Bonivit N Uses

How do you administer this medicine?

What is Bonivit N?

Reducing itching, redness, and swelling associated with skin conditions of the scalp. It may also be used for other conditions as determined by your doctor.

Bonivit N foam is a topical corticosteroid. It works by depressing the formation, release, and activity of different cells and chemicals that cause swelling, redness, and itching.

Bonivit N indications

An indication is a term used for the list of condition or symptom or illness for which the medicine is prescribed or used by the patient. For example, acetaminophen or paracetamol is used for fever by the patient, or the doctor prescribes it for a headache or body pains. Now fever, headache and body pains are the indications of paracetamol. A patient should be aware of the indications of medications used for common conditions because they can be taken over the counter in the pharmacy meaning without prescription by the Physician.

Bonivit N Foam, 0.12% is a medium potency topical corticosteroid indicated for relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses of the scalp.

How should I use Bonivit N?

Use Bonivit N foam as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Bonivit N foam.

Uses of Bonivit N in details

There are specific as well as general uses of a drug or medicine. A medicine can be used to prevent a disease, treat a disease over a period or cure a disease. It can also be used to treat the particular symptom of the disease. The drug use depends on the form the patient takes it. It may be more useful in injection form or sometimes in tablet form. The drug can be used for a single troubling symptom or a life-threatening condition. While some medications can be stopped after few days, some drugs need to be continued for prolonged period to get the benefit from it.

This medication is used to treat a variety of skin conditions (e.g., eczema, dermatitis, allergies, rash). Bonivit N reduces the swelling, itching, and redness that can occur in these types of conditions. This medication is a medium-strength corticosteroid.

How to use Bonivit N topical

Use this medication on the skin only. However, do not use it on the face, groin, or underarms unless directed to do so by your doctor.

Wash and dry your hands before using. Clean and dry the affected area. Apply a thin film of medication to the affected area and gently rub in, usually 1-3 times daily or as directed by your doctor. Do not bandage, cover, or wrap the area unless directed to do so by your doctor. If used in the diaper area on an infant, do not use tight-fitting diapers or plastic pants.

After applying the medication, wash your hands unless you are using this medication to treat the hands. When applying this medication near the eyes, avoid getting it in the eyes because this may worsen or cause glaucoma. Also, avoid getting this medication in the nose or mouth. If you get the medication in these areas, rinse with plenty of water.

Use this medication only for the condition for which it was prescribed. Do not use it for longer than prescribed.

Inform your doctor if your condition persists or worsens after 2 weeks.

Bonivit N description


Bonivit N Cream: Bonivit N contains Bonivit N 0.1% as 17-valerate in a water-miscible base.

It also contains the following excipients: Chlorocresol, macrogol cetostearyl ether, cetostearyl alcohol, white soft paraffin, liquid paraffin, sodium acid phosphate, phosphoric acid, sodium hydroxide and purified water.

Bonivit N RD Cream: Bonivit N RD Cream contains Bonivit N 0.025% as the valerate ester in a water-miscible base.

It also contains the following excipients: Cetostearyl alcohol, macrogol cetostearyl ether, white soft paraffin, liquid paraffin, chlorocresol, anhydrous disodium hydrogen phosphate, citric acid monohydrate and purified water.

Bonivit N Scalp Application: Bonivit N Scalp Application contains Bonivit N 0.1% w/w as valerate. The vehicle contains 50% of isopropyl alcohol, which has antibacterial activity. This preparation complies with the specifications for Bonivit N Scalp Application BP.

It also contains the following excipients: Carbomer, isopropyl alcohol, sodium hydroxide and purified water.

Bonivit N dosage


Bonivit N Cream/Bonivit N RD Cream: A small quantity should be applied to the affected area 2 or 3 times daily until improvement occurs. It may then be possible to maintain improvement by applying once a day or even less often or by using the appropriate ready-diluted (1 in 4) preparation Bonivit N RD Cream.

