with no clear advantages found regarding use of one corticosteroid over another.

Betamethasone dipropionate description

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Each gram of Betamethasone dipropionate (Betamethasone dipropionate*) Cream* contains: 640 mcg Betamethasone dipropionate dipropionate (equivalent to 500 mcg Betamethasone dipropionate).

Each gram of Betamethasone dipropionate (Betamethasone dipropionate*) Ointment* contains: 640 mcg Betamethasone dipropionate dipropionate (equivalent to 500 mcg Betamethasone dipropionate).

Betamethasone dipropionate (Betamethasone dipropionate*) Cream and Ointment contain Betamethasone dipropionate dipropionate, a synthetic corticosteroid with anti-inflammatory activity to be administered topically.

Betamethasone dipropionate dipropionate is a white to creamy white odorless crystalline powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol. It has a molecular weight of 504.16 and the empirical formula C28H37FO7; a chemical name of 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,17,21-dipropionate.

Betamethasone dipropionate dosage

Apply a thin film of Betamethasone dipropionate, 0.5% (augmented) to the affected skin areas once or twice daily. Therapy should be discontinued when control is achieved. Betamethasone dipropionate, 0.5% (augmented)is a high-potency corticosteroid. Treatment with Betamethasone dipropionate, 0.5% (augmented)should not exceed 50 g per week because of the potential for the drug to suppress the hypothalamic-pituitary-adrenal (HPA) axis.

Betamethasone dipropionate, 0.5% (augmented)should not be used with occlusive dressings unless directed by a physician.

Betamethasone dipropionate, 0.5% (augmented)is for topical use only. It is not for oral, ophthalmic, or intravaginal use.

Avoid use on the face, groin, or axillae, or if skin atrophy is present at the treatment site.

Betamethasone dipropionate interactions

See also:
What other drugs will affect Betamethasone dipropionate?

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There are no known drug interactions with topical Betamethasone dipropionate dipropionate.

Betamethasone dipropionate side effects

See also:
What are the possible side effects of Betamethasone dipropionate?

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In controlled clinical trials, involving 242 adult subjects, the adverse reaction associated with the use of Betamethasone dipropionate, 0.5% (augmented)reported at a frequency of 0.4% was stinging. It occurred in 1 subject.

In a controlled clinical trial involving 67 pediatric subjects from 3 months to 12 years of age, the adverse reactions associated with the use of Betamethasone dipropionate, 0.5% (augmented)occurred in 7 of 67 (10%) subjects. Reported reactions included signs of skin atrophy (telangiectasia, bruising, shininess).

Postmarketing Experience

Because adverse reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

Postmarketing reports for local adverse reactions to topical corticosteroids may also include: burning, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, hypertrichosis, skin atrophy, striae, and miliaria.

Hypersensitivity reactions, consisting of predominantly skin signs and symptoms, e.g., contact dermatitis, pruritus, bullous dermatitis, and erythematous rash have been reported.

Betamethasone dipropionate contraindications

See also:
What is the most important information I should know about Betamethasone dipropionate?

Betamethasone dipropionate, 0.5% (augmented)is contraindicated in patients who are hypersensitive to Betamethasone dipropionate Dipropionate, to other corticosteroids, or to any ingredient in this preparation.

What is Gentamicin sulfate?

Treating surface eye infections caused by certain bacteria.

Gentamicin sulfate is a topical antibiotic. It works by slowing the growth of, or killing, sensitive bacteria.

Gentamicin sulfate indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Gentamicin sulfate and other antibacterial drugs, Gentamicin sulfate should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Gentamicin sulfate Sulfate Injection, USP is indicated in the treatment of serious infections caused by susceptible strains of the following microorganisms: Pseudomonas aeruginosa, Proteus species (indole-positive and indole-negative), Escherichia coli, Klebsiella-Enterobacter-Serratia species, Citrobacter species, and Staphylococcus species (coagulase-positive and coagulase-negative).

Clinical studies have shown Gentamicin sulfate Sulfate Injection, USP to be effective in bacterial neonatal sepsis; bacterial septicemia; and serious bacterial infections of the central nervous system (meningitis), urinary tract, respiratory tract, gastrointestinal tract (including peritonitis), skin, bone and soft tissue (including burns).

Aminoglycosides, including Gentamicin sulfate, are not indicated in uncomplicated initial episodes of urinary tract infections unless the causative organisms are susceptible to these antibiotics and are not susceptible to antibiotics having less potential for toxicity.

Specimens for bacterial culture should be obtained to isolate and identify causative organisms and to determine their susceptibility to Gentamicin sulfate.

