Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
Category C: Either studies in animals have revealed adverse effects on the foetus (teratogenic or embryocidal or other) and there are no controlled studies in women or studies in women and animals are not available. Drugs should be given only if the potential benefit justifies the potential risk to the foetus.
Betamethasone Valerate breastfeeding
When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!
There are no data on the excretion Betamethasone Valerate into human milk. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
References for pregnancy information
Sybulski S "Effect of antepartum Betamethasone Valerate treatment on cortisol levels in cord plasma, amniotic fluid, and the neonate." Am J Obstet Gynecol 127 (1977): 871-4
Derks JB, Mulder EJH, Visser GHA "The effects of maternal Betamethasone Valerate administration on the fetus." Br J Obstet Gynaecol 102 (1995): 40-6
Ballard RA, Ballard PL "Use of prenatal glucocorticoid therapy to prevent respiratory distress syndrome. A supporting view." Am J Dis Child 130 (1976): 982-7
Anderson AB, Gennser G, Jeremy JY, Ohrlander S, Sayers L, Turnbull AC "Placental transfer and metabolism of Betamethasone Valerate in human pregnancy." Obstet Gynecol 49 (1977): 471-4
Maltau JM, Stokke KT, Moe N "Effects of Betamethasone Valerate on plasma levels of estriol, cortisol and HCS in late pregnancy." Acta Obstet Gynecol Scand 58 (1979): 235-8
Petersen MC, Nation RL, Ashley JJ, McBride WG "The placental transfer of Betamethasone Valerate." Eur J Clin Pharmacol 18 (1980): 245-7
Ohrlander S, Gennser G, Batra S, Lebech P "Effect of Betamethasone Valerate administration on estrone, estradiol-17 beta, and progesterone in maternal plasma and amniotic fluid." Obstet Gynecol 49 (1977): 148-53
DailyMed. "BETAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
Human Metabolome Database (HMDB). "Betamethasone: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).
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