Bonivit N Cream: Bonivit N creams are especially appropriate for moist or weeping surfaces.

In the more resistant lesions eg, the thickened plaques of psoriasis on elbows and knees, the effect of Bonivit N can be enhanced, if necessary, by occluding the treatment area with polythene film. Overnight occlusion only is usually adequate to bring about a satisfactory response in such lesions thereafter, improvement can usually be maintained by regular application without occlusion.

Bonivit N RD Cream: A small amount of Bonivit N RD Cream may be applied up to 3 times daily. Bonivit N RD Cream is especially appropriate for moist or weeping surfaces.

Bonivit N Scalp Application: A small quantity of Bonivit N Scalp Application should be applied to the scalp night and morning until improvement is noticeable. It may then be possible to sustain improvement by applying once a day or less frequently.

Due to the flammable nature of Bonivit N Scalp Application, patients should avoid smoking, heat including the use of hair dryer or being near an open flame during application and immediately after use.

Children: Bonivit N is contraindicated in children <1 year.

Children are more likely to develop local and systemic side effects of topical corticosteroids and in general, require shorter courses and less potent agents than adults.

Care should be taken when using Bonivit N to ensure the amount applied is the minimum that provides therapeutic benefit.

Elderly: The greater frequency of decreased hepatic or renal function in the elderly may delay elimination if systemic absorption occurs. Therefore, the minimum quantity should be used for the shortest duration to achieve the desired clinical benefit.

Renal/Hepatic Impairment: In case of systemic absorption (when application is over a large surface area for a prolonged period), metabolism and elimination may be delayed therefore increasing the risk of systemic toxicity. Therefore, the minimum quantity should be used for the shortest duration to achieve the desired clinical benefit.

Bonivit N interactions

See also:
What other drugs will affect Bonivit N?

Concurrent use of barbiturates, carbamazepine, phenytoin, primidone or rifampicin may enhance the metabolism and reduce the effects of systemic corticosteroids. Conversely, oral contraceptives or ritonavir may increase plasma concentrations of corticosteroids.

Use of corticosteroids with potassium-depleting diuretics eg, thiazides or furosemide may cause excessive potassium loss. There is also an increased risk of hypokalemia with concurrent amphotericin B or bronchodilator therapy with xanthines or β2 agonist.

There may be an increased incidence of gastrointestinal bleeding and ulceration when corticosteroids are given with NSAIDs. Corticosteroids may alter response to anticoagulants increasing requirements of antidiabetic drugs and antihypertensives.

Corticosteroids may decrease serum concentrations of salicylates and may decrease the effect of antimuscarinics in myasthenia gravis.

Bonivit N side effects

See also:
What are the possible side effects of Bonivit N?

The most frequent adverse event was burning/itching/ stinging at the application site; the incidence and severity of this event were as follows:

Incidence and severity of burning/itching/stinging


Total incidence

Maximum severity




Bonivit N Foam, 0.12%


34 (54%)

28 (44%)

5 (8%)

1 (2%)

Bonivit N

Valerate Lotion


33 (52%)

26 (41%)

6 (10%)

1 (2%)

Placebo Foam


24 (75%)

13 (41%)

7 (22%)

4 (12%)

Placebo Lotion


20 (67%)

12 (40%)

5 (17%)

3 (10%)

Other adverse events which were considered to be possibly, probably, or definitely related to Bonivit N Foam, 0.12% occurred in one patient each; these were paresthesia, pruritus, acne, alopecia, and conjunctivitis.

The following additional local adverse reactions have been reported with topical corticosteroids, and they may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximately decreasing order of occurrence: irritation, dryness, folliculitis, acneiform eruptions hypopigmentation, perioral dermatitis, allergic contact dermatitis, secondary infection, skin atrophy, striae, and miliaria.

Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing’s syndrome, hyperglycemia, and glucosuria in some patients.

