Bividerm Actions

sponsored
What is the dose of your medication?

Consists of Betamethasone dipropionate, Fusidic acid

Actions of Betamethasone dipropionate (Bividerm) in details

infoThe action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
sponsored

Corticosteroids play a role in cellular signaling, immune function, inflammation, and protein regulation; however, the precise mechanism of action of Betamethasone dipropionate (Bividerm), 0.5% (augmented)in corticosteroid responsive dermatoses is unknown.

How should I take Betamethasone dipropionate (Bividerm)?

It is very important that you use Betamethasone dipropionate (Bividerm) only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.

Betamethasone dipropionate (Bividerm) is for use on the skin only. Do not get it in your eyes, mouth, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.

Betamethasone dipropionate (Bividerm) should only be used for skin conditions that your doctor is treating. Check with your doctor before using it for other conditions, especially if you think that a skin infection may be present. Betamethasone dipropionate (Bividerm) should not be used to treat certain kinds of skin infections or conditions, such as severe burns.

To help clear up your skin problem completely, it is very important that you keep using Betamethasone dipropionate (Bividerm) for the full time of treatment, even if your symptoms begin to clear up after a few days. Do not miss any doses.

Do not use the topical cream, gel, lotion, and ointment on the face, groin, or underarms unless directed to do so by your doctor.

To use:

  • Wash your hands with soap and water before and after using Betamethasone dipropionate (Bividerm).
  • Apply a thin layer of Betamethasone dipropionate (Bividerm) to the affected area of the skin. Rub it in gently.
  • With the lotion, protect the skin from water, clothing, or anything that causes rubbing until the medicine has dried.
  • Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.
  • If the medicine is applied to the diaper area of an infant, do not use tight-fitting diapers or plastic pants unless directed to do so by your doctor.
  • If your doctor ordered an occlusive dressing or airtight covering to be applied over the medicine, make sure you know how to apply it. Occlusive dressings increase the amount of medicine absorbed through your skin, so use them only as directed. If you have any questions about this, check with your doctor.

Dosing

The dose of Betamethasone dipropionate (Bividerm) will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Betamethasone dipropionate (Bividerm). If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage forms (cream, gel, lotion, and ointment):
    • For redness, itching, and swelling of the skin:
      • Adults and teenagers—Apply to the affected area of the skin once or two times per day.
      • Children up to 12 years of age—Use is not recommended.

Missed Dose

If you miss a dose of Betamethasone dipropionate (Bividerm), apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Betamethasone dipropionate (Bividerm) administration

infoAdministration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.
sponsored

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the instructions on your prescription label.

Betamethasone topical will not treat a bacterial, fungal, or viral skin infection.

Wash your hands before and after each application, unless you are using betamethasone topical to treat a hand condition.

Apply a small amount to the affected area and rub it gently into the skin.

Avoid using this medication on your face, near your eyes or mouth, or on body areas where you have skin folds or thin skin.

If you are using the dental paste, apply the medication in a thin layer, just enough to cover the mouth ulcer. The paste may stick better if you dry the mouth ulcer before applying the medication.

Do not cover treated skin areas with a bandage or other covering unless your doctor has told you to. If you are treating the diaper area of a baby, do not use plastic pants or tight-fitting diapers. Covering the skin that is treated with betamethasone topical can increase the amount of the drug your skin absorbs, which may lead to unwanted side effects. Follow your doctor's instructions.

Contact your doctor if your condition does not improve or if it gets worse after using this medication for several days. It is important to use betamethasone topical regularly to get the most benefit.

Store betamethasone topical at room temperature away from moisture and heat.

Betamethasone dipropionate (Bividerm) pharmacology

infoPharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.
sponsored

The corticosteroids are a class of compounds comprising steroid hormones secreted by the adrenal cortex and their synthetic analogs. In pharmacologic doses, corticosteroids are used primarily for their anti-inflammatory and/or immunosuppressive effects.

