Betonil Uses

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What is Betonil?

Betonil sodium phosphate and Betonil acetate combination injection provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, lung or breathing problems, blood or bone marrow problems, eye or vision problems, lupus, serious skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Betonil sodium phosphate and Betonil acetate combination is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions.

Betonil sodium phosphate and Betonil acetate is to be given only by or under the direct supervision of your doctor.

Betonil indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Betonil Suspension is indicated for the treatment of acute and chronic corticosteroid-responsive disorders. Corticosteroid hormone therapy is an adjunct to, and not a replacement for conventional therapy.

Musculoskeletal and Soft Tissue Conditions: Rheumatoid arthritis, osteoarthritis, bursitis, ankylosing spondylitis, epicondylitis, radiculitis, coccydynia, sciatica, lumbago, torticollis, ganglion cyst, exostasis and fasciitis.

Allergic Conditions: Chronic bronchial asthma (including adjunctive therapy for status asthmaticus), hay fever, angioneurotic edema, allergic bronchitis, seasonal or perennial allergic rhinitis, drug reactions, serum sickness and insect bites.

Dermatologic Conditions: Atopic dermatitis (nummular eczema), neurodermatitis (circumscribed lichen simplex), contact dermatitis, severe solar dermatitis, urticaria, hypertrophic lichen planus, necrobiosis lipoidica diabeticorum, alopecia areata, discoid lupus erythematosus, psoriasis, keloids, pemphigus, dermatitis herpetiformis and cystic acne.

Collagen Diseases: Disseminated lupus erythematosus, scleroderma, dermatomyositis, periarteritis nodosa.

Neoplastic Diseases: Palliative management of leukemias and lymphomas in adults; acute leukemia of childhood.

Other Conditions: Adrenogenital syndrome, ulcerative colitis, regional ileitis, sprue, podiatric conditions (bursitis under heloma durum, hallux rigidus, digiti quinti varus), affections requiring subconjunctival injection, corticosteroid-responsive blood dyscrasias, nephritis and nephrotic syndrome.

Primary or secondary adrenocortical insufficiency may be treated with Betonil Suspension but should be supplemented with mineralocorticosteroids, if applicable.

Betonil Suspension is recommended for intramuscular injection in conditions responsive to systemic corticosteroids; injection directly into the affected soft tissues where indicated; intra-articular and periarticular injection in arthritides; intralesional injection in various dermatologic conditions; and local injection in certain inflammatory and cystic disorders of the foot.

How should I use Betonil?

Use Betonil solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Betonil solution.

Uses of Betonil in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

Use: Labeled Indications


Allergic states: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions

Dermatologic diseases: Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome)

Endocrine disorders: Congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Note: Hydrocortisone or cortisone is the drug of choice in primary or secondary adrenocortical insufficiency. Synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy mineralocorticoid supplementation is of particular importance

Gastrointestinal diseases: During acute episodes in regional enteritis and ulcerative colitis

Hematologic disorders: Acquired (autoimmune) hemolytic anemia, Diamond-Blackfan anemia, pure red cell aplasia, selected cases of secondary thrombocytopenia

Neoplastic diseases: Palliative management of leukemias and lymphomas

Nervous system: Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor or craniotomy. Note: Treatment guidelines recommend the use of high-dose IV or oral methylprednisolone for acute exacerbations of multiple sclerosis (AAN [Scott 2011]; NICE 2014).

Ophthalmic diseases:

Sympathetic ophthalmia, temporal arteritis, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids

Renal diseases: To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus

Respiratory diseases: Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis

Rheumatic disorders: Adjunctive therapy for short-term administration in acute gout flares; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy); treatment of dermatomyositis, polymyositis, and systemic lupus erythematosus.

Miscellaneous: Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used with appropriate antituberculous chemotherapy

Intra-articular or soft tissue administration:

Adjunctive therapy for short-term administration in acute gout flares, acute and subacute bursitis, acute nonspecific tenosynovitis, epicondylitis, rheumatoid arthritis, synovitis of osteoarthritis


Treatment of alopecia areata; discoid lupus erythematosus; keloids; localized hypertrophic, infiltrated, inflammatory lesions of granuloma annulare, lichen planus, lichen simplex chronicus (neurodermatitis), and psoriatic plaques; necrobiosis lipoidica diabeticorum

Off Label Uses

Accelerate fetal lung maturation

According to systematic reviews of randomized controlled trials using Betonil or dexamethasone, evidence supports the use of a single course of antenatal corticosteroids to accelerate fetal lung maturation in women at risk for preterm delivery, with no clear advantages found regarding use of one corticosteroid over another.

Betonil description


Each gram of Betonil (Betonil*) Cream* contains: 640 mcg Betonil dipropionate (equivalent to 500 mcg Betonil).

Each gram of Betonil (Betonil*) Ointment* contains: 640 mcg Betonil dipropionate (equivalent to 500 mcg Betonil).

Betonil (Betonil*) Cream and Ointment contain Betonil dipropionate, a synthetic corticosteroid with anti-inflammatory activity to be administered topically.