Gentamicin sulfate sulfate may be considered as initial therapy in suspected or confirmed gram-negative infections, and therapy may be instituted before obtaining results of susceptibility testing. The decision to continue therapy with this drug should be based on the results of susceptibility tests, the severity of the infection, and the important additional concepts contained in the “WARNINGS box”. If the causative organisms are resistant to Gentamicin sulfate, other appropriate therapy should be instituted.

In serious infections when the causative organisms are unknown, Gentamicin sulfate sulfate may be administered as initial therapy in conjunction with a penicillin-type or cephalosporin-type drug before obtaining results of susceptibility testing. If anaerobic organisms are suspected as etiologic agents, consideration should be given to using other suitable antimicrobial therapy in conjunction with Gentamicin sulfate. Following identification of the organism and its susceptibility, appropriate antibiotic therapy should then be continued.

Gentamicin sulfate sulfate has been used effectively in combination with carbenicillin for the treatment of life-threatening infections caused by Pseudomonas aeruginosa. It has also been found effective when used in conjunction with a penicillin-type drug for the treatment of endocarditis caused by group D streptococci.

Gentamicin sulfate Sulfate Injection, USP has also been shown to be effective in the treatment of serious staphylococcal infections. While not the antibiotic of first choice, Gentamicin sulfate may be considered when penicillins or other less potentially toxic drugs are contraindicated and bacterial susceptibility tests and clinical judgment indicate its use. It may also be considered in mixed infections caused by susceptible strains of staphylococci and gram-negative organisms.

In the neonate with suspected bacterial sepsis or staphylococcal pneumonia, a penicillin-type drug is also usually indicated as concomitant therapy with Gentamicin sulfate.

In this dosage form, Gentamicin sulfate Sulfate Injection, USP is to be used with an ADD-Vantage antibiotic diluent flexible plastic container..

How should I use Gentamicin sulfate?

Use Gentamicin sulfate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Gentamicin sulfate.

Uses of Gentamicin sulfate in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This medication is used to treat minor skin infections (such as impetigo, folliculitis) or minor infections related to some skin conditions (such as eczema, psoriasis, minor burns/cuts/wounds). Gentamicin sulfate works by stopping the growth of certain bacteria. It belongs to a class of drugs known as aminoglycoside antibiotics.

This antibiotic only treats bacterial infections. It will not work for virus or fungus infections. Unnecessary use or overuse of any antibiotic can lead to its decreased effectiveness.

How to use Gentamicin sulfate topical

This medication is for use on the skin only.

Wash your hands before using. Clean and dry the affected area as directed. If you are treating impetigo, remove any dried, crusty skin to increase contact between the antibiotic and the infected area. Then gently apply a small amount of medication in a thin layer as directed by your doctor, usually 3 to 4 times a day. You may cover the area with a sterile gauze bandage if so directed. Keep the infected area clean. Wash your hands after use, unless you are using this product to treat the hands.

Avoid getting this medication in your eyes, nose, or mouth. If this occurs, wipe off the medication and rinse thoroughly with water.

Dosage and length of treatment is based on your medical condition and response to treatment.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same times each day. Do not apply large amounts of this medication, use it more often, or use it for longer than prescribed. Your condition will not improve any faster, and your risk of side effects may increase.

Continue to use this medication for the full length of treatment prescribed, even if symptoms disappear after a few days. Stopping the medication too early may allow bacteria to continue to grow, which may result in a return of the infection.

Tell your doctor if your skin infection persists or if it worsens.

Gentamicin sulfate description

Gentamicin sulfate also contains the following ingredients: Methyl paraben 1.8 mg, propyl paraben 0.2 mg, sodium bisulfite 3.2 mg, disodium ethylenediaminetetraacetate 0.1 mg and water for injection.

Gentamicin sulfate sulfate injection is a sterile solution of Gentamicin sulfate sulfate water for injection. It contains the equivalent of not less than 90% and not more than 125% of the labeled amount of Gentamicin sulfate. It may contain suitable buffers, preservatives, sequestering agents, unless it is intended for intrathecal use, in which case it contains only suitable tonicity agents.

Gentamicin sulfate dosage

Gentamicin sulfate Sulfate Injection, USP is administered by intravenous infusion only after dilution in a 50 or 100 mL ADD-Vantage Flexible Diluent Container of 5% Dextrose Injection, USP or 0.9% Sodium Chloride Injection, USP.

The patient’s pretreatment body weight should be obtained for calculation of correct dosage. The dosage of aminoglycosides in obese patients should be based on an estimate of the lean body mass. It is desirable to limit the duration of treatment with aminoglycosides to short term.

