The action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
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Pharmacotherapeutic Group:
Topical cortcosteroid and anti-infective in combination.
Mechanism of Action: Betamethasone/Gentamicin cream or ointment combines the sustained anti-inflammatory, antipruritic and vasoconstrictive actions of betamethasone dipropionate with the wide-spectrum bactericidal activity of gentamicin sulfate.
Microbiology: Bacteria susceptible to gentamicin include sensitive strains of Staphylococcus aureus (coagulase-positive, coagulase-negative and some penicillinase-producing strains) and the gram-negative bacteria: Pseudomonas aeruginosa, Aerobacter aerogenes, Escherichia coli, Proteus vulgaris and Klebsiella pneumoniae.
Toxicology: The effect of subacute administration of Betamethasone/Gentamicin ointment on both the intact and abraded skin of rabbits and guinea pigs was studied under the conditions of the study. No adverse effects were observed on the intact and abraded skin. No systemic effects were seen that could be attributed to percutaneous absorption of corticosteroids.
The antibacterial activity, toxicity, local and systemic tolerance, local anti-inflammatory activity and side effects of Betamethasone/Gentamicin ointment was determined. Betamethasone/Gentamicin ointment had potent antibacterial activity and marked local anti-inflammatory effects. It was nontoxic and had extremely good systemic tolerance. There was no evidence of undesirable side effects at the dosage and route recommended for clinical use.
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References
DailyMed. "GENTAMICIN SULFATE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
DailyMed. "BETAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
NCIt. "Gentamicin C1: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
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