Bio Megaflam powder packets is an NSAID. Exactly how it works is not known. It may work by blocking certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes those symptoms.
Bio Megaflam indications
An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.
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Carefully consider the potential benefits and risks of Bio Megaflam tablets and other treatment options before deciding to use Bio Megaflam tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
Bio Megaflam tablets are indicated:
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For treatment of primary dysmenorrhea
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For relief of mild to moderate pain
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For relief of the signs and symptoms of osteoarthritis
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For relief of the signs and symptoms of rheumatoid arthritis
How should I use Bio Megaflam?
Use Bio Megaflam powder packets as directed by your doctor. Check the label on the medicine for exact dosing instructions.
Bio Megaflam powder packets comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get Bio Megaflam powder packets refilled.
Do not open a packet of Bio Megaflam powder packets until you are ready to take a dose.
To use Bio Megaflam powder packets, mix the contents of 1 packet with 2 to 4 tablespoons (30 to 60 mL) water. Do not use a liquid other than water. Mix well and drink right away. Do not store the mixed medicine for future use.
Bio Megaflam powder packets may be taken with food if it upsets your stomach. Taking it with food may make it less effective. Taking it with food may not lower the risk of stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or pharmacist if you have persistent stomach upset.
Only 1 dose of Bio Megaflam powder packets is required. If you miss your dose of Bio Megaflam powder packets and you still have a migraine, take it as soon as you remember.
Ask your health care provider any questions you may have about how to use Bio Megaflam powder packets.
Uses of Bio Megaflam in details
There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.
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Bio Megaflam is used to relieve pain and swelling (inflammation) from various mild to moderate painful conditions. It is used to treat muscle aches, backaches, dental pain, menstrual cramps, and sports injuries. It also reduces pain, swelling, and joint stiffness caused by arthritis. Reducing these symptoms helps you do more of your normal daily activities. This medication is known as a nonsteroidal anti-inflammatory drug (NSAID).
If you are treating a chronic condition such as arthritis, ask your doctor about non-drug treatments and/or using other medications to treat your pain. See also Warning section.
OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.
This medication may also be used to treat gout attacks.
How to use Bio Megaflam
Read the Medication Guide provided by your pharmacist before you start using Bio Megaflam and each time you get a refill. If you have any questions, ask your doctor or pharmacist.
Take this medication by mouth with a full glass of water (8 ounces /240 milliliters) unless your doctor directs you otherwise. Do not lie down for at least 10 minutes after taking this drug. To prevent stomach upset, take this medication with food, milk, or an antacid.
There are different brands and forms of this medication available. Because different brands deliver different amounts of medication, do not switch brands of Bio Megaflam without your doctor's permission and directions.
The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To minimize side effect risks (such as stomach bleeding), use this medication at the lowest effective dose for the shortest possible length of time. Do not increase your dose or take it more often than prescribed. For chronic conditions such as arthritis, continue taking it as directed by your doctor. Discuss the risks and benefits with your doctor or pharmacist.
For certain conditions (such as arthritis), it may take up to 2 weeks of regular use before the full benefits of this drug take effect.
If you are taking this drug on an "as needed" basis (not on a regular schedule), remember that pain medications work best if they are used as the first signs of pain occur. If you wait until the pain has worsened, the medication may not work as well.
Tell your doctor if your condition worsens.
Bio Megaflam description
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Bio Megaflam tablet also contains the following excipients: Core: Magnesium stearate, povidone, anhydrous colloidal silica, sodium starch glycollate, maize starch, calcium phosphate.
Sugar Coating: Microcrystalline cellulose, polyethylene glycol 8000, red iron oxide (E172) and titanium dioxide (E171) (dispersed Anstead), povidone, talc, sucrose.
Polish: Polyethylene glycol 8000, sucrose.
Imprint: Brown printing ink for 25 mg and white for 50 mg.
Bio Megaflam is potassium-[0-[(2,6-dichlorophenyl)-amino]-phenyl]-acetate.
In Bio Megaflam, the sodium ion of Bio Megaflam sodium (Voltaren) has been replaced by a potassium ion.
Bio Megaflam dosage
Carefully consider the potential benefits and risks of Bio Megaflam immediate-release tablets and other treatment options before deciding to use Bio Megaflam tablets. Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals.