Patients with Normal Renal Function

Adults: The recommended dosage of Gentamicin sulfate sulfate for patients with serious infections and normal renal function is 3 mg/kg/day, administered in three equal doses every eight hours (Table 3).

For patients with life-threatening infections, dosages up to 5 mg/kg/day may be administered in three or four equal doses. The dosage should be reduced to 3 mg/kg/day as soon as clinically indicated (Table 3).

It is desirable to measure both peak and trough serum concentrations of Gentamicin sulfate to determine the adequacy and safety of the dosage. When such measurements are feasible, they should be carried out periodically during therapy to assure adequate but not excessive drug levels. When monitoring peak concentrations after intravenous administration, dosage should be adjusted so that prolonged levels above 12 mcg/mL are avoided. When monitoring trough concentrations (just prior to the next dose), dosage should be adjusted so that levels above 2 mcg/mL are avoided. Determination of the adequacy of a serum level for a particular patient must take into consideration the susceptibility of the causative organism, the severity of the infection, and the status of the patient’s host-defense mechanisms. In patients with extensive burns, altered pharmacokinetics may result in reduced serum concentrations of aminoglycosides. In such patients treated with Gentamicin sulfate, measurement of serum concentrations is recommended as a basis for dosage adjustment.

Table 3 Dosage Schedule Guide For Adults With Normal Renal Function
* The dosage of aminoglycosides in obese patients should be based on an estimate of the lean body mass.

** For q6h schedules, dosage should be recalculated.

(Dosage at Eight-Hour Intervals)

Patient’s

Weight*

Usual Dose

for Serious Infections

Dose for Life-Threatening

Infections (Reduce as Soon as Clinically Indicated)

kg

(lb)

1 mg/kg q8h

(3 mg/kg/day)

1.7 mg/kg q8h**

(5 mg/kg/day)

mg/dose

q8h

mg/dose

q8h

40

(88)

40

66

45

(99)

45

75

50

(110)

50

83

55

(121)

55

91

60

(132)

60

100

65

(143)

65

108

70

(154)

70

116

75

(165)

75

125

80

(176)

80

133

85

(187)

85

141

90

(198)

90

150

95

(209)

95

158

100

(220)

100

166

NOTE: For further information concerning the use of Gentamicin sulfate in infants and children, see pediatric Gentamicin sulfate sulfate injection product information.

The usual duration of treatment for all patients is seven to ten days. In difficult and complicated infections, a longer course of therapy may be necessary. In such cases monitoring of renal, auditory, and vestibular functions is recommended, since toxicity is more apt to occur with treatment extended for more than ten days. Dosage should be reduced if clinically indicated.

For

Intravenous Administration

The intravenous administration of Gentamicin sulfate may be particularly useful for treating patients with bacterial septicemia or those in shock. It may also be the preferred route of administration for some patients with congestive heart failure, hematologic disorders, severe burns, or those with reduced muscle mass. For intermittent intravenous administration in adults, a single dose of Gentamicin sulfate sulfate may be diluted in 50 or 100 mL of sterile 0.9% Sodium Chloride Injection, USP or in a sterile solution of 5% Dextrose Injection, USP. The solution may be infused over a period of one-half to two hours.

Gentamicin sulfate sulfate should not be physically premixed with other drugs, but should be administered separately in accordance with the recommended route of administration and dosage schedule.

Patients with Impaired Renal Function

Dosage must be adjusted in patients with impaired renal function to assure therapeutically adequate, but not excessive blood levels. Whenever possible, serum concentrations of Gentamicin sulfate should be monitored. One method of dosage adjustment is to increase the interval between administration of the usual doses. Since the serum creatinine concentration has a high correlation with the serum half-life of Gentamicin sulfate, this laboratory test may provide guidance for adjustment of the interval between doses. The interval between doses (in hours) may be approximated by multiplying the serum creatinine level (mg/100 mL) by 8. For example, a patient weighing 60 kg with a serum creatinine level of 2.0 mg/100 mL could be given 60 mg (1 mg/kg) every 16 hours (2x8).

In patients with serious systemic infections and renal impairment, it may be desirable to administer the antibiotic more frequently but in reduced dosage. In such patients, serum concentrations of Gentamicin sulfate should be measured so that adequate, but not excessive levels result. A peak and trough concentration measured intermittently during therapy will provide optimal guidance for adjusting dosage. After the usual initial dose, a rough guide for determining reduced dosage at eight-hour intervals is to divide the normally recommended dose by the serum creatinine level (Table 4). For example, after an initial dose of 60 mg (1 mg/kg), a patient weighing 60 kg with a serum creatinine level of 2.0 mg/100 mL could be given 30 mg every eight hours (60 ÷ 2). It should be noted that the status of renal function may be changing over the course of the infectious process.