Betonil dipropionate is a white to creamy white odorless crystalline powder insoluble in water; freely soluble in acetone and in chloroform; sparingly soluble in alcohol. It has a molecular weight of 504.16 and the empirical formula C28H37FO7; a chemical name of 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,17,21-dipropionate.

Betonil dosage

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Kit, Injection:

Pod-Care 100C: Betonil sodium phosphate 3 mg and Betonil acetate 3 mg per 1 mL [contains benzalkonium chloride, disodium edta]

ReadySharp Betonil: Betonil sodium phosphate 3 mg and Betonil acetate 3 mg per 1 mL [contains benzalkonium chloride, disodium edta]

Suspension, Injection:

Betonil Soluspan: Betonil sodium phosphate 3 mg and Betonil acetate 3 mg per 1 mL (5 mL) [contains benzalkonium chloride, edetate disodium]

Generic: Betonil sodium phosphate 3 mg and Betonil acetate 3 mg per 1 mL (5 mL)

Dosing: Adult

Note: Dosages expressed as combined amount of Betonil sodium phosphate and Betonil acetate; 1 mg is equivalent to Betonil sodium phosphate 0.5 mg and Betonil acetate 0.5 mg.

Usual dosage range: IM: Initial: 0.25 to 9 mg/day (based on severity of disease and patient response).

Indication-specific dosing:

Antenatal fetal maturation (off-label use): IM: 12 mg every 24 hours for a total of 2 doses (ACOG 171 2016). A single course of Betonil is recommended for women between 24 and 34 weeks of gestation, including those with ruptured membranes or multiple gestations, who are at risk of delivering within 7 days. A single course may be appropriate in some women beginning at 23 weeks gestation or late preterm (between 34 0/7 weeks and 36 6/7 weeks gestation). A single repeat course may be considered in some women with pregnancies less than 34 weeks gestation at risk for delivery within 7 days and who had a course of antenatal corticosteroids >14 days prior (ACOG 171 2016; ACOG 713 2017, ACOG 188 2018).

Bursitis (other than of foot): Intra-articular: 3 to 6 mg (0.5 to 1 mL) for one dose; additional injections may be required for acute exacerbations or chronic conditions; generally, injections should be separated by a minimum of 4 to 6 weeks and limited to ≤4 injections per year. If symptoms are not improved after 1 or 2 injections, additional injections are unlikely to provide benefit (Cardone 2002); following resolution of acute episodes, reduced doses may be warranted for chronic conditions.

Dermatologic conditions: Intradermal: 1.2 mg/cm displayed a good or excellent response (Chowdri, 1994). Another trial (n=25, age range: 7 weeks to 2 years) used lower doses of 3 to 12 mg (in combination with triamcinolone); 16 patients experienced a marked response (Kushner, 1985).

Betonil interactions

See also:
What other drugs will affect Betonil?


Concurrent use of phenobarbital, phenytoin, rifampin or ephedrine may enhance the metabolism of corticosteroids, reducing their therapeutic effects.

Patients receiving both a corticosteroid and an estrogen should be observed for excessive corticosteroid effects.

Concurrent use of corticosteroids with potassium-depleting diuretics may enhance hypokalemia. Concurrent use of corticosteroids with cardiac glycosides may enhance the possibility of arrhythmias or digitalis toxicity associated with hypokalemia. Corticosteroids may enhance the potassium depletion caused by amphotericin B. In all patients taking any of these drug therapy combinations, serum electrolyte determinations, particularly potassium levels, should be monitored closely.

Concurrent use of corticosteroids with coumarin-type anticoagulants may increase or decrease the anticoagulant effects, possibly requiring adjustment in dosage.

Combined effects of nonsteroidal anti-inflammatory drugs or alcohol with glucocorticosteroids may result in an increased occurrence or increased severity of gastrointestinal ulceration.

Corticosteroids may decrease blood salicylate concentrations. Acetylsalicylic acid should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia.

Dosage adjustments of an antidiabetic drug may be necessary when corticosteroids are given to diabetics.

Concomitant glucocorticosteroid therapy may inhibit the response to somatotropin. Doses of Betonil in excess of 300-450 mcg (0.3-0.45 mg)/m2 of body surface per day should be avoided during administration of somatotropin.

Laboratory Tests: Corticosteroids may affect the nitro-blue tetrazolium test for bacterial infection and produce false-negative results.

Betonil side effects

See also:
What are the possible side effects of Betonil?

Applies to Betonil topical: topical application cream, topical application foam, topical application gel/jelly, topical application lotion, topical application ointment

Other dosage forms:

In addition to its needed effects, some unwanted effects may be caused by Betonil topical (the active ingredient contained in Betonil). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking Betonil topical:

More common:

Less common: Incidence not known:

Minor Side Effects

Some of the side effects that can occur with Betonil topical may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common:

Incidence not known:

Betonil contraindications

See also:
What is the most important information I should know about Betonil?

You should not use this medication if you are allergic to Betonil, or if you have a fungal infection anywhere in your body.

