Bi alcofan Pregnancy

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Pregnancy of Bi alcofan in details

Pregnancy is always a special situation where every action or side effect of the drug varies when compared to a situation of a non-pregnant patient. It is not only because the pregnant woman's metabolism differs due to the hormonal and other changes happened to her, but also because every medicine or its metabolite passes to the baby and shows its action there. The only thing is, be cautious, attentive and well supervised when you take any single drug in pregnancy. The interactions can vary in pregnancy, and the dosage may differ as well. Strict supervision of the Physician is mandatory.
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Bi alcofan has been assigned to pregnancy category C by the FDA. Animal studies failed to reveal evidence of embryotoxicity or teratogenicity except at doses which produced significant maternal toxicity. There are no controlled data in human pregnancy. When used late in pregnancy, it may cause premature closure of the ductus arteriosus and prolong labor and delivery. Bi alcofan is only recommended for use during pregnancy when benefit outweighs risk. Bi alcofan should be avoided near term.

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Bi alcofan breastfeeding

When a drug is taken when the patient is breast feeding, a part of the drug is secreted in her breast milk and is passed to the baby. The dosage of the medicine to mother and baby are different, and many drugs actions are side effects when you take them without a disease, and what if you the baby takes them without a disease? What if the drug is contraindicated in newborns, infants or children? So, breastfeeding is a very alarming situation when the mother is on medications. Ask your Physician or Pediatrician about the effect of the drug on the baby and how much is excreted in breast milk and if it harms the baby!

There are no data on the excretion of Bi alcofan into human milk. The manufacturer recommends that due to the adverse reaction of prostaglandin-inhibiting drugs on neonates, use in nursing women should be avoided.

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References for pregnancy information

  1. Koren G, Pastuszak A, Ito S "Drugs in pregnancy." N Engl J Med 338 (1998): 1128-37
  2. "Product Information. Orudis (Bi alcofan)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  3. Ostensen M "Optimisation of antirheumatic drug treatment in pregnancy." Clin Pharmacokinet 27 (1994): 486-503

References for breastfeeding information

  1. "Product Information. Orudis (Bi alcofan)." Wyeth-Ayerst Laboratories, Philadelphia, PA.


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References

  1. DailyMed. "KETOPROFEN: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. PubMed Health. "Ketoprofen (By mouth): This section provide the link out information of drugs collectetd in PubMed Health. ". http://www.ncbi.nlm.nih.gov/pubmedhe... (accessed September 17, 2018).
  3. Human Metabolome Database (HMDB). "Ketoprofen: The Human Metabolome Database (HMDB) is a freely available electronic database containing detailed information about small molecule metabolites found in the human body.". http://www.hmdb.ca/metabolites/HMDB0... (accessed September 17, 2018).

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