It is important to recognize that deteriorating renal function may require a greater reduction in dosage than that specified in the above guidelines for patients with stable renal impairment.

Table 4 Dosage Adjustment Guide for Patients with Renal Impairment

(Dosage at Eight-Hour Intervals After the Usual Initial Dose)

Serum

Creatinine

(mg%)

Approximate Creatinine

Clearance Rate

(mL/min/1.73M2)

Percent of Usual Doses

Shown in Table 3

≤1.0

>100

100

1.1 — 1.3

70 —100

80

1.4 — 1.6

55 — 70

65

1.7 — 1.9

45 — 55

55

2.0 — 2.2

40 — 45

50

2.3 — 2.5

35 — 40

40

2.6 — 3.0

30 — 35

35

3.1 — 3.5

25 — 30

30

3.6 — 4.0

20 — 25

25

4.1 — 5.1

15 — 20

20

5.2 — 6.6

10 — 15

15

6.7 — 8.0

<10

10

In adults with renal failure undergoing hemodialysis, the amount of Gentamicin sulfate removed from the blood may vary depending upon several factors including the dialysis method used. An eight-hour hemodialysis may reduce serum concentrations of Gentamicin sulfate by approximately 50%. The recommended dose at the end of each dialysis period is 1 to 1.7 mg/kg depending upon the severity of infection.

The above dosage schedules are not intended as rigid recommendations but are provided as guides to dosage when the measurement of Gentamicin sulfate serum levels is not feasible.

A variety of methods are available to measure Gentamicin sulfate concentrations in body fluids; these include microbiologic, enzymatic and radioimmunoassay techniques.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Gentamicin sulfate interactions

See also:
What other drugs will affect Gentamicin sulfate?

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring.

To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products) before starting treatment with this product. While using this product, do not start, stop, or change the dosage of any other medicines you are using without your doctor's approval.

Some products that may interact with this drug include: aminoglycoside antibiotics given by injection (such as amikacin, Gentamicin sulfate, tobramycin).

This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

Gentamicin sulfate side effects

See also:
What are the possible side effects of Gentamicin sulfate?

Nephrotoxicity: Adverse renal effects, as demonstrated by the presence of casts, cells or protein in the urine or by rising BUN, NPN, serum creatinine or oliguria, have been reported. They occur more frequently in patients with a history of renal impairment and in patients treated for longer periods or with larger dosages than recommended.

Neurotoxicity: Serious adverse effects on both vestibular and auditory branches of the eighth nerve have been reported, primarily in patients with renal impairment (especially if dialysis is required) and in patients on high doses and/or prolonged therapy. Symptoms include dizziness, vertigo, tinnitus, roaring in the ears and also hearing loss, which, as with the other aminoglycosides, may be irreversible. Hearing loss is usually manifested initially by diminution of high-tone acuity. Other factors which may increase the risk of toxicity include excessive dosage, dehydration and previous exposure to other ototoxic drugs.

Peripheral neuropathy or encephalopathy, including numbness, skin tingling, muscle twitching, convulsions, and a myasthenia gravis-like syndrome, have been reported.

NOTE: The risk of toxic reactions is low in patients with normal renal function who do not receive Gentamicin sulfate Sulfate at higher doses or for longer periods of time than recommended.

Other reported adverse reactions possibly related to Gentamicin sulfate include: Respiratory depression, lethargy, confusion, depression, visual disturbances, decreased appetite, weight loss and hypotension and hypertension; rash, itching, urticaria, generalized burning, laryngeal edema, anaphylactoid reactions, fever, and headache; nausea, vomiting, increased salivation, and stomatitis; purpura, pseudotumor cerebri, acute organic brain syndrome, pulmonary fibrosis, alopecia, joint pain, transient hepatomegaly and splenomegaly.

Laboratory abnormalities possibly related to Gentamicin sulfate include: Increased levels of serum transaminase (SGOT, SGPT), serum LDH and bilirubin; decreased serum calcium, magnesium, sodium and potassium; anemia, leukopenia, granulocytopenia, transient agranulocytosis, eosinophilia, increased and decreased reticulocyte counts and thrombocytopenia. While clinical laboratory test abnormalities may be isolated findings, they may also be associated with clinically related signs and symptoms. For example, tetany and muscle weakness may be associated with hypomagnesemia, hypocalcemia and hypokalemia.

While local tolerance of Gentamicin sulfate Sulfate is generally excellent, there has been an occasional report of pain at the injection site. Subcutaneous atrophy or fat necrosis suggesting local irritation has been reported rarely.

