Betamethasone Overdose

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How do you administer this medicine?

What happens if I overdose Betamethasone?

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local, or emergency room immediately.

Proper storage of Betamethasone solution:

Store Betamethasone solution at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Betamethasone solution out of the reach of children and away from pets.

Overdose of Betamethasone in details

When a dose is taken in higher dose than the recommended doses, it is called Overdose. Overdose always needs a clinical supervision. Any medicine or drug when consumed in Overdose produces untoward side effects on one or various organs in the body. A medicine is excreted in the kidney or metabolized in the liver most of the times. This process goes without any hurdles when taken in normal dose, but when taken in an overdose, the body is not able to metabolize it or send it out properly which causes the effects of anoverdose.

Symptoms: Excessive or prolonged use of topical corticosteroids can suppress pituitary-adrenal function, resulting in secondary adrenal insufficiency and produce manifestations of hypercorticism, including Cushing's disease.

A single overdose of gentamicin would not be expected to produce symptoms. Excessive or prolonged use of topical antibiotics may lead to overgrowth of lesions by non-susceptible organisms.

Systemically, tolnaftate is pharmacologically inactive.

Clioquinol rarely produces iodism.

Treatment: Appropriate symptomatic treatment is indicated. Acute hypercorticoid symptoms are usually reversible. Treat electrolyte imbalance, if necessary. In case of chronic toxicity, slow withdrawal of corticosteroids is advised.

If overgrowth by non-susceptible organisms occurs, stop treatment with Betamethasone, Gentamicin, Tolnaftate, Clioquinol (Betamethasone) Cream and institute appropriate therapy.

What should I avoid while taking Betamethasone?

Avoid getting this medicine in your eyes. If contact does occur, rinse with water. Do not use Betamethasone topical on broken or infected skin. Also avoid using this medicine in open wounds.

Avoid applying Betamethasone topical to the skin of your face, underarms, or groin area without your doctor's instruction.

Do not use Betamethasone topical to treat any condition that has not been checked by your doctor.

Betamethasone warnings

Warnings are a mix of Precautions. Contraindications and interactions and serious harmful effects associated with the medicine intake. A diabetic or Hypertensive patient need to be warned about few drug interactions. A known hypersensitivity patient needs to be careful about the reactions or anaphylactic shock. A pregnant woman or a breastfeeding woman should be warned of certain medications. A Hepatitis [liver disease] patient or a cardiac patient should avoid few drugs.

Do not use if you are

pregnant or intend to

become pregnant, or

breast feeding.

Occlusive dressings

should not be used if you

have a skin infection.

Betamethasone should not

be used in children under

the age of 1 year, unless

advised by your doctor.

Do not use Betamethasone

after the expiry date

(EXP.) printed on the


If you use it after the expiry

date has passed, it may

have no effect at all, or worse, it may give an

entirely unexpected effect.

Do not use Betamethasone if

the packaging shows signs

of tampering or if the seal

on the tube is broken, or

if the product does not

look quite right.

If it has expired or is

damaged, return it to your

pharmacist for disposal.

Before you start to use it

You must tell your doctor


• You are allergic to any

other medicines, foods,

dyes or preservatives.

• You have any other

health problems,

especially if you have

an infection

• You are pregnant or

intend to become


• You are breast-feeding

or intend to breastfeed.

If you have not told your

doctor about any of the

above, tell them before

you start to use


Use in Children

Betamethasone is not

recommended for use in

children, unless your doctor

tells you to do so.

Immediately discontinue

using Betamethasone if an

irritation or sensitisation


Do not use Betamethasone

under occlusive dressings

(airtight covering) or on

large areas of skin unless

your doctor tells you to.

Do not use Betamethasone in

or near the eyes.

Do not stop using

Betamethasone or change the

amount, area or method of

application, without first

checking with your doctor.

Do not give Betamethasone to

anyone else even if his or

her symptoms seem similar

to yours.