Before taking Betonil, tell your doctor about all of your medical conditions, and about all other medicines you are using. There are many other diseases that can be affected by steroid use, and many other medicines that can interact with steroids.

Your steroid medication needs may change if you have any unusual stress such as a serious illness, fever or infection, or if you have surgery or a medical emergency. Tell your doctor about any such situation that affects you during treatment.

Steroid medication can weaken your immune system, making it easier for you to get an infection or worsening an infection you already have or have recently had. Tell your doctor about any illness or infection you have had within the past several weeks.

Avoid being near people who are sick or have infections. Call your doctor for preventive treatment if you are exposed to chicken pox or measles. These conditions can be serious or even fatal in people who are using steroid medication.

Do not receive a "live" vaccine while you are taking Betonil. Vaccines may not work as well while you are taking a steroid.

Do not stop using Betonil suddenly, or you could have unpleasant withdrawal symptoms. Talk to your doctor about how to avoid withdrawal symptoms when stopping the medication.

Carry an ID card or wear a medical alert bracelet stating that you are taking a steroid, in case of emergency.

Active ingredient matches for Betonil:

Betamethasone in Pakistan.

List of Betonil substitutes (brand and generic names)

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Unit description / dosage (Manufacturer)Price, USD
Betopic 0.1 % x 10 g x 1's (Armoxindo Farma)$ 2.48
Betosone 0.1 % x 5 g (T. O. Chemicals)
Betosone 0.1 % x 15 g (T. O. Chemicals)
Betosone 0.1 % x 450 g (T. O. Chemicals)
Betosone cream 0.1 % 5 g x 1's (T. O. Chemicals)
Betosone cream 0.1 % 15 g x 1's (T. O. Chemicals)
Betosone cream 0.1 % 450 g x 1's (T. O. Chemicals)
BETSONE Capsule/ Tablet / 1mg / 20 units (Medopharm)$ 0.12
Betsone 0.5mg TAB / 20 (Medopharm)$ 0.11
Betsone 1mg DS-TAB / 10 (Medopharm)$ 0.08
Betsone 4mg x 1mL AMP / 1ml (Medopharm)$ 0.08
0.5 mg x 20's (Medopharm)$ 0.11
1 mg x 10's (Medopharm)$ 0.08
4 mg x 1 mL x 1ml (Medopharm)$ 0.08
Betsone 0.5 mg Tablet (Medopharm)$ 0.01
Betsone 4 mg Injection (Medopharm)$ 0.08
BETSONE 0.5 MG TABLET 1 strip / 10 tablets each (Medopharm)$ 0.06
BETSONE 0.5 MG TABLET 1 strip / 20 tablets each (Medopharm)$ 0.06
BETSONE 1 MG TABLET 1 strip / 20 tablets each (Medopharm)$ 0.06
BETSONE 4 MG INJECTION 1 vial / 1 ML injection each (Medopharm)$ 0.07
BETSONE DS TABLET 1 strip / 10 tablets each (Medopharm)$ 0.07
Betsone 0.5mg TAB / 20 (Medopharm)$ 0.11
Betsone 1mg DS-TAB / 10 (Medopharm)$ 0.08
Betsone 4mg x 1mL AMP / 1ml (Medopharm)$ 0.08
Betsone 0.5mg Tablet (Medopharm)$ 0.01
Betsone 1mg Tablet (Medopharm)$ 0.00
Betsone 4mg Injection (Medopharm)$ 0.07
Betsone NA Tablet (Medopharm)$ 0.01
Betsone DS 1 mg Tablet (Medopharm)$ 0.01
Mousse; Topical; Betamethasone Valerate 0.12% (Berren)
Betzee M Skin 15 gm Cream (Skinnova (Apex Laboratories Limited))$ 0.33
BETZEE M CREAM 1 tube / 15 GM cream each (Skinnova (Apex Laboratories Limited))$ 0.48
Betzee M Cream (Skinnova (Apex Laboratories Limited))$ 0.48
Betzee-G Betamethasone dipropionate0.05 % w/w, Gentamicin 0.1 %w/w, Zinc sulphate 2.5 % w/w. CRM / 15g (Apex (Skinnova))$ 0.30
15g (Apex (Skinnova))$ 0.30
BETZEE-G cream 15g (Apex (Skinnova))$ 0.14


  1. DailyMed. "BETAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "betamethasone". (accessed September 17, 2018).
  3. DrugBank. "betamethasone". (accessed September 17, 2018).


The results of a survey conducted on for Betonil are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Betonil. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported useful

No survey data has been collected yet

Consumer reported price estimates

No survey data has been collected yet

1 consumer reported time for results

To what extent do I have to use Betonil before I begin to see changes in my health conditions?
As part of the reports released by website users, it takes 1 month and a few days before you notice an improvement in your health conditions.
Please note, it doesn't mean you will start to notice such health improvement in the same time frame as other users. There are many factors to consider, and we implore you to visit your doctor to know how long before you can see improvements in your health while taking Betonil. To get the time effectiveness of using Betonil drug by other patients, please click here.
1 month1

2 consumers reported age


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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