Gentamicin sulfate contraindications

See also:
What is the most important information I should know about Gentamicin sulfate?

Gentamicin sulfate Sulfate Sterile Ophthalmic Solution is contraindicated in patients with known hypersensitivity to any of the components.

What is Miconazole nitrate?

Miconazole nitrate topical is an antifungal medication. Miconazole nitrate topical prevents fungus from growing on your skin.

Miconazole nitrate topical is used to treat skin infections such as athlete's foot, jock itch, ringworm, tinea versicolor (a fungus that discolors the skin), and yeast infections.

Miconazole nitrate topical may also be used for purposes other than those listed in this medication guide.

Miconazole nitrate indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Adwizole (Miconazole nitrate nitrate) Spray is indicated for the treatment of fungal infections in dogs and cats caused by Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes.

How should I use Miconazole nitrate?

Use Miconazole nitrate as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Miconazole nitrate.

Uses of Miconazole nitrate in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Miconazole nitrate is an imidazole (organic compound) antifungal agent used to treat fungal and associated bacterial super infections of the skin and nails Miconazole nitrate is also used for oral treatment and prevention of fungal infections of the mouth, throat and food pipe Miconazole nitrate is effectively used in vulvovaginal (vagina and external genital organs) candidiasis (thrush) and other yeast infection of the vagina. Further, Miconazole nitrate is also prescribed for napkin rash and inflammation of the folds of tissue surrounding the nails of toes or fingers (paronychia).

Miconazole nitrate description

Miconazole nitrate: Each mL of solution contains Miconazole nitrate nitrate, in a soothing, cooling solution, which helps to keep the infection site dry.

Miconazole nitrate Tinea: Each gram of cream contains Miconazole nitrate nitrate, dimethicone and phenethyl alcohol in a lanolin-free aqueous soft cream base. It has a pH of 5.

Each gram of powder contains Miconazole nitrate nitrate in a zinc oxide menthol and talc powder base.

All cream products are lanolin-free, propylene glycol-free, colour-free, perfume-free and paraben-free to avoid irritant reactions.

Miconazole nitrate dosage

Miconazole nitrate Dosage

Generic name: Miconazole nitrate nitrate

Dosage form: Cream

See also:

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Sufficient Miconazole nitrate Cream should be applied to cover affected areas twice daily (morning and evening) in patients with tinea pedis, tinea cruris, tinea corporis, and cutaneous candidiasis, and once daily in patients with tinea versicolor. If Miconazole nitrate Cream is used in intertriginous areas, it should be applied sparingly and smoothed in well to avoid maceration effects.

Early relief of symptoms (2 to 3 days) is experienced by the majority of patients and clinical improvement may be seen fairly soon after treatment is begun; however, Candida infections and tinea cruris and corporis should be treated for two weeks and tinea pedis for one month in order to reduce the possibility of recurrence. If a patient shows no clinical improvement after a month of treatment, the diagnosis should be redetermined. Patients with tinea versicolor usually exhibit clinical and mycological clearing after two weeks of treatment.

More about Miconazole nitrate (Miconazole nitrate topical)

Consumer resources

Professional resources

Other formulations

Related treatment guides

Miconazole nitrate interactions

See also:
What other drugs will affect Miconazole nitrate?

Oral anticoagulants, sulfonylurea hypoglycemics, phenytoin, carbamazepine, astemizole, cisapride & terfenadine.

Miconazole nitrate side effects

See also:
What are the possible side effects of Miconazole nitrate?

Applies to Miconazole nitrate topical: topical cream, topical gel/jelly, topical kit, topical lotion, topical ointment, topical powder, topical spray, topical tablet effervescent, topical tincture

In addition to its needed effects, some unwanted effects may be caused by Miconazole nitrate topical (the active ingredient contained in Miconazole nitrate). In the event that any of these side effects do occur, they may require medical attention.

Severity: Moderate

If any of the following side effects occur while taking Miconazole nitrate topical, check with your doctor or nurse as soon as possible:

Miconazole nitrate contraindications

See also:
What is the most important information I should know about Miconazole nitrate?

When used by a person taking the anticoagulant medication warfarin, Miconazole nitrate may cause an adverse reaction which can lead to excessive bleeding or bruising.



Active ingredient matches for Betamethasone dipropionate/gentamicin sulfate/miconazole nitrate:

Betamethasone dipropionate/gentamicin sulfate/miconazole nitrate


References

  1. DailyMed. "MICONAZOLE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. DailyMed. "GENTAMICIN SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  3. DailyMed. "BETAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).

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