Do not use plastic pants or

tight-fitting nappies if

Betamethasone is to be used

on the nappy area of young


Do not use Betamethasone to

treat any other conditions

unless your doctor tells you

to do so.

Do not use large amounts

of Betamethasone for a long

period of time.

If you use large amounts

for a long time, the chance

of systemic absorption

through the skin and the

chance of side effects may


Only use Betamethasone on

skin areas that rub together

such as under the arm or in

the groin area if your

doctor tells you to.

Only use Betamethasone on

the face if your doctor tells

you to. If improvement

does not occur within one

week, tell your doctor


Children and adolescents

should be followed closely

by the doctor, since this

medicine is absorbed

through the skin and can

affect growth or cause

other unwanted side


What should I discuss with my healthcare provider before taking Betamethasone?

Some medical conditions may interact with Betamethasone solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Betamethasone solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Betamethasone solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Betamethasone precautions

Certain people who are very sick or very old or who are sensitive show an exacerbation of side effect of the drug which can turn dangerous at times. So, it is very important to remember the precautions while taking the medicine. Pregnancy and Breastfeeding are also special categories wherein extra care or precaution is needed when taking a drug. Few patients may have a hypersensitivity reaction to few medications, and that can be life-threatening rarely. Penicillin hypersensitivity is one example. Diarrhea, rashes are few other symptoms which need a watch. A patient with other co-existing diseases like liver disease, heart disease, kidney disease should take special precautions.

If irritation or sensitization develops with the use of Betamethasone, Gentamicin, Tolnaftate, Clioquinol (Betamethasone) Cream, treatment should be discontinued and appropriate therapy instituted.

Any of the side effects that are reported following systemic use of corticosteroids, including adrenal suppression may also occur with topical corticosteroids, especially in infants and children.

Systemic absorption of Betamethasone, Gentamicin, Tolnaftate, Clioquinol (Betamethasone) Cream will be increased if extensive body surface areas are treated or if the occlusive technique is used. Suitable precautions should be taken under these conditions or when long-term use is anticipated, particularly in infants and children.

Cross-allergenicity among aminoglycosides has been demonstrated.

Systemic absorption of topically applied gentamicin may be increased if extensive body surface areas are treated, especially over prolonged time periods or in the presence of dermal disruption. In these cases, the undesirable effects which occur following systemic use of gentamicin may potentially occur. Cautious use is recommended under these conditions, particularly in infants and children.

Prolonged use of topical antibiotics occasionally may result in overgrowth of non-susceptible organisms. If this occurs or if irritation, sensitization or superinfection develops, treatment with Betamethasone, Gentamicin, Tolnaftate, Clioquinol (Betamethasone) Cream should be discontinued and appropriate therapy instituted. Slight staining of linens or clothing due to clioquinol may occur.

Betamethasone, Gentamicin, Tolnaftate, Clioquinol (Betamethasone) Cream is not for ophthalmic use.

Use in Children: Pediatric patients may demonstrate greater susceptibility to topical corticosteroid-induced hypothalamic-pituitaryadrenal (HPA) axis suppression and to exogenous corticosteroids effects than mature patients because of greater absorption due to large skin surface area to body weight ratio.

HPA axis suppression, Cushing's syndrome, linear growth retardation, delayed weight gain, and intracranial hypertension have been reported in children receiving topical corticosteroids. Manifestations of adrenal suppression in children include low plasmacortisol levels and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include a bulging fontanelle, headaches and bilateral papilledema.

What happens if I miss a dose of Betamethasone?

When you miss a dose, you should take it as soon as you remember, but you should take care that it should be well spaced from the next dose. You should not take an extra dose at the time of the second dose as it will become a double dose. The double dose can give unwanted side effects, so be careful. In chronic conditions or when you have a serious health issue, if you miss a dose, you should inform your health care provider and ask his suggestion.

Call your doctor for instructions if you miss an appointment for your Betamethasone injection.


  1. DailyMed. "BETAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. DrugBank. "betamethasone". (accessed September 17, 2018).
  3. MeSH. "Anti-Asthmatic Agents". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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