After observing the response to initial therapy with Bio Megaflam tablets, the dose and frequency should be adjusted to suit an individual patient’s needs.
For treatment of pain or primary dysmenorrhea the recommended dosage is 50 mg three times a day. With experience, physicians may find that in some patients an initial dose of 100 mg of Bio Megaflam tablets, followed by 50 mg doses, will provide better relief.
For the relief of osteoarthritis the recommended dosage is 100 to 150 mg/day in divided doses, 50 mg twice a day, or three times a day.
For the relief of rheumatoid arthritis the recommended dosage is 150 to 200 mg/day in divided doses, 50 mg three times a day or four times a day.
Different formulations of Bio Megaflam [Voltaren® (Bio Megaflam sodium enteric-coated tablets); Voltaren®-XR (Bio Megaflam sodium extended-release tablets); Bio Megaflam tablets] are not necessarily bioequivalent even if the milligram strength is the same.
Not to be given IV to patients who are receiving other NSAIDs or anticoagulants including low dose heparin. Renal function may be worsened when used with ciclosporin or triamterene. Altered absorption when given with sucralfate, colestyramine or colestipol. Ophthalmic application of Bio Megaflam may reduce the efficacy of ophthalmic acetylcholine and carbachol. Increased risk of GI ulceration and bleeding when used with corticosteroids, aspirin or anticoagulants.
Potentially Fatal: Increases blood levels of digoxin, lithium and methotrexate. Potentiate potassium-sparing diuretics.
Food Interaction
Slow absorption of enteric-coated tab when given with food.
The following serious adverse reactions are discussed elsewhere in the labeling:
Cardiovascular thrombotic events
Gastrointestinal effects
Hepatic effects
Hypertension
Congestive Heart Failure and Edema
Renal Effects
Anaphylactoid Reactions
Serious Skin Reactions
The most common adverse reactions reported with Bio Megaflam for
Oral Solution are nausea and dizziness.
The most common adverse events resulting in discontinuation of patients following Bio Megaflam for
Oral Solution dosing in controlled clinical trials were urticaria (0.2%) and flushing (0.2%).
Clinical Studies Experience With Bio Megaflam for
Oral Solution
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.
The safety of a single dose of Bio Megaflam for
Oral Solution was evaluated in 2 placebo-controlled trials with a total of 634 migraine patients treated with Bio Megaflam for
Oral Solution for a single migraine headache. Following treatment with Bio Megaflam (either Bio Megaflam for
Oral Solution or Bio Megaflam immediate-release tablets [as a control]), 5 subjects (0.8%) withdrew from the studies; following placebo exposure, 1 subject (0.2%) withdrew. No withdrawals were due to a serious reaction.
The most common adverse reactions (i.e., that occurred in 1% or more of Bio Megaflam for
Oral Solution -treated patients) and more frequent with Bio Megaflam for
Oral Solution than with placebo were nausea and dizziness.
Table 1: Treatment-Related Adverse Reactions With Incidence >1% and Greater Than Placebo in Studies 1 and 2 Combined
Disorder
Event
Bio Megaflam FOR ORAL SOLUTION
N=634
Placebo
N=646
Gastrointestinal
Nausea
3%
2%
Nervous System
Dizziness
1%
0.5%
Adverse Reactions Reported With Bio Megaflam and Other NSAIDs
In patients taking Bio Megaflam or other NSAIDs, the most frequently reported adverse reactions occurring in approximately 1% to 10% of patients are: GI reactions (including abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gross bleeding/perforation, heartburn, nausea, GI ulcers [gastric/duodenal], and vomiting), abnormal renal function, anemia, dizziness, edema, elevated liver enzymes, headaches, increased bleeding time, pruritus, rashes, and tinnitus.
Additional adverse reactions reported in patients taking NSAIDs include occasionally:
Oral Solution is contraindicated in patients with known hypersensitivity (e.g., anaphylactoid reactions and serious skin reactions) to Bio Megaflam.
Bio Megaflam for
Oral Solution is contraindicated in patients who have experienced asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic-like reactions to NSAIDs have been reported in such patients.
Bio Megaflam for
Oral Solution is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery.
DailyMed. "DICLOFENAC EPOLAMINE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
The results of a survey conducted on ndrugs.com for Bio Megaflam are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Bio Megaflam. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.
User reports
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