Topical corticosteroids, such as Betamethasone dipropionate (Bividerm), are effective in the treatment of corticosteroid-responsive dermatoses primarily because of their anti-inflammatory, anti-pruritic, and vasoconstrictive actions. However, while the physiologic, pharmacologic, and clinical effects of the corticosteroids are well known, the exact mechanisms of their actions in each disease are uncertain. Betamethasone dipropionate (Bividerm), a corticosteroid, has been shown to have topical (dermatologic) and systemic pharmacologic and metabolic effects characteristic of this class of drugs.

Pharmacokinetics

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.

Topical corticosteroids can be absorbed through normal intact skin. Inflammation and/or other disease processes in the skin may increase percutaneous absorption. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids.

Once absorbed through the skin, topical corticosteroids enter pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees, are metabolized primarily in the liver, and excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

Betamethasone dipropionate (Bividerm) (augmented), 0.05% was applied once daily at 7 grams per day for 1 week to diseased skin, in adult patients with psoriasis or atopic dermatitis, to study its effects on the hypothalamic-pituitary-adrenal (HPA) axis. The results suggested that the drug caused a slight lowering of adrenal corticosteroid secretion, although in no case did plasma cortisol levels go below the lower limit of the normal range.

Sixty-seven pediatric patients ages 1 to 12 years, with atopic dermatitis, were enrolled in an open-label, hypothalamic-pituitary-adrenal (HPA) axis safety study. Betamethasone dipropionate (Bividerm) (augmented), 0.05% was applied twice daily for 2 to 3 weeks over a mean body surface area of 58% (range 35% to 95%). In 19 of 60 (32%) evaluable patients, adrenal suppression was indicated by either a <5 mcg/dL pre-stimulation cortisol, or a cosyntropin post-stimulation cortisol <18 mcg/dL and/or an increase of < 7 mcg/dL from the baseline cortisol. Studies performed with Betamethasone dipropionate (Bividerm) (augmented), 0.05% indicate that it is in the high range of potency as compared with other topical corticosteroids.

Actions of Fusidic acid (Bividerm) in details

infoThe action of the drug on the human body is called Pharmacodynamics in Medical terminology. To produce its effect and to change the pathological process that is happening the body and to reduce the symptom or cure the disease, the medicine has to function in a specific way. The changes it does to the body at cellular level gives the desired result of treating a disease. Drugs act by stimulating or inhibiting a receptor or an enzyme or a protein most of the times. Medications are produced in such a way that the ingredients target the specific site and bring about chemical changes in the body that can stop or reverse the chemical reaction which is causing the disease.
sponsored

Fusidic acid (Bividerm) is an antibiotic which mode of action is as inhibitor of bacterial protein synthesis resulting in a bactericidal effect. Fusidic acid (Bividerm) has a powerful antibacterial activity against a number of gram-positive microorganisms. Staphylococci, including the strains resistant to penicillin, methicillin or other antibiotics, are particularly susceptible to Fusidic acid (Bividerm). Fusidic acid (Bividerm) shows no cross-resistance to any other antibiotic agent used in clinical practice.

Fusidic acid (Bividerm) has an unusually good ability to penetrate tissue and is widely distributed in the organism. It is of great clinical importance that Fusidic acid (Bividerm) provides high concentrations not only in areas well supplied with blood, but also in relatively avascular tissue.

Concentrations exceeding the minimum inhibitory concentration (MIC) for Staphylococcus aureus (0.03-0.16 mcg/mL) have been found in pus, sputum, soft tissues, heart tissues, bone tissues, synovial fluid, sequestra, burn crusts, brain abscesses and intraocularly. Fusidic acid (Bividerm) is metabolized in the liver and mainly excreted through the bile, little or none being excreted through the urine. Fusidic acid (Bividerm) is generally atoxic and shows no cross-hypersensitivity to other antibiotics in clinical use, which is why Fusidic acid (Bividerm) also can be used in many cases where other antibiotics are contraindicated eg, in patients allergic to penicillin or other antibiotics.

In severe or deep-seated infections and when prolonged therapy is required, Fusidic acid (Bividerm) should generally be given concurrently with other antistaphylococcal antibiotic therapy to minimize the risk of resistance development. Fusidic acid (Bividerm) may be combined with penicillinase-stable penicillins, cephalosporins, erythromycin, aminoglycosides, lincomycin, rifampicin or vancomycin and thus, an additive or synergistic effect is obtained.