Bonivit N contraindications

See also:
What is the most important information I should know about Bonivit N?

Hypersensitivity to Bonivit N or to any of the ingredients of Bonivit N Cream/Bonivit N RD Cream/Bonivit N Scalp Application.

Bonivit N is contraindicated in dermatoses in infants <1 year, including dermatitis.

Bonivit N Cream/Bonivit N RD Cream: Rosacea; acne vulgaris; perioral dermatitis; perianal and genital pruritus; pruritus without inflammation; primary cutaneous viral infections (eg, herpes simplex, chickenpox).

The use of Bonivit N Cream/Bonivit N RD Cream is not indicated in the treatment of primarily infected skin lesions caused by infection with fungi or bacteria.

Bonivit N Scalp Application: Infections of the scalp.

Active ingredient matches for Bonivit N:

Betamethasone Valerate

Unit description / dosage (Manufacturer)Price, USD
Bonivit N Skin 20 gm Ointment$ 0.31

List of Bonivit N substitutes (brand and generic names):

Betnovate Scalp Application topical soln 0.1% 30 mL x 1's (GlaxoSmithKline)
Cream; Topical; Betamethasone Valerate 0.1% (Essex)
Ointment; Topical; Betamethasone Valerate 0.1% (Essex)
Celestoderm-V 30 gr - 1 Cream (Essex)$ 15.60
Celestoderm-V 30 gr - 1 Ointment (Essex)$ 15.60
Celestoderm-V 0.1 % x 5 g x 1's (Essex)$ 4.14
Celestoderm-V 0.1 % x 10 g x 1's (Essex)$ 6.62
Celestoderm-V 1 tube 15 g (Essex)
Clinivate Cream 0.1 % x 5 g (Bangkok Lab & Cosmetic)
Clinivate Cream 0.1 % x 450 g (Bangkok Lab & Cosmetic)
Clinivate cream 0.1 % 5 g x 1's (Bangkok Lab & Cosmetic)
Clinivate cream 0.1 % 450 g x 1's (Bangkok Lab & Cosmetic)
Derzid cream 0.1 % 15 g x 1's (Unison)
Derzid cream 0.1 % 450 g x 1's (Unison)
Fusigen B Skin 10 gm Cream (Geno Pharmaceuticals Ltd.)$ 0.76
FUSIGEN B 0.1%/0.2% OINTMENT 1 tube / 10 GM ointment each (Geno Pharmaceuticals Ltd.)$ 0.90
Fusigen B 0.1%/2% Ointment (Geno Pharmaceuticals Ltd.)$ 0.09
Fuzi B Skin 10 gm Cream (Adips Laboratories Ltd.)$ 1.02
FUZI B CREAM 1 tube / 10 GM cream each (Adips Laboratories Ltd.)$ 1.22
Genbeta 10 g
Genderon Cream 1 g
Genderon Cream 5 g
Genderon Cream 10 g
Innodesone 0.1 % x 5 g$ 3.64
Kingderm 5 gm Cream (Acron Pharmaceuticals)$ 0.07
Kupderma 1 tube 20 g
Medskin Betamethason 1.2 mg/1 g x 1 tube 5 g
Medskin Betamethason 1.2 mg/1 g x 1 tube 10 g
Medskin Betamethason 1.2 mg/1 g x 1 tube 15 g
Qiliderm Skin 15 gm Cream (Universal Pharma)$ 0.67
Qiliderm Skin 5 gm Cream (Universal Pharma)$ 0.33


  1. DailyMed. "BETAMETHASONE: DailyMed provides trustworthy information about marketed drugs in the United States. DailyMed is the official provider of FDA label information (package inserts).". (accessed September 17, 2018).
  2. PubChem. "betamethasone". (accessed September 17, 2018).
  3. DrugBank. "betamethasone". (accessed September 17, 2018).


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Information checked by Dr. Sachin Kumar, MD Pharmacology

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