How should I take Fusidic acid (Bividerm)?

Dosing

The dose of Fusidic acid (Bividerm) will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of Fusidic acid (Bividerm). If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (tablets):
    • Osteomyelitis (bone and joint infections) or skin and soft tissue infections:
      • Adults—500 mg (2 tablets) three times daily
  • For oral dosage form (suspension):
    • Osteomyelitis (bone and joint infections) or skin and soft tissue infections:
      • Adults—15 milliliters three times daily
      • Children—Up to 1 year of age: 1 milliliter (mL) per kilogram DAILY divided into 3 equal doses; 1 to 5 years of age is 5 mL three times daily; 6 to 12 years of age is 10 mL three times daily.
  • For injection dosage form:
    • Osteomyelitis (bone and joint infections) or skin and soft tissue infections:
      • Adults—500 milligrams three times daily
      • Children—Up to 1 year of age to 12 years: 20 milligrams/kilogram DAILY divided into 3 equal doses, infused over at least 2 hours.

Missed Dose

If you miss a dose of Fusidic acid (Bividerm), take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Fusidic acid (Bividerm) administration

infoAdministration of drug is important to know because the drug absorption and action varies depending on the route and time of administration of the drug. A medicine is prescribed before meals or after meals or along with meals. The specific timing of the drug intake about food is to increase its absorption and thus its efficacy. Few work well when taken in empty stomach and few medications need to be taken 1 or 2 hrs after the meal. A drug can be in the form of a tablet, a capsule which is the oral route of administration and the same can be in IV form which is used in specific cases. Other forms of drug administration can be a suppository in anal route or an inhalation route.

Fusidic acid (Bividerm): Should be taken with food.

Fusidic acid (Bividerm) pharmacology

infoPharmacokinetics of a drug can be defined as what body does to the drug after it is taken. The therapeutic result of the medicine depends upon the Pharmacokinetics of the drug. It deals with the time taken for the drug to be absorbed, metabolized, the process and chemical reactions involved in metabolism and about the excretion of the drug. All these factors are essential to deciding on the efficacy of the drug. Based on these pharmacokinetic principles, the ingredients, the Pharmaceutical company decides dose and route of administration. The concentration of the drug at the site of action which is proportional to therapeutic result inside the body depends on various pharmacokinetic reactions that occur in the body.

Fusidic acid (Bividerm) acts by penetrating the bacterial cell membrane and reversibly binding to the 50 S subunit of bacterial ribosomes or near the “P” or donor site so that binding of tRNA (transfer RNA) to the donor site is blocked. Translocation of peptides from the “A” or acceptor site to the “P” or donor site is prevented, and subsequent protein synthesis is inhibited. Fusidic acid (Bividerm) is effective only against actively dividing organisms. The exact mechanism by which erythmromycin reduces lesions of acne vulgaris is not fully known: however, the effect appears to be due in part to the antibacterial activity of the drug.

References

  1. DailyMed. "BETAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". https://dailymed.nlm.nih.gov/dailyme... (accessed September 17, 2018).
  2. NCIt. "Fusidic Acid: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).
  3. NCIt. "Betamethasone: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.". https://ncit.nci.nih.gov/ncitbrowser... (accessed September 17, 2018).

Reviews

The results of a survey conducted on ndrugs.com for Bividerm are given in detail below. The results of the survey conducted are based on the impressions and views of the website users and consumers taking Bividerm. We implore you to kindly base your medical condition or therapeutic choices on the result or test conducted by a physician or licensed medical practitioners.

User reports

Consumer reported administration

No survey data has been collected yet


Consumer reviews


There are no reviews yet. Be the first to write one!


Your name: 
Email: 
Spam protection:  < Type 16 here

Information checked by Dr. Sachin Kumar, MD Pharmacology

| Privacy Policy
This site does not supply any medicines. It contains prices for information purposes only.
© 2003 - 2019 ndrugs.com All Rights Reserved